- •1.1. Overview
- •1.7. For information about the teachers:
- •1.8. Contact Information:
- •2. Program:
- •2.1. Introduction
- •2.2. The purpose of discipline:
- •2.3. Learning objectives:
- •2.4. Learning outcomes:
- •2.5.Prerequisites and Postdetails.
- •2.6. Summary of discipline:
- •2.7. Thematic plan of lectures, practical classes, srps and the siw Thematic plan of lectures
- •The practical classes thematic plan
- •Topical Plan for siwp
- •Thematic plan for independent student work
- •2.8. Tasks for independent students work : Topics for independent work of students:
- •2.9 Recommended literature :
- •In Russian :
- •In Kazakh:
- •In English :
- •2.11. Criteria and assessment rules:
- •The evaluation system of students' knowledge
- •Competence assessment in discipline "Molecular Biology and Medical Genetics," for 1 course students "General Medicine" specialty.
- •2.Check control
- •Presentation
- •Assessments grading scale
- •It is discussed and approved at faculty meeting from April "12" of 2012 y., the protocol No. 15
- •1. Theme: Implementation of heriditary information
- •3. Theses of lectures:
- •5. Literature:
- •6. Control questions (feedback):
- •3. Theses of lectures:
- •5. Literature:
- •6. Control questions (feedback):
- •3. Theses of lectures:
- •5. Literature:
- •6. Control questions (feedback):
- •3. Theses of lectures:
- •5. Literature:
- •6. Control questions (feedback):
- •3. Theses of lectures:
- •5. Literature:
- •6. Control questions (feedback):
- •3. Theses of lectures:
- •5. Literature
- •6. Control questions (feedback):
- •Specialty – general medicine
- •Year 2012
- •Theme: Introduction to Molecular Biology. Molecular Principles of Heredity
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Theme: Gene Molecular Biology
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Evaluation of competence – practical skills
- •Theme: Realization of Hereditary Information. Dna Replication
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Problem
- •Theme: Transcription
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Literature:
- •Control:
- •7.1. Evaluation of competence – knowledge
- •Theme: Regulation of Gene Expression
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •7.1. Evaluation of competence – knowledge
- •Evaluation of competence – practical skills
- •8.1.Control:
- •8.2. Rating of competence skills.
- •Theme: Genetic Apparatus of the Cell
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •7.1. Evaluation of competence – knowledge
- •7.2. Evaluation of competence – practical skills
- •Theme: Mitotic cycle, Mitosis, Meiosis
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Evaluation of competence – practical skills
- •7.2.6. Solution of standard tasks:
- •1. Theme: Heredity. Types of inheritance. Independent monogenic inheritance of characteristics
- •2. Purpose:
- •3. Learning objectives:
- •4. Key questions the theme:
- •6. Literature
- •7. Control:
- •7.1. Assessment of cognitive competences (knowledge):
- •7.2. Assessment of competence skills
- •7.3. Assessment of the skills of self-improvement:
- •1.Theme: Heredity. Types of inheritance. Monogenic traits linked inheritance
- •2. Purpose:
- •3. Learning objectives:
- •4. Key questions the theme:
- •7.1. Assessment of cognitive competences (knowledge):
- •1. Theme: Effects of gene
- •2. Purpose:
- •3. Learning objectives:
- •4. Key questions the theme:
- •6. Literature
- •7. Control:
- •7.1. Assessment of cognitive competences (knowledge)
- •7.2. Assessment of competence skills
- •1. Theme: Cellular mechanisms of ontogenetic development
- •2. Purpose:
- •3.Learning objectives:
- •4. Key questions the theme:
- •6. Literature:
- •7. Control:
- •7.1. Assessment of cognitive competence - knowledge
- •1.Theme: Genetic mechanisms of ontogenetic development
- •2. Purpose:
- •3. Learning objectives:
- •4. Key questions the theme:
- •6. Literature:
- •7. Control:
- •7.1. Assessment of cognitive competence - knowledge
- •7.2. Assessment of competence skills
- •1. Title: Basics of Genetics populyatsioinoy
- •6. Handout: Test questions. 7. Literature:
- •1.Theme: Fundamentals of Ecological Genetics
- •4. Key questions the theme:
- •6. Литература:
- •7. Control:
- •7.1. Assessment of competencies - knowledge.
- •Some environmental disease caused by
- •Air pollution
- •Contamination of drinking water
- •Intestinal infections
- •7.1.6. The decision of situational problems:
- •7.2. Assessment of competence - legal competence.
- •Theme: Fundamentals of Pharmacogenetics
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Evaluation of competence – practical skills
- •4.Osnovnye topic questions:
- •Specialty-general medicine methodology recommendation for independent work teacher-led
- •8. Control:
- •8.1.3. Filling out tables:escribe the types of apoptosis
- •1. Theme: Variability not hereditary and hereditary.
- •3. Problems of training:
- •4. Main questions of a subject:
- •6. Literature:
- •7. Control:
- •7.1. An assessment of competences – knowledge.
