Добавил:
Sekretar
kiopkiopkiop18@yandex.ru
t.me/Prokururor I Вовсе не секретарь, но почту проверяю
Опубликованный материал нарушает ваши авторские права? Сообщите нам.
Вуз:
Предмет:
Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_47_библиотеки_им_акад_М_И_Перельмана
.pdf
284
bleed either by band ligation or beta blockers, and to establish a screening schedule
over time [196]. Of note, esophageal varices can regress in association with alcohol
abstinence. In a population study from Denmark, hepatocellular carcinoma was
reported to be of low incidence [197]; however, it is a complication of cirrhosis.
Thus, patients with cirrhosis must be screened for this complication every 6months
with a liver sonogram and serum alpha fetoprotein [198]. Patients with decompen-
sated liver disease from alcohol are candidates for liver transplantation.
Acknowledgments The author acknowledges Dr. Cesar del Rosario for having contributed
Figures8.1, 8.2, 8.3 and 8.5.
References
1. Gao B, Bataller R. Alcoholic liver disease: pathogenesis and new therapeutic targets.
Gastroenterology. 2011 Nov;141(5):1572–85.
2. Alcoholism NIoAAa. A pocket guide for alcohol screening and brief intervention 2001.
Available from http://pubs.niaaa.nih.gov/publications/Practitioner/pocketguide/pocket_
guide2.htm.
3. Newsletter NIAAA Drinking Levels Dened. In: Health NIo, editor, 2004.
4. Hrubec Z, Omenn GS.Evidence of genetic predisposition to alcoholic cirrhosis and psycho-
sis: twin concordances for alcoholism and its biological end points by zygosity among male
veterans. Alcohol Clin Exp Res. 1981 Spring;5(2):207–15.
5. Julkunen RJ, Di Padova C, Lieber CS.First pass metabolism of ethanol: a gastrointestinal
barrier against the systemic toxicity of ethanol. Life Sci. 1985 Aug 12;37(6):567–73.
6. Lieber CS, Gentry RT, Baraona E.First pass metabolism of ethanol. Alcohol Alcohol Suppl.
1994;2:163–9.
7. Frezza M, di Padova C, Pozzato G, Terpin M, Baraona E, Lieber CS. High blood alcohol
levels in women. The role of decreased gastric alcohol dehydrogenase activity and rst-pass
metabolism. N Engl J Med. 1990 Jan 11;322(2):95–9.
8. Edenberg HJ.The genetics of alcohol metabolism: role of alcohol dehydrogenase and alde-
hyde dehydrogenase variants. Alcohol Res Health. 2007;30(1):5–13.
9. Li D, Zhao H, Gelernter J. Strong association of the alcohol dehydrogenase 1B gene
(ADH1B) with alcohol dependence and alcohol-induced medical diseases. Biol Psychiatry.
2011 Sep 15;70(6):504–12.
10. Goedde HW, Agarwal DP, Fritze G, Meier-Tackmann D, Singh S, Beckmann G, et al.
Distribution of ADH2 and ALDH2 genotypes in different populations. Hum Genet. 1992
Jan;88(3):344–6.
11. Eng MY, Luczak SE, Wall TL.ALDH2, ADH1B, and ADH1C genotypes in Asians: a litera-
ture review. Alcohol Res Health. 2007;30(1):22–7.
12. Whiteld JB. Meta-analysis of the effects of alcohol dehydrogenase genotype on alcohol
dependence and alcoholic liver disease. Alcohol Alcohol. 1997 Sep–Oct;32(5):613–9.
13. Koop DR, Tierney DJ. Multiple mechanisms in the regulation of ethanol-inducible cyto-
chrome P450IIE1. BioEssays. 1990 Sep;12(9):429–35.
14. Sookoian S, Castano GO, Burgueno AL, Gianotti TF, Rosselli MS, Pirola CJ.A nonsynony-
mous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease
severity. J Lipid Res. 2009 Oct;50(10):2111–6.
15. Rotman Y, Koh C, Zmuda JM, Kleiner DE, Liang TJ, Nash CRN.The association of genetic
variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histo-
logical severity of nonalcoholic fatty liver disease. Hepatology. 2010 Sep;52(3):894–903.
N. V. Bergasa
https://t.me/medicina_free

285
16. Valenti L, Al-Serri A, Daly AK, Galmozzi E, Rametta R, Dongiovanni P, etal. Homozygosity
for the patatin-like phospholipase-3/adiponutrin I148M polymorphism inuences liver bro-
sis in patients with nonalcoholic fatty liver disease. Hepatology. 2010 Apr;51(4):1209–17.
17. Salameh H, Raff E, Erwin A, Seth D, Nischalke HD, Falleti E, et al. PNPLA3 gene poly-
morphism is associated with predisposition to and severity of alcoholic liver disease. Am J
Gastroenterol. 2015 Jun;110(6):846–56.
18. Zimmermann R, Strauss JG, Haemmerle G, Schoiswohl G, Birner-Gruenberger R, Riederer
M, et al. Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase.
Science. 2004 Nov 19;306(5700):1383–6.
19. Romeo S, Huang-Doran I, Baroni MG, Kotronen A.Unravelling the pathogenesis of fatty
liver disease: patatin-like phospholipase domain-containing 3 protein. Curr Opin Lipidol.
2010 Jun;21(3):247–52.
20. Buch S, Stickel F, Trepo E, Way M, Herrmann A, Nischalke HD, etal. A genome-wide
association study conrms PNPLA3 and identies TM6SF2 and MBOAT7 as risk loci for
alcohol-related cirrhosis. Nat Genet. 2015 Dec;47(12):1443–8.
21. Kovarova M, Konigsrainer I, Konigsrainer A, Machicao F, Haring HU, Schleicher E, etal.
The genetic variant I148M in PNPLA3 is associated with increased hepatic retinyl-palmitate
storage in humans. J Clin Endocrinol Metab. 2015 Dec;100(12):E1568–74.
22. Mahdessian H, Taxiarchis A, Popov S, Silveira A, Franco-Cereceda A, Hamsten A, etal.
TM6SF2 is a regulator of liver fat metabolism inuencing triglyceride secretion and hepatic
lipid droplet content. Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8913–8.
