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C. C. Miller et al. Chapter 13 Distal Aortic Perfusion and Selective Visceral Perfusion
https://t.me/med1917
immediate postoperative renal function. The distal anastomosis is completed at the iliac bifurcation, using 3-0
or 2-0 polypropylene sutures (Fig. 13.7 f). Prior to the
completion of this anastomosis, we place the patient in
the head-down position, and then flush the graft proximally and distally. When the anastomosis is completed,
we release the clamp to restore pulsatile flow to the lower extremities.
When the distal extent of the aneurysm is below the
renal arteries, the infrarenal abdominal aorta is
clamped distally, if possible for the final anastomosis.
Sometimes because of excessive aortic calcification or
an overly large aorta, we clamp the left common iliac or
external iliac artery. The reason for clamping the infrarenal or the left common or external iliac artery is that
cooling of the kidneys and viscera can cause the patient's body temperature to drop precipitously, causing
cardiac arrhythmias. Core body temperature is kept between 32 and 33 8C by warming the lower extremities.
Alternatively, we stop the pump, open the infrarenal abdominal aorta and promptly sew the graft to the abdominal aorta above the iliac bifurcation. Once the distal anastomosis is completed, we clamp the graft and
restart the pump. Pulsatile flow is promptly restored to
the legs with completion of the final anastomosis, and
the pump is restarted to continue warming the patient
to a nasopharyngeal temperature of 36±37 8C. A repre-
sentative example of an extent II thoracoabdominal aortic aneurysm repair is shown in Fig. 13.8.
13.3 Impact of Adjuncts on Outcome
Between 1991 and 2004, we performed repair of the
descending thoracic and thoracoabdominal aorta in
1,106 patients [24]. Seven hundred five (64%) patients
were men. The patient distribution was 215 (19.5%) for
extent II and 891 (80.5%) for all others. The median
age of all patients was 68 years (range, 8±92 years).
Three hundred fifty-five (32%) patients were active
smokers at the time of surgery. One hundred and eighteen (11%) patients suffered from cerebrovascular disease. Forty-five (4%) patients presented with acute dissection; 73 (6.6%) with rupture [25]. The adjuncts distal aortic perfusion and CSF drainage with moderate
hypothermia were used in 823/1,106 (74%) patients.
Four hundred thirty-six of 1,106 (39.4%) patients underwent intercostal artery reattachment. The overall 30day mortality was 162/1,106 (14.6%) [25], and the 5year survival rate was between 60 and 70%. Seventy
percent of the patients recover from surgery without
postoperative complications. Risk factors for mortality
were advanced age, renal failure and paraplegia [26].
Remarkably, the use of adjunct distal aortic perfusion
and CSF drainage was found to provide a beneficial effect on long-term survival (Fig. 13.9).
Fig. 13.9. Kaplan±Meier actuarial plot showing the beneficial
10-year survival effect of adjunct distal aortic perfusion and
cerebrospinal fluid drainage (yellow line) compared with no
adjunct (red line)
13.3.1 Neurological Deficit: Immediate and Delayed
In our cumulative experience, neurological deficit has
been reduced by 3.7-fold with the combined adjunct
distal aortic perfusion and CSF drainage [26]. The incidence of neurological deficit for all patients without the
use of adjunct was 5.7%, and 2.4% with adjunct. Aortic
cross-clamp times have increased significantly since
1991, yet the rate of neurologic deficit has declined in
that time. Although other previously established risk
factors remain significantly associated with neurologic
deficit, aortic cross-clamp time is no longer associated
to neurologic deficit (Fig. 13.10a,b). In the high-risk extent II, adjuncts reduced neurological deficit from 21 to
3.3% [24]. Clearly, the adoption of adjunct has impacted the overall incidence of neurological deficit, and
this has led us to redefining the low versus high risk, as
extent ªnon-IIº versus extent II.
Interestingly, as improved spinal cord protection during thoracoabdominal aortic surgery has reduced the
overall incidence of neurological complications, delayed-onset neurological deficit (the onset of paraplegia
or paraparesis after a period of observed normal neurological function) has emerged as a significant clinical
entity [2, 28]. We have observed delayed neurological
deficit as early as 2 h and as late as 2 weeks following
surgery. The exact mechanisms involved in the development of delayed neurological deficit remain unknown.
