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1 ;<–k–r<ft“ DW “ Gau€t“ MH:“ Predi–ti<z“ <f“ –reatizize“ –€earaz–e“ fr<m“ serum“ –reatizize “ Nephron“16:^1[41 “1976 “

Mawer“;E “•z<w€es“BR “Šu–as“SB “Stir€azd“RA “T<<t”“JA:“;<m˜uter[assisted“˜res–riˆizg“ <f“kazamy–iz“f<r“˜atiezts“wit”“reza€“izsuffi–iez–y “Lancet“i;1 [15 “197 “

^ •e€€er“ E “ Reetze“ P “ S–”<€€meyer“ P:“ Drug“ t”era˜y“ iz“ ˜atiezts“ uzderg<izg“ –<ztizu<us“ amˆu€at<ry“˜erit<zea€“dia€ysis:“–€izi–a€“˜”arma–<kizeti–“–<zsiderati<zs “Clin Pharmacokinet“ 18:104[117 “1990 “

4 ž'Briez“ MA “ Mas<z“ NA:“ Systemi–“ aˆs<r˜ti<z“ <f“ iztra˜erit<zea€“ aztimi–r<ˆia€s“ iz“ –<ztizu<us“amˆu€at<ry“˜erit<zea€“dia€ysis “Clin Pharm“11: 46[ 54 “199 “

5 Paa˜“;M “Na”ata“M; “Meztser“MA “Ma”az“JD “Puri“S• “Huˆˆard“JA:“;ef<taŸime“azd“ metaˆ<€ite“dis˜<siti<z“iz“tw<“˜ediatri–“–<ztizu<us“amˆu€at<ry“˜erit<zea€“dia€ysis“˜atiezts “ Ann Pharmacother“ 6:^41[^4^ “199 “

6 Ruˆiz“ J:“ Vaz–<my–iz“ aˆs<r˜ti<z“ fr<m“ t”e“ ˜erit<zea€“ –avity“ durizg“ dia€ysis[re€ated“ ˜erit<zitis “Perit Dial lnt“10: 8^[ 85 “1990 “

7 Sezzesae€“ JJ “ Maes“ VA “ Pierard“ D “ Deˆeuke€aer“ SH “ Verˆee€ez“ DŠ:“ Stre˜t<my–iz“ ˜”arma–<kizeti–s“iz“re€a˜sizg“my–<ˆa–terium“Ÿez<˜i“˜erit<zitis “Am J Nephrol“10:4 [4 5 “ 1990 “

8 Deˆruyze“D “Ry–ke€yz–k“J[P “M<u€iz“M “Hurau€t“de“Šigzy“B “Ševa€tier“B “Big<t“M[;:“ P”arma–<kizeti–s“<f“f€u–<zaz<€e“iz“˜atiezts“uzderg<izg“–<ztizu<us“amˆu€at<ry“˜erit<zea€“ dia€ysis “Clin Pharmacokinet“18:491[498 “1990 “

9 Da”€“ • “ Wa€stad“ RA “ Wider e“ T[E:“ T”e“ effe–t“ <f“ ˜erit<zitis“ <z“ t”e“ trazs˜erit<zea€“ trazs˜<rt“<f“–efur<Ÿime“iz“˜atiezts“<f“;APD“treatmezt “Nephrol Dial Transplant“5: 75[ 81 “ 1990 “

10 Burgess“ED “Gi€€“MJ:“Iztra˜erit<zea€“admizistratizz“<f“a–y–€<vir“iz“˜atiezts“re–eivizg“ –<ztizu<us“amˆu€at<ry“˜erit<zea€“dia€ysis “J Clin Pharmacol ^0:997[1000 “1990 “

11 ;”az“GŠ; “Matzke“GR:“Effe–ts“<f“reza€“izsuffi–iez–y“<z“t”e“˜”arma–<kizeti–s“azd“ ˜”arma–<dyzami–s“<f“<˜i<id“aza€gesi–s “Drug Intell Clin Pharm“ 1:77^[78^ “1987 “

1 G€are“PA “Wa€s”TD:“;€izi–a€“˜”arma–<kizeti–s“<f“m<r˜”ize “Ther Drug Monit“1^:1[“ ^ “ 1991 “

1^ St “Peter“WŠ “Redi–[•i€€“•A “Ha€stezs<z“;E:“;€izi–a€“˜”arma–<kizeti–s“<f“aztiˆi<ti–s“iz“ ˜atiezts“wit”“im˜aired“reza€“fuz–ti<zs “Clin Pharmacokinet“ :169[ 10 “199 “

