ФБТ БИ 2курс / игОрь

Назва білку

Leishmania major

E-число

Gen ID

Ф-я білку

mamA

1e-10

XP_001684907.1

TPR repeat

Query 9 LDEVTLYTHYGLSVA---KKLGANMVDAFRSAFSVNDDIRQVYYRDKGISH--------- 56

LD +THY L ++ K A AF A + DD +Y ++G +

Sbjct 472 LDPRNPFTHYNLGISYDHKGNHARATQAFTRAIEL-DDRHPDFYHNRGFTQRKQGAYAAA 530

Query 57 -------------------------AKAGRYSEAVVMLEQVYDADAFDVEVALHLGIAYV 91

+K GRY EAV D+ + + G A

Sbjct 531 IADYTTAVSLDPKHFKSHYNRAYCFSKLGRYEEAVADYAAALQIDSNNANAYHNRGAALA 590

Query 92 KTGAVDRGTELLERSIADAPDNIKVATVLGLTYVQVQKYDLAVPLLVKVAEANPVNFNVR 151

+ G ++ E R++ P GL Y Q+Q+YD A+ + + N

Sbjct 591 QLGRLEAAVEDFNRALRLNPKLTFALNARGLVYDQLQQYDKALADFTEAIRLDQRNSAWL 650

Query 152 FRLGVALDNLGRFDEAIDSFKIALGLRPNEGKVHRAIAYSYEQMGSHEEALPHFKKA 208

G N+G+ + AI + ++ L P+ + A+++ ++G +E A+ + KA

Sbjct 651 HNRGYTYRNMGKLELAIADYSASIKLAPHSHTAYTNRAFAFRKLGRYEAAIEDYTKA 707

548..610

/region_name="TPR_11"

/note="TPR repeat; pfam13414"

/db_xref="CDD:205592"

mamB

2e-10

XP_001682726.1

Cation efflux family

Members of this family are integral membrane proteins, that are found to increase tolerance to divalent metal ions such as cadmium, zinc, and cobalt. These proteins are thought to be efflux pumps that remove these ions from cells.

Query 122 ASVTVIVNELMYRYQICVGNENNSPAIIANAWDNRSDAISSAAVMVGVIASVIGFPIADT 181

A+ +V+ EL++R+ VG S ++ANA+ +R+DA S ++GV V+G P D

Sbjct 240 ATASVVCKELLFRWTRRVGLRAGSRVVVANAYHHRADAWSGGVALLGVAGQVMGLPGVDG 299

Query 182 IAAIGVSALVGRIGLELIGKAVHGLMD 208

+A + VS + +IG + +V D

Sbjct 300 LAGLAVSLSICKIGYGIFKDSVLEFFD 326

<228..>344

/region_name="Cation_efflux"

/note="Cation efflux family; cl00316"

/db_xref="CDD:213092"

mamO

0.014

XP_001685863.2

Query 412 LVQWDKVKPLIPWGVAGVVIGYFIGNAIGDSVVGVLLGLFALIMAGKAVLEILQPNAGED 471

L W V P P +A V F G + + LL + ++M+GK+ D

Sbjct 45 LCNWSDVNPTDPLYIADVGKNRFTGIPLARRLRYALLQWWRVVMSGKS--------NRPD 96

Query 472 TAEAIAAAEAGDEMDELMALAEGTTRPKTS 501

+ + AEA + +ALA G+ R + +

Sbjct 97 SDDEDDLAEARQQTSPDLALAGGSDRRQRT 126

mamE

0.002

XP_001681348.1

PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this subfamily of protease-associated PDZ domains a C-terminal beta-strand forms the peptide-binding groove base, a circular permutation with respect to PDZ domains found in Eumetazoan signaling proteins.

Query 695 PGATPVAGGGKGA-QVAEVLAGSRAAVAGLQANDLIIEVNNRPVTSPARLDAAIKAATAA 753

PG P + G +GA +V V A AG+ D+++ V NRP+ S ++ AA+ A A

Sbjct 585 PGVLPGSLGRQGAVRVESVTPQQLAERAGVCCGDVLLSVANRPIGSCEQMQAALAAVRAT 644

Query 754 GQQILLKVHRNG-QEFWIV 771

+ L+V+R+ QE V

Sbjct 645 QPSVALEVYRHTIQEIICV 663

576..654

/region_name="PDZ_serine_protease"

/note="PDZ domain of tryspin-like serine proteases, such

as DegP/HtrA, which are oligomeric proteins involved in

heat-shock response, chaperone function, and apoptosis.

May be responsible for substrate recognition and/or

binding, as most PDZ domains bind...; cd00987"

/db_xref="CDD:29044"

mamN

0.022

XP_001685246.1

Uncharacterized proteins involved in stress response, similar to tellurium resistance terD

Tellurium resistance terD like proteins. This family is composed of uncharacterized proteins involved in stress response, such as the tellurium resistance proteins, chemical-damaging agent resistance proteins, and general stress proteins from a variety of organisms. The tellurium resistance proteins are homologous terA,-D,-E,-F,-Z,-X gene products, which confer tellurium resistance mediated by plasmids. Currently, the biochemical mechanism of tellurium resistance remains unknown. The family also contains several ter gene homologues, YceC, YceD, YceE, for which there is no clear evidence for any involvement in the tellurium resistance. A putative cAMP-binding protin CABP1 shows a significant similarity to the terD protein and is also included in this family.

Query 277 CGGSDILFFGGLFVMVGALTSVGILDWAVAWLEGVTAGHDRVRAILLMWMAAGVTIFVGG 336

CG + + L VM+ SVG+ D + ++ + AG D VR

Sbjct 800 CGYFIVHKYDRLRVMLFETASVGVADLDLLSMDALWAGKDNVR----------------D 843

Query 337 GTSAAVFAPVAATLRLDG 354

GT A F PV +RL+G

Sbjct 844 GTLADRFNPVECNVRLEG 861

342..>456

/region_name="TerD_like"

/note="Uncharacterized proteins involved in stress

response, similar to tellurium resistance terD; cd06974"

/db_xref="CDD:132992"

mamM

1e-06

XP_001682726.1

Cation efflux family

Members of this family are integral membrane proteins, that are found to increase tolerance to divalent metal ions such as cadmium, zinc, and cobalt. These proteins are thought to be efflux pumps that remove these ions from cells.

Query 17 GLAVSTVLMVMKAFVGLIGGSQAMLADAMYSLKDMLNALMVIIGTTISSKPL-DAEHPYG 75

G A + V K ++G GGS A++AD +SL D+L ++ + ++S K L P G

Sbjct 57 GGATNVFFCVTKLWIGSAGGSVALVADGFHSLTDILADIISYVAISLSRKKLPRCRFPLG 116

Query 76 HGKVEFILSMVVSVVFIVLTGYLLVHAVQ 104

G++E +++V+ + LLV +++

Sbjct 117 IGRLETSGAVIVAAILFFGGVALLVQSLE 145

63..>153

/region_name="Cation_efflux"

/note="Cation efflux family; pfam01545"

/db_xref="CDD:201849"