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486 P.A. Stangl

Follow-Up

• Clinical observation for ongoing hemorrhage.
• Imaging typically not necessary.
• Hemorrhage related to retained products of conception may require dilatation and
curettage as definitive therapy.
• Normal menses and fertility can be expected in most cases after several months.
• Multiple cases of successful pregnancy and delivery following embolization for
PPH have been reported.
• Recurrence rates of PPH with subsequent deliveries are likely higher than the
incidence in the general population.

Alternative Therapies

• Surgical treatment typically involves ligation of both IIAs.
• Patients with persistent hemorrhage proceed to hysterectomy.
• Surgery can usually be avoided where there are clear protocols in place for the
management of PPH.
• Case selection and utilization of endovascular therapy vary widely across
institutions.
Specific Complications
• Unsuccessful embolizations—minority of cases require repeat embolization, and
failures requiring surgery are rare.
• Non-target embolization resulting in symptomatic lower extremity ischemia has
been described; standard techniques of careful embolization under fluoroscopy should prevent most instances of non-target embolization.
• Ischemic complications in the distribution of the anterior division of the IIA have
been reported i n 3–7% of patients. Such complications include uterine necro­sis, transient ovarian failure, bladder necrosis, vaginal fistulae, muscle pain, and neurological damage.
• Use of temporary embolic agents (gelfoam) or larger particles should minimize
ischemic complications.
• Theoretical concerns about radiation and embolization impacting fertility have
largely been allayed (the alternative, hysterectomy, has a clear impact on fertility).
Keypoints
• Work with the labor and delivery team to develop a strategy and written protocol.
48 Post-partum Hemorrhage: Embolization and Endovascular Management 487
• Embolization for PPH is an established therapy, safe, and effective.
• Negative angiographic findings do NOT contraindicate embolization.
• Embolization is appropriate before, during, after, or instead of surgery.
• Bilateral embolization is necessary for uterine bleeding unless a specific
bleeding source is identified.

Suggested Reading

Banovac F, Lin R, Shah, D, White A, Pelage JP, Spies J. Angiographic and Interventional
Options in Obstetric and Gynecologic Emergencies. Obstetric and Gynecologic Clinics of North America 2007;34(3):599–616
Eriksson LG, Mulic-Lutvica A, Jangland L, Nyman R. Massive Postpartum Hemorrhage Treated
with Transcatheter Arterial Embolization: Technical Aspects and Long-Term Effects on Fertility and Menstrual Cycle. Acta Radiologica 2007;48(6):635–642
Mitty HA, Sterling KM, Alvarez M, Gendler R. Obstetric Hemorrhage: Prophylactic and
Emergency Arterial Catheterization and Embolotherapy. Radiology 1993;188(1):183–187

Index

A
AAA, see Abdominal aortic aneurysm (AAA) Abdominal aortic aneurysm (AAA) endovascular repair, 375
perfusion after endovascular stent-graft
deployment, see Endoleaks
Abdominal embolization, pre-procedure
imaging of
acute gastrointestinal tract hemorrhage,
92–96
trauma, 96–97 Absolute alcohol, 52–53 ACA, see Anterior cerebral artery (ACA) Accessory renal arteries, 217 Acrylamido polyvinyl alcohol microspheres,
32 Acrylic polymer microspheres, 429 ACT, see Activated clotting time (ACT) Activated clotting time (ACT), 420 Active extravasation, 93, 299 AML, see Angiomyolipoma (AML) Amplatzer vascular plug (AVP), 265, 410
deployment of, 24–26 self-expanding nitinol wire mesh, 24–25 sizes of, 25
Analgesia
during embolization procedures, 113–115 following embolization procedures, 117 medications for, 114–115 for PES, 131–133
and sedation, 111 Anchor technique, 22–23, 154, 166 Anesthesia, 65, 387 Aneurysm, 395
rupture of, 285
size of, 388
