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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5394_Библиотеки_им_академика_М_И_Перельмана
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18.3.1.1
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Physical Pharmacy Principles that Explain the Stability
and Formulation of Suspensions
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Fig. 18.1 Schematic diagram showing the relationship between energy and the distance separat-
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Fig. 18.2 Schematic diagram showing the effect of concentration and presence of counter-ions.
Fig. 18.3 Steric and electrostatic stabilization techniques used to achieve colloidal stability.
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=-
2
pM
d /d ( ) / 18 ,Xt d gρρ η
d is the particle diameter,
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r
r
g is the gravitational constant,
h is the viscosity of the medium.
18.3.1.2 Formulation Methodology
SV S T
/.F VV=
( ) ( )
SV SV
flocculated/ deflocculated.DF F=
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18.3.1.3 Manufacturing Process
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18.3.2 Factors To Be Considered in Suspension Development
for the Back of the Eye
18.3.2.1
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Formulation and manufacture:
Formulation Development and Evaluation
Sterilization and pyrogenicity: As indicated above, sterility is a critical factor for
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