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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_1443_Библиотеки_им_академика_М_И_Перельмана.pdf
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- •Foreword
- •Contents
- •Contributors
- •1: The Normal Anus
- •Anal Canal Anatomy and Histology
- •Anal Canal Physiology
- •Primary Staging of Anal Carcinoma
- •Imaging of Anal Fistula
- •Imaging in Faecal Incontinence
- •Summary
- •References
- •2: Anorectal Physiology
- •Introduction
- •Clinical Assessment
- •History
- •Constipation
- •Differentiating Causes Using History
- •Scoring and Questionnaires
- •Incontinence
- •Differentiating Causes Using History
- •Anal Canal Imaging
- •Anal Endosonography
- •Magnetic Resonance Imaging
- •Scoring Systems
- •Examination
- •Inspection
- •Standard Physiology
- •Introduction
- •Manometry
- •Methodology
- •Equipment
- •Protocol
- •Manoeuvres
- •Using Normal Values
- •Interpretation of Results
- •Resting Pressure
- •Squeeze Pressure
- •Endurance Squeeze
- •Involuntary Squeeze
- •Straining/Defaecatory Manoeuvres
- •Advanced Manometric Techniques
- •Vector Volume Manometry
- •High-Resolution Manometry
- •Sensory Measurements
- •Physiology of Rectal Sensation
- •Rectal Compliance
- •Rectal Compliance Curve
- •Pathophysiology of Rectal Compliance
- •Impedance Planimetry
- •Neurophysiology
- •PNTMLs
- •Conclusions
- •References
- •3: Imaging the Normal Anus
- •Introduction
- •Endoanal Ultrasound
- •Basic Technique
- •Normal Anatomy
- •Anatomical Variations
- •Basic Technique
- •Imaging Anatomy
- •Summary
- •References
- •Histological Zones of the Anus
- •The Colorectal Zone
- •The Transitional Zone
- •The Squamous Zone
- •The Anal Glands and Ducts
- •The Anal Musculature
- •The Anal Blood Supply
- •The Anal Nerve Supply
- •The Anal Lymphatic Supply
- •References
- •Introduction
- •Embryology
- •Male Defects
- •Rectoperineal Fistula (Fig. 5.1)
- •Rectourethral Fistula (Fig. 5.2)
- •Rectovesical Fistula (Fig. 5.3)
- •Imperforate Anus Without Fistula
- •Rectal Atresia/Stenosis
- •Female Defects
- •Rectovestibular Fistula (Fig. 5.4)
- •Rectoperineal Fistula
- •Persistent Cloaca (Fig. 5.5)
- •Other Female Defects
- •Clinical Presentation and Diagnosis
- •Associated Anomalies
- •Treatment
- •Colostomy Formation
- •Anorectal Reconstruction
- •Anoplasty
- •High-Resolution Anoscopy
- •Colour
- •Contour
- •Vascular Patterns
- •Anal Intraepithelial Neoplasia
- •Diagnosis of AIN
- •Screening for AIN
- •Treatment of AIN
- •Imiquimod Cream
- •Cidofovir Cream
- •Electrocautery
- •Infrared Coagulation
- •Human Papillomavirus Vaccination
- •Bowen’s Disease of the Anus
- •Paget’s Disease of the Anus
- •Summary
- •References
- •Outcome
- •Further Reading
- •Introduction
- •Clinical Assessment
- •Symptoms
- •Signs
- •Anal Cytology
- •Anatomy
- •Risk Factors
- •Staging
- •Ultrasound
- •PET/CT
- •Sentinel Lymph Node Biopsy
- •Prognostic Factors
- •Surgical Therapy
- •Management of Lymph Nodes
- •Surveillance
- •Follow-Up Imaging
- •Outcomes
- •Complications
- •Quality of Life
- •Salvage Surgery
- •Metastasis
- •Anal Adenocarcinoma
- •Treatment
- •Prognosis
- •Recurrence
- •Prognostic Factors
- •Anal Melanoma
- •Treatment
- •Surgery
- •Chemotherapy
- •Radiation Therapy
- •Patterns of Recurrence
- •Prognosis
- •References
- •Prevalence
- •Aetiology
