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- •Foreword
- •Preface
- •Contents
- •Contributors
- •General
- •1 Redefining the Mesentery as an Organ
- •Definition of the Mesentery
- •Historic Development of the Understanding of the Mesentery
- •Conclusion
- •Suggested Reading
- •2 Embryology of the Mesentery
- •Introduction
- •Embryological Development of the Mesentery and Related Organs
- •The Ventral and Dorsal Mesentery
- •Development of the Upper Region of Mesentery and Associated Organs
- •Development of the Lower Region of Mesentery and Associated Organs
- •Development of the Peritoneum and Peritoneal Cavity
- •Migration Across the Mesentery
- •Regenerative Capacity of the Mesentery and Bioengineering of Abdominal Digestive Organs
- •The Science of the Mesentery
- •Suggested Reading
- •3 General Anatomy of the Mesentery
- •Introduction
- •The Mesentery
- •The Dorsal Mesogatsrium and Mesoduodenum
- •The Greater Omentum
- •The Lower Region of Mesentery
- •Small Bowel Mesentery and Right Mesocolon
- •Mesocolon Distal to Transverse Mesocolon
- •Mesosigmoid and Mesorectum
- •Mechanisms of Attachment
- •Central Mechanisms of Attachment
- •Intermediate Mechanism of Attachment
- •The Peritoneal Reflection
- •Abdominal Digestive System Surgery
- •Suggested Reading
- •Anatomy and Physiology
- •4 Vascular Anatomy of the Mesentery
- •Introduction
- •Suggested Reading
- •5 Introduction to the Physiology of the Mesentery
- •Anatomy
- •Vascular Physiology
- •Immunologic Physiology
- •Neuronal Physiology
- •Role of Mesenteric Adipose
- •Suggested Reading
- •6 Emergence of the Human Gut Microbiota as an Influencer in Health and Disease
- •The Gut Microbiome
- •Bacterial Translocation to Blood and the Mesentery
- •The Microbiome of Mesenteric Fat
- •The Microbiome of Mesenteric Lymph Nodes
- •The Mesentery—A Reservoir for Pathogenic Bacteria?
- •Mesenteric Abscess—A Special Microenvironment for Pathogenic Bacteria in Inflammatory Bowel Disease?
- •Conclusion
- •Suggested Reading
- •7 Cellular Anatomy of the Mesentery
- •Introduction
- •Mesenteric Histology
- •Gene Expression and Protein Synthesis in the Mesentery
- •Mesenteric Derived Mesothelial Cells
- •Connective Tissue Continuity
- •Mesenteric Adipocytes
- •Fibrocytes
- •The Peritoneal Reflection
- •Conventional Angiography
- •Description of Procedure
- •Indications
- •Complementary Procedures
- •Contraindications
- •Preparation of Patient
- •How the Procedure Is Performed
- •Complications
- •PET Scan
- •Description of Procedure
- •Indications
- •Complementary Procedures
- •Relative Contraindications
- •Histology of Toldt’s Fascia
- •The Mesentery in Disease States
- •Future Directions
- •Suggested Reading
- •Diagnostic Procedures
- •8 Radiography of the Mesentery
- •Plain Films of the Abdomen
- •Description of Procedure
- •Indications
- •Complementary Procedures
- •Contraindications
- •Preparation of Patient
- •How the Procedure Is Performed
- •Typical Abnormal Findings
- •Complications
- •Computed Tomography (CT)
- •Description of Procedure
- •Indications
- •Complementary Procedures
- •Contraindications
- •Relative Contraindications
- •Preparation of Patient
- •How the Procedure Is Performed
- •Typical Abnormal Findings
- •Complications
- •Additional Comments
- •Magnetic Resonance Imaging (MRI)
- •Description of Procedure
- •Contraindications
- •Relative Contraindications
- •Preparation of Patient
- •How the Procedure Is Performed
- •Typical Abnormal Findings
- •Complications
- •Preparation of Patient
- •How the Procedure Is Performed
- •Typical Abnormal Findings
- •Complications
- •Additional Comments
- •Ultrasound
- •Description of Procedure
- •Indications
- •Complementary Procedures
- •Contraindications
- •Relative Contraindications
- •Preparation of Patient
- •How the Procedure Is Performed
- •Typical Abnormal Findings
- •Complications