14 Buzke“;M “Ar<z<ff“GR “Šuft“F;:“P”arma–<kizeti–s“<f“–<mm<z“aztiˆi<ti–s“used“iz“ –<ztizu<us“amˆu€at<ry“˜erit<zea€“dia€ysis “Am J Kidney Dis“^:114[117 “198^ “

15 AHFS“Drug“Izf<rmati<z“9^“#“Ameri–az“H<s˜ita€“F<rmu€ary“Servi–e “Bet”esda “MD “ Ameri–az“S<–iety“<f“H<s˜ita€“P”arma–ists “199^ “

16 Evazs“WE “S–”eztag“JJ “Jusk<“WJ“(eds):“Applied Pharmacokinetics – Principles of Therapeutic Drug Monitoring “ed“^ “A˜˜€ied“T”era˜euti–s “Vaz–<uver “199 “

17 Facts and Comparisons “Fa–ts“azd“;<m˜aris<zs “Iz– “St “Š<uis “199^ “

18 G<<dmaz“GA “Ra€€“TW “Nies“AS “Tay€<r“P“(eds):“The Pharmacological Basis of Therapeutics “ed“8 “Pergam<z“Press “E€msf<rd “NY “1990 “

19 A–”tert“G “S–”errmazz“JM “;”ristez“Mž:“P”arma–<kizeti–sZˆi<avai€aˆi€ity“<f“–<€–”i–ize“ iz“”ea€t”y“ma€e“v<€uzteers “Eur J Drug Metab Pharmacokinet“14:^17[^ “1989 “

0 Ag<st<z“S “Vazdezˆr<m“RHG “Wierda“JM•H:“;€izi–a€“˜”arma–<kizeti–s“<f“ zeur<mus–u€ar“ˆ€<–kizg“drugs “Clin Pharmacokinet“ :94[115 “199 “

1 Barrie“JR “M<usda€e“S:“;i˜r<f€<Ÿa–iz“€eve€s“iz“a“˜atiezt“uzderg<izg“vez<[vez<us“ ”aem<diafi€trati<z “Intensive Care Med“18:4^7[4^8 “199 “

B€a–kwe€€“BG “Šeggett“JE “J<”zs<z“;A “Zimmermaz“SW “;raig“WA:“Am˜i–i€€iz“azd“ su€ˆa–tam“˜”arma–<kizeti–s“azd“˜”arma–<dyzami–s“iz“–<ztizu<us“amˆu€at<ry“˜erit<zea€“ dia€ysis“(;APD) “Perit Dial Int“10: 1[ 6 “1990 “

^ B<e€aert“J “Dazee€s“R “Vaz“Šazduyt“HW “S–”urgers“M:“Mu€ti˜€e“d<se“˜”arma–<kizeti–s“<f“ a–y–€<vir“iz“˜atiezts“<z“–<ztizu<us“amˆu€at<ry“˜erit<zea€“dia€ysis“(aˆstra–t) “Antimicrob Agents Chemother“14 “1985 “

4 B<u€ieu“R “Bastiez“ž “B€eyza–“N:“P”arma–<kizeti–s“<f“gaz–i–€<vir“iz“”eart“trazs˜€azt“ ˜atiezts“uzderg<izg“–<ztizu<us“vez<vez<us“”em<dia€ysis “Ther Drug Monit“15:105[107 “ 199^ “

5 Brass“; “Ga€giazi“JN “B€as–”ke“TF “Defe€i–e“R “ž'Rei€€y“RA “Stevezs“DA:“Dis˜<siti<z“<f“ ket<–<zaz<€e “az“<ra€“aztifuzga€ “iz“”umazs “Antimicrob Agents Chemother“ 1:151[“158 “ 198 “

6 Burgess“ED “B€air“AD:“P”arma–<kizeti–s“<f“–eftiz<Ÿime“iz“˜atiezts“uzderg<izg“–<ztizu<us“ amˆu€at<ry“˜erit<zea€“dia€ysis “Antimicrob Agents Chemother“ 4: ^7[“ ^9 “198^ “

