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Legends to figures

Fig. 1. Structural formulae of moenomycins discussed in this work.

Fig. 2. Genetic organization of cosmid moeno 38-6 (see text for details)

Fig. 3. Extracted ion chromatograms corresponding to NoA₂ and its tetrasacharide precursor in methanol extracts from moeno38-6+ M1152 and J1074 strains.

Fig. 4. Levels of Mm biosynthesis by parent and heterologous host strains as measured by IP measurements (a), method of agar blocks (b) and antibiotic disc diffusion assay (c). Column labels: S. gh. – S. ghanaensis wild-type; S.alb m – S. albus moeno38-6; S.ven m – S. venezuelae moeno38-6; S.th m – S. thermospinisporus moeno38-6; M145 m – M145 moeno38-6; M1152 m – M1152 moeno38-6 – rpoB mutant; M1154 m – M1154 moeno38-6 rpoBrpsL mutant. * - the bioactivity value represents total antibiotic activity of Mm and chloramphenicol.

Lopatniuk M. et al. Heterologous expression hosts provide new insights into the regulation of moenomycin production by streptomycetes