See also Abdominal aortic aneurysm
(AAA); Internal iliac artery aneurysm (IIAA)
Angiodysplasia, 346 Angiography, 107, 388, 397, 399
of AVF, 163 of extremity vascular injury, 254–255 of high-flow lesions, 143–144 of inferior pancreaticoduodenal artery
pseudoaneurysm, 338 of internal iliac artery aneurysm, 380 of low-flow lesions, 137 in patient with recurrent hemoptysis, 351 of PAVMs, 152 of pelvic AVM, 143 performing, 107–108 of post-operative hemorrhage, 298 of priapism, 279 of renal metastasis in femur, 122 of trauma, 266 of upper gastrointestinal hemorrhage,
334–335 of upper GI hemorrhage, 337 of uterine artery, 236–237 of vascular large right renal cancer, 216
Angiomyolipoma (AML), 215–216 Angioplasty balloon, 397 Anterior cerebral artery (ACA), 428 Antibiotics for PES, 132 Anticoagulation, 388 Antiemetics for PES, 132–133 Aortocaval fistulae, 166 Arterial anatomy of target lesion
arterial variations, 5 end arterial supply, 6–7
Arteriography
bronchial, 352–354 of hemorrhage in pelvis fracture, 241–242 of neuroendocrine hepatic metastases, 209 selective inferior pancreatico-duodenal,
285 of upper extremity, 252
Transcatheter Embolization and Therapy,
Techniques in Interventional Radiology, DOI 10.1007/978-1-84800-897-7,
C
Springer-Verlag London Limited 2010
489
490 Index
Arteriovenous fistula (AVF), 163, 257
aftercare of, 169–170 angiography, 161–163 cardiovascular effects, 157 diagnostic evaluation
CTA, 158–159 laboratory evaluation, 158 ultrasound, 158
embolization therapy for
anatomical considerations in, 160 ancho approach, 166 arterial approach, 168 catheters in, 160 complications in, 160 contraindications for, 160 embolic agent in, 160–161 indications for, 159 liquid agent in, 167–168 occlusion devices in, 166–167 stents, 168
venous approach, 169 etiology of, 163–164 follow-up, 170 high-output states in, 158 local effects, 157 medications for, 161 physical examination, 157 post-procedure pain medications, 170 renal, 164 surgical interventions for, 159
Arteriovenous shunting (AV), 122 Atherosclerotic disease, 415 Autologous blood clot
applications, 42–43 physical properties, 41 preparation, 42 problems associated with, 43
AV, see Arteriovenous shunting (AV) AV F, see Arteriovenous fistula (AVF) AV P, see Amplatzer vascular plug (AVP) Avulsions, 455 Axial T1-weighted images, loculated
transfacial multicystic mass, 461
Axillary artery injury, 258
B
Balloon remodeling, 388 Benign hypervascular lesions, 186 Benzodiazepine, 410 Biliary drainage, 390 Bioabsorbable polymeric GDC coils, 17 BIPP, see Bismuth iodophore paste (BIPP) Bismuth iodophore paste (BIPP), 421
Bland embolization
in hepatic metastases, 201 vs. TACE, 190–191
Bleeding
around drains, 311 causes of, 293 following biopsy, see Post-biopsy
hemorrhage
following “blind” procedures, 311 Bleomycin, 465–466 Blunt abdominal trauma
alternative therapies for
contraindications to, 263–264 surgery, 263
angiography of
complications associated with, 264
vascular abnormalities, 266 clinical evaluation of, 261–262 clinical features, 261 contrast-enhanced CT of, 262 embolization of
aftercare, 272
embolic agent for, 265
equipment for, 264–265
indications to, 263
kidney, 269–272
liver, 267
spleen, 268–269 FAST scan of, 262 See also Trauma
Blunt injury, 249 Bolus administration, 209 Bone tumor
complications in, 228 contraindications to, 224 diagnostic evaluation, 223–225 embolization
access approach, 225
angiography, 226
complications in, 224
embolic agents, 225
equipment, 225
follow-up, 228
palliative, 227
PES in, 228
pre-operative, 226–227 indications for, 224
Brachial artery access, 192, 254 Brachial artery injury, 258 Bronchial arteries
anastomoses between, 355 anatomy of, 87, 352 filling from internal mammary artery, 354
Index 491
and intercostal arteries, 352 superselective catheterization of, 30
spinal branches of, 352, 354 Bronchial arteriography, 352–354 Bronchial artery embolization (BAE), 349