- •Additional Comments
- •Suggested Reading
- •9 Mesenteric Biopsy
- •Indications
- •Contraindications
- •Description of the Procedure
- •Preparation of Patient
- •Image-Guided Percutaneous Mesenteric Biopsy
- •Diagnostic Laparoscopic Mesenteric Biopsy
- •Complications
- •Suggested Reading
- •10 Diagnosing Mesenteric Diseases: Laparoscopy
- •Indications
- •Traumatic Injury
- •Inflammatory Bowel Disease
- •Neoplastic Disease
- •Pediatric Applications
- •Ischemia
- •Internal Hernia
- •Contraindications
- •Complementary Procedures
- •Intra-operative Perfusion Assessment with Fluorescence
- •Preparation of the Patient
- •Technical Details
- •Abdominal Entry
- •Exploration of the Peritoneal Cavity and Mesentery
- •Abdominal Closure
- •Suggested Reading
- •11 Immunologic Function of the Mesentery
- •Introduction
- •Innate and Adaptive Responses of the Immune System
- •Mesenteric-Specific Immune Cells
- •Mesenteric Immunity and Crohn’s Disease (Also See Chap. 15 Crohn’s Disease)
- •Summary
- •Suggested Reading
- •12 Neurophysiologic Function of the Mesentery
- •Anatomy
- •The Sympathetic Nervous System
- •The Parasympathetic Nervous System
- •Neurologic Regulation of Mesenteric Blood Flow
- •Arterial and Venous Innervation
- •Arterial and Venous Components of Blood Pressure Regulation
- •Neuronal Control of Mesenteric Arteries and Veins
- •Anatomic Organization of Sympathetic Innervation of the Large Intestine
- •Activation of Vascular Innervation by Peripheral Reflexes
- •Innervation of the Lymphatic Vessels
- •The Mesenteric Nervous System and Inflammation
- •Suggested Reading
- •13 Physiology of the Mesenteric Circulation
- •Introduction
- •Review of Mesenteric Microcirculation and Fluid Dynamics
- •Mesenteric Microcirculation
- •Fluid Dynamics
- •The Intrinsic System
- •Metabolic Pathway
- •Oxygen Demand and Supply
- •Metabolic Byproducts
- •Intraluminal Hyperosmolarity
- •Myogenic Pathway
- •Extrinsic System
- •Central Cardiovascular Control
- •Autonomic Neuro-Regulation
- •Sympathetic Nervous System (SNS) Stimulation
- •Parasympathetic Nervous System (PNS) Stimulation
- •Neurohumoral Control
- •Catecholamines
- •Angiotensin II
- •Vasopressin
- •Suggested Reading
- •14 The Role of the Mesentery in Metabolic Syndrome and Diabetes Mellitus
- •Introduction
- •Pathogenesis
- •Treatment
- •Suggested Reading
- •15 Crohn’s Disease and the Mesentery
- •Introduction
- •Mesenteric Immunity and Crohn’s Disease
- •Crohn’s Disease and Fat Wrapping
- •Imaging Studies of the Mesentery in Crohn’s Disease
- •Mesenteric Disorders that Are Associated with Crohn’s Disease
- •Inflammatory Disorders of the Mesentery and Inflammatory Bowel Disease
- •Suggested Reading
- •16 The Role of the Mesentery in Pancreatic Diseases
- •Embryology of the Pancreas and Pancreatic Mesentery
- •Pancreatic Diseases
- •Acute Pancreatitis
- •Mesenteric Panniculitis Involving the Pancreas and Pancreatic Panniculitis
- •Heterotopic Pancreas
- •Suggested Reading
- •Embryology
- •Pancreatitis and Other Diseases
- •Panniculitis
- •Heterotopic Pancreas
- •17 IgG4-Related Diseases and the Mesentery
- •Introduction
- •Pathogenesis
- •Clinical Manifestations
- •Type 1 Autoimmune Pancreatitis (AIP)
- •IgG4-Related Sclerosing Cholangitis (SC)
- •Retroperitoneal Fibrosis, Chronic Sclerosing Aortitis and Periaortitis
- •Diagnosis of IgG4-RD
- •Treatment
- •Suggested Reading
- •18 Role of the Mesentery in Systemic Inflammation Response Syndrome (SIRS) and Multiple Organ Dysfunction Syndrome (MODS)
- •Introduction
- •Pathophysiology
- •MODS Pathophysiology
- •Mesenteric Lymph, SIRS and MODS
- •Interventions Directed at Mesenteric Lymph
- •Mesenteric Duct Ligation and the Inflammatory Response
- •Vagal Nerve Stimulation (VNS)
- •Adipocytes, SIRS and MODS
- •Adiponectin, SIRS and MODS
- •Leptin, SIRS and MODS
- •CRP, Resistin and SIRS/MODS
- •Fibrocytes, SIRS and MODS
