Добавил:
Sekretar
kiopkiopkiop18@yandex.ru
t.me/Prokururor I Вовсе не секретарь, но почту проверяю
Опубликованный материал нарушает ваши авторские права? Сообщите нам.
Вуз:
Предмет:
Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_157_библиотеки_им_акад_М_И_Перельмана
.pdf
123
Egesta Lopci
Luigi Mansi
Editors
Advanced Imaging
and Therapy in
Neuro-Oncology
Advanced Imaging and Therapy in
Neuro-Oncology
Egesta Lopci • Luigi Mansi
Editors
Advanced Imaging and
Therapy in
Neuro-Oncology
ISBN 978-3-031-59340-6 ISBN 978-3-031-59341-3 (eBook)
https://doi.org/10.1007/978-3-031-59341-3
© The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature
Switzerland AG 2024
This work is subject to copyright. All rights are solely and exclusively licensed by the Publisher,
whether the whole or part of the material is concerned, specically the rights of translation,
reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microlms or in any
other physical way, and transmission or information storage and retrieval, electronic adaptation,
computer software, or by similar or dissimilar methodology now known or hereafter developed.
The use of general descriptive names, registered names, trademarks, service marks, etc. in this
publication does not imply, even in the absence of a specic statement, that such names are
exempt from the relevant protective laws and regulations and therefore free for general use.
The publisher, the authors and the editors are safe to assume that the advice and information in
this book are believed to be true and accurate at the date of publication. Neither the publisher nor
the authors or the editors give a warranty, expressed or implied, with respect to the material
contained herein or for any errors or omissions that may have been made. The publisher remains
neutral with regard to jurisdictional claims in published maps and institutional afliations.
This Springer imprint is published by the registered company Springer Nature Switzerland AG
The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
If disposing of this product, please recycle the paper.
Editors
Egesta Lopci
Nuclear Medicine Unit
IRCCS-Humanitas Research Hospital
Rozzano, Milano, Italy
Luigi Mansi
Interuniversity Research Center for
Sustainable Development (CIRPS)
Section Health and Development
Napoli, Italy
v
It brings me great pleasure to introduce this comprehensive publication:
Advanced Imaging and Therapy in Neuro-Oncology. As we reect on the past
years, it is evident that the landscape of neuro-oncology has undergone
remarkable transformations, with breakthroughs in imaging technologies and
therapeutic strategies reshaping the way we understand and approach brain
tumours.
This compilation comprises a series of chapters authored by distinguished
experts and thought leaders in the eld, each offering unique insights into the
multifaceted realm of neuro-oncology. The breadth of topics covered in this
book attests to the interdisciplinary nature of the eld, exploring advance-
ments in brain tumour classication, state-of-the-art imaging techniques, and
novel therapeutic modalities.
The journey begins with an exploration of the rapidly evolving landscape
of brain tumour classication. The rst chapter delves into the complexities
of advancements in this crucial area, presents the latest developments that
hold the potential to redene our understanding of the diverse spectrum of
brain tumours. As we delve deeper into the classication, we lay the founda-
tion for more precise and personalized approaches to diagnosis and
treatment.
The subsequent chapter discusses the pivotal role of conventional and
advanced magnetic resonance imaging techniques. From anatomical details
to functional insights, this section presents an overview of an imaging modal-
ity that is instrumental in guiding clinical decisions and fostering a deeper
understanding of brain architecture.
Positron emission tomography (PET) emerges as a powerful tool for the
evaluation of brain tumours, ranging from the conventional FDG to the more
specic amino acid tracers. This journey through the evolution of PET imag-
ing reveals the dynamic landscape of molecular imaging, providing clinicians
with invaluable information for precise diagnosis and treatment planning.
The surgical realm of brain tumour management is explored in depth from
the current state-of-the-art procedures to the frontiers of surgical innovation.
Simultaneously, the exploration of future frontiers challenges our under-
standing of what is possible, hinting at a landscape in which the limits of
surgical treatment are continually pushed.
As we transition from surgery to therapeutics, the chapters devoted to cur-
rent and future drugs for brain tumour treatment provide a panoramic view of
pharmaceutical interventions. The landscape of drug development and the
Foreword
https://t.me/med1917
vi
promise of novel agents underscore the persistent pursuit of improved out-
comes for patients dealing with brain tumours.
