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Subject Index 351
homogenous plaques, 167, 168 symptomatic and asymptomatic
plaques, univariate analysis, 167,
168 gray-scale median, 172 HDU, 164 histogram parameters, 165 isotope-labelled molecules, 164 morphologic and histologic markers, 165,
166 multicenter trials, 171 STATA 4.0 software, 165 variance analysis and student’s test,
165–166
CAUDLES-EF. See Carotid automated
ultrasound double line extraction
system-edge flow
CBC. See Clinical-based classifier CCA. See Common carotid artery Chronic liver disease (CLD)
CBC decomposition strategy, 259 clinical and pathophysiological
characteristics, 268 definition, 256 stages of, 256–257
Circular symmetric complex Gaussian
(CSCG), 5
Cirrhosis, 256–257
compensated, 256, 258, 269, 271–277 decompensated, 256, 258, 269, 271–277
CLD. See Chronic liver disease Clinical-based classifier (CBC)
biochemical and clinical features, 267–269 clinical data set, 269–270 feature extraction and selection, 270–272 kNN classifier, 272–274 SVM classifier
Gaussian radial-basis kernel, 275–277 polynomial kernel, 274–275
ultrasound image pre-processing
acoustic attenuation coefficient,
261–263
autoregressive model, 265–267 co-occurrence tensor, 263–264 first-order statistics, 263 liver surface contour, 267 wavelet transform, 264–265
Common carotid artery (CCA)
acoustic shadowing, 123 atherosclerosis, 100 Bland–Altman plot, 114, 121 blood–endothelium (intima) interface, 122 childhood-onset chronic kidney disease,
121
CVD, 100 GSM, 103 IL (see Intima layer) image normalization, 104 IMC (see Intima–media complex) inter-and intra-observer variability, 100 Mann–Whitney rank sum test, 108, 111 manual measurements, 105, 114 manual vs. snakes segmented IMT
measurement, 117, 120 media–adventitia interface, 122 ML (see Media layer) regression analysis, 108 risk factors, 124 snakes deformation, 123 statistical analysis, 107 texture analysis, 106 texture features
FCH, 122 GSM, 115 IL vs. ML, 116, 117 Mann–Whitney rank sum test, 117–119 median and inter-quartile range, 115,
116
Wilcoxon rank sum test, 115, 116
two-dimensional ultrasound transducer,
120 ultrasound image recording, 104 Wilcoxon rank sum test, 108–110, 112–113
Compensated cirrhosis, 256, 258, 269,
271–277
Continuous mode ultrasound testing, 288–292 Co-occurrence tensor, 263–264 Coronary atherosclerotic plaque
acoustic properties, 180 cross-validation scheme, 193 data fusion process, 190 data selection process, 193–194 enhanced data set requirements, 190 ex vivo coronary section, histological
image, 178 grey-level intensity and textures, 180 image-based features, 181–182 integrated backscatter parameter/wavelet
coefficients, 179 intima and adventitia layer, 179 intimal-medial segments, 177 in vitro data validation procedure, 179–180 J function design, 195 leave one patient out technique, 190 N-fold cross-validation, 189 pattern recognition, 180 radio frequency-based features
acoustic impedance, 182
352 Subject Index
Coronary atherosclerotic plaque (cont.)