23. Gijon MA, Riekhof WR, Zarini S, Murphy RC, Voelker DR. Lysophospholipid acyl-
transferases and arachidonate recycling in human neutrophils. J Biol Chem. 2008 Oct
31;283(44):30235–45.
24. Yamashita A, Watanabe M, Sato K, Miyashita T, Nagatsuka T, Kondo H, etal. Reverse reac-
tion of lysophosphatidylinositol acyltransferase. Functional reconstitution of coenzyme
A-dependent transacylation system. J Biol Chem. 2003 Aug 8;278(32):30382–93.
25. Freigang S.The regulation of inammation by oxidized phospholipids. Eur J Immunol. 2016
Aug;46(8):1818–25.
26. Atkinson S, Way M, McQuillin A, Morgan MY, Thursz M. A genome-wide association
study identies PNPLA3 and SLC38A4 as risk loci for alcoholic hepataitis. J Hepatol.
2016;64:S134.
27. Engracia V, Leite MM, Pagotto RC, Zucoloto S, Barbosa CA, Mestriner MA.Expression of
class mu glutathione-S-transferase in human liver and its association with hepatopathies. Am
J Med Genet A. 2003 Dec 15;123A(3):257–60.
28. Anstee QM, Daly AK, Day CP.Genetics of alcoholic liver disease. Semin Liver Dis. 2015
Nov;35(4):361–74.
29. Mulligan MK, Ponomarev I, Hitzemann RJ, Belknap JK, Tabakoff B, Harris RA, et al.
Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis.
Proc Natl Acad Sci U S A. 2006 Apr 18;103(16):6368–73.
30. Banerjee N.Neurotransmitters in alcoholism: a review of neurobiological and genetic stud-
ies. Indian J Human Genetics. 2014 Jan;20(1):20–31.
31. Edenberg HJ, Dick DM, Xuei X, Tian H, Almasy L, Bauer LO, etal. Variations in GABRA2,
encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol depen-
dence and with brain oscillations. Am J Hum Genet. 2004 Apr;74(4):705–14.
32. Agrawal A, Edenberg HJ, Foroud T, Bierut LJ, Dunne G, Hinrichs AL, etal. Association
of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism
sample. Behav Genet. 2006 Sep;36(5):640–50.
33. Hart CL, Morrison DS, Batty GD, Mitchell RJ, Davey SG.Effect of body mass index and
alcohol consumption on liver disease: analysis of data from two prospective cohort studies.
BMJ. 2010 Mar 11;340:c1240.
34. Heath RD, Brahmbhatt M, Tahan AC, Ibdah JA, Tahan V.Coffee: the magical bean for liver
diseases. World J Hepatol. 2017 May 28;9(15):689–96.
8
Alcohol Induced Liver Disease
https://t.me/medicina_free

286
35. Klatsky AL, Armstrong MA.Alcohol, smoking, coffee, and cirrhosis. Am J Epidemiol. 1992
Nov 15;136(10):1248–57.
36. Corrao G, Zambon A, Bagnardi V, D'Amicis A, Klatsky A, Collaborative SG.Coffee, caf-
feine, and the risk of liver cirrhosis. Ann Epidemiol. 2001 Oct;11(7):458–65.
37. D’Costa K.Scientic America [Internet]2011. [cited 2019].
38. Kamper-Jorgensen M, Gronbaek M, Tolstrup J, Becker U.Alcohol and cirrhosis: dose--re-
sponse or threshold effect? J Hepatol. 2004 Jul;41(1):25–30.
39. Sy AM, Ching R, Olivares G, Vinas C, Chang R, Bergasa NV.Hispanic ethnicity is associated
with increased morbidity and mortality in patients with alcoholic liver disease. Ann Hepatol.
2017 Jan–Feb;16(1):169–71.
40. Marshall AW, Kingstone D, Boss M, Morgan MY. Ethanol elimination in males and
females: relationship to menstrual cycle and body composition. Hepatology. 1983
Sep–Oct;3(5):701–6.
41. Baraona E, Abittan CS, Dohmen K, Moretti M, Pozzato G, Chayes ZW, etal. Gender differ-
ences in pharmacokinetics of alcohol. Alcohol Clin Exp Res. 2001 Apr;25(4):502–7.
42. Eagon PK.Alcoholic liver injury: inuence of gender and hormones. World J Gastroenterol.
2010 Mar 21;16(11):1377–84.
43. Setiawan VW, Stram DO, Porcel J, Lu SC, Le Marchand L, Noureddin M. Prevalence of
chronic liver disease and cirrhosis by underlying cause in understudied ethnic groups: the
multiethnic cohort. Hepatology. 2016 Dec;64(6):1969–77.
44. Bouchery EE, Harwood HJ, Sacks JJ, Simon CJ, Brewer RD.Economic costs of excessive
alcohol consumption in the U.S., 2006. Am J Prev Med. 2011 Nov;41(5):516–24.
45. Rehm J, Samokhvalov AV, Shield KD.Global burden of alcoholic liver diseases. J Hepatol.
2013 Jul;59(1):160–8.
46. Hatton J, Burton A, Nash H, Munn E, Burgoyne L, Sheron N.Drinking patterns, depen-
dency and life-time drinking history in alcohol-related liver disease. Addiction. 2009
Apr;104(4):587–92.
47. Askgaard G, Gronbaek M, Kjaer MS, Tjonneland A, Tolstrup JS. Alcohol drinking pat-
tern and risk of alcoholic liver cirrhosis: a prospective cohort study. J Hepatol. 2015
May;62(5):1061–7.
48. Esser MB, Hedden SL, Kanny D, Brewer RD, Gfroerer JC, Naimi TS.Prevalence of alcohol
dependence among US adult drinkers, 2009-2011. Prev Chronic Dis. 2014 Nov 20;11:E206.
49. Tan CH, Hungerford DW, Denny CH, McKnight-Eily LR.Screening for alcohol misuse:
practices among U.S. primary care providers, DocStyles 2016. Am J Prev Med. 2018
Feb;54(2):173–80.