aftercare, 360
catheters for, 355–356
for cystic fibrosis, 351
embolic agents for, 356
for hemoptysis, 30, 351
medication in, 356–357
patient follow-up, 360
procedure, 359
safety, 361 Bronchial artery false aneurysm, 358 Bronchial circulation, pathological, 357
C
Capillary malformation, 173–174 Caroticum, see Carotid body Carotid body, 425 Catheter, 122, 387
blocking of, 125–126
for bone tumor embolization, 225
factors influencing selection of
anatomy of target vessel, 75 diagnostic angiography, 75–76 embolic agents, 76–77
need for co-axial system, 77 handling properties of, 77, 79–80 for HCC embolization, 189 hydrophilic, 80 non-selective, 151 position, 123 prophylactic placement of, 484–486 reverse curve, 77–78 selective, 151 shapes, 75–77 for trauma embolization, 264–265
Catheter angiography
extremity trauma, 251 extremity vascular injury, 251 systemic arteriovenous fistulae, 158 vs. MDCT, 92–93
Catheter-induced vasospasm, 357 Cavernosal blood gas analysis, 276 CECT, see Contrast-enhanced computed
tomography (CECT)
Celiac artery, 385
anatomical variations of, 264
Celiac axis arteriogram of liver with
hypervascular lesions, 210
CEMRI, see Contrast-enhanced MRI (CEMRI) Chemoembolization premedication regimen,
209
Chylothorax
causes of, 471 contraindications to, 475 embolization
case study, 479 embolic agent for, 476 equipment, 476 guidewire, 477–478 midline skin puncture in, 477 occlusion of proximal thoracic duct,
478 etiology of, 471 imaging of, 472 surgical intervention for, 473, 475 thoracentesis in, 472 treatment of, 478
etilefrine, 474 MCT diet, 474 somatastatin/octreotide, 474
unremitting, 472
CIN, see Contrast-induced nephropathy (CIN) Closed system, 154 Coagulation disorders, 416 Coagulopathies, 299 Coaxial technique, 22 Cobra catheter, 10 Coil embolization, 16
anchoring techniques, 22–24 in AVF, 164 coil extrusion, 21–22 coil introduction, 21 minimizing complications associated with,
26 stable catheter positioning, 20–21
Coil pusher, 21 Coils, see Embolization coils Collateral supply, 122
from branch of cystic artery, 131 from gastroduodenal artery, 6 from right renal artery, 217 from uterine arteries, 235
Colonoscopy
for diverticular hemorrhage, 346 elective, 346
Common iliac artery, 243 Completion venogram post-embolization, 408 Computed tomography angiography (CTA)
with 3D reconstruction of AVF, 158–159 of extremity vascular injury, 249 of lower GI hemorrhage, 341
492 Index
of massive hematemesis, 335 of upper gastrointestinal hemorrhage,
331–332, 337
Computed tomography (CT) scan
of blunt abdominal trauma, 268 with intravenous contrast in
distal splenic embolization, 269 proximal splenic embolization, 269
of patient with massive hematemesis, 285,
287
in patient with severe hypotension after
biopsy of right kidney, 313 of pelvis, 245 of post-pancreatitis pseudoaneurysm, 286
Congenital arteriovenous fistulae, 163 Congenital bronchial atresia, 92 Congenital pulmonary varix, 92 Contralateral lobe puncture, 407 Contrast-enhanced computed tomography
(CECT) of endoleaks, 376 of metastatic neuroendocrine tumor, 211 of pancreatic hemorrhage, 283 of PAVMs, 149 of post-operative hemorrhage, 294 of trauma, 262
Contrast-enhanced MRI (CEMRI)
of UAE, 232
Contrast-enhanced multidetector computed
tomography, 105 image reconstruction in, 106 purpose of, 106
Contrast-induced nephropathy (CIN)
definition of, 118 prevention of, 118 risk factors for, 118
Contrast media, safe administration of, 118 Cook Bentson wire, 84 Coronal T2-weighted image, microcystic
lympangioma, 460
CTA, see Computed tomography angiography
(CTA)
CT scan, see Computed tomography (CT) scan Cyanoacrylate, 420 Cyanoacrylate glue, 408
D
DEB-TACE, see Drug-eluting
bead-transarterial
chemoembolization (DEB-TACE)
Deep vein thrombosis (DVT), 445 Detachable coils, 24–26 Detectable microspheres, 37
Digital subtraction angiogram, 165
after coil embolization of right lumbar