- •Summary
- •Suggested Reading
- •Medical Disorders of the Mesentery
- •19 Mesenteric Hemorrhage
- •Definition
- •Epidemiology and Risk Factors
- •Pathophysiology
- •Symptoms
- •Physical Findings
- •Imaging and Diagnosis
- •Management
- •Suggested Reading
- •20 Mesenteric Panniculitis
- •Definition and Nomenclature
- •Epidemiology
- •Patients at Risk
- •Pathophysiology
- •Symptoms and Signs
- •Diagnosis
- •Physical Findings
- •Laboratory Testing
- •Imaging
- •Biopsies and Histologic Findings
- •Treatments
- •Medical
- •Surgery
- •Sugggested Reading
- •21 PPP Syndrome: Pancreatitis, Panniculitis, Polyarthritis
- •Definition
- •Epidemiology
- •Patients at Risk
- •Pathophysiology
- •Signs and Symptoms
- •Diagnosis
- •Physical Findings
- •Laboratory Testing
- •Imaging
- •Histologic Findings
- •Treatments
- •Medical
- •Surgical
- •Additional Comments
- •Suggested Reading
- •22 Mesenteric Adenitis
- •Definition
- •Epidemiology
- •Patients At Risk
- •Pathophysiology
- •Symptoms
- •Physical Findings
- •Laboratory Testing
- •Imaging
- •Treatment
- •Medical
- •Surgical
- •Suggested Reading
- •23 Mesenteric Abscess
- •Definition
- •Pathophysiology
- •Epidemiology
- •Symptoms
- •Physical Findings
- •Laboratory Testing
- •Diagnosis and Imaging
- •Treatment
- •Suggested Reading
- •24 Mesenteric Venous Thrombosis
- •Introduction
- •Epidemiology
- •Anatomy
- •Pathophysiology
- •Patient At Risk for MVT
- •Clinical Presentation
- •Diagnosis
- •Imaging
- •Laboratory Findings
- •Treatment
- •Nonoperative Management
- •Interventional Radiology Procedures
- •Surgery
- •Prognosis
- •Suggested Reading
- •25 Mesenteric Arterial Occlusion
- •Definition and Description of the Disease
- •Epidemiology
- •Anatomy
- •Pathophysiology
- •Signs and Symptoms
- •Diagnosis
- •Physical Findings
- •Laboratory Findings
- •Imaging
- •Treatment
- •Overview
- •Surgical
- •Surgical Revascularization
- •Endovascular Procedures
- •Medical Therapy
- •Prognosis
- •Suggested Reading
- •26 Ischemic Enteropathy (Also Called Mesenteric Ischemia)
- •Definition and Description of the Disease
- •Classification and Terminology
- •Intestinal Vascular Anatomy
- •Epidemiology
- •Patients at Risk
- •Pathophysiology
- •Acute Mesenteric Ischemia of Arterial Origen
- •SMA Thrombosis (SMAT)
- •Nonocclusive Mesenteric Ischemia (NOMI)
- •Focal Segmental Ischemia (FSI)
- •Acute Mesenteric Ischemia of Venous Origen (MVT)
- •Signs and Symptoms of Ischemic Enteropathy
- •Diagnosis
- •Physical Findings
- •Laboratory Findings
- •Imaging
- •Histologic Findings
- •Treatments for Acute Mesenteric Ischemia
- •Medical
- •Surgical
- •Treatments for Chronic Mesenteric Ischemia
- •Medical
- •Surgical
- •Prognosis
- •Suggested Reading
- •27 Colonic Ischemia (Also Known as Ischemic Colitis)
- •Introduction
- •Epidemiology
- •Risk Factors
- •Pathophysiology
- •Clinical Presentations
- •Diagnosis
- •Laboratory Findings
- •Imaging
- •Colonoscopy
- •Histologic Findings
- •Treatments
- •Medical
- •Complications
- •Suggested Readings
- •28 Mesenteric Lymphangioma
- •Definition
- •Epidemiology
- •Patients at Risk
- •Pathophysiology
- •Clinical Presentation
- •Physical Findings
- •Laboratory
- •Histology
- •Imaging
- •Diagnosis
- •Treatment
- •Medical
- •Surgery
- •Suggested Reading
- •29 Radiation-Induced Mesenteric Injury
- •Pathophysiology of Radiation-Induced Tissue Injury
- •Radiation-Induced Intestinal Injury-Enteropathy and Colopathy
- •Medical Literature on Radiation and the Mesentery
- •Basic Research
- •Clinical Publications
- •Summary
- •Suggested Reading
- •30 Drug Induced Mesenteric and Retroperitoneal Diseases
- •Definition
- •Epidemiology
- •Patients at Risk
- •Pathophysiology
- •Diagnosis, Physical Findings and Laboratory Findings
- •Imaging
- •Treatment
- •Prognosis
- •Angiotensin Converting Enzyme (ACE)-Inhibitor Induced Visceral Edema
- •Definition
