
- •Section I Control of the initial level of knowledge. Biochemical constituents of the cell. Methods of biochemical investigations.
- •Examples of Krok 1 tests
- •Clinical cases and Situational tasks
- •77. Discribe the method, shown at the picture below:
- •78. Discribe the method, shown at the picture below:
- •Section іі Enzymes, structure and classification. Regulation of metabolism
- •Е. Whatever part of polypeptide chain of enzyme molecule.
- •Substrate concentration at which reaction rate is half maximal
- •The second enzyme has higher affinity to substrate
- •Competitive
- •Examples of Krok 1 tests
- •Cysteine
- •B. Amylase
- •Peptidases
- •Enteropeptidase
- •Clinical cases and Situational tasks
- •Section ііi Metabolic pathways and bioenergetics. Tricarboxylic acid cycle. Biological oxidation and oxidative phopshorylation
- •1. When atp forms amp:
- •B. Protons
- •Examples of Krok 1 tests
- •Clinical cases and Situational tasks
- •Section іv Structure and metabolism of carbohydrates
- •19. Chose the reaction of glycolysis catalyzed by an enzyme phosphofructokinase:
- •A. Liver
- •Examples of Krok 1 tests
- •Acetoacetate, β-hydroxybulyrate, and acetone
- •Clinical cases and Situational tasks
- •Section іv Structure and metabolism of lipids
- •Examples of Krok 1 tests
- •143. A patient with high rate of obesity was advised to use carnitine as a food additive in order to enhance "fat burning". What is the role of carnitine in the process of fat oxidation?
- •144. Lipids are obvious energetic material for the body. What is the main pathway of fatty acids metabolism in mitochondria?
- •Clinical cases and Situational tasks Situational tasks
- •179. The patient is observed an allocation of undigested fat in the faeces. What are the possible causes for this?
- •184. Free cholesterol can affect cholesterol metabolism in the body by inhibiting cholesterol biosynthesis. By which step free cholesterol can inhibit its biosynthesis?
- •186. Explain the mechanism of phospholipids breakdown, shown at the scheme below:
- •Section VI Structure and metabolism of amino acids
- •B. Amylase
- •Examples of Krok 1 tests
- •112. According to clinical indications a patient was administered pyridoxal phosphate. What processes is this medication intended to correct?
- •Clinical cases and Situational tasks
- •145. In a patient 10 g of urine per day is excreted. Evaluate this result.
- •151. Skin color is the aggregate result of the expression of a number of genes modified by ethnic origin and genetic inheritance. What can cause the hypopigmentation?
- •Section VII Principles of molecular biology and molecular genetics
- •Examples of Krok 1 tests
- •Clinical cases and Situational tasks
- •108. List and describe properties of the genetic code.
- •113. Fill in the blanks.
- •114. Put the numbers of the enzymes on their place in the picture. Using arrows indicate the direction of replication and direction of synthesis of leading and lagging strands.
- •Section VIII Molecular mechanisms of hormone action on target cells. Biochemistry of hormonal regulation
- •Examples of Krok 1 tests
- •78. For analgesia, a certain substance which imitates the physiological properties of morphine but is synthesized inside the human brain can be used. Name this substance.
- •80. A patient suffering from rheumatism was administered glucocorticoid therapy. What changes in carbohydrate metabolism in liver can be expected?
- •88. In blood of a patient a hypercalcemia, hypophosphatemia, in urine – hyperphosphaturia is observed. What is a possible cause of this state?
- •90. In 13 years old girl a hypotension and polyuria is observed. Preliminary diagnosis – diabetes insipidus. It is caused by deficiency of:
- •93. Signaling via prostanoids begins by interaction of the prostanoid with its receptor. The receptor involved is usually located in which part of the cell?
- •Clinical cases and Situational tasks
- •97. In 13 years old girl a hypotension and polyuria is observed. Preliminary diagnosis – diabetes insipidus. Which hormone deficiency can cause this disease?
- •99. The thyroid hormones t3 and t4 are synthesized in the follicular cells of the thyroid gland. From which of the following essential amino acids are the thyroid hormones synthesized?
- •101. Name types of signalling:
- •Section IX Biochemistry of the nervous tissue
- •С. Ketone bodies
- •24. What compound may be used by the cns cells after extensive physical exercises and prolonged starvation?
- •Examples of Krok 1 tests
- •Clinical cases and Situational tasks
- •114. Describe the structure of a synapse and explain how it operates?
- •Section X Biochemistry of the Muscular tissue
- •D. Glycogenolysis in muscles
- •С. Fatigue faster compared to the red fibers
- •Examples of Krok 1 tests
- •Clinical cases and Situational tasks
- •Section XI Biochemistry of nutrition
- •1. Note substance, which activates pepsinogen to pepsin:
- •2. Chose the enzyme which plays an important role in production of hydrochloric acid by parietal cells of gastric mucosa glands:
- •3. Which of the following is not a function of the pancreas?
- •Examples of Krok 1 tests
- •Clinical cases and Situational tasks
- •62. The clinical and laboratory examination of the patient evaluated the presence of the lactic acid in his gastric juice. What does it indicate? What should be recommended to the patient?
