Учебники / Hair Cell Regeneration, Repair, and Protection Salvi 2008

Regeneration of hearing, after acoustic trauma, 6–7

Regeneration response, trigger, 52–54 Reinnervation, hair cells, 65–66

Repair and protection, hair cells, 14ff, 39ff, 56–58, 199ff

Replacement cells, progenitors, 46 Replacement, hair cells, 56–58

Rescue therapies, neuronal survival, 236ff REST, neurogenesis, 169–170

Restoration of hair cells, nonproliferative, 54ff Retina, regeneration, 146–147

Retinoic acid, ear development, 279 RNA, amplicons, 265

tester representations, 265 ROS, protection, 226ff, 229

Salicylate, ROS scavenger, 228 Sensory epithelia, morphological

organization, 42

Serinus canaria (Canary), 119–120, 121 Sound conditioning, protection from damage to

inner ear, 16–17, 230ff

Spatial tuning curves, bird auditory nerve, 95 Spectral resolution, during hair cell loss and

recovery, 127

Spiral ganglion neurons, survival, 15–16 Spontaneous activity, chicken auditory nerve,

86ff

Starlings, see Sturnus vulgaris

Stem cells, 257ff

delivery to inner ear, 291–292 development, 282ff

fetal and adult, 283ff

hair cell regeneration, 22–23, 51–52 inner ear, 23, 285ff

mammalian hair cell production, 62–63 in mouse cochlea, 287–288 transplantation, 288ff

Stereocilia, damage, 55–56 repair, 217

Stress, free radical scavenging, 231–232 heat shock proteins, 17

Stress-activated protective mechanisms, sound conditioning, 231–232

Stress-activated protein kinase (SAPK), 206 Stress-induced apoptosis, 205–206

Stripe lesion, bird basilar papilla, 78 Sturnis vulgaris (European starling),

DPOAE, 100

hearing recovery after ototoxic drugs, 122 Superoxide dismutases (SOD), defense against

free-radical damage, 216

Index 315

Supporting cells, role in hair cell regeneration, 5–6, 60

differentiation, 12–14, 161–162 hair cell regeneration, 143ff

mammalian hair cell production, 62–63 organ of Corti, 172–173, 174 phenotypic conversion, 179–180 repair of sensory epithelium, 208ff types in regeneration, 148–149

T961Cn mutation, ototoxic susceptibility, 214 T aeniopygia guttata (zebra finch), 119–120 T bx1 gene, neuronal survival, 234–235 Tectorin genes, 270

Tegmentum vasculosum, injury in birds, 79–80 Temporal resolution, during hair cell loss and

recovery, 127–128

Temporary threshold shift (TTS), recovery, 218 birds, 8

TGF- , hair cell proliferation in mammals, 175ff

TGF- , inhibition of cell division, 177 TGF 1, upregulation in nerve, 237. TGF R1, upregulation of receptor, 237 Threshold recovery, see Hearing recovery Threshold sensitivity, chicken tuning

curves, 86ff

Threshold shift, following acoustic overexposure in birds, 118ff

Tip-links, endocochlear potential in birds, 79 regeneration, 218–219

Toughening, hair cells, 230ff Transcription factors, differentiation of hair

cells, 13

signaling mechanisms, 258 Transdifferentiation, 163–164 Transdifferentiation, hair cells, 163–164 Transient evoked otoacoustic emissions

(TEOAE), hypothermia, 233–244

TUNEL staining, DNA fragmentation, 201–202 Tuning curves, chicken, 84ff

recovery from trauma, 85ff

Tuning sharpness, chicken tuning curves, 86ff Two-tone rate suppression (TTRS), chickens,

90–91

UB/OC-1, 276, 278

Utricle, development in mammals, 270 immortalized cell lines, 274

Vestibular dysfunction, acquired, 206ff Vestibular hair cells, patterns of loss, 208

316 Index

Vestibular system, hair cell proliferation in birds, 48

hair cell recovery in mammals, 49–50 hair cell regeneration in mammals, 6,

171–172

Vestibular tissue, regeneration, 286

Virus vectors, neurotrophic factors, 236–237 Vocal production, following hair cell loss,

133–135

Vocalization recognition, Melopsittacus undulatus after hair cell loss, 131–133

Vocalizations, recognition during hair cell loss and recovery, 128ff

Xenotransplantation, 290–291

Zebra finch, see Taeniopygia guttata