Section іv Structure and metabolism of lipids

1. Essential fatty acids cant by synthesized because mammals do not possess the enzymes for their biosynthesis. Which of the following is an essential fatty acid:

1. Linoleic acid

2. Palmitic acid

3. Oleic acid

4. Steraric

5. Butyric

2. Phosphoglycerides are complex lipids, represented by:

1. Phosphatidylcholine

2. Sphingomyelin

3. Galactocerebroside

4. Thromboxane A

5. Ganglioside GM-2

3. Sphingomyelin contains residues of the following substance:

1. Sphingosine

2. Glycerol

3. Galactose

4. Inositol

5. Sulfuric acid

4. Glycolipids contain the following constituent:

1. Glycerol

2. Sulfuric acid

3. Sialic acid

4. Phosphoric acid

5. Choline

5. Cholesterol is a starting material for biosynthesis of:

A. Bile acids

B. N-acetyl-galactosamine

C. Lecithin

D. Prostaglandins

E. Sphingomyelin

6. Gangliosides have the following physiological significance:

1. Provide hydrophilic and negative charge to the cell surface.

2. Are used as energetic material

3. Activate transcription processes in cell nucleus

4. Catalyze the cleavage of proteins in cell cytoplasm

5. Are involved in activation of amino acids.

7. The following constituent is incorporated into gangliosides:

1. Ceramide

2. Serine.

3. Glycerol

4. Choline

5. Phosphoric acid

8. Phosphatidylinositol has the following functional significance:

1. Produces inositol phosphates as secondary messengers of hormones

2. Serves as an energetic material

3. Is a constituent of inner mitochondrial membrane

4. Regulates folding of DNA in nuclear chromatin

5. Induce phosphorylation of glucose

9. Ceramide is:

1. A derivative of sphingosine and fatty acid

2. A derivative of glycerol and fatty acid

3. Composed of fatty acid and several monosaccharide residues

4. Involving phosphate residue as a constituent

5. A compound with macroergic bond

10. Fatty acids differ from one another due to differences in:

1. All of the above

2. The number of carbon atoms

3. The degree of saturation

4. The number of double bond

11. Arachidonic acid as essential nutrient is needed for normal growth and development of animal and man. It is a precursor of biologically active substances. Indicate what compound is synthesized from arachidonic acid:

1. Prostaglandine E₁

2. Ethanolamine

3. Triiodothyronine

4. Choline

5. Noradrenalinе

12. Triacylglycerols:

1. In the average individual, represent sufficient energy to sustain life for several weeks.

2. Would be expected to be good emulsifying agents.

3. Yield about the same amount of ATP on complete oxidation as would an equivalent weight of glycogen.

4. Are stored as hydrated molecules.

5. Are generally negatively charged molecules at physiological pH.

13. All of the following statements describe phosphoglycerides EXCEPT:

1. They are a major store of metabolic energy

2. They are both amphipathic and amphoteric

3. They arise from glycerol-3-phosphate

4. They are found in cell membranes

5. They contain two fatty acid moieties

14. Chose the lipid related compound which is primarily used as a source of metabolic energy:

1. Ketone bodies

2. Phosphoglycerides

3. Steroids

4. Sphingomyelin

5. Triglycerides

15. Chose from listed below a hormone, which stimulates the formation of glycogen and triacylglycerols:

1. insulin

2. norepinephrine

3. glucagons

4. epinephrine

5. thyroxine

16. What bioactive compound (tissue hormone) is derived from 5-hydroperoxy eicosatetraenoic acid (5-HPETE) and modulates a variety of biologic functions?

1. Leukotriene

2. Prostaglandin E₂

3. Thromboxane

4. Glucocorticoid

5. Sphingomyelin

17. What compound of lipid nature may contain a carbohydrate moiety and is presented in most cell membranes?

1. Ganglioside GM₂

2. Sphingomyelin

3. Phosphatydylserine

4. Cholesterol

5. Leukotrienes

18. Lipids are the most valuable energetic material for an organism. What is the main pathway of fatty acids metabolism in cell mitochondria?

1. –oxidation

2. Decarboxylation

3. Reduction

4. -oxidation

5. -oxidation

19. In digestion of dietary lipids there is a need of one of the digestive secretions. What secretion listed below takes part in lipids emulsification?