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7 Davez˜<rt“A “G<e€“S “Ma–kezzie“J;:“Neur<t<Ÿi–ity“<f“a–y–€<vir“iz“˜atiezts“wit”“ezd[stage“ reza€“fai€ure“treated“wit”“–<ztizu<us“amˆu€at<ry“˜erit<zea€“dia€ysis “Am J Kidney Dis“0:647[649 “199 “

8 Deˆruyze“D “Ry–ke€yz–k“J[P:“;€izi–a€“˜”arma–<kizeti–s“<f“f€u–<zaz<€e “Clin Pharmacokinet“ 4:10[ 7 “199^ “

9 Deˆruyze“D “Ry–ke€yz–k“J[P “Hurau€t“de“Šigzy“B “M<u€iz“M:“P”arma–<kizeti–s“<f“ ˜i˜era–i€€iz“iz“˜atiezts“<z“˜erit<zea€“dia€ysis“wit”“azd“wit”<ut“˜erit<zitis “J Pharm Sci“ 79:99[10 “1990 “

^0 D<y€e“GD “Ša”er“M “•e€€y“JG “Byrze“MM “;€arks<z“A “Zussmaz“BD:“T”e“ ˜”arma–<kizeti–s“<f“˜ar<Ÿetize“iz“reza€“im˜airmezt “Acta Psychiatr Scand“80“(su˜˜€“ ^50):89[90 “1989 “

^1 Driessez“JJ “Vree“TB “Gue€ez“PJM:“T”e“effe–ts“<f“a–ute“–”azges“iz“reza€“fuz–ti<z“<z“t”e“ ˜”arma–<kizeti–s“<f“midaz<€am“durizg“€<zg[term“izfusi<z“iz“I;U“˜atiezts “Acta Anaesthesiol Belg“4 :149[155 “1991 “

^ Fitzgera€d“J:“Nar–<ti–“aza€gesi–s“iz“reza€“fai€ure “Conn Med“55:701[704 “1991 “

^^ F€et–”er“;V “Beatty“; “Ba€f<ur“Jr“HH:“Gaz–i–€<vir“dis˜<siti<z“iz“˜atiezts“wit”“reza€“ izsuffi–iez–y:“im˜€i–ati<zs“f<r“d<se“adŒustmezt“(aˆstra–t) “Pharmacotherapy“11: 77 “1991 “

^4 Gr<ss“MŠ “S<mazi“P “Riˆzer“BS “Raeader“R “Freimer“EH “Higgizs“Jr“JT:“;eftiz<Ÿime“ e€imizati<z“kizeti–s“iz“–<ztizu<us“amˆu€at<ry“˜erit<zea€“dia€ysis “Clin Pharmacol Ther“ ^4:67^[680 “198^ “

^5 Guay“DRP “Awzi“WM “Fizd€ay“JWA “et“a€:“P”arma–<kizeti–s“azd“˜”arma–<dyzami–s“<f“ –<deize“iz“ezd[stage“reza€“disease “Clin Pharmacol Ther“4^:6^[71 “1988 “

^6 Ha€v<rsez“M^ “W”itmer“JT “Ha€stezs<z“;E:“Hem<dia€ysis“–€earaz–e“<f“ez–aizide“azd“ metaˆ<€ites “Ther Drug Monit“1^:^75[^78 “1991 “

^7 Harf<rd“AM “Si–a“DA “Tartag€i<ze“T “P<€k“RE “Da€t<z“HP “P<yzer“W:“Vaz–<my–iz“ ˜”arma–<kizeti–s“iz“–<ztizu<us“amˆu€at<ry“˜erit<zea€“dia€ysis“˜atiezts“wit”“˜erit<zitis “ Nephron“4^: 17[ “1986 “

^8 H<yer“J “S–”u€te“•[Š “Šezz“T:“;€izi–a€“˜”arma–<kizeti–s“<f“azgi<tezsiz“–<zvertizg“ ezzyme“(A;E)“iz”iˆit<rs“iz“reza€“fai€ure “Clin Pharmacokinet“ 4: ^0[ 54 “199^ “

^9 Hui“•• “Du–”iz“•Š “•ri˜a€azi“•J “;”az“D “•ramer“P• “Yazagawa“N:“P”arma–<kizeti–s“ <f“f<siz<˜ri€“iz“˜atiezts“wit”“vari<us“degrees“<f“reza€“fuz–ti<z “Clin Pharmacol Ther“ 49:457[467 “1991 “

