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- •Preface
- •Contributors’ Addresses
- •Contents
- •Abbreviations
- •Basic Concepts
- •History
- •Oscillation, Sound Wave
- •Reflection and Refraction
- •Scattering
- •Interference
- •Diffraction
- •Absorption
- •Generating the Image
- •Pulse-Echo Procedure
- •Time Gain Compensation
- •A-Mode
- •B-Mode
- •M-Mode
- •The Sound Field
- •Resolution
- •Focusing
- •Scanning Procedures
- •Principle of Operation
- •Linear Array Scanner
- •Curved or Convex Array Scanner
- •Sector Scanner
- •Phased Array Scanner
- •Mechanical Sector Scanners
- •Rotary Principle
- •Wobbler Principle
- •Annular Phased Array Transducer
- •Ultrasound Artifacts
- •Distal Acoustic Shadowing
- •Dorsal Sound Amplification
- •Disadvantages of Mechanical Scanners
- •The Generation of Ultrasound
- •Physical Effects
- •Margin Shadow
- •Side Lobe
- •Slice Thickness Artifact
- •Repetition Artifact
- •Doppler Sonography
- •Fundamentals of Doppler Sonography
- •Geometrical Distortion
- •Continuous Wave Doppler Systems
- •Pulsed Wave Doppler systems
- •Alias Phenomenon in Pulsed Doppler
- •Baseline Shift
- •Wall Filter
- •Color-Coded Doppler Sonography
- •Amplitude-Coded Flow Display
- •Safety Aspects
- •Thermal Effects
- •Mechanical Effects
- •Important Definitions
- •Acoustic Output
- •Acoustic Power
- •Intensity
- •Intensity Special Peak Time Average
- •Risks of Individual Ultrasound Procedures
- •B-Mode
- •M-Mode
- •CW Doppler
- •PW Doppler
- •Color-Coded Doppler Sonography
- •Summary
- •Important Instrument Settings
- •Selecting the Most Suitable Transducer
- •B-Mode Settings
- •Depth of Penetration
- •Gain
- •Focusing
- •Setting the Doppler Parameters
- •Sample Volume
- •PRF and Baseline Shift
- •Scaling the Time Axis
- •Wall Filter
- •Orientation of the Tracings of Spectra
- •Color-Coded Doppler
- •Size of the Color Window
- •Color Gain
- •2 Indices for the Evaluation of Doppler Sonograms
- •Introduction
- •Quantitative Measurements
- •Qualitative Measurements
- •Angle Problems
- •Wall Filter
- •Indices Used to Evaluate Two-Dimensional Doppler Sonograms
- •Indices of Velocity
- •Indices of Acceleration
- •Path Length Index
- •Temporal Indices
- •Relative Flow Index
- •Optical Classification
- •Clinical Procedure
- •Vascular Supply of the Uteroplacentofetal Unit
- •Uteroplacental Blood Supply
- •Fetoplacental Blood Supply
- •Fetal Blood Supply
- •Reference Curves
- •Index Quotients
- •Summary
- •Suggestions for Obstetric Practice
- •Methods of Examining Specific Vessels
- •Displaying the Maternal Vessels
- •Displaying the Peripheral Fetal Vessels
- •Examining the Central Fetal Vessels
- •4 Blood Flow Analysis During Pregnancy
- •Uteroplacental Vessels
- •Reference Values
- •Physiological Flow Changes
- •Fetoplacental Vessels
- •Umbilical Vessels
- •Reference Values
- •Abnormal Flow Changes
- •Medications
- •Physiological Flow Changes
- •Pathological Flow Changes
- •Morphological Changes
- •Umbilical Vein
- •Reference Values
- •Physiological and Pathological Flow Alterations
- •Fetal Vessels
- •Aorta
- •Evaluation Criteria
- •Reference Values
- •Physiological Flow Changes
- •Arteries Supplying the Brain
- •Reference Values
- •Physiological Flow Changes
- •Renal Arteries
- •Evaluation Criteria
- •Reference Values
- •Ductus Arteriosus
- •Inferior Vena Cava
- •Evaluation Criteria
- •Reference Values
- •Physiological Flow Changes
- •Pathological Flow Changes
- •Ductus Venosus Arantii
- •Hepatic Veins
- •Effect of Therapeutic Measures
- •Prostaglandins
- •Antihypertensives
- •β-blockers
- •Calcium Antagonists
- •Epidural Anesthesia
- •5 Documentation
- •Sample Documentation Records
- •Correct Display of Vessels with Normal Instrument Settings
- •Role of the Angle in the Doppler Examination
- •Possible Sources of Error in Doppler Ultrasound Examinations of Maternal and Fetal Vessels
- •Displaying the Uterine Artery
- •Displaying the Umbilical Artery
- •Displaying the Fetal Aorta
- •Displaying the Middle Cerebral Artery
