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Interdisciplinary Biotechnological Advances
SankhadipBose
AmriteshChandraShukla
MirzaR.Baig
SabyasachiBanerjeeEditors
Concepts in
Pharmaceutical
Biotechnology
and Drug
Development
Interdisciplinary Biotechnological Advances
Series Editors
JayantaKumarPatra, Research Institute of Integrative Life Sciences, Dongguk
University, Ilsandong, Goyang,Kyonggi-do,Korea (Republic of)
GitishreeDas, Research Institute of Integrative Life Sciences, Dongguk
University, Goyang,Korea (Republic of)
This series is an authoritative resource that explains recent advances and emerging
directions in biotechnology, reecting the forefront of research clearly and reliably,
without excessive hype. Each volume is written by authors with excellent reputations
and acknowledged expertise in the topic under discussion. The volumes span the
entire eld from an interdisciplinary perspective, covering everything from
biotechnology principles and methods to applications in areas including genetic
engineering, transgenic plants and animals, environmental problems, genomics,
proteomics, diagnosis of disease, gene therapy, and biomedicine. The signicance
of these applications for the achievement of UN Sustainable Development Goals is
highlighted. The series will be highly relevant for Master’s and PhD students in
Biotechnology, Nanochemistry, Biochemical Engineering, and Microbiology,
medical students, academic and industrial researchers, agricultural scientists,
farmers, clinicians, industry personnel, and entrepreneurs.
Sankhadip Bose • Amritesh Chandra Shukla
Mirza R. Baig • Sabyasachi Banerjee
Editors
Concepts in Pharmaceutical
Biotechnology and Drug
Development
Editors
https://t.me/med1917
Sankhadip Bose
School of Pharmacy
The Neotia University
West Bengal, West Bengal, India
Amritesh Chandra Shukla
Department of Botany
University of Lucknow
Lucknow, India
Mirza R. Baig
Department of Clinical Pharmacy and
Pharmacotherapeutics
Dubai Pharmacy College for Girls
Sabyasachi Banerjee
Department of Pharmaceutical Chemistry
Gupta College of Technological Sciences
Asansol, West Bengal, India
Dubai, United Arab Emirates
ISSN 2730-7069 ISSN 2730-7077 (electronic)
Interdisciplinary Biotechnological Advances
ISBN 978-981-97-1147-5 ISBN 978-981-97-1148-2 (eBook)
https://doi.org/10.1007/978-981-97-1148-2
© The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore
Pte Ltd. 2024
This work is subject to copyright. All rights are solely and exclusively licensed by the Publisher, whether
the whole or part of the material is concerned, specically the rights of translation, reprinting, reuse of
illustrations, recitation, broadcasting, reproduction on microlms or in any other physical way, and
transmission or information storage and retrieval, electronic adaptation, computer software, or by similar
or dissimilar methodology now known or hereafter developed.
The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication
does not imply, even in the absence of a specic statement, that such names are exempt from the relevant
protective laws and regulations and therefore free for general use.
The publisher, the authors, and the editors are safe to assume that the advice and information in this book
are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the
editors give a warranty, expressed or implied, with respect to the material contained herein or for any
errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional
claims in published maps and institutional afliations.
This Springer imprint is published by the registered company Springer Nature Singapore Pte Ltd.
The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721,
Singapore
Paper in this product is recyclable.
Preface
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The book Concepts in Pharmaceutical Biotechnology and Drug Development provides comprehensive coverage of the development of new pharmaceuticals and the
enhancement of existing ones. There is a growing recognition among companies in
various industrial sectors about the signicance of sustainable development and the
promising opportunities presented by biotechnology. The implementation of biotechnology has the potential to enhance the eco-friendliness of industrial processes
and reduce both nancial and operating expenses. Additionally, it has the potential
to decrease the usage of raw materials and energy while also minimizing waste. The
primary objective is to offer a comprehensive understanding of pharmaceutical biotechnology, including its underlying principles and practical applications from an
industrial standpoint. The book provides a thorough overview of the ways in which
biotechnology inuences drug development, production, and regulation, and is a
valuable resource for those seeking to enhance their understanding in this area. This
book is designed to support educators in their teaching efforts and offers a readerfriendly exploration of the various stages involved in the development of new pharmaceuticals through biotechnology. This book is a valuable resource for individuals
at various stages of their academic and professional careers, including undergraduates, graduates, pharmaceutical scientists, clinicians, and academic researchers. It
provides convenient access to current practices in pharmaceutical biotechnology,
making it particularly useful for those working in the interdisciplinary eld of biochemistry, pharmacology, biopharmaceutics,and biotechnology. This book's concise and impartial content structure may also prove advantageous to corporate
researchers.
