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Necrosectomy

913

 

 

STEP 4

Postoperative management of cavity

 

Having removed all loose necrotic material, the guide wire stiffener is re-passed along

 

 

the dilated tract.

 

A 34-Fr. soft tube drain is passed over the stiffener.

 

An 8-Fr. umbilical catheter is sutured to the larger drain to allow continuous cavity

 

lavage postoperatively.

 

Cavity lavage is commenced at 250ml/h using dialysis fluid via a blood warmer.

 

A median of three procedures/patient will be required prior to resolution.

 

Steps 1 and 3 are omitted as the dilatation/access is not required.

 

The Amplatz sheath is again not required.

914

SECTION 6

Pancreas

 

 

 

 

Postoperative Considerations

 

 

Close hemodynamic and respiratory monitoring and support in an ICU

 

 

Appropriate antibiotic and antifungal therapy guided by cultures

 

 

Parenteral nutrition or preferably an elemental enteral diet, especially with extensive

 

 

pancreatic parenchymal necrosis

 

Local Postoperative Complications

Short term:

Pancreatic and gastrointestinal fistulae

Recurrent peripancreatic abscess

Colonic necrosis – abscess/fistula

Intra-abdominal hemorrhage

Sepsis syndrome

Wound infection

Long term:

Endocrine pancreatic insufficiency

Exocrine pancreatic insufficiency

Incisional hernia

Pseudocyst (rare); if present, usually from an isolated remnant or disconnected duct syndrome secondary to complete necrosis of the neck of the pancreas

Recurrent pancreatitis (rare)

Necrosectomy

915

 

 

Tricks of the Senior Surgeon

Open Necrosectomy with Closed Postoperative Lavage

Blunt necrosectomy: necrotic tissue is removed by blunt digital dissection without instruments; use of scissors increases the risk of excising still viable tissue, injuring portal, splenic, or mesocolic vessels, or causing difficult-to-control bleeding.

Retroperitoneal necrosis: Even if the necrotic process in the retroperitoneum extends into the pelvis, blunt digital necrosectomy can be performed via an anterior, supracolic approach through the lesser sac dissecting inferiorly, following the necrosis.

Biliary pancreatitis: ERC can be performed before necrosectomy in patients with gallstone pancreatitis, clearing the common duct of stones, and thereby only cholecystectomy is performed with exploration of bile duct omitted, reducing the risk of bile duct injury.

Diverting ileostomy: With extension of the necrotic process behind the colon, we often perform a diverting ileostomy to reduce the risk of colonic fistula during the course of disease; intestinal continuity is restored 3months after discharge.

Necrosectomy and Closed Packing

Have the recent CT in the operating room. It is your road map to be sure you do not leave collections of necrosis undrained.

Bleeding inevitably ensues during the debridement. Unless this is copious, finish the debridement before attempting to stop it. It usually stops spontaneously or with the packing.

Planned Repeated Necrosectomy

Resist operating early on patients with necrotizing pancreatitis, even with hemodynamic and metabolic instability. Make every effort to operate as late as possible, even with proof of infected necrosis, provided that the patient remains stable with maximal intensive medical therapy; the necrotizing process will have thus ceased and all viable and devitalized tissue will have defined. In such a case, a single complete necrosectomy and primary abdominal wall closure will be usually enough.

Operative planning based on the preoperative CT is of paramount importance. All areas with fluid collections demonstrated on preoperative CT should

be sought for, unroofed, and debrided. Do not rely solely on visual and manual exploration of the peritoneal cavity and the retroperitoneum.

The initial necrosectomy offers the best possible exposure, and thus every attempt at a complete and safe necrosectomy should be pursued at this time.

Resist the urge to “debride” a possible “bridge” of tissue traversing the lesser sac cavity after blunt necrosectomy; this “bridge” most probably represents the middle colic vessels.

Percutaneous Necrosectomy

Use of a “level 1” fluid warmer provides pressurized warm fluid for intraoperative irrigation.

Be prepared to come back another day or two later rather than be overzealous with the initial or subsequent debridement.

Significant bleeding may be controlled by balloon tamponade, while laparotomy access and surgical control is obtained.

Discontinue the procedure if the patient shows signs of cardiovascular instability; resuscitate the patient, lavage the cavity, and come back another day.

Laparoscopic Staging of Periampullary Neoplasms

Kevin C. Conlon, Sean M. Johnston

Introduction

The global concept of preoperative staging of malignancies is to select, as best as possible, those patients who are or are not candidates for operative resection. In the case of periampullary neoplasms, we have good, non-operative “palliation” for patients with non-curable neoplasms. Because a celiotomy for a periampullary neoplasm that proves to be non-resectable is not therapeutic and obligates the patient to an “unnecessary” postoperative recuperation/recovery, preoperative staging laparoscopy can help to select those patients who are at highest chance for potentially curative resection and will prevent celiotomy in most of those with unresectable disease.

