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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5731_Библиотеки_им_академика_М_И_Перельмана.pdf
for DPharm, BPharm and BSc Courses
Viva Voce in
Pharmaceutical
Chemistry
Viva Voce in
Pharmaceutical
Chemistry
1.
Viva Voce in
Organic and Pharmaceutical Chemistry for
BPharm, DPharm and BSc Courses (PB)
2. Pharmaceutical Chemistry Laboratory Manual for First Year
Diploma in Pharmacy, 2e (PB)
3.
Viva Voce in
Inorganic Chemistry for BPharm, DPharm and BSc
Courses (PB)
Other Books by the Same Author
Amrita Parle MPharm
Associate Professor
Delhi Institute of Pharmaceutical
Sciences and Research
Pushp Vihar, MB Road
New Delhi
Former Head
Department of Pharmacy
Meerabai Institute of Technology
Maharani Bagh
New Delhi
CBS Publishers & Distributors Pvt Ltd
New Delhi • Bengaluru • Chennai • Kochi • Kolkata • Lucknow • Mumbai
Hyderabad • Jharkhand • Nagpur • Patna • Pune • Uttarakhand
for DPharm, BPharm and BSc Courses
Viva Voce in
Pharmaceutical
Chemistry
Viva Voce in
Pharmaceutical
Chemistry
Disaimer
978-93-490-5781-4
First 5
Branches
th
nd
st
Representatives
to
The Omnipotent
The Omnipresent
The Omnificent Almighty
I
t is a pleasure to write the Preface of the book Viva Voce
in Pharmaceutical Chemistry. This book would be of great use in
reducing anxiety of the students while appearing for oral
examination of practical organic and inorganic chemistry. The
book would be appropriate for DPharm, BPharm and BSc
students. The book has covered all the aspects given in the
ER 2020 Diploma in Pharmacy syllabus. The study of this book
would appraise them with 961 questions and answers. The book
covers the topics like apparatus used, its cleaning, calibration,
periodic table, purification processes, limit tests, identification
tests, volumetric analysis, quantitative organic analysis,
qualitative organic analysis, etc. The reason behind the use of a
particular reagent, maintaining specific pH, principles involved,
chemical reactions occurring in the experiment, calculations
involved, etc. are dealt in detail.
I am ever grateful to the omnipotent Almighty for whatever
little I could share with the students.
I am thankful to Mr YN Arjuna and Mr SK Jain of CBS
Publishers & Distributors Pvt Ltd for publishing the book.
Amrita Parle
Preface
Preface vii
General Questions 1
Laboratory apparatus, cleaning and calibration 5
Weighing 9
Purification processes 12
Periodic table 14
Laboratory hazards and first aid 15
1. Limit Tests 18
General questions 18
Limit test for chlorides 22
Limit test for sulphates 25
Limit test for iron 27
Limit test for heavy metals 30
2. Identification Tests for Anions and Cations 33
Tests for identification of cations 33
Ammonium ion 33
Barium ion 34
Calcium ion 35
Magnesium ion 36
Potassium ion 37
Sodium ion 38
Tests for identification of anions 39
Bicarbonate ion 39
Chloride ion 40
Citrate ion 40
Gluconate ion 42
Contents
x
Viva Voce in
Pharmaceutical Chemistry
Iodide ion 43
Sulphate ion 44
Thiosulphate ion 45
3. Fundamentals of Volumetric Analysis 46
General questions 46
Molecular weight and equivalent weight 47
Normality/molarity/preparation of solutions 49
Standard solutions 54
Indicators 56
Calculations 58
Neutralisation titrations 63
Preparation and standardization of hydrochloric acid
solution 66
Preparation and standardization of sodium hydroxide
solution 68
Redox titrations 71
Equivalent weight of oxidising and reducing agents 72
Permanganometry 75
Preparation and standardization of potassium
permanganate 77
Iodimetric and iodometric titrations 78
Preparation and standardization of sodium
thiosulphate solution 80
Precipitation titrations 83
Mohr’s method 84
Volhard’s method 85
Preparation and standardization of 0.1 M silver nitrate
solution 88
Preparation and standardization of ammonium
thiocyanate solution 90
Complexometric titrations 92
General questions 92
Preparation and standardization of edetate
solution 100
4. Assays 105
Assay of ferrous sulphate 105
Assay of calcium gluconate 107
Contents xi
Assay of sodium chloride 110
Assay of Ascorbic acid 112
Assay of Ibuprofen 114
5. Fundamentals of Preparative Organic Chemistry 116
General questions 116
Solubility 119
Storage 121
Melting point 122
Boiling point 124
6. Preparation of Organic Compounds 126
Acetylation 126
Bromination 127
Nitration 128
Hydrolysis 130
Esterification 131
Benzoylation 133
Diazotization 134
Oxidation 136
Reduction 136
General questions related to synthesis 137
Preparation of benzoic acid from benzamide 140
Preparation of picric acid from phenol 141
7. Identification and Test for Purity of Pharmaceuticals 142
Identification tests 142
Chemical tests for identification of aspirin 142
Chemical tests for identification of caffeine 143
Chemical tests for identification of sulphanilamide 144
Chemical tests for identification of paracetamol 147
8. Systematic Qualitative Analysis 148
Preliminary examination 148
Extra elemental detection 151
Functional group detection 156
Carboxylic acids 157
Alcohols/aliphatic hydroxy group 163
Phenols/aromatic or phenolic hydroxy group 166