- •69. Discribe the mechanism of hydrochloric acid production shown at the picture:
- •Section XII Functional role of water soluble and fat soluble vitamins in metabolism and providement of cell functions
- •Examples of Krok 1 tests
- •Clinical cases and Situational tasks
- •100. A deficiency in thiamine (vitamin b1) would most likely lead to which clinical manifestations?
- •Section XIII Biochemistry and pathobiochemistry of blood
- •Examples of Krok 1 tests
- •Clinical cases and Situational tasks
- •89. The blood clotting cascade in humans is represented in the picture below. Using this scheme answer the following questions:
- •Section XIV Functional and clinical biochemistry of liver tissue. Biotransformation of xenobiotics and endogenous toxic compounds
- •Examples of Krok 1 tests
- •Clinical cases and Situational tasks
- •Section XV Water and mineral metabolism
- •Examples of Krok 1 tests
- •Clinical cases and Situational tasks
- •Section XVI Functional role of kidneys in urinogenesis. Normal and pathological constituents of urine
- •Examples of Krok 1 tests
- •Clinical cases and Situational tasks
- •Section XVII Biochemical constituents of connective tissue
- •Examples of Krok 1 Tests
- •Clinical cases and Situational tasks
- •34. Patient with burn disease is at the risk of formation of blood clots in blood vessels. What glycosaminoglycan may be used to prevent formation of blood clots?
- •Section XVIII Biochemistry of saliva and tooth tissue
- •Examples of Krok 1 tests
- •Clinical cases and Situational tasks
- •Section XIX. Biochemical reactions
- •References:
Examples of Krok 1 tests
46. In a patient in the course of the investigation of gastric juice lactic acid was detected. The latter was detected by:
A. Uffelman reaction
B. Benzidine test
C. Urease test
D. Resorcinol test
E. Fehling test
47. In a patient in the course of the clinical and laboratory investigation in gastric juice a compound was detected, suggesting a malignant tumor in stomach. This compound may be:
A. Lactic acid
B. Pepsin
C. Pepsinogen
D. Rennin
E. Castle intrinsic factor
48. In a child, consuming a meal of plant origin exclusively after some period a growth retardation, anemia and kidney impairment were observed. The cause of this state is deficiency in diet of the next nutrients:
A. Essential amino acids
B. Carbohydrates
C. Lipids
D. Mineral macroelements
E. Carotene
49. In a patient an insufficiency of enzyme production in gastric mucosa was recognized. The investigation of what enzyme will be not informative in gastric diseases in adults?
A. Rennin
B. Pepsin A
C. Uropepsin
D. Gastricsin
E. Pepsin B
50. An inborn baby after feeding with breast milk manifested dyspepsia, vomiting. These symptoms disappeared after feeding with glucose solution. The lack of what enzyme, participating in carbohydrates digestion, causes these disturbances?
Lactase
Maltase
Sucrase
Amilase
Isomaltase
51. The child after consumption of fresh milk developed disorders of the digestive tract whereas consumption of the other products, containing carbohydrates, does not cause these symptoms. The genetically mediated lack of what enzyme may be the reason of these disorders?
Lactase
Phosphoglucomutase
Glycogensynthase
Hexokinase
Glucose-6-phosphate-isomerase
52. A dentist with the aim of plague prophylaxis administered a 2 year child a medication, containing:
А. F
В.J
С. Br
D. Fe
Е. Mn
53. A patient, living in the mountain region, has an enlarged thyroid gland. This is most evidently caused by the deficiency of the following trace element in food:
А. J
В. Br
С. F
D. Fe
Е. Mn
54. In a patient an enhanced level of total bilirubin in blood was detected, in urine bilirubin glucuronides were detected, fecal stercobilin content was decreased. What vitamins insufficiency can be suggested in this case?
A.B1 , B2 .
B.PP, C
C.K
D.H, N (lipoic acid)
E. B15 (pangamic acid).
55. In dietary deficiency or insufficient production of endogeneous lipotropic factors in humans is developing fat liver degeneration. What substances from listed below can be considered as lipotropic factor?
A. Choline
B.Pyridoxine
C.Triacylglycerols
D.Cholesterol
E. Fatty acids
56. A sick child manifested the enlargement of abdomen, curvature of lower limbs, skul enlargement, general weakness. What nutrient insufficiency can cause the developement of such manifestations?
A. Vitamin D
B. Carbohydrates
C.Vitamin C
D.Iron
E.Lipids
57. A patient complains for a loss of weight, general weakness, bleeding of gums, loosening and hasitation and fall out of teeth. What vitamin deficiency is observed in a patient?
A. Ascorbic acid
B.Pyridoxine
C.Phylloquinone
D. Cyanocobalamine
E.Tocoferol
58. In treatment of gastric ulcer besides conventional drugs it is recommended to drink juice from fresh cabbage. What substance in this nutritional product favors healing of ulcer?
A. Vitamin U
B. Pyridoxine
C. Vitamin H
D. Vitamin B15
E. Vitamin P (bioflavonoids)
59. In the piece of gastric mucosa, excised from the patient with gastric ulcer disease, Helicobacter pylori was detected. What enzyme can be detected simultaneously in the tissue specimen?
A. Urease
B. Dehydrogenase
C. Alanine AT
D. Aspartate AT
E. Carboxypeptidase