Radiation oncology takes centre stage in the subsequent chapters, offering
a comprehensive exploration of established techniques and emerging tech-
nologies. From conventional radiation therapy to the cutting-edge realm of
heavy ion therapy, each chapter sheds light on the evolving landscape of
radiation- based treatments, promising enhanced precision and efcacy.
In the ever-expanding arena of diagnostic tools, the exploration of new
radiopharmaceuticals for brain tumour imaging reects the relentless pursuit
of innovation. These radiopharmaceuticals hold the potential to revolutionize
our ability to detect and monitor brain tumours, offering unprecedented
insights into their behaviour and response to treatment.
The compilation concludes with an exploration of the incremental role of
radiomics and articial intelligence in shaping the future of neuro-oncology.
The transformative potential of these technologies to unravel complex pat-
terns within imaging data promises to usher in a new era of precision
medicine.
In closing, Advanced Imaging and Therapy in Neuro-Oncology is a testa-
ment to the remarkable advances made in recent years. I am condent that
this collection will serve as a valuable resource for clinicians, researchers,
and students alike, inspiring new advances in the quest to unravel the myster-
ies of neuro-oncology and improve the lives of people affected by brain
tumours.
I extend my heartfelt gratitude to the editors and authors for their meticu-
lous work in crafting this exceptional book in imaging and therapy in neuro-
oncology. Happy reading and here’s to more years of progress and discovery
in the fascinating world of precision medicine and theranostics!
Nuclear Medicine and Diagnostic Imaging Section,
Division of Human Health,
Department of Nuclear Sciences and Applications
DianaPaez
International Atomic Energy Agency,
Vienna, Austria
Foreword
https://t.me/med1917
vii
Is It Possible toCure Brain Tumors?
In recent years, research in the battle against cancer has yielded remarkable
advancements in various areas, thanks to the potential for earlier and more
precise diagnosis, accurate prognostic characterization, and the adoption of
new, increasingly effective, sustainable, and personalized therapeutic strate-
gies. However, these advancements have not been equally realized for all
types of tumors, including brain tumors, particularly glioblastoma, for which
improving outcomes, duration, and quality of life remains very challenging.
In fact, detecting brain tumors on time is highly challenging, except for
incidentalomas, as there are currently no widely recommended screening
methods for early detection. The initial symptoms of early-stage brain tumors
are often fortuitous and difcult to interpret. Similarly, identifying an initial
recurrence is not easy due to the presence of many non-specic features that
do not distinguish between disease relapse and post-therapeutic changes.
Neuroimaging has made signicant advancements with the introduction of
revolutionary computerized equipment such as Computed Tomography (CT),
Positron Emission Tomography (PET), and Magnetic Resonance Imaging
(MRI), which complement invasive radiological methods and electroenceph-
alographic techniques. Since the 1980s, further progress, facilitated by hybrid
machines, advanced functional and molecular imaging, technological evolu-
tion, articial intelligence, and new therapeutic approaches, has led to
improved classication and characterization of individual cases and the adop-
tion of better overall strategies. This progress is also attributed to the advance-
ment of preclinical and pharmacological research, which has contributed to
the development of targeted therapies. However, despite these advancements,
gliomas, particularly in patients with glioblastoma, remain challenging to
cure, and their prognosis remains grim.
This book is being published during an “interlocutory” phase in the ght
against brain tumors. Unlike other types of cancer, personalized therapies that
can effectively treat individual patients have not yet been validated. This is in
contrast to the progress seen in other types of cancer. As shown by a recent
systematic review on personalized therapeutic approaches to glioblastoma,
such personalized therapy has not been proven to signicantly ameliorate the
survival of patients with glioblastoma, and there is currently no therapy ready
for regular clinical use. Nevertheless, ongoing endeavors are focused on
Preface
https://t.me/med1917
viii
advancing personalized medicine in the treatment of brain tumors, including
glioblastoma, through innovative strategies such as mRNA vaccines and
immunotherapies.