integrated backscatter, 182–183 power spectrum, 183–184 textural and spectral features, 184 tissue properties, 182
wavelet-based approach, 184 SFFS algorithm, 191–193 test in vitro, 196–197 test in vivo, 197–198 tissue classification
decision tree, 185–186
ECOC, 186–187
ensemble architecture, 187–189
feature space, 185
probabilistic model, 185 tissue morphology and composition, IVUS,
178 Coupled active geometric functions, 245–247 Cryoblation, prostate
contraindications, 303 cryotherapy, 299–300 imaging techniques, 302–303 indications, 303 Joule–Thompson effect, 303–304 long-term complications, 308–309 post-operative follow-up, 306–307 real-time transrectal ultrasonography,
301–302
short-term complications, 308 treatment technique, 303–306
CSCG. See Circular symmetric complex
Gaussian
D
DAQ systems
free-hand ultrasound, 207–208 real time data acquisition and visualization,
204
robotic arm prototype, 205–207
Decompensated cirrhosis, 256, 258, 269,
271–277 Decomposition coefficients, 328 Denoising algorithm, 261 Derivative of Gaussian (GD), 135–136 Detailed plaque texture analysis (DPTA), 172 Difference of offset Gaussian (DOOG),
135–136 Discrete wavelet packet frame (DWPF), 326 Double line (LI/MA) border estimation
edge flow magnitude and direction
edge flow vector, 135 flow propagation and boundary
detection, 139–141
GD and DOOG, 135–136 intensity edge flow, 136–138 parameters, 136
texture edge flow, 138–139 grayscale guidance zone, 134 guidance zone mask estimation, 135 weak LI and LI missing edge estimation,
144–146
weak MA/missing MA edge estimation
area ratio, 142
disconnected edge objects, 141
edge object classification, 143–144
incorrect edge objects, 141, 142
small edge objects, 141–143
E
ECOC framework. See Error-correcting output
code framework Elasticity imaging, 302 EM algorithm. See Expectation maximization
algorithm Envelope radio frequency (ERF)
data histogram extraction, 15, 17, 19 Gamma and Rayleigh distributions, 13, 20 GoF test, 5 gray-scale image appearance, 18 image retrieval method, 12 Kullback–Leibler distances, 19, 20 LCM, 7–8 nonlinear compression model, 6 Rayleigh statistics, 4, 5 RF image retrieval (decompression)
method, 15 Error-correcting output code (ECOC)
framework, 35, 186–187 Euler–Mascheroni constant, 10 Europen Carotid Stenosis Trial (ECST), 172 Expectation maximization (EM) algorithm, 28,
32
F
Familial hypercholesterolemia (FCH), 122 Far adventitia estimation
tracing, 134
AD
F
automatic recognition, 132–133 fine to coarse down-sampling, 133 Gaussian kernels, 134 higher order Gaussian derivative filter, 134 speckle reduction, 133
up-sampling, 134 Figure of merit (FoM), 86 Fisher-Tippet distribution, 10
Subject Index 353
G
Gabor filters, 137 Gaussian probability function, 50 Gaussian radial-basis kernel, 275–277 Generalized Gaussian distribution (GGD), 54 Gibbs distribution, 77 Goodness of Fit (GoF) test, 20, 22 Gradient vector flow (GVF), 226 Gray-scale median (GSM), 103 Guidance zone mask estimation, 135
H
Hammersley–Clifford theorem, 77 Hausdorff distance (HD), 147 Hepatitis, 256 Hessian matrix, 80 High definition ultrasonography (HDU), 164 Hilbert transform, 52
I
Intima layer (IL)
acoustic holes, 102 automated segmentation and measurement,
102 box plots, 114, 115 Mann–Whitney rank sum test, 108, 111,
117–119 manual measurements, 105, 108–110 median and inter-quartile range, 115, 116 vs. ML, texture characteristics, 116, 117 snakes segmentation, 105–106 statistical analysis, 107 texture analysis, 106 ultrasound image recording, 104 Wilcoxon rank sum test, 108, 112–113,
115, 116
Intima–media complex (IMC), 100, 101
box plots, 114, 115 Mann–Whitney rank sum test, 108, 111,
117–119 manual measurements, 105, 108–110 median and inter-quartile range, 115, 116 snakes segmentation, 105–106 statistical analysis, 107 texture analysis, 106 ultrasound image recording, 104 Wilcoxon rank sum test, 108, 112–113,
115, 116
Intima-media thickness (IMT). See Common
carotid artery
Intravascular ultrasound (IVUS) image, 62–63
albeit vulnerable plaque, 26
analog to digital converter, 26 automatic quantitative method, 27 data acquisition, 314–315 display, 314–315 EM algorithm, 28, 32 hypothetical acoustic tissue model, 27 image formation, 314–315 inner arterial wall, 26 lumen borders, automatic detection
brushlet analysis, 317–319
2.5-D magnitude–phase histogram, 320–321
experimental results, 323–324 frequency tiling and overcomplete
representation, 319
motivations, 316–317 signal modeling, 320
surface function actives, 322–323 monolithic description, 33 pixel-wise classification, 28 plaque echo-morphology, 28 RMM (see Rayleigh mixture model) speckle formation, 28 speckle signal, 26
J
Joule–Thompson effect, 303–304
K
k-Nearest Neighbor (kNN) classifier, 272–274 Kullback–Leibler (KL) divergence, 38, 39
L
LCL. See Log–Compression Law LCM. See Log–compression model Lemarie-Battle wavelet, 329 Linear homogeneous mask area filter
(LHMAF), 84 Linear scaling filter (LSF), 84 Liver surface contour, 267 Local hypoechogenic region labeling
3D reconstruction, 215, 216 energy function, 214 gray-scale mapping, 218 heterogeneous plaque, 212 labeling procedure, 213 P40 3D maps, 216, 217 penalization function, 214 piecewise smooth region detection, 214,
