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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5720_Библиотеки_им_академика_М_И_Перельмана
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Index 235
cyclic, 95, 131, 185
prion, 212, 213
protein-bindig, 184
Permeability, 46, 105, 111, 132, 175
Pharmacokinetics, 132
Phase, 47, 107, 135
lag, 213
pseudo, 46
pseudostationary, 85
reverse, 58
solid, 49, 57, 67, 69, 84, 93, 96, 186
stationary, 83, 84
Phenylbutazone, 105
Photoluminiscence, 125
Photostability, 193
Phthalocyanine, 68
Piroxicam, 105, 135
Plaque
amyloidogenic, 209
senile, 214
Plasmodium falciparum, 171
Plasmodium vivax, 171
Polydispersity, 45, 84, 85, 178
Polymer, 1, 2, 12, 33, 45
, 46, 49, 50, 64, 65,
85, 89, 107, 108, 118, 131, 135, 143,
146, 149, 153, 199
block, 136
branched, 135
brush, 107
cationic, 144
co-, 135, 165
dendrigraft, 2
dendrimeric, 45
dendritic, 2, 50, 95, 134, 135, 164, 200
dendronized, 12, 152
enantioselective, 84
homo-, 50
hyperbranched, 2, 12, 45, 107, 121, 122,
134, 135
linear, 135
monodisperse, 1
spherical, 142
starburst, 45
Polymerization, 50
atom transfer radical, 65,
107, 121
co-, 107
dispersion, 125, 193
electrochemical, 192
free radical, 112
ring-opening, 107, 133
Polysaccharide, 1, 25, 68, 149, 154, 155, 178,
199
Pool, 25, 94, 223
Porphyrin, 29, 30, 177
PPI, 30, 87, 88, 100, 108, 121–123, 149, 164,
210–213
Prednisone, 107
Preparation
dendrimeric (see Dendrimer)
Principle, 9, 55, 63, 83, 95, 155, 224
majority rules, 50
sergeants and soldiers, 50
Prion, 209, 209, 209–213
Probe, 46
, 49, 57, 66, 88, 122, 123, 134, 152,
155, 172, 179, 185, 191, 194, 213,
216
Process, 2, 48, 64–66, 100, 121, 123, 143, 144,
152, 161, 163, 183, 184, 200, 201,
215
adhesion (see Adhesion)
aggregation, 213
equilibrium driven selection, 95
recognition, 12, 13, 120, 180
self-assembly, 215
separation, 84
signal transduction, 23
surface energy transfer, 121, 184, 194
Prodrug, 172
Proscillaridin A, 179
Protease, 47, 61
, 209–212, 216
aspartyl, 179
cysteine, 179
HIV-1, 70
K, 210
serine, 179
Protein, 1, 3, 12–14, 23, 24, 46, 47, 57, 60–62,
68, 70, 88, 94, 95, 115, 116, 119,
135, 149, 152, 154, 155, 163, 164,
166, 171, 176, 179, 180, 183–185,
188, 192, 194, 198, 201, 203, 204,
209, 210,
214, 216, 217, 223
amyloid, 210, 212
carbohydrate binding (see Lectin)
circumsporozoite, 171
extracellular matrix, 184
G, 197, 198
green fluorescent, 141, 144
M, 200
NS3, 204
pathological, 209
prion, 209, 210, 212, 213
toxic, 209
Proteinase. See also Protease
cathepsin L, 172
Proteolysis, 47, 201
Proteome, 23
Proteomics, 23, 94
Prulifloxacin, 105
Данная книга находится в списке для перевода на русский язык сайта https://meduniver.com/
236 Index
Pseudomonas aeruginosa, 13, 67, 93, 153–154,
184, 186
Pseudorotaxane, 135
Purification, 55, 57, 64, 84, 85, 223
Purity, 57, 83, 85, 87, 94, 223
Quantum dot, 15, 108, 112, 121, 122, 179, 199,