- •7.2. An assessment of competences – legal competence.
- •3. Problems of training:
- •4. Main questions of a subject:
- •6. Literature:
- •7. Control:
- •7.1. An assessment of competences – knowledge.
- •3.Learning objectives:
- •5.Key questions the theme:
- •7. References:
- •8. Control:
- •3.Learning objectives:
- •5.Tasks related to:
- •6.Handout material: test-2 version with 10 questions
- •7.References:
- •7.3.Konichev a .S. Sevyastanova g.A. Molecular biology m. 2005 p.N 150-196.351-379.
- •7.4.Teylor d.Grin. N.Staut u.Biology m.2002 part 3 p.N 215-242.
- •8. Control:
- •8.1.1 Quiz on topics.
- •8.1.5.The solution to the problem of restriction of dna.
- •8.1.6. Working with the human genomic databases: problem solving.
- •8.3. Control:
- •1 . Title: Control of landmark forum: "Molecular Biology of the Cell"
- •7. References: The main
- •Theme: Human Hereditary Diseases. Chromosomal Diseases
- •Object:
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Impairment related to different types of human aneuploidy
- •Evaluation of competence – practical skills
- •Theme: Human Hereditary Diseases. MonogenicMendelian Diseases
- •Object:
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Evaluation of competence –communicative skills
- •Solution of situational problems
- •Title: Monogenic nonmendelian human disease
- •Aims: To generate in students the knowledge of nonmendelian monogenic human disease.
- •Learning objectives:
- •Tasks related to:
- •Handout material: test-2 version with 10 questions
- •References:
- •Control:
- •Theme: Polygenic (Multifactor) Human Diseases
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Collection of anamnesis (determine the data that permit to reveal families with increased risk of birth of a child with hereditary pathology)
- •In case of chromosomal diseases In case of genic diseases
- •Title: Modern methods of prevention and treatment genetic diseases
- •Key questions the theme:
- •6. Handout: test questions.
- •7. References:
- •8.Control:
- •8.5.An algorithm preventing hereditary diseases, to determine the indications
- •6. Handout: test questions.
- •7. References:
- •8. Control:
- •1.Theme: Section control on the section "Basis of medical genetics"
- •3.Tasks of teaching:
- •7. References:
- •8. Control:
- •8.2. Rating of competence skills.
- •Title: Monogenic nonmendelian human disease
- •Learning objectives:
- •Tasks related to:
- •Handout material: test-2 version with 10 questions
- •References:
- •Control:
- •6. Handout: test questions.
- •7. References:
- •6. Handout: tests
- •7.Bibliography:
- •8. Control:
- •Title: Modern methods of prevention and treatment genetic diseases
- •Key questions the theme:
- •7. References:
- •8.Control:
- •8.5.An algorithm preventing hereditary diseases, to determine the indications
- •3.Tasks of teaching:
- •5. The main themes:
- •7. References:
- •8. Control:
- •8.2. Rating of competence skills.
- •1. Theme #1. Telomers. Telomerase activity
- •3. The tasks:
- •5. Performance criteria:
- •5. Performance criteria:
- •8. Bibliography:
- •8. Bibliography:
- •9. Check:
- •1. Theme #5. Genomics, proteomics and metabolonomics
- •3. The tasks:
- •5. Performance criteria:
- •8. Bibliography:
- •9. Check:
- •1. Theme #6. Cloning of organisms and cells
- •3. The tasks:
- •5. Performance criteria:
- •8. Bibliography:
- •8. Bibliography:
- •9. Check:
- •1. Theme #9. Molecular and genetic mechanisms of aging
- •3. The tasks:
- •5. Requirements to presentation making up:
- •8. Bibliography:
- •8. Bibliography:
- •8. Bibliography:
- •9. Check:
- •1. Theme #13. Human genetic passport
- •3. The tasks:
- •5. Requirements to abstract work design:
- •8. Bibliography:
- •8. Bibliography:
- •8. Bibliography:
- •8. Bibliography:
- •8. Bibliography:
- •8. Bibliography:
- •9. Check:
- •Control and measuring means for the assessment of knowledge, skills in molecular biology and medical genetics
- •2012 Year
- •I. Examination questions:
- •II. The test exam questions:
- •Molecular biology
- •Replication
- •II. Molecular Cell Biology
- •Cell Cycle
- •Ontogenezis
- •Mutations
- •Oncogenetics
- •III. Fundamentals of general genetics
- •Ekogenetic
- •Pharmacogenetics
- •IV. Fundamentals of medical genetics
- •The list of questions to assess the practical skills: Molecular biology
- •Genetics
Evaluation of competence – practical skills
Health care of citizens and general safety requirements to medicinal preparations (Chapter 5, 15, Code of the Republic of Kazakhstan On People’s Health and Health Care System, 2009)
Lesson number 20
1.Title; Landmark control line. (Fundamentals of General Genetics)
2. Aims: To determine the level of understanding and assimilation of knowledge by students in general genetics and its role as the place of values in modern medicine and health.