50. Bellentani S, Saccoccio G, Costa G, Tiribelli C, Manenti F, Sodde M, The Dionysos Study
Group, etal. Drinking habits as cofactors of risk for alcohol induced liver damage. Gut. 1997
Dec;41(6):845–50.
51. Simpson RF, Hermon C, Liu B, Green J, Reeves GK, Beral V, etal. Alcohol drinking patterns
and liver cirrhosis risk: analysis of the prospective UK Million Women Study. Lancet Public
Health. 2019 Jan;4(1):e41–e8.
52. Becker U, Deis A, Sorensen TI, Gronbaek M, Borch-Johnsen K, Muller CF, etal. Prediction
of risk of liver disease by alcohol intake, sex, and age: a prospective population study.
Hepatology. 1996 May;23(5):1025–9.
53. Fleming KM, Aithal GP, Card TR, West J. The rate of decompensation and clinical pro-
gression of disease in people with cirrhosis: a cohort study. Aliment Pharmacol Ther. 2010
Dec;32(11–12):1343–50.
54. Pares A, Caballeria J, Bruguera M, Torres M, Rodes J. Histological course of alco-
holic hepatitis. Inuence of abstinence, sex and extent of hepatic damage. J Hepatol.
1986;2(1):33–42.
55. Verrill C, Markham H, Templeton A, Carr NJ, Sheron N. Alcohol-related cirrhosis—early
abstinence is a key factor in prognosis, even in the most severe cases. Addiction. 2009
May;104(5):768–74.
N. V. Bergasa
https://t.me/medicina_free

287
56. Lackner C, Spindelboeck W, Haybaeck J, Douschan P, Rainer F, Terracciano L, et al.
Histological parameters and alcohol abstinence determine long-term prognosis in patients
with alcoholic liver disease. J Hepatol. 2017 Mar;66(3):610–8.
57. Teli MR, Day CP, Burt AD, Bennett MK, James OF.Determinants of progression to cirrhosis
or brosis in pure alcoholic fatty liver. Lancet. 1995 Oct 14;346(8981):987–90.
58. Dam-Larsen S, Franzmann M, Andersen IB, Christoffersen P, Jensen LB, Sorensen TI,
etal. Long term prognosis of fatty liver: risk of chronic liver disease and death. Gut. 2004
May;53(5):750–5.
59. Haidadottir S, Jonasson JG, Norland H, Einarsdottir SO, Kleiner DE, Lund SH, et al.
Long-
term follow-up and liver-related death rate in patients with non-alcoholic and alcoholic
related fatty liver disease. BMC Gastroenterol. 2014 Sep 27;14:166.
60. Deltenre P, Rufat P, Hillaire S, Elman A, Moreau R, Valla D, etal. Lack of prognostic useful-
ness of hepatic venous pressures and hemodynamic values in a select group of patients with
severe alcoholic cirrhosis. Am J Gastroenterol. 2002 May;97(5):1187–90.
61. Pessione F, Ramond MJ, Peters L, Pham BN, Batel P, Rueff B, et al. Five-year survival
predictive factors in patients with excessive alcohol intake and cirrhosis. Effect of alcoholic
hepatitis, smoking and abstinence. Liver Int. 2003 Feb;23(1):45–53.
62. Bell H, Jahnsen J, Kittang E, Raknerud N, Sandvik L.Long-term prognosis of patients with
alcoholic liver cirrhosis: a 15-year follow-up study of 100 Norwegian patients admitted to
one unit. Scand J Gastroenterol. 2004 Sep;39(9):858–63.
63. D’Amico G, Garcia-Tsao G, Pagliaro L.Natural history and prognostic indicators of survival
in cirrhosis: a systematic review of 118 studies. J Hepatol. 2006 Jan;44(1):217–31.
64. Jepsen P, Ott P, Andersen PK, Sorensen HT, Vilstrup H.Clinical course of alcoholic liver cir-
rhosis: a Danish population-based cohort study. Hepatology. 2010 May;51(5):1675–82.
65. Jepsen P, Vilstrup H, Ott P, Keiding S, Andersen PK, Tygstrup N.The galactose elimination
capacity and mortality in 781 Danish patients with newly-diagnosed liver cirrhosis: a cohort
study. BMC Gastroenterol. 2009 Jun 30;9:50.
66. Jepsen P, Ott P, Andersen PK, Vilstrup H.The clinical course of alcoholic cirrhosis: effects
of hepatic metabolic capacity, alcohol consumption, and hyponatremia--a historical cohort
study. BMC Res Notes. 2012 Sep 18;5:509.
67. Dionigi E, Garcovich M, Borzio M, Leandro G, Majumdar A, Tsami A, et al. Bacterial
infections change natural history of cirrhosis irrespective of liver disease severity. Am J
Gastroenterol. 2017 Apr;112(4):588–96.
68. Force USPST.Screening and behavioral counseling interventions in primary care to reduce
alcohol misuse: recommendation statement. Ann Intern Med. 2004 Apr 6;140(7):554–6.
69. Smith PC, Schmidt SM, Allensworth-Davies D, Saitz R.Primary care validation of a single-
question alcohol screening test. J Gen Intern Med. 2009 Jul;24(7):783–8.
70. Ewing JA. Detecting alcoholism. The CAGE questionnaire. JAMA. 1984 Oct
12;252(14):1905–7.
71. O'Brien CP. The CAGE questionnaire for detection of alcoholism: a remarkably useful but
simple tool. JAMA. 2008 Nov 5;300(17):2054–6.
72. Davis KM, Wu JY.Role of glutamatergic and GABAergic systems in alcoholism. J Biomed
Sci. 2001 Jan-Feb;8(1):7–19.
73. Perry EC.Inpatient management of acute alcohol withdrawal syndrome. CNS Drugs. 2014
May;28(5):401–10.
74. Beckett AG, Livingstone AV, Hill KR. Acute alcoholic hepatitis. Br Med J. 1961 Oct
28;2(5260):1113–9.
75. Kalaitzakis E, Gunnarsdottir SA, Josefsson A, Bjornsson E.Increased risk for malignant
neoplasms among patients with cirrhosis. Clin Gastroenterol Hepatol. 2011 Feb;9(2):168–74.