40 It<“M• “Smit”“AR “Šee“MŠ;“Ti–€<˜idize:“a“zew“˜€ate€et“aggregati<z“iz”iˆit<r “Clin Pharm“ 11:60^[617 “199 “

41 J<”zs<z“; “Zimmermaz“S “Šeggett“J “et“a€:“P”arma–<kizeti–s“azd“˜”arma–<dyzami–s“<f“ am˜i–i€€izZsu€ˆa–tam“iz“;APD“˜atiezts“(aˆstra–t) “Perit Dial Int“7“(su˜˜€);S40 “1987 “

4 J<”zs<z“RJ “B€air“AD “A”mad“S:“•et<–<zaz<€e“kizeti–s“iz“–”r<zi–“˜erit<zea€“dia€ysis “Clin Pharmacol Ther“^7:^ 5[^ 9 “1985 “

4^ J<sse€s<z“J “Narazg“P• “Adir“J “Ya–<ˆi“A “Sad€er“IH:“Brety€ium“kizeti–s“iz“reza€“ izsuffi–iez–e“Clin Pharmacol Ther“^^:144[150 “198^ “

44 •aiser“G “A–kermazz“R “Si<ufi“A:“P”arma–<kizeti–s“<f“a“zew“azgi<tezsiz[–<zvertizg“ ezzyme“iz”iˆit<r “ˆezaze˜ri€“”ydr<–”€<ride “iz“s˜e–ia€“˜<˜u€ati<zs “Am Heart J“117:746[ 751 “1989 “

45 •e€€er“E “Fe–”t“H “B<”€er“J “S–”<€€meyer“P:“Sizg€e[d<se“kizeti–s“<f“imi˜ezemZ–i€astatiz“ durizg“–<ztizu<us“arteri<vez<us“”aem<fi€trati<z“iz“iztezsive“–are“˜atiezts “Nephrol Dial Transplant“4:640[645 “1989 “

46 •e€€y“JG “ž'Ma€€ey“•:“;€izi–a€“˜”arma–<kizeti–s“<f“t”e“zewer“A;E“iz”iˆit<rs “Clin Pharmacokinet“19;177[196 “1990 “

47 •ir–”“W “Rams–”“•D “Du”rsez“U “ž”z”aus“EE:“;€izi–a€“˜”arma–<kizeti–s“<f“ zim<di˜ize“iz“z<rma€“azd“im˜aired“reza€“fuz–ti<z “Int J Clin Pharmacol Res“4:^81[^84 “ 1984 “

48 •<wa€sky“SF “E–”<€s“M “S–”wartz“MT “Bai€ie“GR “M–;<rmi–k“E:“P”arma–<kizeti–s“<f“ –i˜r<f€<Ÿa–iz“iz“suˆŒe–ts“wit”“varyizg“degrees“<f“reza€“fuz–ti<z“azd“uzderg<izg“ ”em<dia€ysis“<r“;APD “Clin Nephrol“^9:5^[58 “199^ “

49 Šaw€ess“ST “Restaiz<“I “Aziz“S “;<rddry“D:“Effe–t“<f“–<ztizu<us“arteri<vez<us“ ”aem<fi€trati<z“<z“˜”arma–<kizeti–s“<f“amriz<ze “Clin Pharmacokinet“ 5;80[8 “199^ “

50 Š<wezt”a€“DT “Saris“SD “Paraz“E “;rista€“N:“T”e“use“<f“trazsderma€“–€<zidize“iz“t”e“ ”y˜ertezsive“˜atiezt“wit”“–”r<zi–“reza€“fai€ure “Clin Nephrol“^9:^7[4 “199^ “

51 Mar•uardt“ED “Is”isaka“DY “Batra“•• “;”iz“8:“Rem<va€“<f“et”<suŸimide“azd“ ˜”ez<ˆarˆita€“ˆy“˜erit<zea€“dia€ysis“iz“a“–”i€d Clin Pharm“11:10^0[10^1 “199 “

5 Murd<–”“D “M–Tavis”“D:“Sertra€ize “A“review“<f“its“˜”arma–<dyzami–“azd“˜”arma[“ –<kizeti–“˜r<˜erties “azd“t”era˜euti–“˜<teztia€“iz“de˜ressi<z“azd“<ˆsessive[–<m˜u€sive“ dis<rder “Drugs“44:604[6 4 “199 “

