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Enteric Drainage of Pancreatic Fistulas with Onlay Roux-en-Y Limb

801

 

 

STEP 2

If possible, a catheter or probe is passed through the fistulous tract into the pancreatic duct.

If the pancreatic duct is identified, opening the anterior wall (spatulating the duct) increases the effective diameter of the anastomosis and facilitates the conduct of the anastomosis.

Pancreatography can be obtained if not done already.

The pancreatic duct should be imaged proximally and distally.

The jejunum is transected about 15 cm distal to the ligament of Treitz. The blind end of the jejunum is closed by a stapling device or sutures.

Enteric continuity is reestablished by end-to-side jejunojejunostomy at least 60cm from the closed end of the Roux limb.

The anastomosis is constructed by suturing the side of the jejunum to the pancreatic duct or the rim of scarred tissue at the fistulous tract at its point of origin on the pancreas. For details of construction of the Roux-en-Y limb see Sect.2, chapter “Subtotal Gastrectomy, Antrectomy, Billroth II and Roux-en-Y Reconstruction and Local Excision in Complicated Gastric Ulcers.”

802

SECTION 6

Pancreas

 

 

 

STEP 3

A posterior row of Lembert-type sutures is placed using 4-0 silk.

Next a row of absorbable sutures (4-0 or 5-0 polyglycolic acid) are placed full thickness through the pancreatic duct and the jejunum.

A catheter can be left as a stent through the anastomosis and brought out of the anterior abdominal wall, allowing the anastomosis to be studied postoperatively through the catheter if indicated.

Enteric Drainage of Pancreatic Fistulas with Onlay Roux-en-Y Limb

803

 

 

STEP 4

If the pancreatic duct cannot be identified definitively, the jejunum can be sewn over the fistulous tract as an onlay anastomosis to the pancreatic parenchyma; it would be optimal to keep a stent across this onlay anastomosis.

A soft closed suction drain is placed adjacent to the anastomosis.

804

SECTION 6

Pancreas

 

 

 

 

Postoperative Tests

 

 

Hemodynamic and respiratory monitoring in intensive or intermediate care unit.

 

Measure daily drain output; note changes after beginning oral intake. Drains are

 

 

removed after resumption of oral intake and output is <50ml/day.

 

 

Measure drain amylase if persistent significant drainage >50ml/day. If fluid is

 

 

 

amylase rich, convert drains from closed suction drains to passive drains after 7days,

 

 

then advanced 1–2cm/day.

 

Local Postoperative Complications

Anastomotic leak, possible recurrent fistula

Abscess

Pancreatitis

Pancreatic pseudocyst

Intra-abdominal hemorrhage

Tricks of the Senior Surgeon

Patience, adequate drainage, and complete preor intraoperative imaging is paramount for definition of the fistula and associated ductal anatomy; should marked disease remain in the duct, an alternative procedure, e.g., resection or lateral pancreaticojejunostomy, might be a better choice.

One goal of fistula drainage is to preserve pancreatic endocrine and exocrine function. If the fistula arises from the tail of the pancreas, resection of the distal pancreas may be the best option if minimal loss of functional pancreatic tissue is anticipated.

Spontaneous closure of the pancreatic fistula can be aided with a somatostatin analogue; success may be predictable based on radiographic evaluation. Fistulae that arise from a divided duct will not resolve.

Closure of fistulae that radiographically connect to the GI tract may be facilitated by transpapillary pancreatic stents and by ensuring that strictures and obstructing calculi are addressed.

Internal drainage of the fistulous tract into the stomach is not suggested; rather a defunctionalized Roux limb of jejunum is preferred when resection is not the best option.

Sew to the pancreatic parenchyma at the point of origin of fistula and not to the fistulous tract; the parenchyma is usually thickened and scarred.

If internal drainage is not possible (high operative risk or anatomic considerations), chronic external drainage is the best option.

Amylase-rich fluid in the drain signifies breakdown of the anastomosis; management is considerably easier if a stent is placed across anastomosis at operation. The anastomosis can be evaluated radiographically; as the output decreases, the stent is converted from closed suction to passive drainage and then advanced 1cm/day.

Early intra-abdominal hemorrhage is best treated by reoperation and direct vessel ligation. Late hemorrhage may be a sentinel bleed from a pseudoaneurysm; immediate angiography and vessel embolization are indicated.

Sphincteroplasty for Pancreas Divisum

Andrew L. Warshaw

Indications and Contraindications

Indications

Strong: recurrent episodes of documented acute pancreatitis (typical pain, increased

 

 

serum amylase) in patients with congenital pancreas divisum or other variants of a

 

 

dominant dorsal duct (absent duct of Wirsung, filamentous communication to duct

 

 

of Wirsung)

 

Weak: patients with pancreas divisum and episodic “obstructive pancreatic pain”

 

 

(pain with characteristics and location attributable to a pancreatic origin but without

 

 

objective substantiation by hyperamylasemia or pancreatic edema).

 

 

Chronic pancreatitis (fibrosis, major duct dilation, pseudocyst, segmental duct

Contraindications

 

 

obstruction, calcification)

 

Pancreatitis from alcoholism, hypercalcemia, hyperlipidemia, gallstones, or trauma

 

Recent severe acute pancreatitis, significant residual inflammation/swelling

Preoperative Investigation and Preparation for the Procedure

History:

Recurrent episodes of epigastric pain, especially with radiation

 

through to the mid back; pain starts sporadically, with bouts

 

months apart, but may become frequent and even constant; attacks

 

are usually mild, more common in young women; mean onset is at

 

34years but can occur in childhood, onset is uncommon after age

 

50years.

