- •На правах рукописи
- •Глава 2. Материалы и методы исследования………………………………….58
- •Глава 3. Результаты исследования……………………………………………...62
- •Глава 4. Обсуждение результатов……………………………………………….88
- •Список сокращений
- •Введение
- •Глава 1. Обзор литературы
- •1.1. Изменения поведения как проявление старения мозга
- •1.1.1. Изменения поведения в онтогенезе
- •1.1.2. Изменения поведения при физиологическом старении и нейродегенеративных расстройствах
- •1.2. Возможные механизмы возрастных изменений
- •1.3. Окислительный стресс и старение мозга
- •1.3.1.Роль активных форм кислорода в физиологических процессах
- •1.3.2. Окислительный стресс в механизмах старения и патогенезе связанных с ним нейродегенеративных заболеваний
- •1.4. Антиоксиданты как геропротекторы
- •1.4.1. Адресованные в митохондрии антиоксиданты -
- •1.5. Крысы oxys – модель преждевременного старения и
- •Заключение
- •Глава 2. Материалы и методы исследования
- •2.1.Животные и методы воздействия на них
- •2.1.1. Оценка возрастных изменений поведения крыс oxys и Вистар
- •2.1.2. Магнитно-резонансная томография
- •2.1.3. Офтальмологические осмотры
- •2.1.4. Влияние антиоксидантов на поведение
- •2.2. Статистический анализ
- •Глава 3. Результаты исследования
- •3.1. Изменения поведения крыс oxys и Вистар с возрастом
- •3.1.1. Тест «открытое поле»
- •3.1.2. Приподнятый крестообразный лабиринт
- •3.1.3. Водный лабиринт Морриса
- •3.2. Поведение крыс oxys и развитие катаракты и ретинопатии
- •3.3. Магнитно-резонансная томография мозга
- •3.4. Влияние антиоксидантов на поведение крыс oxys и Вистар
- •3.4.1. Влияние антиоксидантов на поведение
- •3.4.2. Влияние длительного приёма SkQ1 на поведение крыс oxys и Вистар
- •3.4.3. Влияние SkQ1 на поведение годовалых крыс oxys и Вистар
- •Глава 4. Обсуждение результатов
- •Список литературы
Список литературы
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