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Examples of Krok 1 tests

93. Examination of a patient suffering from cancer of urinary bladder revealed high rate of serotonin and hydroxyanthranilic acid. It is caused by excess of the following amino acid in the organism:

A. Tryptophan

B. Alanine

C. Histidine

D. Methionine

E. Tyrosine

94. High levels of serotonin and 3-oxianthranilate are revealed in the blood of a patient suffering from urinary bladder cancer. By the disturbance of the metabolism of what amino acid is it caused?

A. Tryptophan.

B. Alanine.

C. Histidine.

D. Methionine.

E. Tyrosine.

95. Glutamate decarboxylation results in formation of inhibitory transmitter in CNS. Name it:

A. GABA

B. Glutathione

C. Histamine

D. Serotonin

E. Asparagine

96. Biochemical function of glutathion in an organism is connected with reduction and detoxification of organic peroxides. During an interaction of glutathion with hydroperoxides harmless organic alcohols are formed with subsequent further oxidation. Indicate an amino acid composing glutathion.

  1. Glutamate

  2. Valine

  3. Lysine

  4. Isoleucine

  5. Tryptophan

97. A patient diagnosed with carcinoid of bowels was admitted to the hospital. Analysis revealed high production of serotonin. It is known that this substance is formed of tryptophane aminooacid. What biochemical mechanism underlies this process?

A. Decarboxylation

B. Desamination

C. Microsomal oxydation

D. Transamination

E. Formation of paired compounds

98. A patient with a cranial trauma manifests repeated epileptoid seizures. The biosynthesis of what biogenic amine is disturbed in this clinical situation?

A. GABA

B. Histamine

C. Adrenaline

C. Serotonin

E. Dopamine

99. 12 hours after an accute attack of retrosternal pain a patient presented a jump of aspartate aminotransferase activity in blood serum. What pathology is this deviation typical for?

A. Myocardium infarction

B. Viral hepatitis

C. Collagenosis

D. Diabetes mellitus

E. Diabetes insipidus

100. In experimental animals hold prolonged time on protein free diet, a fat degeneration of liver has been developed. The possible cause may be insufficiency of methylating agents. Indicate an amino acid, donor of methyl groups

  1. Methionine

  2. Phenylalanine

  3. Lysine

  4. Cysteine

  5. Arginine

101. The product of oxidase reactions is hydrogen peroxide, a very toxic substance for cells. An important role in its reduction plays glutathion. Indicate an amino acid present in glutathion structure.

  1. Cysteine

  2. Serine

  3. Alanine

  4. Aspartate

  5. Thyrosine

102. Biogenic amines, namely histamine, serotonin, dopamine etc., are very active substances that affect markedly various physiological functions of the organism. What biochemical process is the principal pathway for biogenic amines production in body tissues?

A. Decarboxylation of amino acids.

B. Deamination of amino acids.

C. Transamination of amino acids.

D. Oxidation of amino acids.

E. Reductive animation.

103. In diagnostics of an acute viral hepatitis estimation of the next enzymatic activity in blood serum is the most valuable:

A. Alanyl aminotransferase

B. Glutathion peroxidase

C. Creatine kinase

D. Amylase

E. Alkaline phosphatase

104. In psychiatric practice, biogenic amines and their derivatives arc used for the treatment of certain diseases of the central nervous system. Name the substance of the mentioned below biochemical class which acts as an inhibitory mediator.

A. GABA.

B. Histamine.

C. Serotonin.

D. Dopamine.

E. Taurine.

105. In human body are synthesized 10 amino acids only from 20 ones needed for protein biosynthesis. What amino acid from listed below is produced in human body?

  1. Tyrosine

  2. Histidine

  3. Lysine

  4. Methionine

  5. Phenylalanine

106. In course of histidine catabolism a biogenic amine is formed that has powerful vasodilatating effect. Name it:

A. Histamine

B. Serotonin

C. Dioxyphenylalanine

D. Noradrenalin

E. Dopamine

107. In clinical practice for parentheral nutrition a protein hydrolysate is used. Amino acid constituents of such hydrolysate were separated with the aid of paper chromatography into acidic and basic. Chose an acidic amino acid from listed below:

A. Aspartate

B. Threonine

C. Serine

D. Glycine

E. Lysine

110. A 7-year-old child was admitted to an emergency clinic in the state of allergic shock provoked by a wasp sting. High concentration of histamine was determined in the patient's blood. Which biochemical reaction leads to the production of this amine?

A. Decarboxylation.

B. Hydroxylation.

C. Dehydration.

D Deamination.

E. Reduction.

111. During hypersensitivity test a patient got subcutaneous injection of an antigen which caused reddening of skin, edema, pain as a result of histamine action. This biogenic amine is generated as a result of transformation of the following histidine amino acid:

A. Decarboxylation

B. Methylation

C. Phosphorylation

D. Isomerization

E. Deaminization

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