A. Bile

B. Intestinal juice

C. Pancreatic juice

D. Saliva

E. Gastric juice

20. Phospholipids are important cell membrane components because:

1. They have both polar and non polar portions

2. They have glycerol

3. They can form bilayers in water

4. They combine covalently with proteins

5. They consist of fatty acids

21. Dietary fats after absorption appear in the circulation as:

1. Chylomicron

2. HDL

3. VLDL

4. LDL

5. Free fatty acids

22. Which one of the following is not a phospholipids:

1. Lysolecithin

2. Lecithin

3. Plasmalogen

4. Phosphatidylinositol

5. Phosphatydylethanolamine

23. Lipids have the following properties:

1. All of these

2. Insoluble in water and soluble in fat solvent

3. High energy content

4. Structural component of cell membrane

5. Precursors in biosynthesis of prostaglandins

24. Indicate which from listed below disorders of lipid metabolism occur in fat tissue:

A. Obesity

B. Steatorrhea

C. Ketosis

D. Retention hyperlipemia

E. Fatty infiltration of liver

25. Hepatic liponenesis is stimulated by:

1. Insulin

2. cAMP

3. Glucagon

4. Epinephrine

5. Cortisol

26. Pancreatic lipase converts triacylglycerols into:

1. 2-Monoacylglycerol

2. 2, 3-Diacylglycerol

3. 1-Monoacylglycerol

4. 3-Monoacylglycerol

5. 1, 3-Diacylglycerol

27. Lipids are stored in the body mainly in the form of:

1. Triglycerides

2. Glycolipids

3. Phospholipids

4. Fatty acids

5. Steroids

28. Pancreatic lipase requires for its activity:

1. Co-lipase

2. Bile salts

3. Phospholipids

4. Amino acids

5. All of these

29. Waxes contain higher alcohols named as:

1. Cetyl

2. Methyl

3. Ethyl

4. Phytyl

5. Propionyl

30. β -Galactosidase is deficient in:

1. Krabbe’s disease

2. Fabry’s disease

3. Gaucher’s disease

4. Metachromatic leukodystrophy

5. Tay-sach’s disease

31. Bile acids are necessary for fat digestion. They are produced in the liver from the next precursor:

1. Cholesterol

2. Protoporphyrine IX

3. Corticosterol

4. Lecithin

5. Arachidonic acid

32. Adipose tissue lacks:

1. Glycerol kinase

2. Hormone-sensitive lipase

3. cAMP-dependent protein kinase

4. Glycerol-3-phosphate dehydrogenase

33. Which one of the following enzymes is NOT involved in the degradation of dietary lipids during digestion?

A. Lipoprotein lipase;

B. Pancreatic lipase;

C. Gastric lipase;

D. Phospholipase A₂;

E. Cholesterol ester hydrolase

34. Free fatty acids are transported in the blood:

1. Combined with albumin

2. Combined with fatty acid binding protein

3. Combined with β -lipoprotein

4. In unbound free salts

5. Combined with globulin

35. Which one of the following substances is an intermediate in the synthesis of both glycerol-containing phospholipids and triacylglycerol?

A. Phosphatidic acid

B. Choline

C. Acetoacetyl CoA;

D. CDP-Ethanolamine

E. 3-Hydroxyburyrate

36. The nitrogenous base in lecithin is:

1. Choline

2. Ethanolamine

3. Serine

4. Betaine

5. Alanine

37. The next substance is known as bile acid:

A. Taurocholate

B. Succinate

C. Lignoceric acid

D. Mevalonate

E. Phosphatidic acid

38. Lipid stores are mainly present in:

1. Adipose tissue

2. Liver

3. Brain

4. Muscles

5. Kidneys

39. Co-lipase is a:

1. Protein

2. Vitamin

3. Bile salt

4. Phospholipid

5. Amino acid

40. Number of carbon atoms in cholesterol is:

1. 27

2. 17

3. 19

4. 30

5. 35

41. Hexosaminidase A is deficient in:

1. Tay-Sachs disease

2. Gaucher’s disease

3. Niemann-Pick disease

4. Fabry’s disease

42. The form in which most dietary lipids are packaged and exported from the intestinal mucosa cells is as follows:

A. Chylomicrons

B. Mixed micelles

C. Free triacylglycerol

D.2-monoacylglycerol

E. Free fatty acids

43. Characteristic finding in Gaucher’s disease is:

1. Hepatosplenomegaly

2. Night blindness

3. Renal failure

4. Deafness

5. Nephropathy

44. The intermediates in fatty acid synthesis are linked to acyl carrier protein (ACP), a component of fatty acid synthase. The prosthetic group of ACP is:

