Books for lectures / !!! SignMolecDiffProlif Pictures

Chronic Myeloid Leukemiaa

!CML results from a translocation betweenn chromosomes 9 and 22

!Result is termed the Ph+ chromosome

!ABL gene on chromosome 9 placed nextt toto BRC gene on 22 results in a fusion proteinein bcr-abl

!abl is a non-receptor Y-kinase

!bcr is member of the Rho family of small GTPasesPases

!Similar translocation occurs in ALL

!CML is target of Y-kinase inhibitor Glivecc

Non-Hodgkin’s Lymphoma

!80-90% of NHL show chromosomal aberrations

!t(8;14) most frequent, also 1st chromosomeme abnormality to be molecularly characterizedized

!Also found in Burkitt lymphoma

!MYC on 8 placed near immunoglobulin heavyheavy chain gene enhancer on 14

!Another common translocation is t(14;18)8)

!BCL2 gene on 18 is disrupted, bcl2 involvedlved in control of apoptosis, disruption leads toto loss of induced apoptosis