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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5628_Библиотеки_им_академика_М_И_Перельмана.pdf
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- •Preface
- •1.1: Polymer Chains Behavior in Solutions
- •1.1.1: Basic Interaction of Polymer Chain in Solution
- •1.2.1: Self-Assembly of Block Copolymers
- •1.2.2: Self-Assembly of Liposomes
- •1.2.2.1: Formation of liposomes
- •1.1.2: Solubility of Polymer
- •1.1.2.1: Solubility parameter
- •1.1.2.2: Real polymer solutions
- •1.1.3.1: Dynamics of self-assembly
- •1.1.3.2: Free energy of self-assembly systems
- •1.1.3.3: Basic morphology of self-assembly systems
- •1.2.2.2: Phase behaviors of lipid bilayers
- •1.3: Stability of Nanosystems in Solutions
- •1.3.1: DLVO Theory
- •1.3.1.1: Interaction energy between nanoparticles
- •1.3.1.2: Effects of DLVO theory
- •1.3.3: Limitations of Classical DLVO
- •1.4: The Powerful Tool for Study of Nano Physical Pharmaceutics
- •1.4.1.1: Scattering by a small particle
- •1.4.2.1: Power spectrum of scattered light
- •2.1: Classification of Micelle
- •2.1.1: Ionic Surfactant Micelle
- •2.1.2: Non-Ionic Surfactant Micelle
- •2.1.3: Mixed Micelle
- •2.2: Preparation of Micelles
- •2.3: Effects on Micelle Assembly
- •2.3.1: Critical Micelle Concentration
- •2.3.2: Mechanism of Micellization
- •2.3.3: Influence of the Surfactant Structure on CMC
- •2.3.3.1: Volume of hydrophobic groups
- •2.3.3.2: Chemical structure and volume of hydrophilic groups
- •2.3.4: Influence of External Conditions on CMC
- •2.3.4.1: Temperature
- •2.3.4.2: Electrolytes
- •2.3.4.3: Organic substances
- •2.4: Structure and Stability of Polymeric Micelles
- •2.4.1: Thermodynamical Stability
- •2.4.2: Structural Stability
- •2.4.3: Micelle Structural Tailoring
- •2.5: NPP of Polymeric Micelles in Drug Delivery
- •2.5.1: Physiochemical Properties of Micelles
- •2.5.1.2: Critical micelle concentration
- •2.5.1.3: Zeta potential
- •2.5.2: Stability of Micelles
- •2.5.3: Drug-Loading Profile of Micelles
- •2.5.4: Endocytosis of Micelles
- •2.5.5: Drug Release Behavior of Micelles
- •2.5.6.1: pH-responsive micelles
- •2.5.6.2: Redox-responsive micelles
- •2.5.6.3: Temperature-responsive micelles
- •2.5.6.4: Photo-responsive micelles
- •2.6: Summary and Perspective
- •3.1: Classification of Liposome
- •3.2: Preparation of Liposomes
- •3.2.2: Reverse-Phase Evaporation Method
- •3.2.3: Injection Method
- •3.2.4: Detergent Depletion Method
- •3.3: Theory of Liposome Formation
- •3.4: NPP of Liposomes in Drug Delivery
- •3.4.1: Physiochemical Properties of Liposome
- •3.4.1.1: Size of liposome
- •3.4.1.2: Phase transition temperature of liposome
- •3.4.1.3: Membrane permeability of liposome
- •3.4.1.4: Membrane charge of liposome
- •3.4.2: Drug-Loading Behavior of Liposome
- •3.4.3: Stability of Drug-Loaded Liposome
- •3.4.3.1: Physical stability of drug-loaded liposome
- •3.4.3.2: Chemical stability of drug-loaded liposome
- •3.4.4: Clearance and in vivo Circulation of Liposome
- •3.4.5: Targeting Ability of Liposome
- •3.4.6: Drug Release Behavior of Liposome
- •3.5: Summary and Perspective
- •4.1: Classification of Inorganic Nanoparticles
- •4.3.1: Nucleation Mechanism of Inorganic Nanoparticles
- •4.3.2: Growth Mechanism of Inorganic Nanoparticles
- •4.3.3: Morphology Control Strategy
- •4.3.3.1: Control of nucleation rate
- •4.3.3.2: Control of growth phases
- •4.3.4: Dynamic Stability
- •4.3.4.1: Brownian motion