215 Local hypoechogenic region labeling (cont.)
354 Subject Index
plaque texture, 217, 218 potential application, 216, 218
thresholding procedure, 215 Log–Compression Law (LCL), 4, 7–8 Log–compression model (LCM)
block diagram, ultrasound imaging system,
7 BUS image formation, 8, 9 compressed image statistics, 4 LCL, 7–8
Log-Euclidean potential function (LEPF), 79 Low-intensity ultrasound, 284 Lumen borders, automatic detection
brushlet analysis, 317–319
2.5-D magnitude–phase histogram,
320–321 experimental results, 323–324 frequency tiling and overcomplete
representation, 319 motivations, 316–317 signal modeling, 320 surface function actives, 322–323
Lumen–intima (LI) boundary, 130
M
MAP estimation. See Maximum a posteriori
estimation
Markov random field (MRF), 55 Maximum a posteriori (MAP) estimation, 54,
55
Maximum homogeneity over pixel
neighborhood filter (MHOPNF), 84
Maximum likelihood (ML) estimation, 32, 54 Mean preservation variance reduction (MPVR)
method, 85
Media–adventitia (MA) boundary, 130 Media layer (ML)
automated segmentation and measurement,
102 box plots, 114, 115 vs. IL, texture characteristics, 116, 117 Mann–Whitney rank sum test, 108, 111,
117–119 manual measurements, 105, 108–110 median and inter-quartile range, 115, 116 snakes segmentation, 105–106 statistical analysis, 107 texture analysis, 106 ultrasound image recording, 104 Wilcoxon rank sum test, 108, 112–113,
115, 116
Media layer thickness (MLT), 102 Median fiters (MF), 84
ML estimation. See Maximum likelihood
estimation Modified Gabor filters (MGFs), 56, 84 Multi-channel wavelet analysis, 326–328
N
Non-local means filter (NLMF), 84 Non-parametric kNN classifier, 259–260
O
One-vs-One coding technique, 187 Oriented Speckle Reduction Anisotropic
Diffusion (OSRAD) algorithm, 55
filter robustness, 58, 61, 62 in vivo experiments
pairwise error comparison, 65–67 snake manual and automatic
segmentation, 63–65
normalized intensity profile, denoised
images, 58, 59
P
PDF. See Probability density function Point spread function (PSF), 51 Polyline distance (PD), 147–148 Polynomial kernel, 274–275 Portal hypertension, 268 Probability density function (PDF), 20, 51 Prostate cryoblation
contraindications, 303 imaging techniques, 302–303 indications, 303 Joule–Thompson effect, 303–304 long-term complications, 308–309 post-operative follow-up, 306–307 real-time transrectal ultrasonography,
301–302
short-term complications, 308 treatment technique, 303–306
Pulsed mode ultrasound testing, 292–295
R
Radio frequency (RF) ultrasound estimation
compression law, 5 CSCG, 5 decompression method
anatomical structures/tissues, 15, 16 carotid plaque and contour, 20, 21 data histogram extraction, 15, 17–19 ERF, 12
Subject Index 355
gray-scale image appearance, 18 interpolation operation., 21 Kullback–Leibler distance, 19, 20 Monte Carlo tests, 13, 14 parameter estimation, 10–12 RF image retrieval application, 15
speckle noise contamination, 13 3D US reconstruction problem, 6 fractional moments iterative algorithm, 6 GoF test, 20, 22 intensity signal, 5 LCM
block diagram, ultrasound imaging
system, 7 BUS image formation, 8, 9 compressed image statistics, 4 LCL, 7–8
maximum likelihood estimation, 20 probability density function, 20 Rayleigh statistics, ERF, 4, 5 speckle recognition, BUS, 4
speckle reduction, 4 Rayleigh-log total variation (RLTV) filter, 75 Rayleigh mixture model (RMM)
ECOC framework, 35
features weight analysis, 44–45
in–vitro data processing, 33–35
Lagrange multiplier, 31