However, we speculate that delayed neurological deficit
after thoracoabdominal aortic repair may result from a
ªsecond hitº phenomenon [29]. That is, although adjuncts can protect the spinal cord intraoperatively and
reduce the incidence of immediate neurological deficit,
the spinal cord is still ªvulnerableº during the early
147

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III. Treatment of Thoracic Degenerative Aortic Aneurysms
a
with delayed neurological deficits. In exploring other
possible causes of delayed neurological deficit we have
found no outstanding single risk factor. Using multivariable analyses, however, we have identified acute dissection, extent II and renal insufficiency as significant
preoperative predictors for delayed-onset neurological
deficit [30]. Postoperative clinical predictors of delayed
neurological deficit include hemoglobin level less than
9 g/dL, mean arterial pressure less than 90 mmHg and
CSF drain complications [31].
To optimize postoperative spinal cord perfusion and
oxygen delivery, we keep the mean arterial pressure
above 90±100 mmHg, hemoglobin above 10 mg/dL and
cardiac index greater than 2.0 L/min. If delayed neurological deficit occurs, measures to increase spinal cord
perfusion are instituted immediately. The patient is
placed flat in the supine position and patency and function of the drain is ascertained at once. If the drain has
been removed, the CSF catheter is reinserted immediately and CSF is drained freely until the CSF pressure
drops below 10 mmHg. The systemic arterial pressure is
raised, blood transfusion is liberally infused and oxygen
saturation is increased, as indicated earlier. CSF drainage is continued for at least 72 h for all patients with
delayed-onset neurological deficit. Using this approach,
we have seen improvement in neurological function in
57% of our patients [30]. Patients who developed delayed neurological deficit but did not have CSF drainage
failed to recover function.
b
Fig. 13.10. Multiple logistic regression analyses according to
risk of neurologic deficit and cross-clamp time without (a) and
with (b) adjunct use
postoperative period. Additional ischemic insults, such
as hemodynamic instability or malfunction of the CSF
drainage catheter, may constitute a second hit, causing
delayed neurological deficit. Furthermore, in the rigid
unyielding spinal column, any rise in CSF pressure
could lead to an increase in compartment pressure,
with consequent decreased spinal cord perfusion.
Hence, our reason for intermittent perioperative CSF
drainage is to maintain the compartment pressure below 10 mmHg, and the same rationale applies to our
approach using continuous CSF drainage in patients
13.3.2 Renal Failure
We have used and appraised many different forms of renal protection. including distal aortic perfusion, warm
blood visceral perfusion, antegrade cold blood visceral
perfusion, retrograde cold blood perfusion and the
perioperative use of a renal protective pharmacologic
agent, fenoldopam. None of these yielded overly promising results. Using multivariable analyses, we found
preoperative renal failure (creatinine above 2.8 g/dL),
left renal artery reattachment, visceral perfusion and
clamp-and-go technique as predictors of acute renal
failure [32]. In the past, we had used visceral perfusion
without cooling and without systemic heparin, and this
was likely the reason for the negative effect of visceral
perfusion on renal protection. We recently reviewed the
impact of various adjuncts on renal function. Distal
aortic perfusion has emerged as protective, but only for
aortic repair that does not directly involve the renal arteries. There is evidence, however, that patients treated
with cold blood visceral perfusion have superior survival and recovery rates, and this may be related to improved liver protection. None of the adjuncts thus far
evaluated have clearly prevented acute renal failure. The
major predictors of postoperative renal dysfunction re-

C. C. Miller et al. Chapter 13 Distal Aortic Perfusion and Selective Visceral Perfusion
https://t.me/med1917
main preoperative renal function, cross-clamp time and
repair extending to the renal arteries. In our cumulative
experience of descending thoracic and thoracoabdominal aortic repairs, we found that acute renal failure occurred in 17.8% of our patients overall. The incidence
for descending thoracic repairs was 7.2% and 22.8% for
thoracoabdominal aortic repairs. Thirty-day mortality
among patients with acute renal failure was 30% compared with 10% mortality for all other patients.
Although we had theorized that patients with the most
extensive thoracoabdominal aortic aneurysm (extent II)
would be at highest risk for the development of postoperative renal failure, multivariable analyses did not find
aneurysm extent to be a significant predictor. Approximately one third of our patients who developed acute
renal failure remained on hemodialysis, and long-term
survival for patients on hemodialysis has been dismal.