217
Quinacrine, 212, 215
Radioactivity, 180
Radioisotope, 85
RAFT, 29, 30, 185, 215
Rational design, 131
Reaction, 55, 57, 60, 64, 84, 99, 117, 120,
122, 143, 180, 191
, 199. See also
Cycloaddition
asymmetric aldol, 99
catalytic, 99
chemoselective, 61
click (see Chemistry, click)
competitive, 191
coupling, 223
dendritic chain, 48, 49
diazo transfer, 152
Diels–Alder (see Cycloaddition,
Diels–Alder)
domino-like, 48
electron-transfer, 192
enzymatic, 192
hydroformylation, 100
immuno, 192
ligation (see ligation)
Michael addition, 125
nitro-Michael addition, 99
perfectly controlled, 65
photooxidation, 100
polyaddition, 165
real-time polymerase chain, 199
reversible, 60, 94
Sonogashira cross coupling, 188
sulfanyl-capture, 61
thermal, 87
Wacker oxidation, 100
Receptor, 13, 46, 57, 68, 93, 115, 118, 119,
121–123, 125, 133, 134, 152, 161,
164, 176–179
, 183, 185, 187, 188,
193, 198, 200, 217
adenosine, 217
dectin, 134, 144, 200
fibroblast growth factor, 134
G protein-coupled, 67, 198
GABAB, 142
immuno-, 197
langerin, 200
lectin, 176, 178
lipopolysacharide toll like, 200
melanocortin, 67
nicotinic acetylcholine, 142
P2Y
14
, 198
toll-like, 155, 176
Recognition, 12, 13, 25, 47, 58, 87, 88, 120,
125, 150, 163, 180, 183, 185, 187,
188, 194, 201, 203
Relative potency, 13, 14, 150, 152
RNA, 141, 142
RNAi, 142, 145
Robustness, 84
Rotaxane, 33, 69, 69, 135
Ruggedness, 84
Scaffold, 29, 58, 67–69, 94, 95, 108, 118–120,
131, 151, 153, 177, 181,
184–186,
201, 203
Scale, 163
atomic, 115
kilogram, 45
nanometer, 115
Scattering
laser light, 83
multi-angle laser light, 85
small-angle neutron, 83, 217
small-angle X-ray, 83
Schistosoma mansoni, 171
Schistosomiasis, 171
Sensor, 125, 152, 153, 191, 193, 194
amperometric, 125
electrochemical immuno-, 191, 192
fluorescent, 88, 122, 191
turn-on, 192, 193
shpDNA, 143
shpRNA, 143
Sialidase. See Neuraminidase
Signal, 23, 48, 49, 87, 180, 217
intercellular, 197
nuclear localization, 95
Signal amplification, 48, 49
Signal-to-noise ratio, 66
Signaling, 46, 69, 177, 180, 183, 191,
197, 216
intracellular, 197
Signaling cascade, 217
siRNA, 134, 142–145
Solubility, 100, 105–108, 117, 135, 137, 142,
145, 165
Solubility enhancement, 105, 107
Index 237
Solubilization, 105–108, 117, 118, 121, 185,
209, 212
mode of, 105
Solubilizer, 105, 210
Spectrometry. See Spectroscopy
mass (see MS)
Spectroscopy
dielectric, 83
electron paramagnetic resonance (see EPR)
fluorescence, 49, 57, 83, 88, 94
FTIR, 66, 85, 213
IR, 83
non-linear optical, 83
Raman, 83
time-resolved, 83
UV-VIS, 49, 83, 88
Sporozoite, 171
Stability, 61, 66, 111, 115, 117, 121, 123, 163,
191, 192
Stereospecific, 64
Stereospecificity, 64
Strategy, 15, 88, 95, 151,
152, 154, 161–163,
171, 177–179, 203, 211, 214, 215,
217
convergent, 55–57, 58, 59, 60
divergent, 55–57, 57–58
LEGO (see Chemistry, LEGO)
multi-targeted, 213
screening, 118
tandem, 60
Streptococcus pyogenes, 200