76. Salazar Salgado H, Ramos Martinez E, Lifshitz A. [Primary alcoholic cardiac disease and
alcoholic liver disease. Anatomopathological study]. La Prensa medica mexicana. 1978 Sep–
Oct;43(9–10):278–81. Enfermedad cardiaca alcoholica primaria y enfermedad hepatica alco-
holica. Estudio anatomopatologico.
8
Alcohol Induced Liver Disease
https://t.me/medicina_free

288
77. Estruch R, Fernandez-Sola J, Sacanella E, Pare C, Rubin E, Urbano-Marquez A.Relationship
between cardiomyopathy and liver disease in chronic alcoholism. Hepatology. 1995
Aug;22(2):532–8.
78. Mene-Afejuku TO, Shady A, Akinlonu A, et al. Alcoholic cardiomyopathy and liver dis-
ease in a community hospital in east Harlem in New York City. Gastroenterol Hepatol Open
Access. 2020;11(4):149‒151. https://doi.org/10.15406/ghoa.2020.11.00431.
79. Fernandez-Sola J, Nicolas JM, Oriola J, Sacanella E, Estruch R, Rubin E, etal. Angiotensin-
converting enzyme gene polymorphism is associated with vulnerability to alcoholic cardio-
myopathy. Ann Internal Med. 2002 Sep 3;137(5 Part 1):321–6.
80. Jing L, Jin C, Lu Y, Huo P, Zhou L, Wang Y, etal. Investigation of microRNA expression
proles associated with human alcoholic cardiomyopathy. Cardiology. 2015;130(4):223–33.
81. Hung CL, Chang SC, Chang SH, Chi PC, Lai YJ, Wang SW, etal. Genetic polymorphisms
of alcohol metabolizing enzymes and alcohol consumption are associated with asymptomatic
cardiac remodeling and subclinical systolic dysfunction in large community-dwelling Asians.
Alcohol Alcohol. 2017 Nov 1;52(6):638–46.
82. Caine D, Halliday GM, Kril JJ, Harper CG. Operational criteria for the classication
of chronic alcoholics: identication of Wernicke’s encephalopathy. J Neurol Neurosurg
Psychiatry. 1997 Jan;62(1):51–60.
83. Galvin R, Brathen G, Ivashynka A, Hillbom M, Tanasescu R, Leone MA, etal. EFNS guide-
lines for diagnosis, therapy and prevention of Wernicke encephalopathy. Eur J Neurol. 2010
Dec;17(12):1408–18.
84. Jain J, Singh R, Banait S, Verma N, Waghmare S. Magnitude of peripheral neuropa-
thy in cirrhosis of liver patients from central rural India. Ann Indian Acad Neurol. 2014
Oct;17(4):409–15.
85. Koike H, Iijima M, Sugiura M, Mori K, Hattori N, Ito H, etal. Alcoholic neuropathy is
clinicopathologically distinct from thiamine-deciency neuropathy. Ann Neurol. 2003
Jul;54(1):19–29.
86. Koike H, Sobue G.Alcoholic neuropathy. Curr Opin Neurol. 2006 Oct;19(5):481–6.
87. Koike H, Mori K, Misu K, Hattori N, Ito H, Hirayama M, etal. Painful alcoholic polyneu-
ropathy with predominant small-ber loss and normal thiamine status. Neurology. 2001 June
26;56(12):1727–32.
88. Finnerup NB, Attal N, Haroutounian S, McNicol E, Baron R, Dworkin RH, et al.
Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis.
Lancet Neurol. 2015 Feb;14(2):162–73.
89. Collier J.Bone disorders in chronic liver disease. Hepatology. 2007 Oct;46(4):1271–8.
90. Goel V, Kar P.Hepatic osteodystrophy. Trop Gastroenterol. 2010 Apr–June;31(2):82–6.
91. Marignani M, Angeletti S, Capurso G, Cassetta S, Delle FG.Bad to the bone: the effects of
liver diseases on bone. Minerva Med. 2004 Dec;95(6):489–505.
92. Mobarhan SA, Russell RM, Recker RR, Posner DB, Iber FL, Miller P.Metabolic bone dis-
ease in alcoholic cirrhosis: a comparison of the effect of vitamin D2, 25-hydroxyvitamin D,
or supportive treatment. Hepatology. 1984 Mar–Apr;4(2):266–73.
93. Lopez-Larramona G, Lucendo AJ, Gonzalez-Delgado L. Alcoholic liver disease and
changes in bone mineral density. Revista Espanola de Enfermedades Digestivas. 2013
Nov–Dec;105(10):609–21.
94. Jorge-Hernandez JA, Gonzalez-Reimers CE, Torres-Ramirez A, Santolaria-Fernandez F,
Gonzalez-Garcia C, Batista-Lopez JN, et al. Bone changes in alcoholic liver cirrhosis. A
histomorphometrical analysis of 52 cases. Dig Dis Sci. 1988 Sep;33(9):1089–95.
95. Bansal RK, Kumar M, Sachdeva PR, Kumar A.Prospective study of prole of hepatic osteo-
dystrophy in patients with non-choleastatic liver cirrhosis and impact of bisphosphonate
supplementation. United European Gastroenterol J. 2016 Feb;4(1):77–83.
96. Loria I, Albanese C, Giusto M, Galtieri PA, Giannelli V, Lucidi C, et al. Bone disorders
in patients with chronic liver disease awaiting liver transplantation. Transplant Proc. 2010
May;42(4):1191–3.
N. V. Bergasa
https://t.me/medicina_free

289
97. Lupoli R, Di Minno A, Spadarella G, Ambrosino P, Panico A, Tarantino L, etal. The risk
of osteoporosis in patients with liver cirrhosis: a meta-analysis of literature studies. Clin
Endocrinol. 2016 Jan;84(1):30–8.
98. Eastell R, Dickson ER, Hodgson SF, Wiesner RH, Porayko MK, Wahner HW, etal. Rates of
vertebral bone loss before and after liver transplantation in women with primary biliary cir-
rhosis. Hepatology. 1991 Aug;14(2):296–300.