1. phosphopantetheine

2. methionine

3. thiamine

4. biotin

5. Cobalamin

45. Chylomicron remnants are catabolised in:

1. Liver

2. Adipose tissue

3. Intestine

4. Liver and intestine

5. Kidneys

46. Adipose tissue responds to low insulin/glucagon ratio by:

1. Stimulating hormone-sensitive lipase.

2. Dephosphorylating the interconvertible enzymes.

3. Stimulating the deposition of fat.

4. Increasing the amount of pyruvate kinase.

5. Stimulating phenylalanine hydroxylase

47. In adipose tissue, glycerol-3-phosphate required for the synthesis of triglycerides comes mainly from:

1. Dihydroxyacetone phosphate formed in glycolysis

2. Hydrolysis of pre-existing triglycerides

3. Hydrolysis of phospholipids

4. Free glycerol

5. Cholesterol

48. Glycerol released from adipose tissue by hydrolysis of triglycerides is mainly:

1. Taken up by liver

2. Taken up by extrahepatic tissues

3. Reutilised in adipose tissue

4. Excreted from the body

49. Mental retardation occurs in:

1. All of these

2. Tay-Sachs disease

3. Gaucher’s disease

4. Niemann-Pick disease

50. Free glycerol cannot be used for triglyceride synthesis in:

1. Adipose tissue

2. Liver

3. Kidney

4. Intestine

51. The rate-limiting step of fatty acid synthesis is catalyzed by:

1. acetyl-CoA carboxylase

2. ATP-citrate lyase

3. acyl-CoA synthetase

4. Malic enzyme

5. malonyl transacylase

52. Long chain fatty acids are first activated to acetyl-CoA in:

1. Cytosol

2. Microsomes

3. Nucleus

4. Mitochondria

5. Ribosome

53. β-Oxidation of fatty acids:

1. Occurs by a repeated sequence of four reactions

2. Generates ATP in reactions of substrate level phosphorylatin.

3. Is controlled primarily by allosteric effectors.

4. Uses only even-chain, saturated fatty acids as substrates.

5. Uses NADP.

54. One functional sub-unit of multi-enzyme complex for de novo synthesis of fatty acids contains:

1. Two —SH groups

2. One —SH group

3. Three —SH groups

4. Four —SH groups

5. Five —SH groups

55. The enzyme acyl-CoA synthase catalyses the conversion of a fatty acid of an active fatty acid in the presence of:

A. ATP

B. ADP

C. AMP

D. GTP

E. UDP

56. The high glucagon/insulin ratio seen in starvation:

1. All of the above

2. Stimulates -oxidation by inhibiting the production of malonyl CoA.

3. Leads to increased concentrations of ketone bodies in the blood.

4. . Promotes mobilization of fatty acids from adipose stores.

5. None of the above.

57. Long chain fatty acids penetrate the inner mitochondrial membrane:

A. As carnitine derivative

B. As acyl-CoA derivative

C. Requiring Na dependent carrier

D. Freely

E. Requiring Ca dependent carrier

58. De novo synthesis of fatty acids occurs in:

A. Cytosol

B. Mitochondria

C. Microsomes

D. All of these

E. None of these

59. Acyl Carrier Protein contains the vitamin:

A. Pantothenic acid

B. Lipoic acid

C. Biotin

D. Folic acid

E. Ascorbic acid

60. Which of the following is required as a reductant in fatty acid synthesis?

A. NADPH

B. NADH

C. FADH₂

D. FMNH₂

E. FAD

61. An enzyme required for the synthesis of ketone bodies as well as cholesterol is:

A. HMG CoA synthetase

B. Acetyl CoA carboxylase

C. HMG CoA reductase

D. HMG CoA lyase

E. HMG CoA dehydrogenase

62. Ketone bodies are synthesized in:

A. Liver

B. Adipose tissue

C. Muscles

D. Brain

E. Kidney

63. Carnitine is required for the transport of:

A. Long chain fatty acids into mitochondria

B. Triglycerides into mitochondria

C. Short chain fatty acids into mitochondria

D. Triglycerides out of liver

E. Glycerol into cytosol

64. What process of lipid metabolism requires a protein with covalently bound prosthetic group derived from pantothenic acid?

