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61\ Vete{ans Administ{ati<n Systems Se˜sis ;<<˜e{ative Study G{<u˜: Effect <f high d<se g€uc<c<{tic<id the{a˜y <n m<{ta€ity in ˜atients with c€inica€ signs <f systemic se˜sis\ N Engl J Med ^17:659-665 1987\

62\ Šuce JM M<ntg<me{y AB Ma{¨s JD et a€: Ineffectiveness <f high-d<se methy€˜{ednis<- €<ne in ˜{eventing ˜a{enchyma€ €ung inŒu{y and im˜{<ving m<{ta€ity in ˜atients with se˜tic sh<c¨\ Am Rev Respir Dis 1^8:62-68 1988\

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64\ B<ne R; S€<tman G Maunde{ R et a€: Rand<mized d<uˆ€e-ˆ€ind mu€ticente{ study <f ˜{<stag€andin E1 in ˜atients with the adu€t {es˜i{at<{y dist{ess synd{<me\ Chest 96:114-119 1989\

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67\ B{ent BN Mah€e{ D Ve{ge{ HJ et a€: Augmentati<n <f {ight vent{icu€a{ ˜e{f<{mance in ch{<nic <ˆst{uctive ˜u€m<na{y disease ˆy te{ˆuta€ine: a c<mˆined {adi<nuc€ide and hem<- dynamic study\ Am J Cardiol 50:^1^-^19 1982\

68\ Ringsted ;V E€iasen • Ande{sen JB et a€: Venti€ati<n-˜e{fusi<n dist{iˆuti<ns and cent{a€ hem<dynamics in ch{<nic <ˆst{uctive ˜u€m<na{y disease: effects <f te{ˆuta€ine administ{a- ti<n\ Chest 96:976-98^ 1989\

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71\ B{<wn SE Pa¨{<n FJ Mi€ne N et a€: Effects <f dig<Ÿin <n eŸe{cise ca˜acity and {ight vent{icu€a{ functi<n du{ing eŸe{cise in ch{<nic ai{f€<w <ˆst{ucti<n\ Chest 85:187-191 1984\ 72\ Mathu{ PN P<w€es A;P Puˆs€ey Sž et a€: Effect <f €<ng-te{m administ{ati<n <f dig<Ÿin <n eŸe{cise ˜e{f<{mance in ch{<nic ai{f€<w <ˆst{ucti<n\ Eur J Respir Dis 66:27^-28^ 1985\ 7^\ •im YS Aviad< DM: Digita€is and the ˜u€m<na{y ci{cu€ati<n. Am Heart J 62:680-686

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74\ G{een ŠH Smith TW: The use <f digita€is in ˜atients with ˜u€m<na{y disease\ Ann Intern Med 87:459-465 1977\

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76\ B{ent BN Be{ge{ HJ Matthay RA et a€: ;<nt{asting acute effects <f vas<di€at<{s (nit{<- g€yce{in nit{<˜{usside and hyd{a€azine) <n {ight vent{icu€a{ ˜e{f<{mance in ˜atients with ch{<nic <ˆst{uctive ˜u€m<na{y disease and ˜u€m<na{y hy˜e{tensi<n: a c<mˆined {adi<nu- c€ide-hem<dynamic study\ Am J Cardiol 51:1682-1689 198^\

77\ ;<{{iveau MŠ Minh V-D D<€an GF: Š<ng-te{m effects <f hyd{a€azine <n venti€ati<n and ˆ€<<d gas va€ues in ˜atients with ch{<nic <ˆst{uctive ˜u€m<na{y disease and ˜u€m<na{y hy˜e{tensi<n\ Am J Med 8^:886-892 1987\

78\ ;<{{iveau MŠ R<sen BJ •e€€e{ ;A et a€: Effect <f ˜<stu{e hyd{a€azine and nifedi˜ine <n hem<dynamics venti€ati<n and gas eŸchange in ˜atients with ch{<nic <ˆst{uctive ˜u€- m<na{y disease\ Am Rev Respir Dis 1^8:1494-1498 1988\

79\ Da€ N<ga{e AR Ruˆin ŠJ: The effects <f hyd{a€azine <n eŸe{cise ca˜acity in ˜u€m<na{y hy˜e{tensi<n sec<nda{y t< ch{<nic <ˆst{uctive ˜u€m<na{y disease\ Am Rev Respir Dis 1^^:^85-^89 1986\

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84\ Pac¨e{ M G{eenˆe{g B Massie B et a€: De€ete{i<us effects <f hyd{a€azine in ˜atients with ˜u€m<na{y hy˜e{tensi<n\ N Engl J Med 1^06:1^26-1^^1 1982\

85\ Ag<st<ni P D<{ia E Ga€€i ; et a€: Nifedi˜ine {educes ˜u€m<na{y ˜{essu{e and vascu€a{ t<ne du{ing sh<{t # ˆut n<t €<ng # te{m t{eatment <f ˜u€m<na{y hy˜e{tensi<n in ˜atients with ch{<nic <ˆst{uctive ˜u€m<na{y disease\ Am Rev Respir Dis 1^9:120-125 1989\