99. Peris P, Pares A, Guanabens N, Pons F, Martinez de Osaba MJ, Caballeria J, etal. Reduced
spinal and femoral bone mass and deranged bone mineral metabolism in chronic alcoholics.
Alcohol Alcohol. 1992 Nov;27(6):619–25.
100. Williams BO, Insogna KL.Where Wnts went: the exploding eld of Lrp5 and Lrp6 signaling
in bone. J Bone Mineral Res. 2009 Feb;24(2):171–8.
101. Gonzalez-Reimers E, Martin-Gonzalez C, de la Vega-Prieto MJ, Pelazas-Gonzalez R,
Fernandez-Rodriguez C, Lopez-Prieto J, etal. Serum sclerostin in alcoholics: a pilot study.
Alcohol Alcohol. 2013 May–June;48(3):278–82.
102. Moschen AR, Kaser A, Stadlmann S, Millonig G, Kaser S, Muhllechner P, etal. The RANKL/
OPG system and bone mineral density in patients with chronic liver disease. J Hepatol. 2005
Dec;43(6):973–83.
103. Garcia-Valdecasas-Campelo E, Gonzalez-Reimers E, Santolaria-Fernandez F, De la Vega-
Prieto MJ, Milena-Abril A, Sanchez-Perez MJ, etal. Serum osteoprotegerin and RANKL
levels in chronic alcoholic liver disease. Alcohol Alcohol. 2006 May–June;41(3):261–6.
104. Bang CS, Shin IS, Lee SW, Kim JB, Baik GH, Suk KT, etal. Osteoporosis and bone fractures
in alcoholic liver disease: a meta-analysis. World J Gastroenterol. 2015 Apr 7;21(13):4038–47.
105. Diez-Ruiz A, Garcia-Saura PL, Garcia-Ruiz P, Gonzalez-Calvin JL, Gallego-Rojo F, Fuchs
D.Bone mineral density, bone turnover markers and cytokines in alcohol-induced cirrhosis.
Alcohol Alcohol. 2010 Sep–Oct;45(5):427–30.
106. Gatta A, Verardo A, Di Pascoli M, Giannini S, Bolognesi M.Hepatic osteodystrophy. Clin
Cases Mineral Bone Metab. 2014 Sep;11(3):185–91.
107. McLoughlin RM, Mills KH. Inuence of gastrointestinal commensal bacteria on the
immune responses that mediate allergy and asthma. J Allergy Clin Immunol. 2011
May;127(5):1097–107.
108. Casafont Morencos F, de las Heras Castano G, Martin Ramos L, Lopez Arias MJ, Ledesma
F, Pons Romero F.Small bowel bacterial overgrowth in patients with alcoholic cirrhosis. Dig
Dis Sci. 1996 Mar;41(3):552–6.
109. Rao R.Endotoxemia and gut barrier dysfunction in alcoholic liver disease. Hepatology. 2009
Aug;50(2):638–44.
110. Daviss B.Growing pains for metabolomics. Scientist. 2005;19(8):25–8.
111. Ellis DI, Dunn WB, Grifn JL, Allwood JW, Goodacre R.Metabolic ngerprinting as a diag-
nostic tool. Pharmacogenomics. 2007 Sep;8(9):1243–66.
112. Riva A, Patel V, Kurioka A, Jeffery HC, Wright G, Tarff S, etal. Mucosa-associated invariant
T cells link intestinal immunity with antibacterial immune defects in alcoholic liver disease.
Gut. 2018 May;67(5):918–30.
113. Mutlu EA, Gillevet PM, Rangwala H, Sikaroodi M, Naqvi A, Engen PA, et al. Colonic
microbiome is altered in alcoholism. Am J Physiol Gastrointest Liver Physiol. 2012 May
1;302(9):G966–78.
114. Bode C, Kugler V, Bode JC.Endotoxemia in patients with alcoholic and non-alcoholic cir-
rhosis and in subjects with no evidence of chronic liver disease following acute alcohol
excess. J Hepatol. 1987 Feb;4(1):8–14.
115. Hanck C, Rossol S, Bocker U, Tokus M, Singer MV.Presence of plasma endotoxin is cor-
related with tumour necrosis factor receptor levels and disease activity in alcoholic cirrhosis.
Alcohol Alcohol. 1998 Nov–Dec;33(6):606–8.
116. Mookerjee RP, Stadlbauer V, Lidder S, Wright GA, Hodges SJ, Davies NA, etal. Neutrophil
dysfunction in alcoholic hepatitis superimposed on cirrhosis is reversible and predicts the
outcome. Hepatology. 2007 Sep;46(3):831–40.
8
Alcohol Induced Liver Disease
https://t.me/medicina_free

290
117. Bajaj JS, Heuman DM, Hylemon PB, Sanyal AJ, White MB, Monteith P, etal. Altered prole
of human gut microbiome is associated with cirrhosis and its complications. J Hepatol. 2014
May;60(5):940–7.
118. Rosa H, Silverio AO, Perini RF, Arruda CB.Bacterial infection in cirrhotic patients and its
relationship with alcohol. Am J Gastroenterol. 2000 May;95(5):1290–3.
119. Fukui H, Brauner B, Bode JC, Bode C.Plasma endotoxin concentrations in patients with
alcoholic and non-alcoholic liver disease: reevaluation with an improved chromogenic assay.
J Hepatol. 1991 Mar;12(2):162–9.
120. Schafer C, Parlesak A, Schutt C, Bode JC, Bode C.Concentrations of lipopolysaccharide-
binding protein, bactericidal/permeability-increasing protein, soluble CD14 and plasma lip-
ids in relation to endotoxaemia in patients with alcoholic liver disease. Alcohol Alcohol. 2002
Jan-Feb;37(1):81–6.
121. Yang AM, Inamine T, Hochrath K, Chen P, Wang L, Llorente C, etal. Intestinal fungi contrib-
ute to development of alcoholic liver disease. J Clin Invest. 2017 June 30;127(7):2829–41.
122. Hartmann P, Seebauer CT, Schnabl B.Alcoholic liver disease: the gut microbiome and liver
cross talk. Alcohol Clin Exp Res. 2015 May;39(5):763–75.
