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III.2.15 |
Pd-CATALYZED CONJUGATE SUBSTITUTION 787 |
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Cl2Pd(MeCN)2 |
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O |
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RCOCl |
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DMF |
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CH(OEt)2 |
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CH(OEt)2 |
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57−89% |
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NC |
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SnBu3 |
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Pd(PPh3)4 |
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dioxane, LiCl |
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OHC |
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TfO |
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OHC |
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88% |
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OSiEt3 |
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(E)-PhSO2CH=CHOTs |
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OSiEt3 |
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SO2Ph |
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SnBu3 |
Cl2Pd(PPh3)2 |
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CuI, LiCl, THF |
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[72] |
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65−70% |
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R1SnBu3 |
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SO2CF3 |
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Pd(PPh3)4 |
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SO2CF3 |
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R2 |
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H |
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R2 |
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H |
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77−93% |
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Cl2Pd(MeCN)2 |
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DMF |
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[74] |
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R2 |
SnBu3 |
R4 |
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SOTol- p |
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R2 |
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R4 |
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76−92% |
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Scheme 10
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789 |
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