- •Epidemiology
- •Patients at Risk
- •Pathophysiology
- •Signs and Symptoms
- •Laboratory Findings
- •Imaging
- •Drug Induced Retroperitoneal Fibrosis
- •Definition, Description, and Epidemiology
- •Pathophysiology
- •Diagnosis, Physical Findings and Laboratory Findings
- •Imaging
- •Histologic Findings
- •Treatments
- •Surgical
- •Prognosis
- •Drug Induced Pancreatitis
- •Introduction
- •Suggested Reading
- •Neoplasms of the Mesentery
- •31 Primary Solid Neoplasms
- •Introduction
- •Desmoid Tumor of the Mesentery
- •Symptoms and Signs
- •Pathophysiology
- •Diagnosis
- •Treatment
- •Prognosis
- •Primary Leiomyosarcoma of the Mesentery
- •Symptoms and Signs
- •Pathophysiology
- •Diagnosis
- •Treatment
- •Prognosis
- •Primary Carcinoid Tumors of the Mesentery
- •Symptoms and Signs
- •Pathophysiology
- •Diagnosis
- •Treatment
- •Prognosis
- •Primary Liposarcoma of the Mesentery
- •Symptoms and Signs
- •Pathophysiology
- •Diagnosis
- •Treatment
- •Prognosis
- •Primary Stromal Tumor of the Mesentery
- •Symptoms and Signs
- •Pathophysiology
- •Diagnosis
- •Treatment
- •Prognosis
- •Summary
- •Suggested Reading
- •32 Metastatic Diseases of the Mesentery
- •Symptoms
- •Pathophysiology
- •Diagnosis
- •Treatment
- •Malignant Bowel Obstructions and Palliative Care
- •Conclusion
- •Suggested Reading
- •33 Mesenteric Lymphoma
- •Symptoms and Signs
- •Pathophysiology
- •Diagnosis
- •Treatment
- •Prognosis
- •Summary
- •Suggested Reading
- •34 Castleman Disease with Mesenteric Involvement
- •Definition and Description of the Disease
- •Epidemiology
- •Patients at Risk
- •Pathophysiology
- •Signs and Symptoms
- •Diagnosis
- •Physical Findings
- •Laboratory Findings
- •Imaging
- •Histologic Findings
- •Treatments
- •Prognosis
- •Suggested Reading
- •Surgical Diseases of the Mesentery
- •35 Mesenteric Resection in Upper Abdominal Surgery
- •Indications for Surgery
- •Contraindications
- •Description of Surgery
- •Small Bowel Resection with Adjacent Mesentery (Open Approach, Hand Sewn Anastomosis)
- •Complications
- •Summary
- •Suggested Reading
- •36 Mesenteric Considerations in Surgery of the Colon and Rectum
- •Introduction
- •Mesenteric Role in Diseases of the Colon and Rectum
- •Malignancy
- •Benign Disease
- •Colon Cancer Principles
- •Studies of Anatomy and Embryology
- •Surgical Principles
- •Preoperative Vascular Anatomical Considerations
- •Surgical Approach
- •Surgical Management of Colon Cancer
- •Cecal and Ascending Colon Carcinoma
- •Hepatic Flexure Carcinoma
- •Transverse Colon Carcinoma
- •Splenic Flexure Carcinoma
- •Descending Colon Carcinoma
- •Sigmoid Carcinoma
- •Total Mesorectal Excision Principles
- •Surgical Quality
- •Surgical Complications
- •Conclusion
- •Suggested Readings
- •37 Mesocolic Resection in Colon Cancer
- •Description of the Procedure
- •Indications
- •Contraindications
- •Preparation of the Patient
- •How the Procedure Is Performed
- •General Principles
- •Specific Considerations
- •Right Colon
- •Transverse Colon and Flexures
- •Left and Sigmoid Colon
- •Anatomical Variants and Typical Abnormal Findings
- •Complications
- •Outcomes
- •Conclusion
- •Suggested Reading
- •38 Mesenteric Resection in Rectal Cancer
- •Description of Rectal Cancer and the Mesorectum
- •Indications for Surgery of the Rectum and Mesorectum
- •Contraindications of Surgery of the Rectum and Mesorectum
- •Surgical Management: Technique
- •Surgical Complications
- •Early
- •Late
- •Summary
- •Suggested Readings
- •39 Mesenteric Resection in Crohn’s Disease
- •Introduction
- •Gross Features of the Bowel and Mesentery in Crohn’s Disease
- •Histopathologic Features of the Bowel and Mesentery in Crohn’s Disease
- •Mesenteric Adipose Tissue and Crohn’s Disease
- •Lymphatic System, Mesenteric Lymph Nodes Granulomas and Crohn’s Disease
- •Timing of Mesenteric Events in CD
- •Risk Factors for Recurrence and Extended Mesenteric Resection