123. Salaspuro M.Use of enzymes for the diagnosis of alcohol-related organ damage. Enzyme.
1987;37(1–2):87–107.
124. De Ritis F, Coltorti M, Giusti G. An enzymic test for the diagnosis of viral hepatitis; the
transaminase serum activities. Clin Chim Acta. 1957 Feb;2(1):70–4.
125. Cohen JA, Kaplan MM.The SGOT/SGPT ratio: an indicator of alcoholic liver disease. Dig
Dis Sci. 1979 Nov;24(11):835–8.
126. Hietala J, Puukka K, Koivisto H, Anttila P, Niemela O.Serum gamma-glutamyl transferase
in alcoholics, moderate drinkers and abstainers: effect on gt reference intervals at population
level. Alcohol Alcohol. 2005 Nov-Dec;40(6):511–4.
127. Sharpe PC.Biochemical detection and monitoring of alcohol abuse and abstinence. Ann Clin
Biochem. 2001 Nov;38(Pt 6):652–64.
128. Diehl AM, Potter J, Boitnott J, Van Duyn MA, Herlong HF, Mezey E.Relationship between
pyridoxal 5′-phosphate deciency and aminotransferase levels in alcoholic hepatitis.
Gastroenterology. 1984 Apr;86(4):632–6.
129. Zieve L.Jaundice, hyperlipemia and hemolytic anemia: a heretofore unrecognized syndrome
associated with alcoholic fatty liver and cirrhosis. Ann Intern Med. 1958 Mar;48(3):471–96.
130. Morse EE. Mechanisms of hemolysis in liver disease. Ann Clin Lab Sci. 1990
May–June;20(3):169–74.
131. Costa Matos L, Batista P, Monteiro N, Ribeiro J, Cipriano MA, Henriques P, etal. Iron stores
assessment in alcoholic liver disease. Scand J Gastroenterol. 2013 Jun;48(6):712–8.
132. Harrison-Findik DD, Schafer D, Klein E, Timchenko NA, Kulaksiz H, Clemens D,
et al. Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcrip-
tion and leads to increased duodenal iron transporter expression. J Biol Chem. 2006 Aug
11;281(32):22974–82.
133. Pietrangelo A.Genetics, genetic testing, and management of hemochromatosis: 15 years
since hepcidin. Gastroenterology. 2015 Oct;149(5):1240–51.
134. Chrostek L, Panasiuk A. Liver brosis markers in alcoholic liver disease. World J
Gastroenterol. 2014 July 7;20(25):8018–23.
135. Quinn SF, Gosink BB.Characteristic sonographic signs of hepatic fatty inltration. AJR Am
J Roentgenol. 1985 Oct;145(4):753–5.
136. Berzigotti A, Abraldes JG, Tandon P, Erice E, Gilabert R, Garcia-Pagan JC, et al.
Ultrasonographic evaluation of liver surface and transient elastography in clinically doubtful
cirrhosis. J Hepatol. 2010 Jun;52(6):846–53.
137. Yeom SK, Lee CH, Cha SH, Park CM.Prediction of liver cirrhosis, using diagnostic imaging
tools. World J Hepatol. 2015 Aug 18;7(17):2069–79.
138. Bydder GM, Chapman RW, Harry D, Bassan L, Sherlock S, Kreel L.Computed tomography
attenuation values in fatty liver. J Comput Tomogr. 1981 Mar;5(1):33–5.
N. V. Bergasa
https://t.me/medicina_free

291
139. Furnari M, Ahmed I, Erpecum KJ, Savarino V, Giannini EG.Breath tests to assess alcoholic
liver disease. Rev Recent Clin Trials. 2016;11(3):185–90.
140. Hall PDLM.Alcoholic liver disease. In: MacSween RNM, Anthomy PP, Scheuer PJ, Burt
AD, Portmann BC, editors. Pathology of the liver, vol. 1. 3rd ed. Edinburgh: Churchill
Livingstone; 1994. p.317–48.
141. Uchida T, Kao H, Quispe-Sjogren M, Peters RL.Alcoholic foamy degeneration: a pattern of
acute alcoholic injury of the liver. Gastroenterology. 1983 Apr;84(4):683–92.
142. Roth N, Kanel G, Kaplowitz N.Alcoholic foamy degeneration and alcoholic fatty liver with
jaundice: often overlooked causes of jaundice and hepatic decompensation that can mimic
alcoholic hepatitis. Clin Liver Dis. 2015 Dec;6(6):145–8.
143. Shibao K, Hirata K, Robert ME, Nathanson MH.Loss of inositol 1,4,5-trisphosphate recep-
tors from bile duct epithelia is a common event in cholestasis. Gastroenterology. 2003
Oct;125(4):1175–87.
144. Minagawa N, Nagata J, Shibao K, Masyuk AI, Gomes DA, Rodrigues MA, etal. Cyclic
AMP regulates bicarbonate secretion in cholangiocytes through release of ATP into bile.
Gastroenterology. 2007 Nov;133(5):1592–602.
145. Franca A, Carlos Melo Lima Filho A, Guerra MT, Weerachayaphorn J, Loiola dos Santos M,
Njei B, etal. Effects of endotoxin on type 3 inositol 1,4,5-trisphosphate receptor in human
cholangiocytes. Hepatology. 2019 Feb;69(2):817–30.
146. Nakano M, Worner TM, Lieber CS.Perivenular brosis in alcoholic liver injury: ultrastruc-
ture and histologic progression. Gastroenterology. 1982 Oct;83(4):777–85.
147. Sheron N, Bird G, Koskinas J, Portmann B, Ceska M, Lindley I, etal. Circulating and tissue
levels of the neutrophil chemotaxin interleukin-8 are elevated in severe acute alcoholic hepati-
tis, and tissue levels correlate with neutrophil inltration. Hepatology. 1993 July;18(1):41–6.
148. Dominguez M, Miquel R, Colmenero J, Moreno M, Garcia-Pagan JC, Bosch J, etal. Hepatic
expression of CXC chemokines predicts portal hypertension and survival in patients with
alcoholic hepatitis. Gastroenterology. 2009 May;136(5):1639–50.
