Добавил:
kiopkiopkiop18@yandex.ru t.me/Prokururor I Вовсе не секретарь, но почту проверяю Опубликованный материал нарушает ваши авторские права? Сообщите нам.
Вуз: Предмет: Файл:

Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5713_Библиотеки_им_академика_М_И_Перельмана

.pdf
Скачиваний:
0
Добавлен:
12.10.2026
Размер:
5 Мб
Скачать
☆
214
Metals in Medicine, Volume 1
  
Appl. Mater. Today. 2022, 29, 101646.
105.          
Curr. Med. Chem. 2017, 24 (2), 193–214.
https://t.me/med1917
Metals in Medicine, Volume 1: Metals for Tissue Engineering and Pharmaceutical Applications.
Sonali Sundram, Rishabha Malviya, and GSN Koteswara Rao
© 2025 Apple Academic Press, Inc. Co-published with CRC Press (Taylor & Francis)


Vision College of Pharmaceutical Sciences, JNTUH, Hyderabad,
Telangana, India
CHAPTER 9
ABSTRACT
-
-
      


         
     
   
resistant to deterioration, and have high biocompatibility since hard tissues
         

    

        -


   

           


https://t.me/med1917
216
Metals in Medicine, Volume 1

Human skeletal tissues have intricated internal layouts and three-dimensional

          
      -




resistance, and have good biocompatibility.
1,2
Biomaterials are synthetic or
natural substances that are used to build implants or other structures that
           
damaged.
3,4




     
4
A metal


5




6
           
     


7


       
its mechanical qualities.
8
     

9

          
         

    
-
neering strategy that integrates several research domains.
10,11
Because the
-

https://t.me/med1917

217
metals that have already been demonstrated to be biocompatible is a crucial

12



 
         

13




14,15
According to reports,

devices that can pass through biological barriers.
15

  
-
tional materials.
16

-
porting medications selectively to the target region, reducing the negative
    
17,18
  
    
based on nanotechnology have been developed to treat bone-related disor-

       
durability.
19,20
Because their structural, mechanical, and occasionally chemical quali-
      
     
biomimetic methods.
20,21
Porosity, complexity, chemical composition, and

  -


spheres, and nets.
22,23
       
          
        
         

Additionally , methods to improve mechanical qualities, bioactive properties,
and biocompatibility are provided.
https://t.me/med1917
218
Metals in Medicine, Volume 1




  
combines clinical medicine, biochemistry, biology, and materials science.
        



substitute.
-

 
       


-


protective against physiological stress.
24
     

  -
       
        
  
non-expended cells.
25,26

       
qualities is crucial.
      -
        



 
25
   
         
     
healing process.
https://t.me/med1917

219


-

27,28


28





          
        
           

29
Additionally , the

biomaterials has recently been put into practice, and their immune-modula-
tory properties control the immune system (i.e., reduced NK cell activity and


-

26
biological


is no doubt that biological materials and structures cannot be used to make
   
      -

      
30
   

        
 
31
  


Recently, it has been suggested that bioactive composite materials could

https://t.me/med1917
220
Metals in Medicine, Volume 1
       -
       
32
Polymer-ceramic composites have good mechanical properties and are
      

natural bones hydroxyapatite (HA), calcium phosphate (CP), and tricalcium
   

33



-lactide-

       
collagen and bioglass have improved ALP expression and early mineral-
      

ceramics, and collagens, can increase biocompatibility or boost bioreactivity .

      



34


    
34,35
    
  
       
biodegradable metals.
2

deposits on their grids demonstrated good biocompatibility.


-
pedic surgery to replace lost bone, help bones heal, or treat bone problems.
1
-

     

37,38
https://t.me/med1917

221
    -

  
39,40
In
         


41


 
42

     


treatment.
42,43
On the contrary, some metallic materials, depending on the
-




44
 

      
        
https://t.me/med1917
222
Metals in Medicine, Volume 1
      
45
Addi-
       



46,47

    
48
Addition-
       

-
tional orthopedic implant materials, even though this technology is still in its

1,49
.
       
al.
50


  

         


49
applying NaOH to

-
  

2
O
5


2
O
5

     
histologically examined by Wauthle et al.
52




   
53
removed dorsal subcutaneous
        
        
        



 

https://t.me/med1917

223


       
     
54
do not cause an

in cell attachment.
55



bearing biomaterial in biomedical applications, such as coronary stents.
54,56



57
Mg–Ca alloys have recently
-
cations in vitro and in vivo.
58
-
       
59,60
        
    
alloys such as WE43, LAE442, AZ31, AZ91, and Mg–Mn–Zn alloys,
61–63




       
bone regeneration.
64,65
For instance, activating the canonical Wnt signaling

2+


66

          
         


2

67,68

     
the oxide coating, such as crystallinity and impurity segregation, have been

https://t.me/med1917