pseudoaneurysm, 315 of cecal bleeding, 342 of common hepatic artery, 165 of PPH, 484
Dimethyl sulfoxide (DMSO), 55–57 Diode lasers
for E VLA, 63 for occlusion of blood vessels, 62
Direct fluoroscopic angiography, 374 Distal embolization, 269 Diverticular hemorrhage, 341 DMSO, see Dimethyl sulfoxide (DMSO) Double-curve catheters, 78 Doxorubicin-eluting microspheres, 35 Doxycycline, 466, 467 Drainage catheter upsizing, 311–312 Drug-eluting beads
for HCC embolization, 190, 193 for neuroendocrine hepatic metastases
embolization, 207
Drug-eluting bead-transarterial
chemoembolization (DEB-TACE),
197 in hepatic metastases, 201
Drug-eluting microspheres
factors influencing, 35 types of, 34–35
DVT, see Deep vein thrombosis (DVT) Dysplastic nodules, 186
E
ECA, see External carotid artery (ECA) Ehlers–Danlos syndrome, 384 Embolic material, 151, 254, 407
for AVF embolization, 159 for blunt abdominal trauma embolization,
265 for bone tumor embolization, 225 for chylothorax embolization, 476 classification, 29–30 delivery of, 11–12 developments of, 69 for endoleak embolization, 373 for extremity vascular injury embolization,
254 factors influencing selection of, 7, 15, 122 for HCC embolization, 190 for high-flow lesions, 144 for IIAA embolization, 380 liquid, see Liquid embolic agents for Lower GI hemorrhage embolization,
343–344, 347
Index 493
for neuroendocrine hepatic metastases
embolization, 208
for pancreatic hemorrhage embolization,
287–288 PAVM embolization, 151 permanent particulate, see Permanent
particulate embolization agents for post-biopsy hemorrhage embolization,
316 for post-operative hemorrhage
embolization, 297, 299 for priapism embolization, 278 pulmonary arterial hemorrhage
embolization, 366 silk suture, 17 temporary, see Temporary embolic agents for trauma embolization, 265 tris-acryl microspheres, 29, 33 for UGIH embolization, 334
Embolization coils, 16
deployment steps
anchoring techniques, 22–24 coil extrusion, 21–22 coil introduction, 21 stable catheter positioning, 20–21
materials of
issues associated with, 18
physical properties of, 17–19 retrieval of, 126–127 shapes of, 19 sizes of, 20 terminology, 20 thrombogenicity of, 18–19
Embolization therapy
access equipments for
catheter, see Catheter
guidewires, 83
microcatheters, 80–81
occlusion balloons, see Occlusion
balloons
vascular sheaths, 82–83 adverse outcomes of, 111 choice of particle size for, 38 collateral pathways in, 5–7 complications
blocked catheter, 125–126
detection and recognition, 124–125
non-target embolization, 126
prevention, 121–124
tissue necrosis, 127 goal of, 179 indications for
high-flow lesions, 143
low-flow lesions, 137 inducing cell replication, 71 of large hepatoma, 131 likely outcomes of, 7–8 objectives, 3 performing
informing patient and clinicians in,
8–9
vascular access, 9 planning
pathological process, 4
roles of alternative therapies, 4
target lesion identification, 5 post-procedural considerations, 112
administration of contrast media, 118
imaging modalities, 125
sedation and analgesia administration,
117 pre-procedural considerations, 112 preserving vessels in, 12 procedural considerations, 112–113
complications, 115–116 medications, 114–115 sedation and analgesia administration,
113–115
staff and care e quipement, 113–114
selective catheterization in, see Selective
catheterization target of
disease process, 182 patients, 181 target organs, 181
vascular occlusion in, 7
Embolized tissue/organ
long-term effects of, 181 short-term effects of, 180
Embolotherapy, see Embolization therapy Emergency equipment, 114 End arteries
embolization of, 7 occlusion of, 6
Endoleaks
angiography of, 374 contrast-enhanced CT scan of, 376 definition, 371 embolization, 371
aftercare, 375 catheters for, 373 embolic agents for, 373
patient follow-up, 375 imaging, 372 lesion assessment, 374 medication for, 373
494 Index
treatment plan, 374–375