149. Colmenero J, Bataller R, Sancho-Bru P, Bellot P, Miquel R, Moreno M, etal. Hepatic expres-
sion of candidate genes in patients with alcoholic hepatitis: correlation with disease severity.
Gastroenterology. 2007 Feb;132(2):687–97.
150. Degre D, Lemmers A, Gustot T, Ouziel R, Trepo E, Demetter P, etal. Hepatic expression of
CCL2in alcoholic liver disease is associated with disease severity and neutrophil inltrates.
Clin Exp Immunol. 2012 Sep;169(3):302–10.
151. Li W, Amet T, Xing Y, Yang D, Liangpunsakul S, Puri P, etal. Alcohol abstinence ameliorates
the dysregulated immune proles in patients with alcoholic hepatitis: a prospective observa-
tional study. Hepatology. 2017 Aug;66(2):575–90.
152. Reynolds TB, Hidemura R, Michel H, Peters R. Portal hypertension without cirrhosis in
alcoholic liver disease. Ann Intern Med. 1969 Mar;70(3):497–506.
153. Poynard T, Degott C, Munoz C, Lebrec D.Relationship between degree of portal hyperten-
sion and liver histologic lesions in patients with alcoholic cirrhosis. Effect of acute alcoholic
hepatitis on portal hypertension. Dig Dis Sci. 1987 Apr;32(4):337–43.
154. Goodman ZD, Ishak KG.Occlusive venous lesions in alcoholic liver disease. A study of 200
cases. Gastroenterology. 1982 Oct;83(4):786–96.
155. Pariente EA, Degott C, Martin JP, Feldmann G, Potet F, Benhamou JP. Hepatocytic PAS-
positive diastase-resistance inclusions in the absence of alpha-1-antitrypsin deciency—high
prevalence in alcoholic cirrhosis. Am J Clin Pathol. 1981 Sep;76(3):299–302.
156. Gerber MA, Thung SN. Hepatic oncocytes. Incidence, staining characteristics, and ultra-
structural features. Am J Clin Pathol. 1981 Apr;75(4):498–503.
157. Brown WR, Kloppel TM.The liver and IgA: immunological, cell biological and clinical
implications. Hepatology. 1989 May;9(5):763–84.
158. Moro-Sibilot L, Blanc P, Taillardet M, Bardel E, Couillault C, Boschetti G, etal. Mouse and
human liver contain immunoglobulin A-secreting cells originating from Peyer’s patches and
directed against intestinal antigens. Gastroenterology. 2016 Aug;151(2):311–23.
8
Alcohol Induced Liver Disease
https://t.me/medicina_free

292
159. NIH.ANTABUSE- disulram tablet In: Medicine NUNLo, editor. 2012.
160. Skinner MD, Lahmek P, Pham H, Aubin HJ.Disulram efcacy in the treatment of alcohol
dependence: a meta-analysis. PLoS One. 2014;9(2):e87366.
161. Krystal JH, Cramer JA, Krol WF, Kirk GF, Rosenheck RA.Veterans affairs naltrexone coop-
erative study G. naltrexone in the treatment of alcohol dependence. N Engl J Med. 2001 Dec
13;345(24):1734–9.
162. Rosner S, Hackl-Herrwerth A, Leucht S, Vecchi S, Srisurapanont M, Soyka M.Opioid antag-
onists for alcohol dependence. Cochrane Database Syst Rev. 2010 Dec;8(12):CD001867.
163. Littleton JM.Acamprosate in alcohol dependence: implications of a unique mechanism of
action. J Addict Med. 2007 Sep;1(3):115–25.
164. Akbar M, Egli M, Cho YE, Song BJ, Noronha A.Medications for alcohol use disorders: an
overview. Pharmacol Ther. 2018 May;185:64–85.
165. Addolorato G, Leggio L, Ferrulli A, Cardone S, Vonghia L, Mirijello A, etal. Effectiveness
and safety of baclofen for maintenance of alcohol abstinence in alcohol-dependent
patients with liver cirrhosis: randomised, double-blind controlled study. Lancet. 2007 Dec
8;370(9603):1915–22.
166. Mosoni C, Dionisi T, Vassallo GA, Mirijello A, Tarli C, Antonelli M, etal. Baclofen for the
treatment of alcohol use disorder in patients with liver cirrhosis: 10 years after the rst evi-
dence. Front Psych. 2018;9:474.
167. Minozzi S, Saulle R, Rosner S.Baclofen for alcohol use disorder. Cochrane Database Syst
Rev. 2018 Nov 26;11:CD012557.
168. Barrault C, Lison H, Roudot-Thoraval F, Garioud A, Costentin C, Behar V, etal. One year
of baclofen in 100 patients with or without cirrhosis: a French real-life experience. Eur J
Gastroenterol Hepatol. 2017 Oct;29(10):1155–60.
169. drugs.com. Revia. 2018.
170. UNIVERSITY CC.FDA-approved medications.
171. Yen MH, Ko HC, Tang FI, Lu RB, Hong JS.Study of hepatotoxicity of naltrexone in the
treatment of alcoholism. Alcohol. 2006 Feb;38(2):117–20.
172. Bergasa NV.Pruritus of cholestasis. In: Carstens E, Akiyama T, editors. Itch: mechanisms
and treatment. Frontiers in neuroscience. Boca Raton, FL: CRC Press; 2014.
173. Alcohol withdrawal syndrome: how to predict, prevent, diagnose and treat it. Prescrire Int.
2007 Feb;16(87):24–31.
174. Maldonado JR, Sher Y, Ashouri JF, Hills-Evans K, Swendsen H, Lolak S, etal. The “predic-
tion of alcohol withdrawal severity scale” (PAWSS): systematic literature review and pilot
study of a new scale for the prediction of complicated alcohol withdrawal syndrome. Alcohol.
2014 Jun;48(4):375–90.
175. Wood E, Albarqouni L, Tkachuk S, Green CJ, Ahamad K, Nolan S, etal. Will this hospital-
ized patient develop severe alcohol withdrawal syndrome?: the rational clinical examination
systematic review. JAMA. 2018 Aug 28;320(8):825–33.
