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Phytochemistry, Pharmacology, and Applications of Phytoecdysteroids
169
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plant are encouraged as dietary supplements with anabolic and adaptogenic
activity, due to their ecdysteroid content.
5.8.11. Cosmetology and Dermatology
The utilization of phytoecdysteroids in dermatology appears to be most
encouraging. This sector provides viewpoints by its simpler therapeutic
access, particularly in the area of topical applications.
Meybeck et al. (1997) took the patent on the utilization of the ecdysteroids
as active substances integrated into liposomes. The patent comprises the
non-limitative plants’ list that can be utilized: Achyranthes aspera, Ajuga
decumbens, Achyranthes bidentata, Ajuga iva, Cyanotis arachnoidea,
Bombyx mori, Cyathula ofcinalis, Leuzea carthamoides, Cyathula
capitata, Lychnis os-cuculi, Paris dunniana, Paris axialis, Paris fargesii,
Paris vietnamensis, Paris polyphylla, Pfafa iresinoides, Polypodium
vulgare, Pfafa paniculata, Rhaponticum integrifolium, Serratula tinctoria,
Serratula sogdiana, Sesuvium portulacastrum, Silene dioica, Silene
brahuica, Silene nutans, Silene scabrifolia, Silene otites, Silene tatarica,
Vitex glabrata, and Silene traemixta. Privileged plant extracts are the
ones of Achyranthes bidentata, Cyanotis arachnoidea, Ajuga decumbens,
Polypodium vulgare, and Leuzea carthamoides. The species Serratula
sogdiana and Rhaponticum integrifolium have the benet that they can
easily be cultivated. Extraction processes are dened according to Imai et al.
(1969). Instances of the formulations are offered with diverse indications:
reinstating the water obstacle of the epidermis, treatment of the psoriatic
skin, hydration of epidermis, reinstating the smoothness of epidermis, and
precautionary treatment of the dry skin and treatment of the ichthyotic skins.
These formulations are made with ecdysterone esters, pure ecdysterone,
or plant extracts. Some properties are given in the public domain, such as
experimental ndings on the in vitro keratinocyte differentiation via 20-OH-
ecdysone.
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Natural Compounds: An Introduction
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