Theophylline pharmacokinetics

In chronic nonspecific intestinal diseases under different introduction to patients

Theophylline pharmacokinetics was investigated upon intro­duction of euphylline (0.15 g) at four levels of gastrointestinal tract: orally (20 patients), into the jejunum (15 patients) at enterogastroduodenoscopy, in the ileocecal area (8 patients) at colonoscopy and rectally (9 patients). Absorption speed de­pended on the variant of the gastrointestinal introduction rather than on the variant of chronic nonspecific intestinal disease, and appeared maximal in the drug introduction into the jeju­num. Concentration and area under curve became maximal in minor participation of the liver in primary capture and bio­transformation of theophylline. Reduced theophylline doses are recommended in lower hepatic metabolism of the drug, in hepatic hypofunction, in rectal route of administration.

(From Terapevtichesky Arkhiv)

Task 18. Use the following words and expressions in sentences of your own to show that you understand their meaning and use:

Use by expiration date; if pain persists; the advice of a health professional; to depend on; reduced doses are recom­mended; rectal route of administration; oral route of admin­istration; intravenous route of administration; subcutaneous route of administration; drug introduction into.

Task 19. Read the text and compare the emotions of the examinees and the applicants with your own in a si­milar situation:

- DOCTOR IN THE HOUSE ' • •

by R. Gordon {an extract)

At noon we arrived in the examination building. The same number of candidates were there, but they were a subdued, muttering crowd, like the supporters of a home team who had just been beaten in a cup tie.

We pushed our way into the large hall on the ground floor. It was packed full with anxious students. On the side of the hall facing us was the foot of a marble staircase. To the left of the staircase was a plain open door, over which had been recent­ly pinned a large black and white card saying EXIT. To the right was a clock, which stood at a few minutes before twelve.

We had heard exactly what would happen. At midday precisely the Secretary of the Committee would descend the stairs and take his place flanked by two uniformed porters, on the lowermost step. Under his arm would be a thick, leather- covered book containing the results. One of the porters would carry a list of the candidates’ numbers and call them out, one after the other. The candidates would step up closely to the Secretary, who would say simply “Pass” or “Failed”. Success­ful men would go upstairs to receive the congratulations and handshakes of the examiners and failures would slink miser­ably out of the exit to seek the opiate of oblivion.

“One thing, it’s quick”, Benskin muttered nervously. “Like the drop,” said Grimsdyke.

One minute to twelve. The room had suddenly come to a frightful, unexpected silence and stillness, like an unexploded bomb. A clock tinged twelve in the distance. My palms were as wet as sponges. Someone coughed, and I expected the windows to rattle. With slow scraping feet that could be heard before they appeared the Secretary and the porters came slowly down the stairs.

They took up their positions; the leather book was opened. The elder porter raised his voice.

“Number two hundred and nine,” he began. “Number thirty seven. Number one hundred and fifty.”

The tension in the room broke as the students shuffled to the front and lined up before the staircase. The numbers were not called in order, and the candidates strained to hear their own over the rumble of conversation and scraping of feet that rose from the assembly.

“Number one hundred and sixty one,” continued the por­ter. “Number three hundred and two. Number three hun­dred and six.“

Grimsdyke punched me hard in the ribs.

“Go on,” he hissed. It’s you!”

I jumped, and struggled my way to the front of the rest­less crowd. My pulse shot high in my ears. My face was burning hot and I felt my stomach had been suddenly plucked from my body.

I lined up in the short queue by the stairs. My mind was empty and numb. I stared at the red neck of the man in front of me, with its rim of blue collar above his coat, and studied it with foolish intensity. Suddenly I found myself on top of the Secretary.

“Number three oh six?” the Secretary whispered, without looking up from the book. “R. Gordon?”

“Yes,” I croaked.

The world stood still. The traffic stopped, the plants ceased growing, men were paralysed, the clouds hung in the air, the winds dropped, the tides disappeared, the sun halted in the sky. “Pass,” the man muttered.

Blindly, like a man just hit by blackjack, I stumbled upstairs. Keys

Шановні Друзі! 1

01054, КШВ-54, 1

м. Житомир: 1

м. Івано-Франківськ: 1

м. Суми: 2

for Medica Students 3

для студентів- медиків 4

Перший Київський медичішм коледж 9

m 10

cM. S'!’* MtHO" 4

Щ ЩП щ ■ 5

Task 11. 1 — g; 2d; 3 — j; 4 — c; 5 — e; 6 i; 7 — f; 8 — b; 9 - h; 10 - a.

Task 12. j; 2 ^ f; 3 X_e; 4 - a; 5 *- b; 6 - c; 7 - h; 8 U g;

9 - i; 10 - d.

Task 13. 1 (mouth); 2 (roof); 3 (tongue); 4 (lips); 5 (rich);

6 (callcd); 7 (cells); 8 (air); 9 (work, spare); 10 (lies);

11 (rare); 12 (meats); 13 (worn); 14 (sought); 15 (cause).