13.3.3 Aortic Dissection
a
During the clamp-and-go era, aortic dissection was
considered a risk factor for neurological deficit in patients undergoing surgery of the thoracoabdominal aorta [18]. With the use of distal aortic perfusion and CSF
drainage, however, chronic dissection no longer poses a
threat [33]. We recently showed similar low rates of
paraplegia for patients who received adjuncts when undergoing thoracoabdominal aortic surgery, whether they
had aortic dissection or not, 3.6% versus 4.7%, respectively. However, various surgical technical modifications
are required in repairing dissected thoracoabdominal
aorta, particularly in the acute phase. Identification of
the true versus the false lumen is imperative. The partition/septum between the two lumens is excised
(Fig. 13.11 a). Before sewing the graft, we usually reinforce both proximal and distal ends of the dissected
aorta with a running 4-0 polypropylene suture. Additional interrupted pledgeted polypropylene sutures are
then placed in the posterior and anterior walls for
further reinforcement (Fig. 13.11b). Whereas we always
attempt to reattach patent lower intercostal arteries during graft replacement of the descending thoracic and
thoracoabdominal aorta, we advocate ligation of all patent intercostal and lumbar arteries in the acutely dissected aorta, to avoid catastrophic bleeding associated
with the friable tissues. Patent lower intercostal arteries
can be safely reattached in chronic dissection using our
described technique. In general, we replace all aneurysmal aortic segments, but leave the nonaneurysmal segment even if dissected.
b
Fig. 13.11. Illustration of a thoracoabdominal aortic aneurysm
repair showing excision of the distal partition/septum between
the true and false lumens, and completed graft replacement
with reinforced anastomoses
13.4 Summary
149
Incredible progress has been made in the treatment of
thoracoabdominal aortic aneurysms since its inception.
The various strategies of organ protection including the
use of distal aortic perfusion, CSF drainage, visceral

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III. Treatment of Thoracic Degenerative Aortic Aneurysms
perfusion, sequential aortic cross-clamp, intercostal artery reattachment and moderate hypothermia, as well
as the evolution of surgical approach have all contributed to the decline in mortality and morbidity. Our refined surgical techniques and use of adjuncts have reduced the overall incidence of neurological deficits following thoracoabdominal aortic aneurysm repair to
2.4%, and to 6.6% for patients with extent II. Our continuing goals are to further decrease the incidence of
neurological deficits and to improve renal protection,
with particular focus on the extent II thoracoabdominal
aortic aneurysm.
Acknowledgement. We are grateful to Carl Clingman for
his illustrative and photographic contributions and to
Kirk Soodhalter for his editorial assistance.
References
1. Etheredge S, Yee J, Smith J, et al. Successful resection of a
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2. De Bakey ME, Creech O Jr, Morris GC Jr. Aneurysm of
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179:763±772.
3. Matas R. An operation for the radical cure of aneurysm
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6. Connolly JE, Wakabayashi A, German JC, Stemmer EA,
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8. Crawford ES. Thoraco-abdominal and abdominal aortic
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the thoracic aorta: initial clinical experience. Ann Surg
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Patel VM. The impact of distal aortic perfusion and somatosensory evoked potential monitoring on prevention
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Cardiovasc Surg 1988; 95:357±367. Erratum in: J Thorac
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drainage. Experimental and early clinical results. J Vasc
Surg 1988; 7:153±160.
13. Crawford ES, Svensson LG, Hess KR, et al. A prospective
randomized study of cerebrospinal fluid drainage to prevent paraplegia after high-risk surgery on the thoracoabdominal aorta. J Vasc Surg 1991; 13:36±45; discussion 45±
46.
14. Crawford ES, Crawford JL, Safi HJ, et al. Thoracoabdominal aortic aneurysms: preoperative and intraoperative
factors determining immediate and long-term results of
operations in 605 patients. J Vasc Surg 1986; 3:389±404.
15. Crawford ES, Coselli JS, Safi HJ. Partial cardiopulmonary
bypass, hypothermic circulatory arrest, and posterolateral
exposure for thoracic aortic aneurysm operation. J Thorac
Cardiovasc Surg 1987; 94:824±827.
16. Kouchoukos NT, Daily BB, Rokkas CK, Murphy SF, Bauer
S, Abboud N. Hypothermic bypass and circulatory arrest
for operations on the descending thoracic and thoracoabdominal aorta. Ann Thorac Surg 1995; 60:67±76; discussion 76±77.
17. Cambria R, Davison J, Zannetti S, et al. Clinical experience with epidural cooling for spinal cord protection during thoracic and thoracoabdominal aneurysm repair. J
Vasc Surg 1997; 25:241±243.