3. Assess the level of knowledge :
- understanding of individual sections of the students studied material.
-Identify the student's ability to recognize the types of inheritance of man.
4.Osnovnye topic questions:
4.1. Gennetika-the science of heredity and variation in the object task methods. Key terms and concepts of genetics. The value of genetics in medicine.
4.2. Mendel's laws.
4.3. Types of inheritance.
4.4.Mendeliruyuschie signs of man. Terms of Mendelian.
4.5. The concept of stsenlenii linkage group.
4.6. linked inheritance
4.7. Crossing-over mechanisms of evolutionary significance.
4.8. Mapping of genes important methods.
4.9. Chromosome theory of heredity basic provisions.
4.10. Genotype. Phenotype: the definition of relationship
4.11. Interaction alleles: recessively. Incomplete dominance. over dominance. Kodominirovanie.
4.12. Multiple alleles. Genetics of blood. The medical importance.
4.13. Vzaymodeystvie no allelic genes: complementarity. epistasis. polymers.
4.14. Penetrance. expressiveness. Pleyotoriya.
4.15. Photocopy. Genokopy.
4.16. Developmental Biology: a definition. types. periods.
4.17. The early stages of ontogeny: gametogenesis. fertilization. plyarnost. egg.
4.18. Cellular mechanisms of ontogeny.
4.19. Differential gene activity.
4.20. Homeotic genes. Homewood in humans and heritable disease.
4.21. Teratogens factors. Teratogens.
4.22.Kriticheskie periods of development.
4.23. Congenital malformations (birth defects): definition and cytogenetic mechanisms of their formation.
4.24. Classification. diagnosis and prevention of birth defects.
4.25. Population. definition. characteristics of the population.
4.27. Species populations and mating structure of populations.
4.28. Genetic characteristics of populations.
4.29. The elementary evolutionary processes. occurring in the populations and characteristics of their action in human populations.
4.30. Genetic load of populations. concept. medical importance.
4.31. Ecology. definition. Relationship of ecology and genetics.
4.32. environmentally caused disease in humans. mechanisms of their development.
4.33. Environmental contaminants. classification. effect.
4.34. Genetic effects of environmental contamination in areas of ecological trouble in Kazakhstan.
4.35. The value of pharmacokinetics in modern medicine and pharmacy.
4.36. Genetic control of the metabolism of drugs. 4.37. Hereditary diseases and conditions, triggered by medication. 4.38. Types of chromosomal sex determination 4.39. The role of the Y chromosome and autosomal genes in primary sex determination. 4.40. Secondary sex determination. 4.41. Dependent on the floor and the only restriction floor signs
4.42. Gynandromorphy, intersexes, hermaphroditic, and other sexual deviations, medical importance. 4.43. Cloning: Past, Present. the future. 4.44. Reproductive cloning. 4.45. Ethical and legal issues of cloning organisms. 4.46. Human Cloning: for and against. 4.47. Possible applications of cloning technology. 4.48. Cell therapy and therapeutic cloning. 4.49. The genetics of aging 4.50. The mechanism of aging
4.51. Tell a manifestation of the aging of molecular-cellular level 4.52. Modern theories of aging 4.53. The history of stem cell research 4.54. Achievements and prospects in the study of stem cells. 4.55. Stem cells in clinical practice 4.56. The synthesis of drugs with the use of gene technology.
4.57. Biotechnological synthesis of drug 4.58. The methodology of finding new drugs, biotechnology products, nennoy engineering in pathological conditions 4.59. The leading factors of ecological trouble in the area of the Semipalatinsk nuclear test site. 4.60. Leading factors ekologichkskogo trouble in the Aral Sea...
4.61. The results of the study of health in these regions.
Methodical Complex.
5. Teaching methods: a combined method of teaching (interview, the decision of situational problems)
6. References: 6.1. Ayala, F., J. Kayger modern genetics. Moscow, 1988 6.2. Alberta B. et al Molecular Biology of the Cell. Moscow, 1994 6.3. Bochkov NP Clinical Genetics. M., 2004. 6.4. Introduction to molecular medicine. Ed. Paltseva MA M., 2004.
6.5. Genetics. Ed. Ivanov, VI M., 2006. 6.6. Ginter EK Medical Genetics. M., 2003. 6.7. SG Inge-Vechtomov Genetics of the basics of breeding. M., 1989. 6.8. IF Zhimulev General and molecular genetics. Novosibirsk, 2003. 6.9. Medical Biology and Genetics. Textbook, ed. Professor. Kuandykrva EW Almaty, 2004. 6.10. Mushkambarov N. Kuznetsov, SL Molecular Biology. Moscow, 2003 6.11. Fuller, DM, Schild D. Molecular Biology of the Cell. M., 2006. 6.12. Mutovin GR Fundamentals of Clinical Genetics. Moscow, 2001
6.13. Teratology man. Sex Ed. Lazyuk G. M., 1991.