1. Fatty acid biosynthesis

2. β-Oxidation of fatty acids

3. Utilization of ketone bodies

4. Bile acid synthesis from cholesterol

5. Utilization of LDL

65. Net ATP generation on complete oxidation of stearic acid is:

A. 146

B. 131

C. 129

D. 148

E. 159

66. Refsum’s disease results from a defect in the following pathway except:

A. Beta-oxidation of fatty acids

B. Alpha-oxidation of fatty acids

C. Gamma-oxidation of fatty acids

D. Omega-oxidation of fatty acids

E. Delta-oxidation of fatty acids

67. The removal of two- carbon units from a fatty acyl coenzyme A (fatty acyl CoA) involves four sequential reactions. Which of the following best describes the reaction sequence?

1. Dehydrogenation, hydratation, dehydrogenation, cleavage

2. Oxidation, dehydration, oxidation, cleavage

3. Reduction, dehydration, reduction, cleavage

4. Hydrogenation, dehydration, hydrogenation, cleavage

5. Reduction, hydration, dehydrogenation, cleavage

68. The enzymes of β-oxidation are found in:

A. Mitochondria.

B. Cytosol.

C. Golgi apparatus.

D. Nucleus.

E. Microsomes.

69. During each cycle of β-oxidation:

A. Two carbon atoms are removed from the carboxyl end of the fatty acid

B. One carbon atom is removed from the methyl end of the fatty acid

C. One carbon atom is removed from the carboxyl end of the fatty acid

D. Two carbon atoms are removed from the methyl end of the fatty acid

Е. Three carbon atom is removed from the methyl end of the fatty acid

70. Obesity generally reflects excess intake of energy and is often associated with the development of:

1. Non-insulin dependent diabetes mellitus

2. Nervousness

3. Hepatitis

4. Colon cancer

71. Net generation of energy on complete oxidation of palmitic acid is:

A. 129 ATP equivalents

B. 131 ATP equivalents

C. 146 ATP equivalents

D. 148 ATP equivalents

E. 159 ATP equivalents

72. NADPH required for fatty acid synthesis can come from:

A. Hexose monophosphate shunt

B. Oxidative decarboxylation of malate

C. Extramitochondrial oxidation of isocitrate

D. Citric acid cycle

E. All of these

73. Citrate stimulates fatty acid synthesis by all of the following EXCEPT:

1. Participating in the production of ATP.

2. Allosterically activating acetyl-CoA carboxylase.

3. Providing a mechanism to transport acetyl CoA from the mitochondria to the cytosol.

4. Participating in a pathway that ultimately produces CO₂ and NADPH in the cytosol.

74. What process of lipid metabolism requires a protein with covalently bound prosthetic group derived from pantothenic acid?

1. Fatty acid biosynthesis

2. β-Oxidation of fatty acids

3. Utilization of ketone bodies

4. Bile acid synthesis from cholesterol

5. Utilization of LDL

75. De novo synthesis and oxidation of fatty acids differ in the following respect:

A. Synthesis occurs in cytosol and oxidation in mitochondria

B. Synthesis is decreased and oxidation increased by insulin

C. NADH is required in synthesis and FAD in oxidation

D. Malonyl CoA is formed during oxidation but not during synthesis

76. De novo synthesis of fatty acids requires all of the following except:

A. NADPH

B. NADH

C. Panthothenic acid

D. ATP

E. Biotin

77. Carnitine is synthesized from:

A. Lysine and methionine

B. Glycine and arginine

C. Aspartate and glutamate

D. Proline and hydroxyproline

E. Lysine and arginine

78. Acetyl CoA carboxylase regulates fatty acid synthesis by which of the following mechanism?

A. All of these

B. Covalent modification

C. Induction and repression

D. Allosteric regulation

E. None of these

79. β-Oxidation of fatty acids requires all the following coenzymes except:

A. NADP

B. FAD

C. NAD

D. CoA

80. Carboxylation of acetyl-CoA to malonyl-CoA takes place in the presence of:

A. Biotin

B. FAD

C. NAD⁺

D. NADP⁺

E. GTP

81. Malonyl-CoA reacts with the central:

A. -SH group

B. -NH₂ group

C. -COOH group

D. -CH₂OH group

E. –OH group

82. Propionyl CoA is formed on oxidation of:

A. Fatty acids with odd number of carbon atoms

B. Polyunsaturated fatty acids

C. Monounsaturated fatty acids

D. Fatty acids with even number of carbon atoms

E. None of these

83. Which of the following can be used as a source of energy in extrahepatic tissues?

A. Acetoacetate

B. Acetone

C. Both (A) and (B)

D. None of these

84. During the prolonged starvation in blood of a person an increase in ketone bodies content occurs. It is caused by the next factors:

