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Figure 4 DynDom [67] analysis of the first two normal modes of human lysozyme. Dark grey and white indicate the two dynamic domains, separated by the black hinge bending region. The vertical line represents a hinge axis that produces a closure motion in the first normal mode. The horizontal line represents a hinge axis that produces a twisting motion in the second normal mode. (Adapted from Ref. 68.) The DynDom program is available from the Internet at http:/ /md. chem.rug.nl/ steve/dyndom.html.
of these applications its weaknesses, in comparison to other simulation techniques, appear still to be outweighed by its strengths.
ACKNOWLEDGMENT
I wish to thank Dr. Akio Kitao for reading the manuscript.
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