- •Clinical Presentation
- •References
- •9: Rectocele Treatment
- •Treatment
- •Medical
- •Surgical
- •Conclusion
- •References
- •Introduction
- •Theories of Continence
- •The Flutter Valve Theory
- •The Flap-Valve Theory
- •Sphincteric Theories
- •Breakdown in Normal Continence
- •Rectal Compliance
- •Anorectal Sensation
- •Nerve Supply
- •Intact Sphincters
- •Obstetric Injuries
- •Surgery for Anal Fissure
- •Surgery for Anal Fistulas
- •Haemorrhoid Surgery
- •History
- •Diagnosis
- •Assessment of Severity
- •Aetiology
- •Examination
- •Investigations
- •Endoanal Ultrasound Scans
- •Manometry
- •Electromyography
- •Rectal Compliance
- •Defecating Proctogram
- •References
- •Introduction
- •Clinical Assessment
- •History Taking
- •Symptom Scores and Diaries
- •Examination
- •Physiological Studies
- •Anal Manometry
- •Standard Anal Manometry
- •Technique and Measurements
- •Clinical Utility
- •Other Manometric Techniques
- •Ambulatory Manometry
- •Vector Volume Manometry (Vectometry)
- •High-Resolution Anorectal Manometry
- •Technique and Measurement
- •Clinical Utility
- •Anal Sensory Testing
- •Technique
- •Clinical Utility
- •Rectal Sensory Testing
- •Electric Sensory Thresholds
- •Technique
- •Clinical Utility
- •Balloon Distension Thresholds
- •Technique
- •Clinical Utility
- •Rectal Compliance Measurement
- •Technique
- •Clinical Utility
- •Electrophysiology
- •Other Functional Tests
- •Rectal Balloon Expulsion Test
- •Stool-Substitute Retention Test
- •Imaging Studies
- •Static Imaging (Tests of Structure)
- •Endoanal Ultrasound
- •Technique
- •Clinical Utility
- •Magnetic Resonance Imaging (MRI)
- •Conclusion
- •References
- •Introduction
- •Conservative Management
- •Repair Sphincteroplasty
- •Postanal Repair
- •Technique
- •Injectables
- •Technique
- •Outcomes
- •Technique
- •Outcomes
- •Technique
- •Outcomes
- •Technique
- •Outcomes
- •Technique
- •Mechanism of Action
- •Outcomes
- •Long-Term Outcomes
- •Complications
- •Percutaneous Technique
- •Outcomes
- •Conclusion
- •References
- •Introduction
- •Anatomy
- •Normal Anatomy and Development
- •Function of Anal Cushions
- •Anatomy of Haemorrhoids
- •Blood Supply
- •Arteries
- •Veins
- •Lymphatic Drainage
- •Innervation
- •Aetiology
- •Theories of Pathogenesis
- •Varicose Vein Theory
- •Vascular Hyperplasia Theory
- •Sliding Anal Lining Theory
- •Predisposing Factors
- •Diet and Stool Consistency
- •Defecatory Position
- •Genetics
- •Abdominal and Pelvic Causes
- •Increased Anal Pressure
- •External Anal Sphincter
- •Internal Anal Sphincter (IAS)
- •Hypertensive Anal Cushions
- •Slow and Ultraslow Waves
- •Author’s Opinion
- •Presentation of Haemorrhoids
- •History
- •Internal Haemorrhoid Symptoms
- •Bleeding
- •Prolapse
- •Pain
- •External Haemorrhoid Symptoms
- •Examination
- •General and Abdominal
- •Anorectum
- •References
- •14: Operative Management
- •Introduction
- •Ambulatory Treatment
- •Sclerotherapy
- •Indications
- •Technique
- •Results
- •Rubber Band Ligation
- •Indications
- •Technique
- •Results
- •Cryotherapy
- •Technique
- •Results
- •Photocoagulation
- •Technique
- •Results
- •Monopolar Diathermy
- •Technique
- •Results
- •Bipolar Diathermy
- •Technique
- •Results
- •Technique
- •Results
- •Operative Treatment
- •Technique
- •Haemorrhoidectomy with LigaSure
- •Laser Haemorrhoidectomy
- •Technique