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}2= ="= C! “2=" 2 %Kƒ%! … *%2%!/ C!%K * ,…, “*%L=! =*% % ,, " C ,=2!,,. t=! =*% % , %2 $…/ C! C=!=2%" K% 2= $…% !=ƒK,!= 2“ " !3 , !=ƒ = . 0 $ =……%L ="/" 2“ %C,“=…, “C , , “*, %“%K ……%“2 L =! =*%2 !=C,, 32 L C% “!="… …, “% "ƒ!%“ / , , C% "%ƒ %›…%“2, %C! …, 2 =! =*% % , “*, !=ƒ , ,L *%2%!/ , 2 …=,K% "=›…% * ,…, “*% ƒ…= …, .

b%ƒ!=“2…/ !=ƒ , , " ! =* , …= *=!“2"= " 2“ C% “"%-L C!,!% *=* =! =*%*,… 2, “*, , 2=* , =! =*% ,…= , - “*, , (6-9). t=! =*%*,… 2,*= %C,“/"= 2 "ƒ=, %“" ƒ$ "% "! …,

› 3 дозой C! C=!=2= , % концентрацией в организме. t=! =*%-,…= ,*= !=“*!/"= 2 “%%2…% …, › 3 2%L концентрацией , "%ƒ…,*= ?, " ! ƒ3 $2=2 ответом.

b 3ƒ*% “ /“ =! =*% ,…= ,*= %ƒ…= = 2 3"“2",2 $- …%“2$ , =!=*2 !,ƒ3 2“ “%%2…% …, *%… …2!= ,, … “" ƒ=……%-% C! C=!=2= (2 %! 2, “*, O " “2 L“2", ; …= C!=*2,* O " C =ƒ ) , " , ,…/ *2=. b K% ,!%*% “ /“ =! =*%-,…= ,*= ƒ=* = 2 " “ K %C,“=…, "“ K,% , , “*, , ,ƒ,%-% , “*, *2%" *=!“2" ……% % " ? “2"= (8).

a Š *“2 =……%L ="/ = 2=*› !,“. 6.1 6. The Pharmacologic Approach to the Critically Ill Patient, Third Edition C! “2=" … Daziel A. No++ermaz M.D. d!3 ,=2 !,= / =……%L ="/ C! “2=" …/: 2=K . 6.1-6.4 , 6.6 # Daziel A. No++ermaz M.D. F.A.A.P. F.;.;.M.; 2=K . 6.5 # Arzo Š. Zari+sky M.D.; 2=K . 6.7 # Ro@olfo I. Go@izez M.D. P”.D. Marye H. Go@izez M.D. , Russell ;. Ra˜”aely M.D.

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3"“2",2 $…%“2$ * *=!“2" ……% 3 C! C=!=23 C! “2=" 2“!= , “*, !=ƒ…/ , “C%“%K= , (8) …=,K% =“2% *=* ƒ=",“,-%“2$ *%… …2!= ,, C! C=!=2= , ,…2 …“,"…%“2, =! =*% % , - “*% % %2" 2=. p,“. 6.1 K% 2= $…% %C,“=……/L " “%%2" 2“2"3 - ? !=ƒ %2!=›= 2 =! =*% ,…= , “*3 ƒ=",“, %“2$ › 3 *%… …2!= , L %C= ,…= , "%ƒ…,*= ?, " ! ƒ3 $2=2 ,…%2!%C…/*2% › 3 % *%" 3 ? …*%" !=ƒ , …% % "%ƒ!=“2= (1©).

b … *%2%!/ “ 3 = %C! ……= … ƒ! %“2$ %! =…,ƒ = %K3- “ %" ,"= 2 C%"/ …, 3"“2",2 $…%“2, * =! =*% % , “*, "%ƒ L“2", . =C!, ! *=* C%*=ƒ=…% …= !,“. 6. *%… …2!= , " *3!%…, … %K % , = 2% % 2%K/ "/ƒ"=2$ 5©œ C% =" …, “3 %!%›…% % …=C! › …, / …$ 3 2 L !3 …% % "%ƒ!=“2= (“! …,L "%ƒ!=“2 6 6 “ ") 3 K% “2=! , (“! …,L "%ƒ- !=“2 41 4 “ ") , , "ƒ!%“ / .

c ="…/ 2! K%"=…, =! =*% ,…= , “*% % =…= ,ƒ= " 2“ C% 3 …, 2% …%L ,… %! = ,, % =! =*%*,… 2,* “%%2" 2“2"3 - ? % C! C=!=2= в конкретной популяции. %“2 C ……% 2% “2=…%",2“ "%ƒ %›…/ 2“*%L =“2, …=“ …, .

& % "$S

t=! =*% ,…= , “*, !=ƒ , , › 3 ! =* , , …= *=!- “2" ……/ C! C=!=2/ 3 2 L , "ƒ!%“ / K3 32 !=““ %2! …/ " *%…- 2 *“2 : a) *2%" *%2%!/ " 2“ 3…,*= $…/ , 2 L ˆ) C%K% …/ *2%" , –) › = / 2 !=C "2, “*, *2%".!, !=““ %2! …,, C%“ … L *=2 %!,, "…, =…, K3 2 “*%… …- 2!,!%"=…% …= *=2 % = ,…= .