- •Mesenteric Resection in Crohn’s Disease
- •Conclusion
- •Suggested Reading
- •40 Mesenteric Resection in Crohn’s Disease
- •Introduction
- •Inclusion of the Mesentery During Ileocolic Resection
- •Long-Term Outcomes
- •Short Term Outcomes
- •Indications for Inclusion of the Mesentery During Surgery for Crohn’s Disease
- •The Mesenteric Transition Zone
- •Advanced Mesenteric Disease Predicts Increased Surgical Recurrence
- •Discussion
- •Conclusion
- •Suggested Reading
- •Surgery for Individual Conditions
- •41 Surgical Management of Intestinal Volvulus
- •Definition and Clinical Features
- •Description of Surgery
- •Indications for Surgery
- •Contraindications
- •Preparation of Patient
- •How the Procedures Are Performed
- •Typical Abnormal Findings
- •Alternatives to Surgery
- •Outcomes
- •Complications
- •Summary
- •Suggested Reading
- •42 Embryologic Abnormalities of the Mesentery
- •Background
- •Malrotations and Indications for Surgery
- •Surgeries for Malrotations and Mesocolic Hernias
- •Complications
- •Summary
- •Suggested Reading
- •43 Mesenteric Hernia
- •Background
- •Clinical Presentation
- •Diagnosis
- •Management
- •Summary
- •Suggested Reading
- •44 Surgical Management of Bands and Adhesions
- •Definition and Clinical Features
- •Description of Procedures
- •Indications for Surgery
- •Contraindications
- •Preparation of the Patient
- •How the Procedure is Performed
- •Typical Abnormal Findings M
- •Outcomes and Complications
- •Summary
- •Suggested Reading
- •45 Mesenteric Trauma
- •Epidemiology
- •Pathophysiology
- •Diagnosis
- •Clinical Exam
- •Diagnostic Peritoneal Lavage (DPL) and Focused Assessment with Sonography in Trauma (FAST)
- •Operative Assessment
- •Grading
- •Predictive Variables
- •Management
- •Concern for Injury
- •High Suspicion for Injury
- •Intraoperative Finding
- •Proximal Mesenteric Injury
- •Future Directions
- •Suggested Reading
- •46 Mesenteric Cysts
- •Cystic Tumors of the Mesentery
- •Description of Condition
- •Mesenteric Lymphangioma
- •Simple Mesothelial Cysts
- •Multicystic Mesothelioma
- •Enteric Duplication Cysts
- •Urogenital Cysts of the Mesentery
- •Mature Cystic Teratoma
- •Mesenteric Pseudocyst
- •Presentation and Diagnosis
- •Diagnostic Studies in Uncomplicated Mesenteric Cysts
- •Physical Exam
- •Imaging
- •Lymphangioma
- •Mesothelial Cysts
- •Multicystic Mesothelioma
- •Enteric Duplication Cysts
- •Mature Cystic Teratoma
- •Mesenteric Pseudocyst
- •Endoscopy and Endoscopic Ultrasound
- •Acute Complications of Mesenteric Cysts
- •Obstruction, Volvulus and Intussusception
- •Ureteral Obstruction
- •Cyst Rupture
- •Cyst Hemorrhage
- •Infected Mesenteric Cyst
- •Peptic Ulceration
- •Management
- •Indications for Surgery
- •Contraindications to Surgery
- •Surgical Options
- •Summary
- •Suggested Reading
- •47 Mesenteric Abscess
- •Description of the Condition
- •Diagnosis of Mesenteric Abscess
- •Management of Mesenteric Abscess
- •Indications, Contraindications, and Challenges of Surgery for Mesenteric Abscess
- •Complications of Mesenteric Abscess
- •Outcome of Mesenteric Abscess
- •Summary
- •Colonic Abscess
- •Definition and Incidence
- •Causes
- •Diagnosis
- •Treatment
- •Conclusions
- •Suggested Reading
- •48 Mesenteric Neoplasms
- •Introduction
- •Description of Mesenteric Neoplasms
- •Lymphoma
- •Desmoid Tumors
- •Mesenteric Gastrointestinal Stromal Tumors
- •Mesenteric Carcinoid Tumors
- •Mesenteric Liposarcoma
- •Castleman’s Disease
- •Cystic Lesions
- •Conclusions
- •Suggested Reading
- •49 Mesenteric Artery Thrombosis and Embolism
- •Description of This Condition
- •Anatomy and Pathophysiology
- •Presentation
- •Laboratory Findings
- •Imaging Workup
- •Treatment
- •Outcomes
- •Suggested Readings
- •Future
- •50 Future Research on the Role of the Mesentery in Health and Disease
- •Introduction