- •Technique
- •Technique
- •Results
- •Comment on Haemorrhoidectomy
- •Unitary Theory of Rectoanal Prolapse
- •Stapled Haemorrhoidopexy (SH)
- •Technique
- •Results
- •Procedure Time
- •Pain
- •Recovery
- •Patient Satisfaction
- •Re-intervention
- •Bleeding
- •Perianal Complications
- •Early Recurrence
- •Late Recurrence
- •Quality of Life
- •Cost-Effectiveness
- •Technique
- •Results
- •Comment on SH and STARR
- •References
- •Presentation
- •Typical vs Atypical
- •High Pressure vs Low Pressure
- •Pathophysiology
- •Internal Anal Sphincter Physiology
- •Initiating Factors
- •Constipation and Diarrhoea
- •Fissures in Pregnancy
- •Perpetuating Factors
- •Internal Anal Sphincter Hypertonia
- •Ischaemia
- •References
- •16: Chronic Anal Fissure
- •Introduction
- •Pathophysiology
- •Manual Dilatation of the Anus
- •Lateral Internal Sphincterotomy
- •Botulinum Toxin A
- •Fissurectomy
- •Advancement Flap
- •Conclusion
- •References
- •Introduction
- •Anatomy
- •Anal Canal
- •Anal Glands
- •Perianal Spaces
- •Pathophysiology
- •Aetiology
- •Bacteriology
- •Spread of Infection
- •Horseshoe Abscess
- •Presentation
- •Clinical Presentation
- •References
- •18: Imaging of Anal Sepsis
- •Introduction
- •Imaging of Fistula-in-Ano
- •Anal Endosonography
- •MRI Technique
- •MRI Interpretation
- •Extensions
- •Which Patients Should Be Imaged?
- •Conclusion
- •References
- •19: Management of Anorectal Sepsis
- •Introduction
- •Acute Anorectal Sepsis
- •Chronic Anal Fistulas
- •Clinical Assessment
- •Treatment Options
- •Sphincter Dividing Techniques
- •Fistulotomy
- •Staged Fistulotomy
- •The Tight Seton
- •The Chemical Seton
- •Sphincter Preserving Techniques
- •Fistulectomy
- •The Loose Drainage Seton
- •Advancement Flaps
- •The Intersphincteric Approach
- •Biological Materials
- •Conclusion
- •References
- •20: Perianal Skin Conditions
- •Introduction
- •Perianal Anatomy and Function
- •Normal Flora
- •Dermatology for the Proctologist
- •Terminology
- •History
- •Box 20.1 Dermatological History
- •Box 20.2 Tips on Taking a Sexual History
- •Examination
- •Diagnosis
- •Treatment
- •Sexual Health for the Proctologist
- •Non-infectious Skin Disorders
- •Dermatitis (Eczema)
- •Atopic Dermatitis (Atopic Eczema)
- •Contact Dermatitis
- •Irritant Contact Dermatitis
- •Allergic Contact Dermatitis
- •Lichen Simplex Chronicus (LSC)
- •Lichen Planus (LP)
- •Skin Tags
- •Fistulae
- •Fissures
- •Abscesses
- •Ulcers
- •Metastatic Crohn’s Disease
- •Summary
- •Behçet’s Disease
- •Pyoderma Gangrenosum
- •Anal Stenosis
- •Skin Pigmentation
- •Perianal Skin Tags
- •Radiation Dermatitis
- •Perianal Ulceration due to Nicorandil
- •Rarities
- •Sexually Transmitted Infections
- •Bacterial STIs
- •Syphilis
- •Lymphogranuloma Venereum
- •Other Bacterial STIs
- •Viral STIs
- •Herpes
- •Human Papillomaviruses
- •Molluscum
- •Ectoparasites
- •Other Perianal Infections
- •Bacterial Infections
- •Pyogenic Bacteria
- •Erythrasma
- •Other Bacterial Infections
- •Viral Infections
- •Fungal Infections
- •Protozoal Infections
- •Helminth Infections
- •Conclusion
- •References
- •21: Pruritus Ani
- •Introduction
- •Biology of Itch
- •Pruritus Ani
- •Box 21.1 Infective
- •Idiopathic Pruritus Ani
- •Dietary
- •Faecal Contamination
- •Infective
- •Underlying Proctological Disease
- •Approach to Idiopathic Pruritus Ani