18. Svensson LG, Crawford ES, Hess KR, Coselli JS, Safi HJ.
Experience with 1509 patients undergoing thoracoabdominal aortic operations. J Vasc Surg 1993; 17:357±368; discussion 368±370.
19. Safi HJ, Hess KR, Randel M, et al. Cerebrospinal fluid
drainage and distal aortic perfusion: reducing neurologic
complications in repair of thoracoabdominal aortic aneurysm types I and II. J Vasc Surg 1996; 23:223±228; discussion 229.
20. Safi HJ, Bartoli S, Hess KR, et al. Neurologic deficit in patients at high risk with thoracoabdominal aortic aneurysms: the role of cerebral spinal fluid drainage and distal
aortic perfusion. J Vasc Surg 1994; 20:434±444; discussion
442±443.
21. Engle J, Safi HJ, Miller CC 3rd, et al. The impact of diaphragm management on prolonged ventilator support
after thoracoabdominal aortic repair. J Vasc Surg 1999;
29:150±156.
22. Huynh TT, Miller CC 3rd, Estrera AL, Sheinbaum R, Allen
SJ, Safi HJ. Determinants of hospital length of stay after
thoracoabdominal aortic aneurysm repair. J Vasc Surg
2002; 35:648±653.
23. Safi H, Miller CI, Carr C, Illiopoulos D, Dorsay D, Baldwin J. The importance of intercostal artery reattachment
during thoracoabdominal aortic aneurysm repair. J Vasc
Surg 1998; 27:58±68.
24. Safi HJ, Estrera AL, Miller CC 3rd, Huynh TT, Porat EE,
Azizzadeh A, Meada R, Goodrick JS. Evolution of risk for
neurologic deficit after descending and thoracoabdominal
aortic repair. Ann Thorac Surg 2005; 80:2173±2179.
25. Huynh TT, van Eps RG, Miller CC 3rd, Villa M, Estrera
AL, Azizzadeh A, Porat EE, Goodrick JS, Safi HJ. Evolution of risk for neurologic deficit after descending and
thoracoabdominal aortic repair. J Vasc Surg 2005; 42:206±
212.
26. Safi HJ, Miller CC 3rd, Huynh TTT, et al. Distal aortic
perfusion and cerebrospinal fluid drainage for thoracoabdominal and descending thoracic aortic repair: Ten years
of organ protection. Ann Surg 2003; 238:372±381.
27. Safi HJ, Miller CC 3rd, Azizzadeh A, Iliopoulos DC. Observations on delayed neurologic deficit after thoracoabdominal aortic aneurysm repair [see comments]. J Vasc
Surg 1997; 26:616±622.
28. Azizzadeh A, Huynh TT, Miller CI, Safi H. Reversal of
twice-delayed neurologic deficits with cerebrospinal fluid
drainage after thoracoabdominal aneurysm repair: a case
report and plea for a national database collection. J Vasc
Surg 2000; 31:592±598.

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29. Huynh TT, Miller CC 3rd, Safi HJ. Delayed onset of neurologic deficit: significance and management. Semin Vasc
Surg 2000; 13:340±344.
30. Estrera AL, Miller CC 3rd, Huynh TT, Azizzadeh A, Porat
EE, Vinnerkvist A, Ignacio C, Sheinbaum R, Safi HJ. Preoperative and operative predictors of delayed neurologic
deficit following repair of thoracoabdominal aortic aneurysm. J Thorac Cardiovasc Surg 2003; 126:1288±1294.
31. Azizzadeh A, Huynh TTT, Miller CC 3rd, et al. Postoperative risk factors for delayed neurologic deficit after thor-
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case-control study. J Vasc Surg 2003; 37:750±754.
32. Safi HJ, Harlin SA, Miller CC, et al. Predictive factors for
acute renal failure in thoracic and thoracoabdominal aortic aneurysm surgery. J Vasc Surg 1996; 24:338±344; discussion 344±345. Erratum in: J Vasc Surg 1997; 25:93.
33. Safi HJ, Miller CC 3rd, Estrera AL, et al. Chronic aortic
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Surg 2002; 23:244±250.