- •Genetic Investigations and Mesenteric Disease
- •Clinical Pharmacology
- •Mesenteric Panniculitis
- •New and Future Developments in Mesenteric Surgery
- •Inflammatory Bowel Disease
- •Radiologic Advances
- •Mesenteric and Bowel Injuries
- •Fluorescence Lymphangiography
- •Use of Next Generation Technology to Advance Our Understanding of the Role of the Mesentery in Human Disease
- •Suggested Reading
- •Medical and Pharmacology
- •Surgery
- •Radiology
- •Next Generation Technology
- •Index

49 Mesenteric Artery Thrombosis and Embolism 495
Treatment
Patients with acute embolic or thrombotic mesenteric ischemia warrant prompt fluid
resuscitation, correction of electrolyte imbalances, and systemic anticoagulation
with heparin to prevent further thrombus propagation. Empiric antibiotics should be
administered with regimens that cover gram-negative enteric flora and anaerobes.
Patients often present with organ dysfunction and require close hemodynamic
monitoring. While these patients may be hypotensive, vasopressors can exacerbate
ongoing intestinally ischemia, thus these patients should undergo fluid resuscitation
with isotonic crystalloid solution before initiation of vasopressors.
The goals of surgical therapy for acute mesenteric ischemia are (1) restoration of
arterial perfusion and (2) resection of non-viable bowel. Prompt laparotomy should
be done in any patient with peritonitis or evidence of threatened intestinal viability.
In embolic SMA disease, laparotomy may reveal intestinal ischemia from the
mid-jejunum to the ascending or transverse colon. Frankly necrotic or perforated
bowel should be resected and left in discontinuity prior to revascularization in order
to limit gross contamination. The SMA may be exposed in one of three approaches.
First, it may be exposed caudal to the inferior border of the by entering the lesser
sac (Fig. 49.6a). Second, the transverse colon may be lifted superiorly and a horizontal incision made in the mesentery, exposing the SMA at the root of the small
bowel mesentery (Fig. 49.6b). Finally, the SMA can be exposed by dividing the
ligament of Treitz and peritoneal attachments and laterally mobilizing the fourth
portion of the duodenum laterally (Fig. 49.6c).
After systemic heparinization, proximal and distal control of the vessel is
achieved with vascular clamps, and a transverse arteriotomy is made sharply.
A balloon thromboembolectomy can then be performed with a 3-Fr or 4-Fr catheter
through the arteriotomy (Fig. 49.7). In the event the embolus has lodged more
distally at the jejunal and ileal branches, thromboembolectomy is best accomplished
with a smaller catheter (i.e., 2 Fr or 3 Fr), given the fragility of this vasculature. This
maneuver is repeated until the balloon is free of thrombus upon withdrawal and
pulsatile flow is restored. Following successful thromboembolectomy, the arteriotomy can be closed primarily using simple interrupted 5–0or6–0 monofilament
sutures or patched using cryopreserved vein. For repair of diminutive branch vessels, vein patch angioplasty is preferred.
In patients with acute mesenteric thrombosis, ischemia typically involves a
heavily atherosclerotic proximal CA or SMA. In these patients, vascular bypass is
required for successful revascularization and typically requires single vessel
reconstruction in order to bypass the in-situ thrombosis. Autogenous or synthetic
materials may be used for the graft. Synthetic bypass grafts of 6–8 mm Dacron or
polytetrafluoroethylene (PTFE) are most often used given their availability, ease of
handling, and size match. In the setting of gross abdominal contamination and risk
of subsequent graft infection, saphenous vein and thigh femoral vein may be used.
Rifampin-soaked Dacron is another option, as vein harvest may be too time consuming in critically ill patients. Several options exist for graft orientation.