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5^ ž–”s“HR “Rau”“HW “Greezˆ€att“DJ “•as–”e€€“HJ:“;€<rze˜ate“di˜<tassium“azd“diaze˜am“ iz“reza€“izsuffi–iez–y:“serum“–<z–eztrati<zs“azd“˜r<teiz“ˆizdizg“<f“diaze˜am“azd“ desmet”y€diaze˜am “Nephron“^7:100[104 “1984 “

54 Parker“;JR “J<zes“JE “Huzter“JM:“Dis˜<siti<z“<f“izfusi<zs“<f“atra–urium“azd“its“ metaˆ<€ite “€audaz<size “iz“˜atiezts“iz“reza€“azd“res˜irat<ry“fai€ure“iz“az“ITU “Br J Anaesth“ 61:5^1[540 “1988 “

55 Prezdergast“BD:“G€yˆuride“azd“g€i˜isize “se–<zd[gezerati<z“<ra€“su€f<zy€urea“ ”y˜<g€y–emi–“agezts “Clin Pharm“^:47^[485 “1984 “

56 Prze–”era“M “Bezge€“D “Ris€er“T:“P”arma–<kizeti–s“<f“imi˜ezemZ–i€astatiz“durizg“ –<ztizu<us“arteri<vez<us“”em<fi€trati<z “Contrib Nephrol“9^:1^1[1^4 “1991 “

57 Re€€<“J “R<g€az“A “Gar–ia[;ases“; “Jaze“F “Net“A:“Effe–t“<f“–<ztizu<us“arteri<vez<us“ ”em<dia€ysis“<z“gaz–i–€<vir“˜”arma–<kizeti–s “Drug Intell Clin Pharm“ 4:544[545 “1990 “

58 Rivey“MP “Tay€<r“JW “Mu€€eziŸ“TA:“DIAS“r<uzds“#“drug“izf<rmati<z“aza€ysis“servi–e “

Drug Intell Clin Pharm“ ^:687[689 “1989 “

59 R<sazsky“SJ “J<”zs<z“•Š “M–;<zze€€“J:“Use“<f“trazsderma€“–€<zidize“iz“–”r<zi–“ ”em<dia€ysis“˜atiezts “Clin Nephrol“^9:^ [^6 “199^ “

60 Ruedy“J:“T”e“effe–ts“<f“˜erit<zea€“dia€ysis“<z“t”e“˜”ysi<€<gi–a€“dis˜<siti<z“<f“<Ÿa–i€€iz “ am˜i–i€€iz“azd“tetra–y–€ize“iz“˜atiezts“wit”“reza€“disease “Can Med Assoc J“94: 57[ 61 “ 1966 “

61 Saˆ<uraud“A “R<–”di“M “Urtizˆerea“M “;”ristez“Mž “A–”tert“G “S–”errmazz“JM:“ P”arma–<kizeti–s“<f“–<€–”i–ize:“a“review“<f“eŸ˜erimezta€“azd“–€izi–a€“data “ Gastroenterology“^0(su˜˜€“1):^5[^9 “199 “

6 S–”eztag“JJ:“;efmetaz<€e“s<dium:“˜”arma–<€<gy “˜”arma–<kizeti–s “azd“–€izi–a€“tria€s “ Pharmacotherapy“11: [19 “1991 “

6^ S–”mit”“VD “Piraiz<“B “Smit”“RB “•r<ˆ<t”“PD;“A€˜raz<€am“iz“ezd[stage“reza€“disease “I “ P”arma–<kizeti–s “J Clin Pharmacol“^1:571[579 “1991 “

64 Segred<“V “;a€dwe€€“JE “Matt”ay“MA “S”arma“MŠ “Gruezke“ŠD “Mi€€er“RD:“Persistezt“ ˜ara€ysis“iz“–riti–a€€v“i€€“˜atiezts“after“€<zg[term“admizistrati<z“<f“ve–ur<zium “N Engl J Med“^ 7:5 4[5 8 “199 “

65 Si–a“DA:“•izeti–s“<f“azgi<tezsiz[–<zvertizg“ezzyme“iz”iˆit<rs“iz“reza€“fai€ure “J Cardiovasc Pharmacol“ 0(Su˜˜€“10):S1^[S 0 “199 “

66 Smit”•€ize“Bee–”am“P”arma–euti–a€s:“Package insert for PaxiTM brand of paroxetine hydrochloride tablets “(uz˜uˆ€is”ed“data) “199^ “