leave-one-patient-out technique, 35
likelihood function, 29–31
ML estimator, 32
PDFs, parameter, 29, 30
pixel intensity, 29
plaque echo-morphology, 32–33
plaque local characterization
C.1, C.2 classifiers, 40, 41 C.3 classifiers, 40–42 kernel size, 39, 40
plaque monolithic
KL divergence, 38, 39 mixture components, 37 monolithic classification, 37 SRM, 37–39 tissue types, 35, 36
statistical analysis, 43–44 Rayleigh probability function, 50 Real–time radio–frequency data, 33, 34 Reflection coefficient
continuous mode ultrasound testing,
291–292
pulsed mode ultrasound testing, 294–295 RF ultrasound estimation. See Radio frequency
ultrasound estimation
RMM. See Rayleigh mixture model
Robotic arm prototype system
acquisition modes, 206, 207 experimental robot setup, 206, 207 image acquisition process, 205 system components, 205, 206
S
Salvage cryotherapy, 303 Sequential floating forward selection (SFFS)
algorithm, 191–193 SFA. See Surface function actives Single Rayleigh model (SRM), 37–39 Speckle reducing anisotropic diffusion (SRAD)
algorithm, 55, 58, 59 Speckle reducing anisotropic diffusion filter
(SRADF), 84 Squeeze box filter (SBF), 84 SRAD algorithm. See Speckle reducing
anisotropic diffusion algorithm SRBF
filter robustness, 58, 61, 62 in vivo experiments
pairwise error comparison, 65–67 snake manual and automatic
segmentation, 63–65
normalized intensity profile, denoised
images, 58, 59 SRM. See Single Rayleigh model Sum of square differences (SSD) criterion, 57 Support vector machine (SVM) classifier
Gaussian radial-basis kernel, 275–277
polynomial kernel, 274–275 Surface function actives (SFA), 322–323 Sylvester–Lyapunov equation, 55
T
TGC function. See Time gain compensation
(TGC) function
Three-dimensional ultrasound plaque
characterization atherosclerosis, 203 carotid disease, 204 DAQ systems, 3D ultrasound
free-hand ultrasound, 207–208 real time data acquisition and
visualization, 204
robotic arm prototype, 205–207
gray-scale median and P
40
, 204
local hypoechogenic region labeling,
graph-cuts
3D reconstruction, 215, 216
356 Subject Index
Three-dimensional ultrasound plaque
characterization (cont.) energy function, 214 gray-scale mapping, 218 heterogeneous plaque, 212 labeling procedure, 213 P40 3D maps, 216, 217 penalization function, 214 piecewise smooth region detection, 214,
215 plaque texture, 217, 218 potential application, 216, 218 thresholding procedure, 215
reconstruction method
data fidelity, 209 de-speckling algorithm, 209, 210 interpolation, 211 MAP, 209 Rayleigh distribution, 212 regularization parameter function, 211 surface rendering, 208–209 total variation, 209 volume rendering, 209 voxel representation, 210
Time gain compensation (TGC) function, 34 Tissue analysis. See Ultrasound
speckle/despeckle image
decomposition
U
Ultrasound despeckle method
anisotropic filters (see Anisotropic filters) denoising process, 49 edge-preservation property, 50 speckle, definition, 49 speckle noise
Gaussian-weighted sinusoidal function,
52 Gaussian white noise, 52 PSF, 51 statistics, 50–51 ultrasound simulator, 51
speckle reduction methods
anisotropic diffusion filters, 55–56 Bayesian filters, 54–55 linear filters, 53 median filters, 53 wavelet-based filters, 54
Ultrasound speckle/despeckle image
decomposition, 75, 76
arterial diseases, 73 AWGN, 74
Bayesian approach, 74 constructive and destructive interference,
74 convex energy function, 79 convex optimization, 80, 81 data fidelity, 76 echogenicity decay, 82–83 echogenicity index, 82 echo-morphology and texture