types, 371 Endovascular treatments, 400 Epistaxis
aftercare
arterial puncture site, 422
post-embolization, 423 anatomy of, 418 angiography
access, 420
angiographic a ppearance, 421
ECA, 420–421 catheters for embolization of, 418–419 clinical features, 415 definition of, 415 diagnostic evaluation
imaging, 416
laboratory, 416
nasal endoscopy, 415 embolic agents, 420 follow-up, 423 management of
contraindications, 417
indications for embolization, 416–417
initial therapy, 416
specific complications, 418 medication, 420 treatment plan and technique
hereditary hemorrhagic telangiectasia,
422 juvenile nasal angiofibroma, 422 spontaneous epistaxis, 421–422 trauma including traumatic
pseudoaneurysms, 422
Ethylene vinyl alcohol (EVOH), 55–57 Etilefrine, 474 EVOH, see Ethylene vinyl alcohol (EVOH) Exchange catheters, 84 External carotid artery (ECA), 418 External iliac artery, 243 Extra-hepatic supply, 188 Extremity vascular injury
alternative therapies for, 251 analgesia and sedation for, 254 angiography of, 254–255 clinical evaluation of, 250 clinical manifestations of, 249 contraindications for, 252 embolization of
catheters for, 253–254 embolic agents for, 254
findings of, 255 imaging of, 250–251
indications for, 251 intervention for, 249 mechanisms of, 249
F
FAST scan, see Focused assessment with
sonography for trauma (FAST)
scan Fibro-muscular dysplasia, 395 Fluoroscopic imaging
contrast injected, 467
direct, 372 Flush aortogram, 397 Foam sclerotherapy injection in breast veins,
456
Focused assessment with sonography for
trauma (FAST) scan
of trauma, 105, 262
G
Gadolinium, 427 Gastroduodenal artery (GDA)
embolization, 336
pseudoeneurysm, 6, 94 GDA, see Gastroduodenal artery (GDA) Gelatin sponge, 43 Gelfoam pledgets, 265
for tract embolization, 307 Gene therapy, 69
challenges in, 70
gene transfer/modulation mechanism, 70
mode of action of, 70
roles for interventional radiology, 71
for vascular embolization, 71 Glycerine trinitrate (GTN), 422 Gonadal vein
embolization, 435
left/right, 438 Gonadal vein reflux, 435
aftercare, 441
alternative therapies for, 437
anatomy of, 438
angiographic a ppearance of, 440
catheters for embolization of, 439
clinical features, 435
clinical scenarios, 440–441
complications
back/scrotal pain, 437 post-embolization syndrome, 437 vasovagal episodes, 437
contraindications
general, 437 specific, 437
diagnostic evaluation, 435
Index 495
females with pelvic pain, 436
males with varicocele, 436 embolic agents, 439 female, 437 follow-up, 442 indications for, 436 male, 436 medication, 439 post-embolization, 442 treatment plan and technique
ovarian vein, 441
spermatic vein, 441 venography
access, 439
jugular route, 439
transfemoral route, 440 venous puncture site, 442
Gonadal venogram, 440 Gore Viabahn-covered stent, 402 Great saphenous vein, EVLA ablation of, 446 Gross great saphenous varicose veins
pre-treatment, 446 GTN, see Glycerine trinitrate (GTN) Guidewires, 83 Guiding catheters, 83
H
HCC, see Hepatocellular carcinoma (HCC) Heat-induced vessel occlusion
applications of, 66 by lasers, 64
by radiofrequency, 65–66 Hemangiopericytoma, 426 Hemoptysis, 349
adjunctive and alternative therapies for, 351
causes of, 349
complications to, 351–352
CT and CXR imaging of, 350
indications for, 351
infection control in, 357
laboratory examination of, 350
pre-procedure imaging of, 87–88
treatment plan and technique, 359 Hemorrhage
following pancreatic surgery, 283
in pancreatitis, 283 Hepatic artery, 188
variability in anatomy of, 188, 208 Hepatic embolization
in clinical scenarios, 267
complications of, 267–268
See also Liver embolization
post-percutaneous biopsy/drainage
Hepatic metastases
clinical features, 197 complications of, 202 diagnostic evaluation
clinical examination, 197 laboratory tests, 198 pre-treatment angiography, 198
embolic therapeutic options for, 197
equipment uses in, 199 treatment procedure, 200