1. Production of acetyl-CoA.

2. Decrease of free fatty acid level in blood plasma

3. Mobilization of high density lipoproteins

4. Enhancment of fatty acids biosynthesis in liver

5. Decrease of triacylglycerols in adipose tissue

85. What process cannot occur in the absence of carnitine?

1. β-Oxidation of fatty acids

2. Cleavage of triacylglycerol

3. Utilization of ketone bodies

4. Fatty acid biosynthesis

5. Biosynthesis of prostaglandin

86. Propionyl CoA formed from the oxidation of fatty acids having an odd number of carbon atoms is converted into:

A. D-Methylmalonyl CoA

B. Acetoacetyl CoA

C. Acetyl CoA

D. Butyryl CoA

E. Acety lCoA

87. What process of lipid metabolism requires a protein with covalently bound prosthetic group derived from pantothenic acid?

1. Fatty acid biosynthesis

2. β-Oxidation of fatty acids

3. Utilization of ketone bodies

4. Bile acid synthesis from cholesterol

5. Utilization of LDL

88. The rate limiting step cholesterol biosynthesis is:

A. HMG CoA reductase

B. Squalene synthetase

C. HMG CoA synthetase

D. Mevalonate kinase

E. Geranyl transferase

89. An experimental animal has been given excessive amount of carbon-labeled glucose for a week. What compound can the label be found in?

