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one to three days to reduce postprocedure bruising and tenderness.
Follow‐Up
Patients are encouraged to walk after the procedure. Follow‐up protocols vary by institution [11]. In general, patients are encouraged to undergo a repeat venous ultrasound to ensure successful occlusion of the treated vein and confirm the absence of deep venous injury, one to three days postprocedure. The patient is also provided a repeat clinical evaluation in one to three weeks. Long‐ term therapy comprises encouraging the use of 20–30 compression stockings regularly [12]. The duration of compression stocking therapy is guided by clinical judgment.
Endovenous Laser Ablation (EVLA)
Step 1. Access to the refluxing superficial vein is first obtained at its lowest point of incompetence under ultrasound guidance (long‐axis views preferred) with a 21G introducer needle and 0.018 in. wire under local anesthesia (1% lidocaine). Utilizing a modified Seldinger technique, a 4 Fr micropuncture sheath is advanced into the vein over the 0.018‐in. wire.
Step 2. Once access is secured, the 0.018‐in. wire is exchanged for a 0.035‐in. guidewire. Then the 4 Fr micropuncture sheath is exchanged for the long
endovenous laser sheath, which is slowly advanced into saphenous vein under ultrasound guidance to the saphenofemoral junction. Intraluminal position of the sheath is confirmed by aspirating nonpulsatile venous blood from the sheath and visualization under ultrasound.
Step 3. Once the sheath is secured in place, a 600 μm laser fiber (Angiodynamics VenaCure EVLT system™, Latham, NY, USA) is advanced through the sheath, to the saphenofemoral junction. While holding the laser fiber in place, the sheath is withdrawn 3 cm to expose the distal
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bare‐tipped laser fiber near the saphenofemoral junction.
Step 4. The sheath and fiber are then pulled back together, so that the tip of the laser fiber is positioned at least 2.5 cm from the saphenofemoral junction. Laser‐ fiber tip positioning is confirmed under ultrasound guidance and with direct visualization of the red beam of the laser fiber through the skin (Figure 17.3).
skin with red beam.
Step 5. Once the catheter is in place, local tumescent anesthetic solution (450 ml 0.9% normal saline, 35 ml
0.1% lidocaine, and 15 ml 0.8% sodium bicarbonate) is injected under ultrasound guidance in the perivenous space of the saphenous vein.
Step 6. Laser generator is then activated, delivering 12 W of energy to the 810‐nm diode laser fiber. While activated, the fiber is slowly withdrawn at an average rate of seven seconds per centimeter to ensure adequate treatment of the venous segments during the slow continuous pull‐back.
Step 7. At the end of the procedure, the catheter and sheath are removed. Hemostasis is achieved by manual compression at the site of venous access. Compression bandages and stockings are applied on the treated leg for one to three days to reduce postprocedure bruising and tenderness.
Nonthermal Techniques
Newer nonthermal techniques have emerged in recent years that do not require tumescent anesthesia (reduces number of needle pricks) or exposure to a heating element (reduces potential for pain and nerve injury)
[13]. Collectively, they are less traumatic and are
associated with fewer local complications with increased patient satisfaction. Cyanoacrylate glue (CAG) ablation and foam sclerotherapy are two forms of noncatheter based, nontumescent, and nonthermal modalities. Here, we will focus on the catheter‐based hybrid model, MOCA. It utilizes a special rotating catheter that not only mechanically damages the endothelium inside the vein but also allows for simultaneously infusion a sclerosant solution through the catheter to further injure the vein wall [14]. Free of tumescent and thermal effects, MOCA has emerged as a valid alternative to RF ablation and EVLA catheter‐based therapies.
Mechanico‐Chemical Ablation (MOCA)
Step 1. Access to the refluxing superficial vein is first obtained at its lowest point of incompetence under ultrasound guidance (long‐axis view preferred [15]) with a 21G introducer needle and 0.018 in. wire under local anesthesia (1% lidocaine). Utilizing a modified Seldinger technique, a 4 Fr micropuncture sheath is advanced into the vein over the 0.018‐in. wire.
Step 2. Intraluminal positioning of the 4 Fr sheath is confirmed by aspirating nonpulsatile venous blood from the sheath and visualization under ultrasound. Once confirmed the 0.018‐in. wire is removed and the catheter (Endovenous ClariVein™, South Jordan, UT, USA) is advanced into the 4 Fr sheath where it is advanced under ultrasound guidance 2.5 cm from saphenofemoral junction. The catheter tip has an angled shape to facilitate directionality during advancement.
Step 3. Tumescent anesthesia is not required for this procedure. Rather, a liquid sclerosant is prepared
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containing of liquid 1.5% sodium tetradecyl sulfate (2.5 ml of 3% STS and 2.5 ml of 0.9% NS). An alternative to the liquid 1.5% STS, the sclerosant can also be prepared in a foam consistency.
Step 4. Sclerosant foam is prepared by the Tessari method, where a 5 cc syringe containing 1 ml of 1.5% STS and 4 ml of room air is connected to second 5 cc syringe by way of three‐way stop cock valve. The syringes are tilted 45° from a flat position and mixed vigorously back and forth 20 times to produce the smallest foam bubbles (Figure 17.4a–c).
Step 5. Once liquid or foam sclerosant is prepared, the catheter is turned on to initiate mechanical damaged to the endothelium, where it rotates 360° at 3500 rpm (high setting). The catheter is then slowly withdrawn at a rate of 2–3 mm/s while simultaneously injecting 0.5 ml of sclerosant (liquid or foam).
Step 6. Once the desired segment is treated, the catheter and 4 Fr micropuncture sheath are withdrawn and hemostasis achieved with manual compression of the venous access site. Compression bandages and stockings are applied on the treated leg for one to three days to reduce postprocedure bruising and tenderness.
