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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5950_Библиотеки_им_академика_М_И_Перельмана
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244
Metals in Medicine, Volume 2
FIGURE 8.3 Isotropic and nonisotropic AUNPs.
enhancement.
24
-
therapy
25
researchers choose recognition sequences as the linker.
15
-
26
light energy that has been absorbed can be converted directly into O
2
and
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Impact of Metallic Nanoparticles for Tissue Engineering and Regenerative Medicine
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27
198
28
tumor volume.
29
Whereas
199
30
payloads delivered to the malignancies.
31
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physics, chemistry, and biology.
32
Depending on their intended use, the biological target, and the methods
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Metals in Medicine, Volume 2
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ibility.
33
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esis, or apoptosis.
AuNPs: in vitro assay and in vivo assay.
In-vitro assays:
34
36
In vivo assays: Any nanomaterial that might be used inside the human
-
35
-
36
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including oral, parenteral, topical, and pulmonary, necessitates their design.
or cells have been extensively researched to meet these objectives.
37
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Impact of Metallic Nanoparticles for Tissue Engineering and Regenerative Medicine
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medicines or antibiotics at particular locations in tissues or cells based on
amino acids are incorporated into NPs as signal transduction to reduce
control cell behavior. AuNPs used in passive targeting are made to have a
-
-
38,39
delivery systems. Multiple drug molecules, recombinant proteins, vaccina-
tions, or nucleotides can be delivered by AuNPs to their intended recipients.
-
40
cells and has typically been employed as an anticarcinogenic medication.
have been employed.
41,42
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Metals in Medicine, Volume 2
8.2.4.3.3Protein Delivery
AuNPs have also been used as protein delivery nanocarriers. Organothiol
-
-
could play a part in nanomedicine and nanopharmacology.
43,44
45
Depending on the required particle dimension and accessibility, there are
-
anticancer activity, absorption, bioavailability, and pharmacokinetic and
pharmacodynamics.
46,47
TABLE 8.1
Shapes of AuNPs Application
Nanorod
Spherical Drug delivery
Nanoshell Cancer therapy and tumor suppression
Nanostars Bioimaging and photothermal therapy
Bipyramids
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-
48
Controlling characteristics such
-
ments due to biological diversity. On the contrary, synthetic polymers do
stable structurally.
49
dissolved into the electrospinning polymer precursor solution.
48
Making
AuNPs hydrogel composites could result in sophisticated controlled mate-
-
nate, chitosan, gelatin, poly(N-isopropylacrylamide) (PNIPAAm), gelatin
AuNPs.
49,47
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50
synthetic or natural polymers that is 3D. Alginate, chitosan, collagen, and
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51
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Metals in Medicine, Volume 2
liver.
52-54
55,56
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57,58
59
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altered.
47,60,61
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62
AuNPs have been
to their great properties.
-
63,64
According
destroying malignant cells.
65
66
imaging, and therapeutic applications:
67
Diagnostic applications
• Pathogen detection
•
• Immunoassay
• Sol particle immunoassay
• Nucleic acid detection
• Biosensors
Imaging applications
• Fluorescence imaging
•
• Photoacoustic imaging
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Metals in Medicine, Volume 2
• Photothermal therapy
• Drug carriers
• Gene delivery
-
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tions in the ventricle.
-
68,69
Parenteral hydrogels depending on nanodevices are injected into the MI
a. Natural cardiac tissue displayed an excellent intercalated disc struc-
-
tion coupling to demonstrate common electrical conduction.
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block.
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the conducive environment, and stem cell delivery injectable hydro-
gels based on conductive NPs are injected into the system.
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they demonstrated improved contractile and myocardial electrophysiological
70
attenuated matrix, thiol-hydroxyethylmethacrylate (thiol-HEMA), and some
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myocytes.
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According to reports, phase I and phase II clinical studies also
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structured materials to natural polymer hydrogel materials (such as alginic
72,73
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