A. Palmitic acid

B. Methionine

C. Vitamin A

D. Choline

E. Arachidonic acid

90. The two final productsi in the β-oxidation of odd chain fatty acids are:

A. Acetyl CoA and propionyl-CoA

B. Acetyl CoA and acetyl CoA

C. Acetyl CoA and malonyl CoA

D. Acetyl CoA and succinyl CoA.

E. Acetyl-CoA and buturyl-CoA

91. In adipose tissue, glycerol-3-phosphate required for the synthesis of triglycerides comes mainly from:

1. Dihydroxyacetone phosphate formed in Glycolysis

2. Hydrolysis of pre-existing triglycerides

3. Free glycerol

4. Hydrolysis of phospholipids

92. The enzymes of β-oxidation are found in:

A. Mitochondria.

B. Cytosol.

C. Golgi apparatus.

D. Nucleus.

E. Microsomes.

93. Cholesterol is a starting material for biosynthesis of:

A. Cholic acid

B. N-acetyl-galactosamine

C. Lecithin

D. Prostaglandins

E. Sphingomyeli

94. Indicate lipid compound which is predominant in low density lipoproteins

A. Cholesterol

B. Phospholipids

C. Triglycerides

D. Sphingomyelin

E. Glucocerebroside

95. Lysolecithin is formed from lecithin by removal of:

A. Fatty acid from position 2

B. Fatty acid from position 1

C. Phosphorylcholine

D. Choline

E. Glycerol

96. Cholesterol is a starting material for biosynthesis of:

A. Cholic acid

B. N-acetyl-galactosamine

C. Lecithin

D. Prostaglandins

E. Sphingomyelin

97. The pathway of cholesterol synthesis begins from the next metabolite:

1. 2-Oxoglutaryl-CoA

2. Succinyl-CoA

3. Acetoacetyl-CoA

4. Acetyl-CoA

5. Lauryl-CoA

98. Lipo-oxygenase is required for the synthesis of:

A. Leukotrienes

B. Prostaglandins

C. Thromboxanes

D. Prostacyclines

E. All of these

99. Chose from listed below compounds the final product of cholesterol metabolism in human body:

1. Chenodeoxycholic acid

2. Cortisol

3. Prostaglandine E₂

4. Cholecalciferol

5. Ergrosterol

100. Triglycerides are transported from liver to extrahepatic tissues by:

A. VLDL

B. Chylomicrons

C. HDL

D. LDL

E. IDL

101. Lipoproteins contain the following constituent:

A. Lecithin

B. Ca ions

C. Albumin

D. Blood plasma proteins

E. Bile acids

102. A compound normally used to conjugate bile acids is:

A. Glycine

B. Serine

C. Glucoronic acid

D. Fatty acid

103. The rate limiting step in cholesterol biosynthesis is:

A. HMG CoA reductase

B. Mevalonate kinase

C. HMG CoA synthetase

D. Squalene synthetase

E. Geranyl transferase

104. Genetic deficiency of lipoprotein lipase causes hyperlipoproteinaemia of the following type:

A. Type I

B. Type IIa

C. Type IIb

D. Type V

E. Type III

105. This lipoprotein removes cholesterol from the body:

A. HDL

B. VLDL

C. IDL

D. Chylomicrons

E. LDL

106. Indicate lipid compound which is predominant in low density lipoproteins:

A. Cholesterol

B. Triglycerides

C. Phospholipids

D. Sphingomyelin

E. Glucocerebroside

107. Chylomicrons are present in fasting blood samples in hyperlipoproteinaemia of the following types:

A. Types I and V

B. Types IIa and IIb

C. Types I and IIa

D. Types IV and V

E. Types V and VI

108. Increase in blood of this class of lipoproteins is beneficial to ward off coronary heart disease:

A. LDL

B. HDL

C. VLDL

D. IDL

E. Chylomicrones

109. Note an intermediate metabolite which is on the cholesterol synthesis pathway and is of multifunctional significance:

A. β-Hydroxy β-methyl glutaryl-CoA (HMG-CoA)

B. Succinyl-CoA

C. Acetoacetate

D. Palmitoyl-CoA

E. 2-Oxoglutaryl-CoA

110. Esterification of cholesterol occurs mainly in:

A. Adipose tissue

B. Liver

C. Muscles

D. Kidneys

E. Brain

111. The next compounds are intermediates in cholesterol synthesis pathway EXCEPT:

A. 2-Oxoglutaryl-CoA

B. Mevalonic acid

C. Hydroxymethylglutaryl- CoA

D. Lanosterol

E. Squalene

112. Bile acids are derivatives of:

A. Cholesterol

B. Heme

C. Sphingomyeline

D. Phosphatidyl choline

E. Long chain fatty acids

113. The β-lipoprotein fraction increases in severe:

A. Diabetes Mellitus

B. Uremia

C. Nephritis

D. Muscular dystrophy

E. Pancreatatis

114. Cholesterol is the precursor for the biosynthesis of:

A. Bile acids

B. Prostaglandins

C. Fatty acid

D. Sphingmyelin

E. Lecitine

115. HDL is synthesized in:

A. Liver

B. Kidneys

C. Intestine

D. Liver and intestine

E. Adipose tissue

116. All the following correctly describe the intermediate 3-OH-3-methyl glutaryl CoA except:

A. It is generated enzymatically in the mitochondrial matrix

B. It is formed in the cytoplasm

C. It is involved in the synthesis of cholesterlol

D. It inhibits the first step in cholesterol synthesis

E. It is involved in the synthesis of ketone bodies

117. Very low density lipoproteins are also known as:

A. Pre β--lipoproteins

B. β-lipoproteins

C. α-lipoproteins

D. None of these

118. Main metabolic end product of cholesterol:

A. Bile acid

B. 5-pregnenolone

C. Coprosterol

D. Glycine

E. Palmytoyl-CoA

119. A man 67 years old suffers from brain vessels atherosclerosis. After investigation hyperlipidemia was detected. What class of lipoproteins in blood plasma will be increased most of all in biochemical investigation?

1. LDL

2. HDL

3. Non esterified fatty acids in complex with albumin

4. Chilomicrons

5. VLDL

120. Chylomicron, intermediate density lipoproteins (IDL), low density lipoproteins (LDL) and very low density lipoproteins (VLDL) all are serum lipoproteins. What is the correct ordering of these particles from the lowest to the greatest density?

A. Chylomicron, VLDL, IDL, LDL

B. LDL, IDL, VLDL, Chylomicron

C. VLDL, IDL, LDL, Chylomicron

D. Chylomicron, IDL, VLDL, LDL

E. IDL, VLDL, LDL, Chylomicron

121. In a patient suffering from diabetes mellitus an increase in concentration of VLDL and triacylglycerols was detected. Cholesterol and HDL content in normal values.What type of lipid metabolism disorder can be classified such changes of indicated data?

1. Hyperlipoproteinemia type IY

2. Hyperlipoproteinemia type II

3. Hyperlipoproteinemia type Y

4. Hypelipoproteinemia type III

5. Hyperlipoproteinemia type II b

122. Lipoprotein lipase:

A. Is stimulated by one of the apoproteins present in VLDL.

B. Is stimulated by cAMP-mediated phosphorylation.

C. Functions to mobilize stored triacylglycerols from adipose tissue.

D. Is an intracellular enzyme.

E. Readily hydrolyzes three fatty acids from a triacylglycerol.