67 S<mazi“P “Freimer“EH “Gr<ss“MŠ “Higgizs“Jr“JT:“P”arma–<kizeti–s“<f“imi˜ezem[ –i€astatiz“iz“˜atiezts“wit”“reza€“izsuffi–iez–y“uzderg<izg“–<ztizu<us“amˆu€at<ry“˜erit<zea€“ dia€ysis “Antimicrob Agents Chemother“^ :5^0[5^4 “1988 “

68 Wa€€a–e“SŠ “Sizger“JZ “Duz–az“GJ “Wig€ey“FM “•uz–€“RW:“Reza€“fuz–ti<z“˜redi–ts“ –<€–”i–ize“t<Ÿi–ity:“guide€izes“f<r“t”e“˜r<˜”y€a–ti–“use“<f“–<€–”i–ize“iz“g<ut “J Rheumatol“ 18: 64[ 69 “1991 “

69 Heim[Dut”<y“•Š “•a€i€“RSN “•asiske“BŠ:“A–ute“reza€“fai€ure “Iz“DiPir<“JT “Ta€ˆert“RŠ “ Hayes“PE “Yee“G; “Matzke“GR “P<sey“ŠM“(eds):“Pharmacotherapy: a Pathophysiologic Approach “A˜˜€et<z“&“Šazge “N<rwa€k “;T “˜˜“660[67 “199^ “

70 A€€<z“M “;<˜kzey“;:“A€ˆuter<€“azd“izsu€iz“f<r“treatmezt“<f“”y˜erka€emia“iz“”em<dia€ysis“ ˜atiezts “Kidney lnt“^8:869[87 “1990 “

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p=ƒ",2, 3…2,!3 ?,. C%!2%*="= $…/. " …%ƒ…/. *% =2 != L%› 2 3 …$ =2$ *2,"…/L C …% …/L *!%"%2%* , 3" , ,- "=2$ *% , “2"% *=!“2" ……/. " ? “2" %“2, = ?,. “,“2 …% % *!%"%%K!=? …, C%“ C!, = "…32!$ (5^ 1 7 1^ 155) }2, ,!3 , ,ƒ … …, =! =*%*,… 2,*, % 32 C%2! K%"=2$ 3 …$ …,%ƒ,!%"*, … *%2%!/. *=!“2" ……/. C! C=!=2%"

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D C! “2=" 2 “%K%L C% %? ……3 !=* , %ƒ/ = Cp — *%… …2!= , *=!“2" ……% % " ? “2"= " “%“2% …,, 3“2%L ,"% %,…= , “*% % !="…%" “, n ,… ,ƒ “C%“%K%" C%“! “2"% *%2%!%-% ƒ=K% "=…, C …, "%ƒ L“2"3 2 …= Vd O %K!=ƒ%"=…, =“ ,2= o!, 2% C!%,“.% ,2 3" , …, %K• = ›, *%“2…/. “! %! =- …,ƒ = j=* K/ % C%*=ƒ=…% 3 K% $…/. “ =“ ,2% …=K = 2“ - *!=2…% 3" , …, Vd C!%C!=…% % = "… ƒ=",“, %“2, %2 3!%"… % “" ƒ/"=…, “ K *= , (18)

a% $ ,…“2"% *=!“2" " C =ƒ *!%", %K!=2, % “" ƒ/"= 2“ “ K *= , O = $K3 ,…= , %K3 ,…= , *,“ / 1- ,*%C!%2 - ,…% ,C%C!%2 ,…= , !3 %C =ƒ ,…% 2!=…“ !!,…% j,“ /*=!“2"= %K/ …% “" ƒ/"= 2“ “ = $K3 ,…= , " 2% "! *=**=!“2" ……/. C! C=!=2%" “% ? % …%L ! =* , L K% .=!=*2 !…= “" ƒ$ “ *,“ / 1- ,*%C!%2 ,…% Š% $*% … “" ƒ=……/ *=!- “2" ……/ " ? “2"= “C%“%K…/ !=“C!%“2!=… 2$“ " 2*=… . , "/ƒ/"=2$=! =*% % , “*,L %2" 2 (68 8 84 1 6 150) o% 2% 3 “2 C …$ “" ƒ/"=…, “ K *= , %*=ƒ/"= 2 “3? “2" ……% " , …, …= .=!=*2 !=! =*% % , “*% % %2" 2= , C=!= 2!/ !=“C! …, *=!- “2" ……/. C! C=!=2%"