Sarisa, West Bengal, India SankhadipBose
Lucknow, India AmriteshChandraShukla
Dubai, United Arab Emirates MirzaR.Baig
Asansol, West Bengal, India SabyasachiBanerjee
v
Contents
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Part I Sec A: Biotechnological Approaches in Formulation
and Drug Design
1 Agro-Wastes-Based Feedstock as a Source
for Bionanomaterials Production: Outcomes and Challenges . . . . . . 3
Pooja Sankaranarayanan, T. A. Anboli, and T. V. Suchithra
2 Application of Biotechnology for Raw Material Analysis . . . . . . . . . . 21
Somsubhra Ghosh, Sujayita Mazumder, Rajeswar Das,
and Sandipan Jana
3 Application of Biotechnology in Pharmaceutical
Manufacturing Control . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31
Gourab Dey, Pallabita Rakshit, Nibir Ghosh, Sabyasachi Banerjee,
Subhasis Banerjee, and Sourav De
4 Applications of Biotechnology in Pharmaceutical
Product Analysis
Mohd Aslam, Anjali Rani, Javed Khan, Bhaskara Nand Pant,
and Garima Pandey
5 Development of Nanoparticles: Recent Developments
and Future Prospects . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 67
Ravichandran Veerasamy
6 Production of Biopharmaceuticals on Genetically
Modified Organisms . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 91
Sandipan Jana, Barun Das Gupta, Amit Kar, Anirbita Ghosh,
Monihar Pervin, Asis Bala, Motlalepula G. Matsabisa,
Rajeswar Das, Somsubhra Ghosh, Pulok K. Mukherjee,
and Pallab K. Haldar
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43
vii
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Contents
7 Drug Delivery in Biotechnology: Present and Future . . . . . . . . . . . . . 103
Seema Yadav, Narahari Narayan Palei, Subas Chandra Dinda,
and Arghya Kusum Dhar
8 Actinomycetes as Nanofactories: Synthesis
and Therapeutic Applications . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 139
Sompreeti Paul, Sindhoora Lakshmi, T. Amala, Dakshitha Akula,
Mrudula Rao, Piyush Mohapatra, and Aswani Thekkangil
Part II Sec B: Current Trends of Biotechnology
in Drug Development
9 Transgenesis: In the Drug Discovery Process,
Including Target Identification and Target Validation . . . . . . . . . . . . 159
Aniruddha Mukherjee, Susovan Das, Nurul Hassan Mondal,
Avijit Choudhury, and Sugato Banerjee
10 Drug Design Models for Human Diseases by Transgenic
Animals . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 189
Sabyasachi Banerjee, Subhasis Banerjee, Sankhadip Bose, Avik Das,
Santanu Banerjee, and Rajendra Gyawali
11 Role of Genomics and Proteomics in Drug Discovery . . . . . . . . . . . . . 207
Jeevandran Sundarasekar and Geethaa Sahgal
12 Immunoinformatics for the Diagnosis and Monitoring
of Autoimmune Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 247
Shalesh Gangwar, Neha Sharma, and Devinder Toor
13 Erythropoietin in the Treatment of Anaemia . . . . . . . . . . . . . . . . . . . . 265
Nibir Ghosh, Gourab Dey, Pallabita Rakshit, and Sourav De
14 Gene Therapy in Molecular Biology and Drug Delivery . . . . . . . . . . . 279
Dinesh Kumar Lakshmi Narayanan
15 Biotechnological Approaches in Infectious Diseases . . . . . . . . . . . . . . 297
Sabyasachi Banerjee, Sankhadip Bose, Amritesh Chandra Shukla,
and Mirza R. Baig
16 Forensic Drug Chemistry: Unravelling Evidence
Through Scientific Analysis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 319
Abu Md Ashif Ikbal, Rabin Debnath, Sabu Thomas,
Debprasad Chattopadhyay, and Partha Palit
17 Artificial Intelligence in Drug Discovery and Development . . . . . . . . 363
Geethaa Sahgal and Jeevandran Sundarasekar
18 AI: Catalyst for Drug Discovery and Development . . . . . . . . . . . . . . . 387
Khushbu Nailwal, Sumit Durgapal, Khushboo Dasauni,
and Tapan Kumar Nailwal
Contents
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19 Artificial Intelligence: A Major Landmark in the Novel
Drug Discovery Pathway for the Remarkable Advancement
in the Healthcare System . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 413
Rabin Debnath, Abu Md Ashif Ikbal, Ankita Choudhury,
Subhash C. Mandal, and Partha Palit
20 Phytopharmaceutical Biotechnology: Integration
of Botany, Pharmacology and Plant Biotechnology
to Deliver the Best Therapeutic Potential of Herbs . . . . . . . . . . . . . . . 437
Suma Krishnaswamy
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Editors and Contributors
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About the Editors
SankhadipBose (b. 05 October 1979) is a Professor
and Head, School of Pharmacy, The Neotia University,
West Bengal. He did his Master of Pharmacy in
Pharmacognosy from K.L.E.S’ College of Pharmacy,
Hubli, Karnataka, and Ph.D. (Pharmaceutical
Technology) from West Bengal University of
Technology, Kolkata. He served as academic person for
more than 17 years in Maulana Abul Kalam Azad
University of Technology and guided more than
20 M. Pharm students in their research projects. Dr.
Bose has successfully handled one Central Government
Research Project from the Department of Science and
Technology (DST), New Delhi, Govt. of India, in 2013.
One Ph.D. has been awarded under the supervision of
Dr. Bose, and presently another three Ph.D. projects are
going on in Maulana Abul Kalam Azad University of
Technology and two projects in The Neotia University
under his supervision. He has published more than 50
research papers/articles in nationally and internationally reputed journals as well as more than 10 book chapters published by CRC Press, Springer Nature, Apple
Academic Press, etc.
Dr. Bose has presented more than 70 research papers
in different national and international conferences.
Recently in 2019, he has presented one of his research
articles in a SPER Sponsored International Conference in
Kathmandu University, Nepal. He has delivered a speech
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