- •Topical Capsaicin
- •Conclusion
- •References
- •Introduction
- •Anatomy
- •Reconstructive Principles
- •Preoperative Planning
- •Role of Faecal Diversion
- •Principles of Anal Reconstruction
- •Skin Grafts
- •Flaps
- •Local Flaps
- •Random Pattern Flaps
- •Perforator Flaps
- •Distant Flaps
- •Rectus Abdominis Myocutaneous Flap
- •Gluteal Perforator Flaps
- •Posterior Thigh Fasciocutaneous Flap
- •Anterolateral Thigh Flap
- •Functioning Muscle Flaps
- •Microvascular Flaps
- •Conclusion
- •References
- •Index

Anus
Richard Cohen
Alastair Windsor
Editors
Surgical Treatment
and Pathology
123

Anus


Richard Cohen • Alastair Windsor
Editors
Anus
Surgical Treatment and Pathology

ISBN 978-1-84882-090-6 ISBN 978-1-84882-091-3 (eBook)
DOI 10.1007/978-1-84882-091-3
Springer London Heidelberg New York Dordrecht
Library of Congress Control Number: 2013957354
© Springer-Verlag London 2014
This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or
part of the material is concerned, specifi cally the rights of translation, reprinting, reuse of
illustrations, recitation, broadcasting, reproduction on microfi lms or in any other physical way,
and transmission or information storage and retrieval, electronic adaptation, computer software,
or by similar or dissimilar methodology now known or hereafter developed. Exempted from this
legal reservation are brief excerpts in connection with reviews or scholarly analysis or material
supplied specifi cally for the purpose of being entered and executed on a computer system, for
exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is
permitted only under the provisions of the Copyright Law of the Publisher's location, in its
current version, and permission for use must always be obtained from Springer. Permissions for
use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable
to prosecution under the respective Copyright Law.
The use of general descriptive names, registered names, trademarks, service marks, etc. in this
publication does not imply, even in the absence of a specifi c statement, that such names are
exempt from the relevant protective laws and regulations and therefore free for general use.
While the advice and information in this book are believed to be true and accurate at the date of
publication, neither the authors nor the editors nor the publisher can accept any legal responsibility
for any errors or omissions that may be made. The publisher makes no warranty, express or
implied, with respect to the material contained herein.
Printed on acid-free paper
Springer is part of Springer Science+Business Media (
www.springer.com)
Editors
Richard Cohen, MD, FRCS
Department of GI Surgery
University College London Hospitals
London
UK
Alastair Windsor, MD, FRCS
(Lon, Ed, Glas)
Department of GI Surgery
University College London Hospitals
London
UK

For our wives Madeleine Cohen and Lily Windsor


vii
The reader might wonder why another textbook on the anus is needed. There
are three main reasons. First anal disease is exceedingly common in all parts
of the world. Secondly treatment is effective in most cases, but when surgery
is performed badly the patient can be disastrously and often irreversibly
worse. Thirdly new developments in the understanding and treatment make
proctology a dynamic fi eld for research and its application to management.