[W`5]X‡W„• cHH•5\„

› 2 L % 32 %K…=!3›,"=2$“ 3…,*= $…/ *2/ *=!- “2" ……/ “! “2". b *= “2" C!, != %›…% C!," “2, ,*= …- 2%ƒ…/ …=!3 …, C!% ““%" !%“2= , , ! … ,= ,, " %! =…,ƒ-*%2%!/ "%ƒ…,*= 2 2% $*% " %C! ……/ C !,% / ›,ƒ…, -%" *= (11). q 3 2 3C% …32$ 2 !=2% …/ %*=ƒ/"= ?, C%K% …%L“2", 2% $*% …= C % (4 7 11-1^). = *=*% -2% 2=C !=ƒ",2,% %“2,› …, %C! ……%L ƒ! %“2, 2, “% !=… 2 23 › %“%- K3 3 ƒ", %“2$ 2% , C % . Š=* 2 2!= ,* ,…/ …=!3 = 2 !%“2 *%“2 L 3 C % = , …%"%!%› ……% % (14) = 2=*› !=ƒ",2, ƒ3K%" 32 L " "%ƒ!=“2 % 6 2 (15-16). j%!2,*%“2 !%, / …=! 3 “ !3-, , … K = %C!, 2…/ , *2= , ƒ= !›,"= 2 !%“2 ! K …*= (17) 2% … %K…=!3›,"= 2“ 3 "ƒ!%“ / .

Š%*“, “*% L“2", …= ! ? " 2“ C!%K %L C!, C!, - … …,, …= , ,*“%"%L *,“ %2/ (18) , 2%! ,…% %…%"/ =…2,K,%2,- *%" 2=*, *=* ,C!% %*“= ,… , …%! %*“= ,… (19 ©). %K %-, % ,ƒK =2$ C!, … …, 2, …%"/ ,…% %…%"/ C!%,ƒ"% …/% 17- 2… % "%ƒ!=“2= *% = !%“2 “* 2= 3› ƒ=" ! … (19 ©).

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"6 I676 h…%2!%C…/L *2 (œ @FZ@+) !=ƒ , …/ %ƒ %C= ,…= 3 ? …-

*%" , "ƒ!%“ / *% *. ›" , …, ,…%2!%C…% % " , …, %C= ,…= …=

,ƒ% ,!%"=……/ › 3 % *, ? …*%" “ "%ƒ!=“2% (ªp<© ©5) " “!="… …,, “

*%…2!% (? …*, ©-7 … "…% % "%ƒ!=“2=). b “*%K*= 3*=ƒ=… "%ƒ!=“2 " … .

(hƒ Dris–oll DJ Gille++e P; Ezrailsoz EG e+ al: Izo+ro˜i– res˜ozse of +”e

zeoza+al –azize myo–ar@ium +o @o˜amize. Pediatr Res 1 :4 1978).

BJBwW„• cHH•5\„

Увеличение частоты побочных эффектов и чувствительности к лекарственным препаратам. 2%* %C!= , , !3 , =…2= %…,“2/ %-= ,…= 2=*, *=* C!% %!C !=ƒ,… (*% C=ƒ,…) = %C !, % ,%!C!% =ƒ,… , 2 !=ƒ…%%K!=ƒ…/ C%*=ƒ=…, * C!, … …, " *!,2, “*, “,23= , ( 1- 4). }2, C! C=!=2/ %!=ƒ % =? "/ƒ/- "= 2 %“2!/ ,“2%…, “*, ! =* ,, 3 2 L , C% !%“2*%" 3 "ƒ!%“ / ( 5- 7). t=! =*%*,… 2, “*,L =…,ƒ !=ƒ",2, 2, ! =* ,L K/ ,““ %"=… , %2" ! …32 ( 5). %"/ …, 3"“2",2 $- …%“2, 0 q * !=ƒ…%%K!=ƒ…/ =…2= %…,“2= % = ,…= %› 2 %K• “- … 2$“ K% "/“%*%L *%… …2!= , L " % % % "%ƒ!=“2 % = ,…--! C2%!%" " % %"…% %ƒ ( 8).

b !=C= , O K %*=2%! *= $ , "/ *=…= %" C!, … ?,L“…, “3C!=" …2!,*3 !…%L 2= ,*=! ,, , !3 , C! “ ! - …/ …=!3 …,L !,2 = 3 2 L ( 9-^1). h 2“ “%%K? …, % !=ƒ- ",2,, 3 !3 …/ 2 L %“2!%L 2 › %L “ ! …%- % …%L … %“2=- 2% …%“2, C%“ "" …, 2% % C! C=!=2= (^ -^4). % 2%L C!, ,… " !=C= , … “ 3 2 ,“C% $ƒ%"=2$ 3 2 L % 1 % = (^^-^5). j “ =-

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