496 S. Parascandola and V. Obias
a
b
c
Fig. 49.6 Exposure of the superior mesenteric artery through a. longitudinal midline incision in
the retroperitoneal tissue immediately inferior to the border of the pancreas. b. At the base of the
transverse mesocolon through a horizontal incision in the mesentery. c. Above the superior margin
of the duodenum by completely mobilizing the fourth portion of the duodenum after incising the
ligament of Treitz and the other peritoneal attachments. Reused with permission. Copyright ©
Elsevier

49 Mesenteric Artery Thrombosis and Embolism 497
Fig. 49.7 Balloon thromboembolectomy through transverse arteriotomy in the superior
mesenteric artery. Reused with permission. Copyright © Elsevier
Retrograde approaches are most often used. For retrograde bypasses, the proximal
anastomosis can be placed on the right common iliac artery (most common),
infrarenal aorta, or left common iliac artery and is performed in an end-to-side
fashion. The distal anastomosis on the SMA can be performed in an end-to-side or
end-to-end fashion. The graft is typically tunneled so that it forms a curve or “C
loop” between the proximal and distal anastomosis as it traverses caudal to
cephalad (Fig. 49.8).
In the cases of prohibitive anatomy, antegrade bypass from the supraceliac aorta
may be considered. The supraceliac aorta is exposed by mobilizing the left triangular ligament of the liver and incising the median arcuate ligament and crus of the
diaphragm. Once the patient is systemically heparinized, the aorta is occluded. An
Fig. 49.8 Completed
retrograde bypass from the
proximal right common iliac
artery to the superior
mesenteric artery. Reused
with permission. Copyright ©
Elsevier

498 S. Parascandola and V. Obias
arteriotomy is made in the aorta and anastomosis performed using 3–0 nonabsorbable, monofilament suture, and 5–0 sutures with felt pledgets. A limited
endarterectomy may be necessary. The distal anastomosis to the celiac artery and
superior mesenteric artery is constructed using an end-to-end and end-to-side
manner, respectively (Fig. 49.9).
After revascularization by thromboembolectomy or bypass, an assessment of the
viability of bowel must be performed an d includes running the entire length of
bowel, assessing the color and peristaltic activity, and palpating the mesenteric
arcades. Adjuncts include Doppler interrogation of the mesenteric arcade, fluorescein injection with Wood’s lamp inspection, or perfusion fluorometry. Non-viable
bowel must be resected. In cases of questionable viability, a second-look procedure
in 24–48 h should be considered. Often the full extent of bowel viability is not
immediately obvious following initial vascularization. Additional non-viable bowel
resections should be performed at that time.
In patients with acute mesenteric thrombosis without evidence of bowel ischemia, successful cases of endovascular treatments for AMI have been reported.
Major drawbacks to endovascular approaches include inability to inspect the viability of bowel both before and after revascularization and the prolonged time that
Fig. 49.9 Completed
antegrade bypass from the
supraceliac aorta to the celiac
axis and the superior
mesenteric artery. Reused
with permission. Copyright ©
Elsevier

49 Mesenteric Artery Thrombosis and Embolism 499
may be required to achieve successful thrombolysis. Given these limitations, purely
endovascular approaches may be used in select groups of patients. Percutaneous
mechanical thrombectomy, aspiration thrombectomy, and intra-arterial thrombolysis, with or without adjuvant angioplasty and stenting, have been increasingly
described in recent literature. To perform an endovascular revascularization, vascular access can be gained through a retrograde femoral approach or antegrade
brachial approach. Once an introducer sheath is placed, a lateral and anteroposterior
aortogram is performed to identify the origin of the CA and SMA. Next, systemic
heparin is given and guidewire placed across the lesion. Once wire placement has
crossed the lesion, the catheter is advanced and its position confirmed by angiogram. Thrombectomy, aspiration, or balloon angioplasty can then be completed and
a postangioplasty angiogram performed. If the completion angiogram demonstrates
incomplete angioplasty, placement of mesenteric stent is warranted. Involvement of
the orifice or proximal vessel should be treated with balloon-expandable stent
(Fig. 49.10a–d). To reduce vasospasm, an intra-arterial infusion of nitroglycerine or
papaverine can be used. Intra-arterial delivery of thrombolytic agents into the
thrombus is another potentially useful treatment modality in acute thrombotic
mesenteric ischemia.
Hybrid approaches to acute mesenteric ischemia offer the ability to examine the
abdominal viscera and control sepsis while employing less invasive mesenteric
revascularization techniques. After laparotomy, the SMA is exposed and a puncture
made in the vessel, though which retrograde guidewire access is gained . The SMA is
clamped to avoid distal embolization. The SMA lesion is then crossed and the
guidewire passed through brachial or femoral access, creating “through-and-through”
access. If thrombectomy is required, an arteriotomy in the SMA is made and Fogarty
balloon passed over the wire and into the aorta. Thrombectomy is performed and
completion and restoration of flow asses sed. If thrombectomy is not required, no
arteriotomy is necessary. Using the through-and-through wire, a stent can be placed in
either an antegrade or retrograde fashion (Fig. 49.11a–d).