Femoral Bypass and Hypothermia
https://t.me/med1917
for the Treatment
of Thoracoabdominal Aneurysms
R. Scott Mitchell
Chapter
14
Contents
14.1 Introduction ......................
14.2 Operative Strategies .................. 153
14.3 Methods .........................154
153
14.1 Introduction
Aneurysms of the descending thoracic and thoracoabdominal aorta range from focal outpouchings of the
thoracic aorta to extensive degenerative aneurysms encompassing the entire thoracoabdominal aorta. Similarly, treatment strategies range from simple clamp techniques, unsupported by distal perfusion, the ªclampand-goº technique, to more complex techniques utilizing distal perfusion, separate visceral perfusion, and hypothermia as an adjunct for preservation of spinal cord
function. This treatise advances our rationale for a
more aggressive perfusion strategy that affords optimal
protection for CNS, spinal cord, and abdominal viscera.
Although the simplicity of a clamp-and-go approach
is attractive, there are severe perturbations that argue
against its utility. Proximal clamping of the descending
thoracic aorta or distal arch presents several major difficulties. First, in many instances with diffuse atheromatous change, clamping of the distal arch may be unsafe,
with central embolization of atheromatous debris into
the cerebral vasculature. Second, proximal clamping
may not afford sufficient normal proximal aorta to allow a secure proximal anastomosis. Third, proximal
clamping also produces severe hemodynamic disturbances, including proximal hypertension, an abrupt increase in afterload, a decrease in distal perfusion pressure, and an increase in cerebrospinal fluid (CSF) pressure [1]. In addition to a profound sympathetic stimulation, there is also requisite distal ischemia, with secondary and injurious metabolic changes, increasing the
likelihood for spinal cord and visceral end-organ injury.
Similarly, with the release of the aortic cross-clamp,
further hemodynamic perturbations are again pro-
duced, many of which will aggravate a previous insult,
including proximal hypotension, washout of ischemic
metabolites, and reperfusion injury, all compounding
the effects of the prior ischemic injury.
Distal aortic perfusion techniques may substantially
reduce many of these ill effects, albeit at the price of introducing negative attributes essential for extracorporeal perfusion, including anticoagulation, stimulation of
the inflammatory response, and alterations in coagulation.
In the absence of distal aortic perfusion, the technique of simple aortic clamping is limited to a ªsafe
ischemic period,º unpredictable, and likely highly variable for different vascular beds. Historically, spinal cord
complications have been noted to rise significantly after
30±35 min of ischemia, with similar end-organ dysfunction becoming apparent after slightly longer ischemic
intervals for kidneys and liver. In an effort to minimize
these secondary perturbations, distal perfusion techniques have been developed to allow longer periods of
ischemia and more complex reconstructions [2]. It is
our contention that femoral±femoral bypass provides a
stable operative environment, facilitates surgical reconstruction, provides good end-organ preservation, and
affords valuable flexibility for improved surgical results,
with only modest negative repercussions.
14.2 Operative Strategies
A thorough preoperative assessment, including physical
examination, assessment of physiologic cardiac, pulmonary, and renal reserve, and scrutiny of available imaging modalities precedes operative intervention. Surgical
as well as perfusion strategies are then decided.
The major downside of femoral±femoral bypass is
the necessity for full heparinization as a membrane
oxygenator is an integral part of the perfusion circuit.
Usually 300 IU/kg is sufficient to maintain an activated
clotting time of more than 400 s. Fully heparin coated
circuitry may allow a lower systemic heparin level,
usually 100 IU/kg heparin and an activated clotting

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III. Treatment of Thoracic Degenerative Aortic Aneurysms
time of more than 180 s. Although expensive, fully
coated circuitry may be associated with less blood loss,
reduced transfusion requirements, and perhaps a decrease in the systemic inflammatory response. Similarly,
the use of aprotinen (Trasolol, Bayer Pharmaceuticals)
has been associated with decreased blood loss and a decreased requirement for transfusion products, but requires ascertainment of adequate heparin effect, namely
a Kaolin-determined activated clotting time of more
than 400 s, and a heparin concentration of more than
3.5 mg/kg.
The major advantage of femoral±femoral bypass is
flexibility. For thoracic or thoracoabdominal aneurysms
in which the distal arch is unsuitable for clamping
(large diameter, severe calcification, intraluminal
atherogenic debris, proximal extension of dissection
flap), hypothermic circulatory arrest (HCA) is the
method of choice for constructing a secure proximal
anastomosis and avoiding cerebral atheroembolic injury.
Similarly, for patients in whom sequential cross-clamping of the aorta is not possible (chronic dissection,
large mural thrombus, or generalized aneurysmal enlargement without focal narrowing), HCA is an excellent method of spinal cord protection, coupled with distal aortic perfusion and CSF drainage [3±5]. The oxygenator also adds flexibility, such as with the patient
with poor oxygenation who may become a ventilatory
problem during single lung ventilation.