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› …$ …, “" ƒ/"=…, *=!“2" ……% % C! C=!=2= “ K *= , C =ƒ / “%C!%"%› = 2“ 3" , …, % *% , “2"= *%2%!% “C%- “%K…% !=“C! ,2$“ " 2*=… . Š=*, %K!=ƒ% 3" , ,"= 2“ *=- ›3?,L“ %K• !=“C! …, C! C=!=2= }2, ,ƒ … …, % 32 " , 2$ …= C !,% C% 3"/" …, ,*= …2%" … ƒ=",“, % %2 !3-,. C=!= 2!%" 2=K% ,ƒ = C%“*% $*3 "! C% 3"/" …, C! - C=!=2= (t1/2) ƒ=",“,2 *=* %2 C% …% % * ,! …“= ,ƒ *!%", (Cl) 2=* , %2 *=›3? %“ %K• = !=“C! …, (Vd):

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“%%2" 2“2",, “ =……%L ƒ=",“, %“2$ C !,% C% 3"/" …,*=!“2" ……/. " ? “2" %› 2 ""% ,2$ " ƒ=K 3› …, C!, C%C/2* %C! ,2$ .=!=*2 ! " , …, C=2% % ,, C …, …= C!% ““ ,. ,-,…= ,, m=C!, ! 3" , …, *=›3? %“ %K• = !=“C! …,*=!“2" ……% % “! “2"= %› 2 “%C!%"%› =2$“ 3" , …, C !,- % = % C% 3"/" …, C!, %2“32“2",, *=*,.- ,K% !3 ,. ! = $…/. ,ƒ … …,L 2=K% , “*%L , ,…= ,, Š=* 3 C= , …2%" “ ƒ=K%-"=…, , C …, …=K = 2“ 3" , …, C !,% = C% 3"/" …,%!=ƒ C= = (79) }2%2 …% … %› 2 K/2$ %K• “… … “*%! 3" ,-…, %K• = !=“C! …, ,*= …2= "“ “2", 3 …$ …, “" ƒ/"=…, " C =ƒ “…,› …, * ,! …“=

%C% … …, * "%ƒ L“2", …= !=“C! …, *=!“2" ,ƒ - … …, “2 C …, “" ƒ/"=…, “ K *= , %› 2 " , 2$ …= C!% ““/, ,…= ,, %ƒ!=“2=…, “"%K% …%L !=* ,, C! C=!=2= " *!%",%› 2 C!,"% ,2$ * C%"/ …, % %“23C…%“2, ! …2=2,"- …% % !=“? C …, , “%%2" 2“2" ……% * 3" , …, %K? % * ,! …- “= … *%2%!/. *=!“2" ` 2% " “"% % ! $ “%*!=?= 2 C !,% C% 3"/" …, C! C=!=2= … ƒ=",“, % %2 *=*,.- ,K% ,ƒ … …,L =*2,"…%“2, ! …2%" 3 =“2"3 ?,. " 2=K% ,ƒ *=!“2" ……/. " ? “2" “= % 3*%!% …, C !,% = C% 3"/" …, 2% K3- 2= , = C!, %“2!% ",!3“…% C=2,2 %K3“ %" …% ,“* ,2 $…% 3 …$ …, % “" ƒ/"=…, “ K *= , C =ƒ / (18 ) a/ % C%*=- ƒ=…% 2% … "ƒ,!= …= "%ƒ!=“2=…, %K? % * ,! …“= 2% K32= , = (“"%K% …% % + “" ƒ=……% %) “" ƒ/"=…, “ K *= , 3 …$ = 2“ = * ,! …“ “"%K% …% % C! C=!=2= %“2= 2“ … ,ƒ ……/

, …, “" ƒ/"=…, C! C=!=2%" “ K *= , C =ƒ / …= ,. =!-=*%*,… 2,*3 2!3 …% C! ", 2$ p *% … = ,, C% C!% …%ƒ,!%"=- …, " , …, C=2% % ,, C …, …= “" ƒ/"=…, ,*= …2%" " …=“2% ? "! %2“32“2"3 2 Š … … %›…% "/ ,2$