Complications after endovascular repair include access site complications (hematoma, pseudoaneurysm, access artery thrombosis, retroperitoneal hematomas),
distal embolization during wire and catheter manipulation, and recurrent stenosis
requiring repeat angioplasty and stenting. A baseline duplex of the treated vessel
should be obtained before discharge, every 6 months for 1 year, and annually thereafter. Cumulative stent patency rate over 3 years is reported between 44 and 88%.
Outcomes
Postoperatively, all patients who undergo revascularization for acute mesenteric
ischemia require close monitoring. The postoperative course for these patients is
frequently complicated by the development of multiple organ dysfunction, which
likely accounts for prolonged hospitalization and is a leading cause of death.
Postoperative care often involves intensive care unit admission, prolonged

500 S. Parascandola and V. Obias
Fig. 49.10 A malperfused area of the small intestine a macroscopically. bIn the SPY mode. c In
the ICG fluorescence mode. d In the Pinpoint semi-quantitative assessment mode. Reused with
permission. Copyright © Springer Nature
endotracheal intubation, and parenteral nutrition. Coagulopathy and thrombocytopenia may be present and can be managed with platelets, plasma, or both.
Depending on the extent of necrosis and/or contamination, broad-spectrum
antibiotic therapy is typically required. In patients who underwent endovascular
revascularization, any new abdominal complaints should immediately raise suspicion for missed intestinal non-viability.
The aggregate mortality rates in patients with acute mesenteric ischemia have
been historically reported as 54 and 74% in patients with acute embolism and
thrombosis, respectively. Risk factors for increased mortality include age greater
than 60 years, intestinal non-viability requiring resection, colon involvement, and
duration of symptoms before treatment.
Recently, there has been increasing utilization of endovascular techniques over
traditional laparotomy as the initial management in patients with AMI. Beaulieu and
colleagues conducted a review using the National Inpatient Sample database which
identified a significant increase in endovascular techniques from 2005 through 2009.
Their study reported that mortality, hospital length of stay, need for bowel resection,

49 Mesenteric Artery Thrombosis and Embolism 501
Fig. 49.11 Endovascular balloon angioplasty and stenting in acute mesenteric thrombosis.
a Introducer sheath placed at the lesion. b Guidewire catheter placement across the lesion.
c Balloon angioplasty. d Stent placement. Reused with permission. Copyright © Springer Nature
and need for postoperative parenteral nutrition were reduced in those patients
receiving endovascular therapy compared to traditional open surgical revascularization. A large study by Arthurs and colleagues compared traditional open surgery
versus endovascular revascularization in 70 patients with acute embolism or
thrombosis. In those who underwent endovascular therapy, technical success rate
was seen in 78% of patients. Endovascular therapy resulted in lower rates of acute
renal failure and pulmonary failure. They noted an overall mortality rate of 39% for
patients undergoing endovascular therapy vs 50% for traditional therapy. Notably, as
abdominal exploration was reserved for peritonitis or clinical deterioration, 31% of
patients who underwent endovascular revascularization did not require laparotomy.

502 S. Parascandola and V. Obias
Fig. 49.12 Retrograde Open Mesenteric Stenting (ROMS). a A guidewire is exteriorized through
the retrograde sheath, establishing through-and-through access between the access site and
superior mesenteric artery (SMA). b Deployment of the balloon-expandable covered stent.
c Completion angiography without residual stenosis. d During catheter manipulations, the distal
SMA and its branches are controlled to avoid distal embolization. Reused with permission.
Copyright © Elsevier
Though an uncommon disease, the physiologic consequences of acute mesenteric embolism and thrombosis are devastating. Early diagnosis and resuscitation is
critical for survival. In addition to prompt recognition, patient-specific and hybrid
management approaches may lead to a reduction in the historically high mortality
rates seen in this disease process.
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with traditional therapy for the treatment of acute mesenteric ischemia. J Vasc Surg.
2011;201:698–705.

49 Mesenteric Artery Thrombosis and Embolism 503
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society of emergency surgery. World J Emerg Surg. 2017;12:38. Published 2017 Aug 7.
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mesenteric ischemia: an NSQIP analysis. Am Surg. 2015;81(11):1170–6.
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Part IX
Future
Соседние файлы в папке Библиотека им академика М.И. Перельмана