The book aims to inform readers about the latest tools for better character-
izing primary brain tumors and evaluating response. It also seeks to facilitate
the early detection of recurrence and assist surgeons and radiotherapists in
performing the most decisive interventions while prioritizing the patient’s
quality of life. These objectives align with the ongoing evolution of brain
tumor imaging, which plays a crucial role in improving preoperative diagno-
sis, predicting tumor grading and patient prognosis, planning surgery and
radiation therapy, and assessing treatment response.
The text also emphasizes the growing necessity for collaboration among
experts from various disciplines, enabling the combined use of advanced
diagnostic and therapeutic approaches. To assemble the most effective team,
it is essential to enlist leading professionals from all relevant elds, creating
a balanced blend of experienced authors and vibrant young scientists. These
individuals should possess the ability to merge creativity, expertise, culture,
and knowledge of the most cutting-edge tools for the adoption and explana-
tion of modern diagnostic and therapeutic techniques.
In our view, this approach represents the most promising way to embrace
the future, while maintaining a strong foundation in preclinical research and
an understanding of the history of science, which serves as the framework for
new discoveries.
Thus, to experts in the pathological and molecular classication of tumors,
we have added professionals skilled in the use of PET with new and more
established radiotracers, neuroimaging experts, surgeons, oncologists, and
radiotherapists. These experts present the latest advancements in their respec-
tive elds of expertise.
We are very proud, as coaches of this team, to have among the authors
some of the leading international authorities in the most important issues
involved.
Our hope is to be able to remove the question mark from our editorial and
rewrite a new edition of this book shortly in which the title of our introduc-
tory comment would be: “It is possible to cure brain tumors.”
P.S.: Egesta Lopci and Luigi Mansi want to thank, for their support, the
Palummo family, organizer since 2019 of the Carla Russo Prize, dedicated to
the memory of a glioblastoma victim, rewarding the best young researchers
contributing in the ght against gliomas. Our purpose, as editors, is to help
turn their pain into hope.
Milano, Italy EgestaLopci
Napoli, Italy LuigiMansi
Preface
https://t.me/med1917
ix
1 Advancements in Brain Tumors Classification . . . . . . . . . . . . . . 1
Imran Noorani and Antonio Di Ieva
2 Conventional and Advanced MRI in Neuro-Oncology . . . . . . . . 9
Patrick L. Y. Tang, Esther A. H. Warnert,
and Marion Smits
3 Positron Emission Tomography from FDG to
Amino Acid Tracers . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31
Arnoldo Piccardo, Valentina Garibotto, Angelo Castello,
Francesco Cicone, Francesco Giammarile,
Luigia Florimonte, Roberto C. Delgado Bolton,
Luigi Mansi, and Egesta Lopci
4 State of the Art of Surgical Treatment in Brain Tumors . . . . . . . 59
Massimiliano Del Bene, Giovanni Carone,
and Francesco DiMeco
5 Next Frontiers in Surgical Management . . . . . . . . . . . . . . . . . . . . 73
Beatrice C. Bono, Edoardo M. Barbieri, Federico Pessina,
and Marco Riva
6 Current and Future Drugs for Brain Tumors Treatment . . . . . . 83
Francesco Bruno, Alessia Pellerino, Elena Maria Marchesani,
and Roberta Rudà
7 Radiation Oncology in Glioblastoma (GBM) . . . . . . . . . . . . . . . . 101
Isacco Desideri, Valerio Nardone, Ilaria Morelli,
Federico Gagliardi, and Giuseppe Minniti
8 Heavy Ion Therapy in Brain Tumors . . . . . . . . . . . . . . . . . . . . . . 137
Giulia Riva, Lucia Pia Ciccone, Alberto Iannal,
and Ester Orlandi
9 New Radiopharmaceuticals for Brain Tumors Imaging . . . . . . . 153
Adrien Holzgreve and Nathalie L. Albert
Contents
https://t.me/med1917
x
10 Incremental Role of Radiomics and Artificial Intelligence . . . . . 161
Laszlo Papp, Clemens Spielvogel, David Haberl, and
Boglarka Ecsedi
11 Supportive Care in Brain Tumors and Quality of Life . . . . . . . . 173
Antonio Tanzilli, Andrea Pace, Dario Benincasa,
and Antonio Silvani
Contents
https://t.me/med1917
Соседние файлы в папке Библиотека им академика М.И. Перельмана