Indications and Contraindications

Indications

Assessment of resectability for:

 

 

Pancreatic cancer (adenocarcinoma)

 

 

Distal bile duct cancer

 

 

Duodenal cancer

 

 

Ampullary carcinoma

 

 

Islet cell neoplasms

 

Staging of locally advanced disease prior to chemoradiation

 

Diagnosis of suspected metastatic disease

 

Histologic confirmation of radiologically unresectable disease

 

 

Patient unfit for general anesthesia

Relative Contraindications

 

Multiple previous upper abdominal operations

 

Intra-abdominal sepsis

918

SECTION 6

Pancreas

 

 

 

Preoperative Investigation and Preparation for Procedure

 

History:

Jaundice, weight loss, abdominal pain, early satiety

 

Clinical evaluation: Signs of jaundice, cachexia, epigastric mass, ascites

 

Laboratory tests:

Liver function tests (albumin, total protein, bilirubin, alkaline

 

 

phosphatase, transaminases), coagulation parameters (PT, APTT),

 

 

urea and electrolytes, full blood count, C-reactive protein, tumor

 

 

markers (CA19–9, CEA)

 

Radiological

Ultrasonography, contrast-enhanced, dynamic, thin-cut CT of the

 

assessment:

pancreas and liver, in selected patients; endoscopic ultrasono-

 

 

graphy (EUS), endoscopic retrograde cholangiopancreatography

 

 

(ERCP), magnetic resonance cholangiopancreatography (MRCP)

 

Instruments and

30-degree angled laparoscope, either 10mm or 5mm

 

laparoscopes:

5-mm laparoscopic instruments

 

 

Maryland dissector

 

 

Blunt tip dissecting forceps

 

 

Cup-biopsy forceps

 

 

Atraumatic grasping forceps

 

 

Liver retractor

 

 

Scissors

10-mm suction device

Laparoscopic ultrasound probe (optional)

Laparoscopic Staging of Periampullary Neoplasms

919

 

 

Procedure

STEP 1

The patient is positioned supine on the operating table. A warming blanket is placed underneath the patient, who is secured appropriately to the table.

Requirements:

General anesthesia

Orogastric tube for stomach decompression

Urinary catheter (optional)

Anesthetic equipment on boom or free standing cart

920

SECTION 6

Pancreas

 

 

 

STEP 2

Trocar placement

 

 

 

 

A multiport technique is used. The initial trocar (10-mm blunt port) is placed using an open cut down usually in the infra-umbilical area. After the skin and subcutaneous tissue is divided, the fascia is grasped between two forceps and incised with either

a knife or cautery, opening the peritoneum under direct vision. Some form of blunt, Hassan-type port is inserted, secured in place, and a pneumoperitoneum established with CO2 gas. An intraperitoneal pressure of 10–12mmHg is considered optimal. The laparoscope is inserted and an initial examination of the peritoneal cavity performed. If no obvious metastases are seen, further ports are inserted in the right (10mm and 5mm) and left (5mm) upper quadrant along the line of an intended incision.

The 30° angled laparoscope is placed in the umbilical port, with the two 5-mm ports used for graspers, scissors, and liver retractor. The right lateral 10-mm port is used for the blunt suction irrigator. This instrument is particularly useful for retraction and “blunt” palpation. The lateral port is also used for the laparoscopic ultrasonography.

Laparoscopic Staging of Periampullary Neoplasms

921

 

 

 

STEP 3

Examination

 

 

 

 

A systematic examination of the abdominal cavity is performed, which mimics that performed during open exploration. Adhesions if present are divided to facilitate examination. Any peritoneal-based mass is biopsied with a cup biopsy forceps.

The sequence of examination is: (1) peritoneal cavity; (2) right and left lobes of the liver; (3) duodenum and the foramen of Winslow; (4) colonic mesocolon and ligament of Treitz; and (5) gastrohepatic omentum, lesser sac, pancreas, gastric pillar, and hepatic artery.

922

SECTION 6

Pancreas

 

 

 

STEP 4

Abdominal exploration (A-1, A-2)

 

 

 

 

After a general inspection of the peritoneal cavity, the patient is tilted approximately 10degrees head up. Examination of the liver begins with the anterior aspect of the left lateral lobe (segments 2 and 3). Palpation is achieved with the 10-mm and 5-mm instruments. The posterior aspect of the left lateral lobe and the anterior and inferior aspects of the right hepatic lobe are then examined in turn.

A-1

A-2

Laparoscopic Staging of Periampullary Neoplasms

923

 

 

 

STEP 5

Inspection of the liver hilus and foramen of Winslow

 

 

 

 

The right lobe of the liver is elevated with the retractor placed through the left upper quadrant port. The structures of the hepatoduodenal ligament can be dissected out and suspicious nodes biopsied if indicated.