The book is not on colon and rectal surgery but rather on proctology in
which anal pathology is set within the context of wider disease where rele-
vant. “ Anus ” is edited by two internationally known and experienced sur-
geons who have themselves contributed to knowledge in the fi eld through
research, publications and teaching. They have brought together authors from
all over the world, who are recognized practitioners in the fi eld. The reader is
given an accurate account of the normal structure and function of the anus
including clinical and radiological anatomy and physiology. The importance
of histopathology is dealt with in a chapter dedicated to diagnosis and the
subsequent chapters then follow from congenital anomalies to neoplasia, pro-
lapse, incontinence, haemorrhoids, fi ssure and anorectal sepsis. There is a
section on dermatological conditions and sexually transmitted disease with
the book ending with an account of plastic procedures around the anus.
Every attempt has been made to incorporate new information regarding
etiology, diagnosis and treatment to give the reader an up-to-date account of
the subject. The use of Tables and Boxes to present data makes the book easy
to read. Many of the chapters contain high quality photographs to illustrate
diseases particularly those due to dermatological and sexual transmission.
The chapters on radiological pathological anatomy contain excellent illustra-
tions which are very useful since they summarise the various pathological
forms of anorectal sepsis and prolapse, enabling the reader to learn the radio-
logical counterpart of clinical examination . Each chapter contains a useful
bibliography which will in itself be a valuable resource enabling the reader to
gain access to the literature including classic publications and recent
developments.
The book will be valuable for consultant practitioners in proctology, but it
will also help colorectal surgeons, gastroenterologists, trainees, specialist
nurses and students who are interested in increasing their knowledge. Proctology
is in many ways still a largely clinical speciality and the theme throughout the
F o r e w o r d

viii
book implicitly recognizes this while at the same time it demonstrates where
investigations are either essential or likely to help clinical decision taking. It is
an authoritative, informed and up-to-date contribution to an important area of
disease.
John Nicholls, MA(Cantab), M.Chir, FRCS(Eng),
EBSQ(Coloproctology), hon FRCP(Lond), hon FACS,
hon FRCSE, hon FRCS(Glasg), hon ASCRS,
hon ACPGBI, hon ESCP, hon BSG
Emeritus Consultant Surgeon,
St. Mark’s Hospital, London, UK
Professor of Colorectal Surgery,
Imperial College, London, UK
Foreword

ix
Contents
1 The Normal Anus. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
Alexis M.P. Schizas and Andrew B. Williams
2 Anorectal Physiology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13
Jonathan Gosling and Anton Emmanuel
3 Imaging the Normal Anus. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35
Michael J. Steward, Steve Halligan, and Stuart A. Taylor
4 Surgical Treatment and Pathology: Normal Histology . . . . . . 43
Ruma Saraswati and Marco Novelli
5 Congenital Abnormalities of the Anus. . . . . . . . . . . . . . . . . . . . 49
Nigel J. Hall and Edward M. Kiely
6 Premalignant Conditions of the Anus . . . . . . . . . . . . . . . . . . . . 61
James Crosbie, Jonathan McCullough, and Paul Boulos
7 Malignant Conditions Including Squamous
Cell Carcinoma and Rare Cancers. . . . . . . . . . . . . . . . . . . . . . . 71
Sarah W. Grahn, Mary R. Kwaan, and Robert D. Madoff
8 Rectocele Pathophysiology and Presentation . . . . . . . . . . . . . . 91
Karen P. Nugent
9 Rectocele Treatment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 97
Bruno Roche
10 Incontinence: Causes and Pathophysiology. . . . . . . . . . . . . . . . 107
Jonathan Randall and Ridzuan Farouk
11 Incontinence Assessment: Physiology and Imaging . . . . . . . . . 115
Mostafa Abdel-Halim
12 Surgical Treatments for Incontinence . . . . . . . . . . . . . . . . . . . . 133
Marylise Boutros, Marc C. Osborne, and Steven D. Wexner
13 Haemorrhoids: Anatomy, Pathophysiology
and Presentation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 157
Ayesha Noorani and Emin Carapeti
14 Operative Management . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 169
Antonio Longo, Adolfo Renzi, and Francesco Prete
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