8. Control:

8.1.Rating of competences knowledge

8.1..1. Quiz on topics.

8.1.2.Tests. 3variants (each variant -10questions).

8.1.3. Diagram of the effects of DNA damage cells carcinogens:

Carcinogen Modification of DNA Mutation

Reparation Apoptosis Transformation

? ? ?

8.1.4. Draw and explain the stages of cell transformation.

8.1.5. Fill in the table: Oncogenes and tumor suppressor genes

The nature of the gene/protein (functions of protein in a cell)	Gene/protein	Tumor
	Myc
	Cyclins D,E
	p15
	p16
	pRB
	p53
	Bcl-2
	Telomerase
	APC
	BRCA1,BRCA2
	Genes repair
	ATM

8.1.6. List the properties of malignant cells and to characterize tumor its features

8.1.7. Show and explain the mechanisms of transformation of proto-oncogene to ontogeny

Lesson number 4

1. Title: Molecular genetics research methods. Genomics. Genetics Engineering

2.Aims: To generate in students the knowledge of modern methods of analyzing the structure and function of DNA, advances in decoding the genomes of living organisms, human principles of genetic engineering research and its implications for modern medicine.

3.Learning objectives:

-To generate in students of the modern methods of investigation of the DNA molecules of living organisms and their application in practical medicine.

- To generate in students of the modern of genetic engineering technology and its application in medicine and pharmacy

- Learn to use with electronic data bases of inherited diseases MakKyussika (OMIM).

4.Type of course: a conversation on the subjects fill the table, the job skills.

5.Tasks related to:

5.1. The structural organization of the human genome. Genomics and its direction. Program "human genome" and its significance.

5.2 Genetic engineering technology. Recent advances of genetic engineering and its prospects

5.3. The main stages of the molecular analysis of DNA.

Molecular methods genticheskie: PCR, restriction DNA blot hybridization techniques, DNA cloning, sekvinirovanie

5.4. Main areas of application of modern molecular-genei technology in medicine.

5.5.Rights and responsibilities in health care and guarantees of their security (Chapter 16, Code of the Republic of Kazakhstan "Nation health and public health system" in 2009)