176. Schabelman E, Kuo D.Glucose before thiamine for Wernicke encephalopathy: a literature
review. J Emerg Med. 2012 Apr;42(4):488–94.
177. Kosten TR, O’Connor PG.Management of drug and alcohol withdrawal. N Engl J Med. 2003
May 1;348(18):1786–95.
178. Schuckit MA.Management of withdrawal delirium (delirium tremens). N Engl J Med. 2015
Feb 5;372(6):580–1.
179. Mendenhall CL, Moritz TE, Roselle GA, Morgan TR, Nemchausky BA, Tamburro CH, etal.
A study of oral nutritional support with oxandrolone in malnourished patients with alcoholic
hepatitis: results of a Department of Veterans Affairs cooperative study. Hepatology. 1993
Apr;17(4):564–76.
180. de Ledinghen V, Beau P, Mannant PR, Borderie C, Ripault MP, Silvain C, etal. Early feed-
ing or enteral nutrition in patients with cirrhosis after bleeding from esophageal varices? A
randomized controlled study. Dig Dis Sci. 1997 Mar;42(3):536–41.
N. V. Bergasa
https://t.me/medicina_free

293
181. Porter HP, Simon FR, Pope CE 2nd, Volwiler W, Fenster LF.Corticosteroid therapy in severe
alcoholic hepatitis. A double-blind drug trial. N Engl J Med. 1971 Jun 17;284(24):1350–5.
182. Lesesne HR, Bozymski EM, Fallon HJ.Treatment of alcoholic hepatitis with encephalopa-
thy. Comparison of prednisolone with caloric supplements. Gastroenterology. 1978 Feb;74(2
Pt 1):169–73.
183. Maddrey WC, Boitnott JK, Bedine MS, Weber FL Jr, Mezey E, White RI Jr. Corticosteroid
therapy of alcoholic hepatitis. Gastroenterology. 1978 Aug;75(2):193–9.
184. Carithers RL Jr, Herlong HF, Diehl AM, Shaw EW, Combes B, Fallon HJ, et al.
Methylprednisolone therapy in patients with severe alcoholic hepatitis. A randomized multi-
center trial. Ann Intern Med. 1989 May 1;110(9):685–90.
185. Ramond MJ, Poynard T, Rueff B, Mathurin P, Theodore C, Chaput JC, etal. A randomized
trial of prednisolone in patients with severe alcoholic hepatitis. N Engl J Med. 1992 Feb
20;326(8):507–12.
186. Phillips M, Curtis H, Portmann B, Donaldson N, Bomford A, O’Grady J.Antioxidants versus
corticosteroids in the treatment of severe alcoholic hepatitis: a randomised clinical trial. J
Hepatol. 2006 Apr;44(4):784–90.
187. Singal AK, Bataller R, Ahn J, Kamath PS, Shah VH.ACG clinical guideline: alcoholic liver
disease. Am J Gastroenterol. 2018 Feb;113(2):175–94.
188. Teschke R. Alcoholic steatohepatitis (ASH) and alcoholic hepatitis (AH): cascade of
events, clinical aspects, and pharmacotherapy options. Expert Opin Pharmacother. 2018
Jun;19(8):779–93.
189. Helman RA, Temko MH, Nye SW, Fallon HJ.Alcoholic hepatitis. Natural history and evalu-
ation of prednisolone therapy. Ann Intern Med. 1971 Mar;74(3):311–21.
190. Depew W, Boyer T, Omata M, Redeker A, Reynolds T.Double-blind controlled trial of pred-
nisolone therapy in patients with severe acute alcoholic hepatitis and spontaneous encepha-
lopathy. Gastroenterology. 1980 Mar;78(3):524–9.
191. Mathurin P, Abdelnour M, Ramond MJ, Carbonell N, Fartoux L, Serfaty L, etal. Early change
in bilirubin levels is an important prognostic factor in severe alcoholic hepatitis treated with
prednisolone. Hepatology. 2003 Dec;38(6):1363–9.
192. Louvet A, Naveau S, Abdelnour M, Ramond MJ, Diaz E, Fartoux L, etal. The Lille model:
a new tool for therapeutic strategy in patients with severe alcoholic hepatitis treated with
steroids. Hepatology. 2007 June;45(6):1348–54.
193. Mathurin P, Louvet A, Duhamel A, Nahon P, Carbonell N, Boursier J, etal. Prednisolone with
vs without pentoxifylline and survival of patients with severe alcoholic hepatitis: a random-
ized clinical trial. JAMA. 2013 Sep 11;310(10):1033–41.
194. Campra JL, Hamlin EM Jr, Kirshbaum RJ, Olivier M, Redeker AG, Reynolds TB.Prednisone
therapy of acute alcoholic hepatitis. Report of a controlled trial. Ann Intern Med. 1973
Nov;79(5):625–31.
195. Mathurin P, Moreno C, Samuel D, Dumortier J, Salleron J, Durand F, etal. Early liver trans-
plantation for severe alcoholic hepatitis. N Engl J Med. 2011 Nov 10;365(19):1790–800.
196. Garcia-Tsao G, Abraldes JG, Berzigotti A, Bosch J.Portal hypertensive bleeding in cirrho-
sis: risk stratication, diagnosis, and management: 2016 practice guidance by the American
Association for the Study of Liver Diseases. Hepatology. 2017 Jan;65(1):310–35.
197. Jepsen P, Ott P, Andersen PK, Sorensen HT, Vilstrup H.Risk for hepatocellular carcinoma in
patients with alcoholic cirrhosis: a Danish Nationwide Cohort Study. Ann Intern Med. 2012
June 19;156(12):841–7.
198. Heimbach JK, Kulik LM, Finn RS, Sirlin CB, Abecassis MM, Roberts LR, etal. AASLD
guidelines for the treatment of hepatocellular carcinoma. Hepatology. 2018 Jan;67(1):358–80.
8
Alcohol Induced Liver Disease
https://t.me/medicina_free
Соседние файлы в папке Библиотека им академика М.И. Перельмана