14.3 Methods
Preoperatively, an epidural catheter and a CSF drain are
placed prior to operative intervention. Full intraoperative monitoring is employed, including radial and femoral artery pressure monitoring, large-bore intravenous
access, and transesophageal echo (TEE). A double-lumen endotracheal tube facilitates operative exposure
and minimizes operative trauma to the left lung. Both
femoral arterial and venous access are attained via an
oblique supra-inguinal crease incision.
Long, flexible, thin-walled venous catheters are avail-
able with tapered over-the-wire dilators that almost uniformly assure access to the right atrium. Endovascular
access through the femoral vein can be ascertained by
TEE visualization of the guide wire emerging from the
inferior vena cava, traversing the right atrium, and entering the superior vena cava. If passage of a soft ªJºtipped guide wire is not successful, a floppy-tip Glidewire (Terumo, Tokyo, Japan) and a Benson catheter frequently assure passage.
Arterial cannulation is either via a transverse arter-
iotomy with a 22-F arterial catheter, or over a guide
wire using a 17-F or a 19-F catheter (DLP).
Successful cannulation is assured by easy aspiration
of venous blood from the venous catheter, and pulsatile
flow from the arterial catheter with a pulsatile wave
form in the cardiopulmonary bypass pump circuitry.
Full thoracoabdominal exposure is attained in the
routine manner. Proximally, the distal arch and proximal descending thoracic aorta are circumferentially dissected, with careful sharp dissection of the phrenic, vagus, and recurrent laryngeal nerves. After careful palpation, inspection, and perhaps interrogation by transesophageal echocardiography, and/or epiaortic ultrasound,
a decision is made whether the aorta can be safely
clamped to allow a secure proximal anastomosis. If not,
femoral±femoral bypass is used to cool the patient to
16±18 8C, and an open proximal anastomosis is constructed to the full-thickness divided aorta of normal
caliber. Great care is taken to prevent any atheromatous
debris from falling into the dependent aortic arch, and
retrograde cerebral perfusion through the long venous
cannula can be used as a partial flush of the arch vessels. Following completion of the anastomosis, the new
graft is cannulated and clamped distally, and retrograde
arterial perfusion of the heart and great vessels is resumed.
If retrograde perfusion from the femoral artery is
thought to entail significant risk for retrograde embolization, separate antegrade cerebral perfusion can be
performed from a previously placed 6-mm Dacron side
limb sewn to the left common carotid artery established
prior to thoracotomy.
If the aorta is focally narrowed so as to allow sequential cross-clamping, then that is done serially down
the aorta, allowing retrograde femoral perfusion to provide visceral perfusion until that aortic segment is
opened. Initially, a distal clamp at mid-chest allows retrograde perfusion of critical intercostal arteries. Then,
clamping just above the celiac axis allows identification
of large paired intercostals at the T8±T12 level which
need to be attached to the graft. Decision-making about
which arteries to reattach is guided by the identification
of the anterior spinal artery on computed tomography
or magnetic resonance imaging [6, 7], loss of either
evoked sensory or motor potentials, and by their general suitability at the time of operation. It should be noted
that while hypothermia is an excellent adjunct for
spinal cord protection, it also effectively silences neural
response, thus limiting the utility of either evoked sensory or motor potentials.
After attachment of the intercostal artery pairs, attention is directed toward the visceral vessels, which are
now individually cannulated with balloon-tipped perfusion catheters and perfused with cold blood. Depending
on the local anatomy, and the quality of this portion of
the aorta, this reconstruction may utilize the island
technique, frequently incorporating the celiac axis, superior mesenteric artery, and right renal artery as one
button, and the left renal artery as a second button. Alternatively, if the quality of the aortic tissues is poor,
individual grafts may be led separately to each visceral

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155
vessel orifice. Preloading short Dacron graft segments
on the balloon catheters prior to initiating perfusion
greatly facilitates this reconstruction, and minimizes
visceral ischemic time.
Distally, after exposure of the aorta in the retroperitoneal plane, the distal end point is determined, and
the aorta is again circumferentially dissected.
Again, if this can be safely clamped, and a secure
anastomosis obtained, then distal aortic perfusion is
used distal to the aortic clamp. If a satisfactory length
of normal aorta is not available, then distal perfusion is
temporarily discontinued, and an open distal full-thickness anastomosis is constructed.