characterization, 75 edge maps, 85, 87, 88 FOM, 86 Hammersley–Clifford theorem, 77 Hessian matrix, 80 image intensity profiles, 85, 87, 89 IVUS image, 86, 89, 91 Kolmogorov–Smirnov conformity test, 85 LEPF, 79 linear filters, 84 line search algorithm, 79 liver steatosis binary classification, 91, 92 local Rayleigh estimator, 82 Log-Euclidean prior, 77–79 MAP, 76 MPVR, 85 MRF, 77 Newton method, 80 noiseless image outcomes, 85, 87 Rayleigh statistics, 74 RLTV filtering, 75, 83–84 speckle decomposition algorithm, 86, 90 speckle, definition, 74 speckle-derived wavelet energies, 83 speckle extraction, 80–81 subject identification, thyroid ultrasound
data, 91–92 tissue-dependent textural features, 89, 92 visual diagnosis, 93
V
Vibratory devices, 284 Vibro-acoutsography, 302
W
Wavelet-based filter (WAVF), 84 Wavelet transform analysis, 264–265 Weighted averaged sensitivity, 195 Weighted median filter (WMF), 53 Weighted Rayleigh maximum likelihood filter
(WRMLF), 84

Biographies of the Editors

Biography of Jo˜ao Miguel Sanches
Jo˜ao Miguel Sanches received the E.E., M.Sc. and Ph.D. degrees from the Instituto Superior T´ecnico (IST) in the Technical University of Lisbon, Portugal, in 1991, 1996 and 2003, respectively. He is Assistant Professor at the recently created Department of Bioengineering at the Instituto Superior T´ecnico, Technical University of Lisbon. Before, he was at the Department of Electrical and Computer Engineering (DEEC) where he has taught in the area of signal processing, systems and control. He has been actively involved in the course of Biomedical Engineering advising master thesis of the Biomedical Engineering course and PhD students of the doctoral program in Biomedical Engineering. He has proposed a PhD course of Medical Image Reconstruction that he has been taught in the last years.
He is researcher at the Institute for Systems and Robotics (ISR) and in the last years his work has been focused on Biomedical Engineering, namely,in Biomedical Image Processing, Physiological-based Modeling of Biological Systems in the perspective of the Systems and Control theory and statistical signal processing
J.M. Sanches et al. (eds.), Ultrasound Imaging: Advances and Applications, DOI 10.1007/978-1-4614-1180-2, © Springer Science+Business Media, LLC 2012
357
358 Biographies of the Editors
of physiological data. His research activity is focused on the morphological and tissue characterization of tissues from Ultrasound (US) images for the diagnosis of the atherosclerotic disease of the carotids and diffuse diseases of the liver. He is also working in functional Magnetic Resonance Imaging (fMRI) and Fluores­cence Confocal Microscope (FCM) imaging in collaboration with the Institute of Molecular Medicine at the Medical School of the University of Lisbon. He is also involved in the development of signal processing algorithms and biomedical applications for mobile phones for the diagnosis of sleep disorders in collaboration with the Electroencephalography and Clinical Neurophysiology Center (Centro de ElectroencefalografiaNeurofisiologiaCl´ınica – CENC), also with the Medical School of the University of Lisbon.
He is member of the IEEE Engineering in Medicine and Biology Society and Associate Member of the Bio Imaging and Signal Processing Technical Committee (BISP-TC) of the IEEE Signal Processing Society. He is also president of the Portuguese Association of Pattern Recognition (APRP).