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…=,K% “3? “2" ……/ ƒ=*%…% !…%“2,: =) “ , %C! ……% ƒ=- K% "=…, C …, …=!3 = 2 “" ƒ/"=…, “ K *= , “2 C …$ C%"! - › …, C …, K3 2 " , 2$ …= C!% …%“2$ “" ƒ/"=…, ,*=-…2%" “ K *= , C =ƒ /; b) ,ƒ … …, “2 C …, “" ƒ/"=…, “ C =ƒ ……/ , K *= , K3 32 K% $ , , .%!% % “" ƒ/"= /.,*= …2%" (>60œ) C %.% “" ƒ/"= /. (<60œ) „%22, %K?, C!=", = , 2 “"%, ,“* …, %…, C%ƒ"% 2 " … *%- 2%!%L “2 C …, % …,2$ " , …, C=2% % ,, C …, …= “" ƒ/"=…, “ K *= , C =ƒ /

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} , ,…= , *=!“2" ……% % C! C=!=2= %C! 2“ *=* % … - %K!=2, % 3K/"=…, " “2 ,ƒ ! …, , "* = 2 2=K% ,ƒ ,*“*! , =›…/ C=!= 2!% " 2“ * ,! …“ *%2%!/L %C! -2“ *=* %2…% …, *%… …2!= ,, *=!“2"= * “*%!%“2, ,-,…= ,, , " 2“ !%L *2,"…%“2, C!% ““= , ,…= ,, q %"=2 $…% %K?,L , , “,“2 …/L * ,! …“ ,ƒ ! 2“ *% , - “2"% C =ƒ / % ,?= %L %2 *=!“2" ……% % " ? “2"= " ,…, 3 "! …, }2= .=!=*2 !,“2,*= %› 2 K/2$ C% 3 …= C32 ,ƒ ! - …, *%… …2!= ,, *=!“2"= " C =ƒ C%“ "" …, % …%*!=2…%L%ƒ/ ( %! 3 = ) , , " !="…%" “…% “%“2% …,, C% %! 3 :

Cl ¡ “*%!%“2$ "" …, C! C=!=2= Z Cpss

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Cpss O !="…%" “…= C =ƒ ……= *%… …2!= , *=!“2" ……% % " ? “2"= j ,! …“ … ƒ=",“,2 %2 ƒ= L“2"%"=……/. .=…,ƒ %" ,-,…= ,, , “ , %…= %“3? “2" 2“ … “*% $*, , C32 , 2% C! - C% = = 2 % …*3 “3 =!…% % *2= 2,. C!% ““%"

o!% ““ C!, *%2%!% “*%!%“2$ , ,…= ,, *=!“2"= C!%C%!-,%…= $…= % *%… …2!= ,, ,ƒ" “2 … *=* *,… 2,*= C !"% % C%- ! *= j,… 2,*= C !"% % C%! *= .=!=*2 !…= … "“ . *=!- “2" ……/. C! C=!=2%" d … *%2%!/. .=!=*2 !…= %ƒ%ƒ=",“, =, ,…= , j ,! …“ " 2,. “ 3 = . … ,… L…/L , % …$ "=!$,!3-2 " ƒ=",“, %“2, %2 %“2, …32%L *%… …2!= ,, C! C=!=2=

j ,! …“ %› 2 K/2$ 2=*› %K%ƒ…= … *=* *2,"…%“2$ 3 = - …, *=!“2" ……/. C! C=!=2%" ! ƒ %! =…/ , ,…= ,, (C …$ , C% *,) o …% …/L * ,! …“ (ClH) %2!=›= 2 *2,"…%“2$ … %K- !=2, % % 3 = …, ,ƒ *!%", *=!“2" C …$ n… %C! 2“!=* , L *=!“2"= 3 = %L ,ƒ *!%", "% "! C!%.%› …,! ƒ C …$ (E) = 2=*› C …% …/ *!%"%2%*% (QH) q%%2…% - …, 2,. C=!= 2!%" "/!=›= 2“ %! 3 %L:

ClH = QH E

(4)

k *=!“2"= C!, … / ˜er <s C! › %“2, $ “,“2 …% % *!%"%2%*= % ›…/ “…= = = C!%L2, ! ƒ C …$ o!, *“2!=* ,,*=!“2" ,ƒ *!%", " C!% ““ C!%.%› …,, ! ƒ C …$ !=*-, %“2, = ?= “,“2 …% % *!%"%2%*= (F) “2=…%",2“ …$ C!,… 2%L %ƒ/ d *=!“2" *%2%!/ C% …%“2$ "“=“/"= 2“ ,ƒ

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