The beauty of hypothermia is that it allows the safe
conduct of these multiple previous maneuvers for all
patients, regardless of the extent of aortic disease, and
without the risk of atheroembolization. Cardiopulmonary bypass is initiated, and the proximal and distal
dissection completed while cooling proceeds to 16±
188C, with assurance of EEG silence. After equilibration
of a core temperature of 16±18 8C for at least 5 min, car-
diopulmonary bypass is discontinued in the head-down
position, and retrograde perfusion through the venous
catheter is commenced at approximately 500 ml/min to
continuously flush the cerebral vasculature. The aneurysm is incised to the level of the renal arteries, and
visceral artery perfusion is instigated with balloontipped catheters. The proximal aorta is transected to allow construction of a full-thickness anastomosis to normal aorta, after which the graft is then cannulated,
clamped distally, and retrograde arterial perfusion established to cardiac and brachiocephalic vessels. Next,
selective intercostal artery reimplantation is effected to
large patent intercostal arteries in the critical zone. Preoperative localization of contributing intercostal pairs
to the anterior spinal artery can be obtained with computed tomographic or magnetic resonance imaging. Excellent spinal cord protection is afforded during this interval by generalized hypothermia and perfusion of collaterals from the left vertebral and hypogastric systems.
The paravisceral aorta is then assessed. For goodquality aorta in the absence of connective tissue disease,
aortic island reconstruction is effected, usually with the
celiac axis, superior mesenteric artery, and right renal
artery as one island, and the left renal artery as a separate full-thickness button. Alternatively, especially for
Marfan patients in whom aneurysmal dilation of the
visceral island has been noted, individual branch vessel
reconstruction with 6-, 8-, or 10-mm Dacron grafts can
be accomplished during continuous perfusion via balloon-tipped catheters. An open distal anastomosis is
then completed, allowing restoration of femoral perfu-
sion after clamping of the graft. Individual visceral
branch vessel grafts can then be reimplanted into the
central aorta graft between clamps, allowing continuous
perfusion of cardiac, cerebral, and intercostal arteries,
and pelvic circulation during reimplantation and warming. Visceral ischemic time is limited to the time necessary to reimplant Dacron side limbs into a central aortic graft, and its effect is minimized by the now regional
hypothermia.
Although full heparinization is necessary, cardiac,
central nervous system, and spinal cord protection is
assured, and the hepatic contribution to postoperative
coagulation is preserved by hypothermia and continuous perfusion.
Although there is a requirement for full heparinization in order to use an oxygenator, this coagulopathy
may be more than offset by avoiding the use of reinfused washed red cells, with their own inherent coagulopathic tendencies. Integrity of all anastomoses can be
easily assured during the period of rewarming, and the
patient can then be weaned from cardiopulmonary bypass. Although a somewhat prolonged cardiopulmonary
bypass run may be necessary, especially in the obese
patient, good end-organ preservation is assured, and
the risk of atheroembolism minimized. With more target-specific anticoagulation, coagulopathies secondary
to a prolonged cardiopulmonary bypass run can be
minimized, and excellent end-organ preservation can be
achieved by these techniques.
References
1. Gelman S. The pathophysiology of aortic cross-clamping
and unclamping. Anesthesiology 1995; 82:1026±1060.
2. Von Segesser LK, Killer I, Jenni R, et al. Improved distal
circulatory support for repair of descending thoracic aortic
aneurysms. Ann Thor Surg 1993; 56:1373±1380.
3. Kouchoukos NT, et al. Hypothermic cardiopulmonary by-
pass and circulatory arrest for operations on the descending
thoracic and thoracoabdominal aorta. Ann Thorac Surg
2002; 74:S1885±1887.
4. Colon R, et al. Hypothermic regional perfusion for protec-
tion of the spinal cord during periods of ischemia. Ann
Thor Surg 1987; 43:639±643.
5. Robertson CS, et al. Protection against experimental isch-
emic spinal cord injury. J Neurosurg 1986; 64:633±642.
6. Kawaharada N, et al. Thoracoabdominal or descending aor-
tic aneurysm repair after preoperative demonstration of the
Adamkiewicz artery by magnetic resonance angiography.
Eur J Cardiothorac Surg 2002; 21:970±974.
7. Jacobs MT, et al. Spinal cord blood supply in patients with
thoracoabdominal aortic aneurysms. J Vasc Surg 2002;
35:30±37.

