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Index
acetylcholine 17, 58, 82, 84, 88, 95–96, 106,
157, 185
acetylsalicylic acid 3, 71
acrolein 152, 168
adenine 139
adrenaline 18, 100, 162
affinity 82–83, 100, 111, 119, 133
agonist 189
alcohol dehydrogenase 48
aldehyde dehydrogenase 48
aldehyde dehydrogenase (ALDH) 49
ampicillin 155
anomeric effect 143–144, 148–149, 160
Antabuse 48
antagonist 54, 60, 83, 90, 94, 106, 109,
185, 189
Aspirin 3, 10, 46, 136, 138, 151–152
atropine 24–25
Aureomycin 23
benzodiazepine 182
bioisostere 62, 64
bioisosterism 57, 60, 62, 64, 184
buprenorphine 170, 172–173
butadiene 168
captopril 45, 53
carbamate 204
carbonic acid 32
catecholamine 10
celecoxib 173
cephalosporin 25
cetylpyridinium 159
chloramphenicol 18, 43, 45, 154
chlordiazepoxide 32
chlorhexadol 16
cholesterol 50
chrysene 21
cilansetron 59
cimetidine 32, 64
cisplatin 101
clonidine 48, 96, 99
clothiapine 37
cocaine 25, 44, 69
conformational 59, 85, 95–96, 107
Craig plot 122, 124, 128
Curare 4
cysteine 103, 139, 153
cytochrome P450 139–140
decamethonium 59, 158
diazepam 15, 30, 141
Diels-Alder 169
disconnection 165–169, 178, 206
distomer 100
disulfiram 48–49
dopamine 82, 141–142
drug–receptor interactions VII, XI, 125
dulcin 58
effective dose 50 (ED
50
) 158
enantiomer 7–9, 99–100, 106
endo 169, 172
endorphins 42, 71, 83
enkephalins 42, 71, 83
enzymatic 84–85, 102, 141, 185
enzyme 10, 46, 51, 85, 103, 111, 132–133, 139, 157,
160, 208
epinephrine 10
estradiol 9, 55, 193
ethinylestradiol 9
ethoxyurea 58
eutomer 100
exo 98, 169
fentanyl 176
FGI (functional group interconversion) 166
fluorene 22
fluoxetine 180, 205–206
fluspirilene 27
Free–Wilson method 5
furan 28, 32, 35, 65, 177, 181
gefitinib 185
glucuronide 149–150, 162
glutathione 151
glycine 82, 149, 162
Grimm’s hydride displacement law 61
guanethidine 32
guanine 85, 103
Hammett 112–115, 128
Hansch equations 111, 122
Hansch–Fujita method 5
https://doi.org/10.1515/9783111316901-010
https://t.me/medicina_free
Hantzsch–Widman method 30
hard drugs 157
hexobarbital 172
homology 185
hyperconjugation 117–119, 148
iminoquinone 152
imipramine 49
ionic channels 83–84
isoprenaline 54, 99
lethal dose 50 (LD
50
) 158
levodopa 104
Librium 30, 32
Lipinski’s rules 137–138
lipophilicity 72, 119–120, 193–194, 196
Mannich 178–179, 206
MAO 132, 142
mass spectrometry 51
metabolism 6, 55, 71, 119, 135, 137–138, 142, 153,
156–158, 160, 175, 185, 204, 208
methadone 17, 142
methotrexate 180, 208
morphine 9–10, 42–44, 69–71, 73
NADP
+
139
NADPH 139
nifedipine 180, 207
nikethamide 67
noradrenaline 82, 99–100, 106
noresteroid 54
omeprazole 7
ondansetron 59
oripavine 172
paracetamol 46–47, 71, 121, 152–153
penicillin XV, 25–26, 44, 50
pentobarbital 170
peptidomimetics 71
phenacetin 141
phenobarbital 170–171
phenylbutazone 185
prednisolone 154
primocarcin 16
procainamide 142–143, 151
procaine 18, 57, 93, 142, 184
prodrug 154
propranolol 52–53
Prozac 180, 205
pyridine 28, 32, 35, 65–67
pyridinium 139, 159
pyrrole 28, 35, 65, 139, 177–179
QSAR IX, 5, 110–111, 125–129, 131–134, 197
quinine 9, 43–44
quinones 152
racemic 6, 8, 206
ranitidine 32, 64
receptor VII, XI, 4–5, 10, 51, 57, 64, 82–85, 88–90,
93–96, 99–101, 103–104, 106–107, 109, 111, 122,
125, 127, 159, 185, 193
rofecoxib 175
salbutamol 7
soft drugs 158
SOSA 45
spiro 26–27, 37–38
stereocenter 7, 9
sulfanitran 20
sulfathiazole 156
sumatriptan 104, 180, 210
suxamethonium 158
synthetic equivalent 167
synthon 167
teprotide 45
testosterone 54, 155
tetracyclines 23
tetrazolyl groups 68
thiophene 177, 181
tolmetin 178–179
transplatin 101
trimethoprim 180, 208
Vilsmeier acylation 178
vinylogy 57–58
214 Index
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