Figure 17.4 The ClariVein device consists of a 9 V
battery‐motorized handle (a) with infusion catheter that has an angled tip (b). Angled tip allows for steering and directionality (c). Tessari method for sclerosant foam preparation.
Limitations
Despite advances in minimally invasive techniques for saphenous vein ablation, we have observed several aspects of disease location and anatomy that need special consideration when selecting treatment modalities. Thermal techniques involving heat elements typically require 10 cm of subcutaneous tissue above the target vein to prevent skin burns or nerve damage. This is most particularly important when performing below the knee interventions, where nonthermal modalities are often preferred. If a thermal modality is considered, decreasing the voltage and ensuring adequate tumescent anesthesia become critical. Similarly, when encountering aneurysmal vein segments (>10 cm diameter), we have
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observed better long‐term occlusion rates with EVLT versus ClariVein. Firm external compression over the vein segments while delivering treatment cycles is a key for successful outcomes.
Summary
Since the introduction of minimal invasive modalities for the treatment of saphenous vein incompetence, many new techniques have emerged. While most techniques report favorable anatomic success rates, more emphasis is now being placed on the secondary treatment outcomes, such as postprocedural pain, hematoma, quality of life, and return to normal activities. Development of the nontumescent, nonthermal techniques promises to offer many of these advantages. Although proficiency in the “gold standard” techniques of RFA and EVLA is vital, learning these newer techniques such as MOCA can prove effective in achieving excellent results with greater patient satisfaction.
References
1 Davies, A.H. (2019). The seriousness of chronic venous
disease: a review of real‐world evidence. Adv. Ther. 36 (Suppl 1): 5–12. https://doi.org/10.1007/s12325‐019‐
0881‐7. Epub 2019 Feb 13. PMID: 30758738.
2 Rabe, E., Guex, J.J., Puskas, A. et al. (2012).
Epidemiology of chronic venous disorders in geographically diverse populations: results from the Vein Consult Program. Int. Angiol. 31 (2): 105–115.
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advanced stages? A review. Adv Ther. 36 (Suppl 1): 13–19. https://doi.org/10.1007/s12325‐019‐0885‐3. Epub 2019 Feb 13.PMID: 30758741.
5 Niedzwiecki, G. (2005). Endovenous thermal ablation
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6 Bootun, T., Lane, R.A., and Davies, A.H. (2016). A
comparison of thermal and non‐thermal ablation. Rev. Vasc. Med. 4–5: 1–8.
7 Bootun, R., Lane, T.R., and Davies, A.H. (2016). The
advent of non‐thermal, non‐tumescent techniques for treatment of varicose veins. Phlebology 31 (1): 5–14.
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8 Bootun, R., Lane, T.R., Dharmarajah, B. et al. (2016).
Intra‐procedural pain score in a randomised controlled trial comparing mechanochemical ablation to radiofrequency ablation: the Multicentre Venefit™
versus ClariVein® for varicose veins trial. Phlebology 31 (1): 61–65.
https://doi.org/10.1177/0268355514551085. Epub
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9 Lane, T., Bootun, R., Dharmarajah, B. et al. (2017). A
multi‐Centre randomised controlled trial comparing radiofrequency and mechanical occlusion chemically assisted ablation of varicose veins ‐ final results of the Venefit versus Clarivein for varicose veins trial. Phlebology 32 (2): 89–98.
https://doi.org/10.1177/0268355516651026. Epub
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10 Wallace, T., Leung, C., Nandhra, S. et al. (2017).
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11 Carroll, C., Hummel, S., Leaviss, J. et al. (2013).
Clinical effectiveness and cost‐effectiveness of minimally invasive techniques to manage varicose veins: a systematic review and economic evaluation. Health Technol. Assess. 17 (48): i–xvi, 1–141.
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(2011). The care of patients with varicose veins and associated chronic venous diseases: clinical practice guidelines of the Society for Vascular Surgery and the American Venous Forum. J. Vasc. Surg. 53 (Suppl): 2S–48S.
13 Tekin, A.İ., Tuncer, O.N., Memetoğlu, M.E. et al.
(2016). Nonthermal, nontumescent endovenous treatment of varicose veins. Ann. Vasc. Surg. 36: 231–
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[PMID: 20223394].
Index
a
Abdominal aortic aneurysm (AAA) 30, 50. See also
Endovascular abdominal aortic aneurysm repair (EVAR)
Access site bleeding 176–179. See also Retroperitoneal
hematoma (RPH)
Access site complications 175–191 Acute deep venous thrombosis (DVT) 196–203 Acute limb ischemia (ALI) 151–160
defined 151 endovascular techniques 151
Angiojet® thrombectomy device 159 aspiration thrombectomy 155, 159 diagnostic angiography 151–152
EKOS™ catheter 153, 155, 159–160 embolic protection devices 153, 158 excimer laser thrombectomy 160 lesion crossing technique 152–153 mechanical adjunct therapies 153, 157
Penumbra Indigo® 159 thrombolytic agents 153, 154 tPA contraindications 153, 157 treating underlying lesion 160
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Acute mesenteric ischemia (AMI) 85–91
arterial thrombosis 85 diagnosis
contrast‐enhanced CT 86–87 history and physical exam 86
laboratory studies 86 etiologies 85 NOMI 85, 86 surgical intervention
angiogram 89, 90
aspiration embolectomy 88–89
endovascular therapy 91
follow‐up 91
infusion 91
SMA selection 87–88
thrombolysis 89–91
vascular access and sheath selection 87
AFX™ graft 60 ALI. See Acute limb ischemia (ALI) Alteplase 153, 154
Alto™ system 52 AMI. See Acute mesenteric ischemia (AMI)
Angiojet® thrombectomy device 159 Angiosomes 140, 141