Structure, 1–3, 10, 11, 23, 25, 55–58, 60, 68,
95, 99, 105, 107, 115, 134, 141, 150,
152, 153, 164, 172, 175, 176
, 178,
186, 188, 194, 201, 203, 211, 223,
224
branched, 1–3, 107
crystal, 15
densely packed, 2
globular, 29
hexagonal, 119
multivalent, 55, 155, 175
primary, 51, 224
resonance, 66
semi-rigid, 185
supramolecular, 47
symmetrical, 117, 144
tertiary, 51, 224
Structure activity relationships, 68, 144, 154
Structure elucidation, 87
Substructure, 3
Sugar ball, 15
Sugar epitope, 12
Sulfadiazine, 134
Sulfamethoxazole, 105
Supramolecular crystal, 123
Supramolecule, 47
Surface plasmon resonance, 14, 88, 95, 176,
183, 186–188, 203, 216
SV40, 95
Synthesis
direct (see
Strategy, divergent)
indirect (see Strategy, convergent)
˛-Synuclein, 209, 216, 217
System, 9, 12, 23, 49, 50, 57, 64, 66, 88, 108,
111, 115–118, 131, 132, 135, 136,
141, 143–145, 164, 178–180, 185,
199, 212, 213, 216, 217
aromatic, 66
BARAC cyclooctyne, 66
central nervous, 164, 184, 217
coding, 24
dopaminergic, 217
electron withdrawing, 66
extraction, 121
heterogeneous, 99
high-density coding, 24
homogeneous, 99
hybrid, 33
immune, 132, 200
information, 223
integrity, 9
macromolecular, 45, 50
nervous, 217
reticuloendothelial, 143
self-organized, 33
self-replicating, 95
supramolecular, 47, 164
T cell, 12, 121, 162–165, 171, 175, 200, 201,
204, 214, 215
TA SP. See also RAFT, 95
TAT, 95
Template, 57, 61, 95, 100, 192, 203, 215
Theranostics, 131
Therapeutics, 68, 131, 171, 175, 210
Therapy, 46, 69, 121, 131, 132, 135, 136, 149,
161, 164, 172, 175, 177, 180,
200,
212–214, 216
adjuvant, 155
chemo-, 162, 179, 180
gene, 141, 142, 145
immuno-, 199, 214
leukemia, 112
photodynamic, 177
radio-, 180
Данная книга находится в списке для перевода на русский язык сайта https://meduniver.com/
238 Index
Toxicity, 65, 112, 111–112, 115, 118, 137, 143,
144, 176, 178, 181, 194, 210, 215,
216
acute, 178
chronic, 178
hemolytic, 134, 178
Toxin, 95, 185, 186
cholera, 153
Trypanosoma cruzi, 172
Trypsin, 47
Tumor, 120, 121, 132–134, 136, 145, 175–181,
198–201
Ulex europaeus, 93, 154
Vaccine, 58, 64, 154, 155, 162, 164, 165, 171,
175, 201,
199–204, 213, 215, 223,
224
anti-HIV, 203
antibacterial, 150
anticancer, 179
antitumor, 175
cholera, 153
dendrimeric peptide, 203, 204
DNA, 201
MUC1–lipopeptide, 58
Vector, 12, 142–145, 191
non-viral, 141, 142, 144
viral, 141
Venlafaxine, 105
Vibrio cholerae, 152–153
Virion, 70, 162, 165, 166
Virus , 95, 120, 161, 223
artificial, 120, 144
classical swine fever, 165, 204
cytomegalo-, 165
foot-and-mouth disease, 204
Hepatitis C, 162
Herpes simplex, 107, 166
human cytomegalo-, 165
human immunodeficiency, 121, 164, 203,
162–203
human papilloma-, 96,
164, 165
influenza, 3, 47, 161, 161, 162, 161–162
influenza A, 161
rabies, 142
simian-human immunodeficiency, 203
Wor m, 171
X-ray diffraction, 83, 209
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