- •4.3.4.2: Sedimentation and sedimentation equilibrium
- •4.3.4.3: Interparticle interactions
- •4.3.5: Thermodynamic Stability
- •4.3.5.1: Electrical double layer theory and zeta potential
- •4.3.5.2: Electrolyte
- •4.3.5.3: DLVO theory
- •4.3.5.4: Stability in aqueous system
- •4.3.5.5: Impact of polymer compounds on stability
- •4.4: NPP of Inorganic Particles
- •4.4.1: Properties of Inorganic Nanoparticles
- •4.4.1.1: Electronic and optical properties
- •4.4.1.2: Magnetism
- •4.4.1.3: Mechanical properties
- •4.4.1.4: Thermal properties
- •4.4.2: Biological Application of Inorganic Nanoparticles
- •4.4.2.1: Au nanoparticles
- •4.4.2.2: Magnetic nanoparticles
- •4.4.2.3: Quantum dots
- •4.4.2.4: Carbon nanotubes
- •4.4.2.5: MXene
- •4.5: Summary and Perspective
- •5.1: Classification of Nanogels
- •5.2: Preparation of Nanogels
- •5.2.1: Non-Covalent Bonding Method
- •5.2.2: Chemical Cross-Linking Reaction
- •5.2.3: Template Method
- •5.3: Mechanism of Nanogel Formation
- •5.3.1: Cross-Linking of Nanogel
- •5.3.1.1: Gelation theory of nonlinear polycondensation
- •5.3.3: Structure and Stability of Nanogel
- •5.4: NPP of Nanogels in Drug Delivery
- •5.4.1: Physiochemical Properties of Nanogels
- •5.4.1.1: Expansion of nanogels
- •5.4.1.2: Swelling mechanism
- •5.4.1.3: Affecting factors of nanogel swelling
- •5.4.1.4: Thixotropy and desizing effect of nanogels
- •5.4.2: In vivo Circulation of Nanogels
- •5.4.3: Drug Release Behavior of Nanogels
- •5.4.4: Factors Affecting the Release of Drug-Loaded Nanogels
- •5.4.4.1: Drug-loading methods
- •5.4.4.2: Medium pH
- •5.4.4.3: Solvent
- •5.4.4.4: Particle size
- •5.4.4.5: Surface charge
- •5.4.5.1: Temperature-responsive nanogels
- •5.4.5.2: pH-responsive nanogels
- •5.4.5.3: Glucose-responsive nanogels
- •5.4.5.4: Photoresponsive nanogels
- •5.4.5.5: Other stimulation-responsive nanogels
- •5.4.6.1: Delivery of small-molecule therapeutic drugs
- •5.4.6.2: Delivery of oligonucleotides
- •5.4.6.3: Delivery of therapeutic proteins
- •5.5: Summary and Perspective
- •6.1: Classification of Microspheres
- •6.2: Preparation of Microspheres
- •6.2.1: Emulsification: Chemical Cross-Linking Method
- •6.2.2: Solvent Evaporation
- •6.2.3: Phase Separation
- •6.2.4: Salting-Out Method
- •6.2.5: Spray Drying
- •6.2.6: Ultrasound Method
- •6.2.7: Supercritical Fluid Method
- •6.3: Mechanism of Microsphere Formation
- •6.3.1: Stability of Nano-Microspheres and DLVO Theory
- •6.3.2: Factors Affect the Potential Energy
- •6.3.3: Factors Affect the Stability of Microspheres
- •6.3.3.1: Properties of polymers
- •6.3.3.2: Surface charge of microspheres
- •6.4: NPP of Microspheres
- •6.4.1: Physicochemical Properties of Microspheres
- •6.4.1.2: Factors affecting the particle size of microspheres
- •6.4.3: Drug Release Behavior of Microspheres
- •6.4.3.1: Mechanism of drug release by microspheres
- •6.4.3.2: PLA microspheres delivery system
- •6.4.4: Route of Administration of Microspheres
- •6.4.4.1: Cavity administration
- •6.4.4.2: Injection administration
- •6.4.4.3: Administration by arterial embolism
- •6.4.4.4: Magnetic microsphere administration
- •6.4.4.5: Oral administration
- •6.4.4.6: Mucosal administration
- •6.4.4.7: Ocular administration
- •6.4.5: Biological Application of Microspheres
- •6.4.5.1: Sustained-release microsphere formulation
- •6.5: Summary and Perspective
- •Index
244
Index
unilamellar 92
see
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