Clinical evaluation: May have tenderness over the pancreas.

Laboratory tests:

Serum amylase and/or lipase.

Imaging:

ERCP or MRCP to elucidate pancreatic ductal anatomy; ERCP must

 

include opacification of the dominant dorsal duct via accessory

 

papilla. Caution: acquired obstruction of the duct of Wirsung by

 

tumor in the pancreatic head can mimic pancreas divisum.

Functional tests:

Transabdominal ultrasonography, endoscopic ultrasonography,

 

or MRCP with secretion stimulation – demonstrates abnormally

delayed return of principal pancreatic duct to normal size after hyperstimulation of pancreatic secretion.

Impaired emptying through stenotic accessory papilla results in persistent (15to 30-min) duct dilation.

806

SECTION 6

Pancreas

 

 

 

 

Procedure

 

 

 

 

STEP 1

Exposure of minor papilla

 

 

An upper midline or right subcostal incision depends on patient habitus.

 

 

 

Extensive mobilization of the duodenum and the head of the pancreas (extended Kocher maneuver) facilitates exposure.

Cholecystectomy is performed if the gallbladder is still present; passage of a biliary Fogarty® catheter via the cystic duct or common duct through the major ampulla into the duodenum aids localization of the accessory papilla.

A transverse duodenotomy is made just proximal to the papilla of Vater, which can usually be felt transduodenally or with the aid of the biliary Fogarty® catheter.

Sphincteroplasty for Pancreas Divisum

807

 

 

STEP 2

Location of minor papilla intraduodenally

 

 

Locate the accessory (minor) papilla 2–3cm proximal and anteromedial to the papilla of

 

 

 

 

Vater; minimize trauma to the duodenal mucosa.

 

 

Secretin (1U/kg intravenously) helps locate the papilla by inducing visible flow of

 

 

pancreatic juice and sometimes by ballooning out the papilla.

 

 

Grasp the duodenal mucosa just distal to the minor papilla to fix its position; insert a

 

 

fine probe or Angiocath into the orifice. (It may be necessary to pierce the membranous

 

 

tip of the papilla when the orifice is miniscule.)

808

SECTION 6

Pancreas

 

 

 

STEP 3

Sphincterotomy of minor duct

 

 

 

 

Fine traction sutures are placed at the distal margins of the accessory papilla; the papilla is incised over a probe in the duct. Pancreatic juice should gush forth, and a dilated vestibule proximal to the papillary membrane should be immediately apparent. The smooth light pink mucosa lining the pancreatic duct is easily distinguished from the duodenal mucosa.

The incision is extended about 1cm, only as far as necessary to lay the duct vestibule widely open.

STEP 4

Sphincteroplasty of minor duct

 

The duodenal mucosa and the pancreatic duct epithelium are approximated with fine

 

 

absorbable synthetic sutures for hemostasis and to facilitate healing without re-stenosis.

Sphincteroplasty for Pancreas Divisum

809

 

 

STEP 5

Duct drainage and duodenal closure

 

 

A small catheter (e.g., 5-French pediatric feeding tube) is passed through the duodenal

 

 

 

 

wall and into the pancreatic duct to insure against postoperative duct obstruction.

 

 

The catheter is inserted within the duodenal wall through a 14-gauge needle or

 

 

commercial catheter fitted on a trocar, tunneled within the duodenal wall, and closed

 

 

with a double-purse-string absorbable suture (A-1). The catheter is brought out through

 

 

the abdominal wall for postoperative drainage and remains in place for 2–3weeks before

 

 

removal (A-2, A-3).

 

 

The duodenotomy is closed transversely in two layers; no right upper quadrant drain

 

 

is needed.

A-3

810

SECTION 6

Pancreas

 

 

 

 

Postoperative Tests

 

 

Routine postoperative surveillance.

 

 

Serum amylase is not necessary unless there is a specific clinical indication.

 

Local Postoperative Complications

Short term:

Acute pancreatitis

Duodenal obstruction

Duodenal leak

Long term:

Recurrent papillary stenosis

Recurrent symptoms, pancreatitis

Failure to cure preoperative pain syndrome

Tricks of the Senior Surgeon

The major papilla (ampulla) of Vater is often palpable through the duodenal wall even without a transcholedochal (e.g., via cystic duct) catheter through the Ampulla of Vater.

The accessory papilla is proximal in the duodenum, perhaps only 3cm from the pylorus; a prominent vessel on the lateral duodenal wall is often noted at this point.

The transverse duodenotomy provides adequate exposure and is less likely to cause postoperative duodenal stenosis than a longitudinal suture line.

The accessory papilla may be difficult to find by visual inspection, it is often small, protrudes minimally from the duodenal surface and is located more easily by gentle palpation of the medial wall of the duodenum. It feels like a small “bump” or nipple.

Application of methylene blue to the duodenal mucosa may help to locate the pancreatic duct orifice; pancreatic secretions, especially after secretin, wash off the blue dye at the orifice.

After cannulating the orifice, do not remove the probing instrument until the incision into the papilla has been completed. Local trauma may make rediscovery of a small, traumatized orifice very difficult.

The dorsal duct of Santorini follows a perpendicular course through the duodenal wall (in contrast to the oblique path of the duct of Wirsung); the sphincteroplasty is therefore necessarily short. Going past the thin membrane of the first centimeter makes the apex of the sphincteroplasty difficult to suture.