treatment results, 201 follow-up of, 200–201 patient preparation, 199 post-procedure medications, 200 pre-procedure medications, 199 See also Hepatocellular carcinoma (HCC)
Hepatocellular carcinoma (HCC)
chemoembolization for, 193–194 diagnosis of, 185
CT and MRI, 185–186 differential diagnosis of, 186 epidemiology of, 185 non-selective angiography of, 192–193 post-procedure care of, 194 post-procedure follow-up, 194 pre-procedure evaluation of, 187 radioembolization for, 191 TAC E fo r
anatomic considerations in, 188
bland embolization vs., 190–191
catheter, 189
embolic agents in, 190
indications and contraindications for,
187 patient consent for performing, 189 selective vs. non-selective, 191
Hereditary hemorrhagic telangiectasia (HHT),
147–148
HHT, see Hereditary hemorrhagic
telangiectasia (HHT)
HIF-1, see Hypoxia inducible factor 1 (HIF-1) High-flow lesions
alternative therapies, 143 anatomy, 144 angiography, 144–145 blood tests, 143 clinical examination, 143 contraindications, 144 embolic agents for, 144 indications for embolization, 143 medication, 144 patient follow-up, 146 post-embolization, 146
496 Index
treatment plan and technique, 145–146
ultrasound and MRI of, 143 High flow priapism, 275 Hydrogel coil, 398 Hydrogel–polyzene F microspheres, 33 Hydrophilic-coated nitinol wire, 84 Hydrophilic hydrogel-coated platinum coils,
17 Hypertension, 395 Hypertrophy of bone and soft tissues, 173 Hypervascular lesions, 208 Hypervascular metastatic bone tumors, 223 Hypervascular paragangliomas, 427 Hypervascular renal cell cancer, 417 Hypotension
CT examination in patient with severe, 313 evaluation and treatment of, 116
Hypoxia i nducible factor 1 (HIF-1), 180
I
Iatrogenic arteriovenous fistulae, 164 Iatrogenic injury during central line placement,
300 Ibuprofen-loaded microspheres, 34 ICA, see Internal carotid artery (ICA) IIAA, see Internal iliac artery aneurysm (IIAA) Iliac artery, 400 IMA, see Internal maxillary artery (IMA) Imaging departments, considerations for, 108 Inferior epigastric artery, 243 Inflow and outflow arteries, occlusion of, 6 Interlocking detachable coils, 22 Internal carotid artery (ICA), 418
pseudoaneurysms of, 421
Internal iliac artery, 243, 245
aneurysm, see Internal iliac artery
aneurysm (IIAA)
bilateral angiograms of, 483
Internal iliac artery aneurysm (IIAA)
angiography of, 380 complications in, 379 contraindications to, 378 diagnostic evaluation
CT/MRI, 378 laboratory examination, 377
embolization of
aftercare, 381–382 catheters for, 379 embolic agents for, 380 patient follow-up, 382
proximal/distal isolation, 381 indications for, 378 symptomatic, 377
Internal iliac artery territory embolization,
indication for, 377 Internal maxillary artery (IMA), 416 Intimal injury and thrombus formation, 16–17 Intra-arterial radioembolization, 37 Ipsilateral lobe access, 407
coil embolization, 409
Irinotecan-loaded microspheres, 34
J
Jaundice, 390 Juvenile nasal angiofibroma, 415
pre-operative embolization of, 416 tumors, 416, 417
K
Kidney, 269
aneurysm and autotransplanting, 400 embolization
contraindications of, 271–272
proximal renal artery, 270 Klatskin tumor, 390 Klippel-Trenaunay syndrome
clinical examination, 176 clinical features
capillary malformation, 173–174
gastrointestinal involvement, 175
hypertrophy of bone and soft tissues,
174 lymphatic vascular malformation, 175 venous malformation, 174–175
diagnosis of, 173
management of, 176–177 Klippel-Trenaunay syndromes, 459 Knee dislocation, 258
L
Laser
effect of heating tissues with, 61–62
fibers, 62–63
for occlusion of blood vessels, 64
dangers specific to, 65 power, 63–64 properties, 62
Lateral flush aortography, 345 Left gastric artery (LGA)
embolization, 336 thick-walled pseudoaneurysm from, 289
Left subclavian artery, large bronchial supply
from, 355 LGA, see Left gastric artery (LGA) Lipiodol, 57–58, 71, 190, 193 Liquid embolic agents
absolute alcohol, 52–53