Branch Stent-Graft Systems and
https://t.me/med1917
Less Invasive Combined Surgical
and Endovascular Treatment
for Descending Thoracic Aortic
Aneurysms
Krassi Ivancev, Bansi Koul
Chapter
15
Contents
15.1 Introduction ......................
15.2 Elongation of the Landing Zone
intheAorticArch ...................
15.3 Total Arch Replacement
with Open Stent-Graft Placement ..........
15.4 Branch Stent-Grafts
fortheThoracicAorticArch .............
15.5 Discussion ........................ 159
157
157
158
159
15.1 Introduction
Endovascular aneurysm repair (EVAR) in the thoracic
aorta has repeatedly been shown to offer advantages
over open surgery thanks to its less traumatic nature.
However, EVAR is limited by the absolute requirement
of an adequate landing zone at least 15 mm in length in
order to provide successful exclusion of an aneurysm or
a dissection. In addition, the landing zone may need to
be even longer when it comes to aneurysms and/or dissections in the aortic arch, where currently available
stent-grafts do not provide an effective hemostatic seal
owing to their relatively high rigidity [1]. For these patients, the alternative is conventional total aortic arch
replacement using hypothermic extracorporeal circulation, which, in spite of recent improvements, continues
to be associated with considerable mortality and the
risk of cerebral complications, especially in patients
with severe comorbidities. Therefore, combining the advantages of EVAR and various types of open vascular
surgery may offer a valuable alternative for this category of patients.
15.2 Elongation of the Landing Zone
in the Aortic Arch
In patients with symptomatic type B dissections or aneurysms in the aortic arch, it is not uncommon to cover
the left subclavian artery as a means of prolonging the
landing zone and thereby achieving a secure hemostatic
seal for a stent-graft. However, such a maneuver may
not be sufficient. The stent-graft may need to be placed
further cephalad and may cover the left carotid artery
as well. In order to provide continuous flow to the
blocked vessels an extraanatomic bypass from the innominate artery to the left carotid and left subclavian arteries may be performed. Such a technique has been
shown to be safe and efficient [2]. Occasionally, though,
currently available stent-grafts may not line up along a
severely angulated aortic arch with a persistent type I
endoleak as a result [1]. Under these circumstances it
may be advisable to place a band of Teflon felt around
the aortic arch once the stent-graft is in place
(Fig. 15.1). This is achieved through a minimal median
sternotomy. The same access may also be used for supraaortic transposition with a bi- or trifurcated graft
originating from the ascending aorta and anastomosing
to the innominate artery, the left carotid artery, and the
left subclavian artery [3, 4]. This is achieved without
hypothermic cardiopulmonary arrest and using a sideclamp in the ascending aorta. With such an approach
the trauma is kept to a minimum, avoiding total arch
replacement or left thoracotomy. If a bypass is performed to the innominate artery the stent-graft may be
extended across the origin of all the supraaortic vessels
(Fig. 15.2).

158
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III. Treatment of Thoracic Degenerative Aortic Aneurysms
a
b
c
Fig. 15.1. a Schematic drawing representing placement of a
band distal to the left subclavian artery in order to create a secure implantation site for a stent-graft.
placement of the stent-graft showing indentation from the
band placed in the aortic arch.
ment of the stent-graft showing a good hemostatic seal.
d Computed tomography (CT) 6 months after stent-graft place-
ment showing a well-excluded aneurysm
Fig. 15.2. Schematic drawing showing a supraaortic transposi-
tion using a trifurcated graft anastomosed to the ascending
aorta and further to the innominate, left carotid, and left subclavian arteries. The stent-graft is placed across the aortic arch
excluding an aneurysm and a type B dissection
c Aortogram following deploy-
b Aortogram during
d
15.3 Total Arch Replacement
with Open Stent-Graft Placement
This technique is recommended when concomitant
heart surgery is performed, including coronary bypass,
graft replacement with or without aortic valve remodeling in the ascending aorta due to aneurysm formation
or type A dissection, or when there is a type A dissection continuing into the descending thoracic aorta [5, 6,
7]. In these situations a stent-graft may be placed from
the distal aortic arch under hypothermic cardiopulmonary arrest and guided either fluoroscopically or by
transesophageal echography. The proximal end of the
stent-graft is then sutured to the posterior wall of the
aorta and possibly attached to a graft used for aortic
arch replacement (Fig. 15.3). There is also a possibility
to use a ªstented elephant trunkº in the case of an an-
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