Biography of Andrew Laine
Andrew F. Laine, D.Sc., is Professor of Biomedical Engineering and Radiology (Physics), and the Director of the Heffner Biomedical Imaging Laboratory in the Department of Biomedical Engineering. Since 2001 he has served as Vice Chair of the Department of Biomedical Engineeringat Columbia. Professor Laine pioneered the application of multiresolution representations for feature analysis of digital mammography and ultrasound.He served as Associate Editor of IEEE Transactions on Image Processing and edited the book, “Wavelet Theory and Applications”, Kluwer, 1995. He has jointly chaired the SPIE conference on “Mathematical Imaging: Wavelet Application in Signal and Image Processing”, during the years 1993–2003, and co-authored several book chapters including“Wavelet Applications in Medicine and Biology”, CRC Press, 1995, and “Time-Frequency and Wavelets
Biographies of the Editors 359
Transforms in Biomedical Engineering,” IEEE Press, 1998. He is a member of the Editorial Board of the book series Emerging Technologies in Biomedical Engineering, sponsored by the IEEE-EMBS Society and on the Editorial Board of the Journal of Visual Communication and Image Representation (Elsevier). He also served on the program committee for the IEEE-EMBS Workshop on Wavelet Applications in Medicine in 1994, 1998, 1999 and 2004. Dr. Laine was recently elected to ADCOM of the IEEE Engineering in Medicine and Biology Society, and is Chair of Technical Committee (TC) on Medical Imaging for the EMBS, and a member of the TC of IEEE Signal Processing Society, BISP (Biomedical Imaging and Signal Processing). He was the Program Chair for the IEEE EMBS conference in 2006, held in New York City and is the Program Co-Chair for IEEE International Symposium on Biomedical Imaging (ISBI) in 2008. He is Vice President elect of Publications for the IEEE EMBS, startingin January 2008.He is a Senior Member of IEEE (Institute of Electrical and Electronics Engineering) and a Fellow of AIMBE (American Institute for Medical and Biological Engineering). His research interests include methods of multi-resolution analysis applied to problems in medical imaging, image analysis and signal processing, computational biology, computed aided diagnosis, pattern recognition in biology, biometrics and applied mathematics.
Biography of Jasjit Suri
Jasjit S. Suri, MS, PhD, MBA, Fellow AIMBE, is an innovator, visionary, scientist, and an internationally known world leader, has spent over 25 years in the field of biomedical engineering/sciences, software and hardware engineering and its management. During his career in biomedical industry/imaging, he has had an upstream growth and responsibilities from scientific Engineer, Scientist, Manager, Director R&D, Sr. Director, Vice President to Chief Technology Officer (CTO) level positions in industries like Siemens Medical Systems, Philips Medical
360 Biographies of the Editors
Systems, Fisher Imaging Corporation and Eigen Inc. & Biomedical Technologies,
respectively and managed up to 100 people.
He has developed products and worked extensively in the areas of breast, mammography, orthopedics (spine), neurology (brain), angiography (blood ves­sels), atherosclerosis (plaque), ophthalmology (eye), urology (prostate), image guided surgery and several kinds of biomedical devices from inception phase to commercialization phase, including 510(K)/FDA clearances. Under his leadership, he has obtained over five FDA clearances in Urology, Angiography and Image Guided Surgery ProductLines ranging from 1000 pages to 5000 pages submissions. He has conducted in vivo and ex vivo validations on biomedical devices and surgery systems. Dr. Suri has developed several collaboration programs between University–Industry partnerships. He has managed funds ranging up to ten million dollars. He has very successfully built IP portfolios during his career bringing attraction for larger OEMs spin-offs. Dr. Suri has over 60 US/European Patents, over 25 books and over 300 peer-reviewed articles. He is a well-known speaker and has spoken over 50 times at national and international levels. Dr. Suri has won over 50 scientific and extracurricular awards during his career.
He received his Masters from University of Illinois, Chicago, Doctorate from University of Washington, Seattle, and Executive Management from Weatherhead School of Management, Case Western Reserve University (CWRU), Cleveland. Dr. Suri was crowned with President’s Gold medal in 1980 and the Fellow of American Institute of Medical and Biological Engineering (AIMBE) for his outstanding contributions at Washington, DC. He believes in “getting a job done” using his strengths of innovation, strategic partnerships and strong team collaborations by bringing cross-functional and multi-disciplinary teams together both in-house and outsourcing relationships.