- •Complete Series of Doppler Ultrasound Examinations, Including Displays of Maternal Uterine and Fetal Peripheral and Central Vessels
- •Basic Concepts: References
- •Blood Flow Analysis During Pregnancy
- •Obstetric Applications of Doppler Ultrasound
- •The Significance of Transvaginal Sonography and Serum hCG
- •Characteristic Sonographic Findings in Ectopic Pregnancy
- •Differential Diagnosis
- •Transvaginal Color Doppler Ultrasound
- •Diagnostic Validity
- •Effectiveness of the Procedure
- •Errors
- •Critical Evaluation
- •Summary
- •8 Indications for Obstetric Ultrasound
- •IUGR and Biological Measurement
- •Basic Principles
- •Some Specific Measurements
- •Skull
- •Abdomen
- •Extremities
- •Cerebellum
- •Procedure when Biological Measurements are Abnormal
- •Growth Restriction
- •Suspected IUGR
- •PIH/Preeclampsia/Eclampsia
- •Status Post Dysmature Delivery/Intrauterine Death
- •Status Post Preeclampsia/Eclampsia
- •Abnormalities in the Recorded Fetal Heart Rate
- •Reasonable Suspicion of Fetal Anomalies or Fetal Disease
- •Multiple Pregnancy with Discordant Growth
- •Suspicion of Cardiac Anomaly or Heart Disease
- •Other Indications
- •First Trimester
- •Third Trimester
- •Second Trimester
- •Validity of a Test
- •Validation of Indices
- •Screening Population
- •Screening for Suspected Fetoplacental Perfusion Disorders and/or IUGR
- •Summary
- •Pathological Changes in Preeclampsia
- •Evaluating the Risk of Preeclampsia in the First and Second Trimesters—Examining the Uteroplacental Arteries
- •Doppler Ultrasound Findings
- •Evidence for or Exclusion of Fetal Risk—Evaluating the Fetal or Fetoplacental Vessels
- •Doppler Sonographic Findings
- •Doppler Sonographic Findings
- •Redistribution of Blood (Brain Sparing)
- •Summary
- •11 Doppler Ultrasound in the Diagnosis of Fetal Anomalies
- •Anomalies in the Region of the Head and Neck
- •Anomalies of the Lung and Diaphragm
- •Fetal Cardiac Malformations
- •Malformations of the Gastrointestinal Tract and the Abdominal Wall
- •Anomalies of the Urogenital System
- •Coccygeal Teratomata
- •Placenta
- •Hydrops Fetalis
- •Anhydramnios
- •Malformations of the Umbilical Cord
- •Doppler Ultrasound Diagnosis of Malformations in Early Pregnancy
- •12 Multiple Pregnancy and Doppler Ultrasound
- •Studies Using Doppler Ultrasound for Multiple Pregnancies
- •Theoretical Considerations Related to the Above Studies
- •Special Considerations for the Use of Doppler Ultrasound in Twin Pregnancies
- •Acardius Acranius, TRAP
- •Crossed Cord Around the Neck
- •Velamentous Insertion and Vasa Previa
- •Hydramnios-Oligohydramnios
- •Summary
- •NonInvasive Procedures for Suspected Fetal Anemia
- •Ultrasonic Imaging
- •Doppler Ultrasound
- •14 Umbilical Cord Complications and Doppler Ultrasound
- •Doppler Ultrasound Findings when Umbilical Cord Complications Affect Hemodynamics
- •Obstetric Applications of Doppler Ultrasound: References
- •Multiple Pregnancy and Doppler Ultrasound
- •15 Doppler Ultrasound and the Cardiotocogram
- •Comparing Tests
- •Comparing Tests to Predict Neonatal Acidosis
- •Information Lead Time Using Doppler Ultrasound
- •Clinical Significance of Doppler Ultrasound
- •16 Doppler Ultrasound Findings Near Term
- •Physiological Findings in the Late Stages of Pregnancy
- •Aorta: Quantitative Analysis
- •Aorta: Qualitative Analysis
- •Cerebral Arteries
- •Common Carotid Artery
- •Middle Cerebral Artery
- •Renal Arteries
- •Changes at Term and Postterm
- •Femoral Arteries
- •The “Term Effect”
- •The Circulatory Balance
- •Clinical Conclusions
- •Doppler Ultrasound during Labor?
- •Summary
- •Studies of Diagnostic Significance
- •Uteroplacental Arteries
- •Umbilical Arteries and Other Fetal Vessels
- •Umbilical Arteries and Fetal Aorta
- •The Umbilical Vein in Arterial Diastolic Block or Reverse Flow
- •Cerebral Arteries and Redistribution of the Circulation
- •Studies of Clinical Significance
- •Uteroplacental Arteries
- •Umbilical Arteries
- •Analysis of Individual Clinical Doppler Studies
- •Cumulative Metaanalysis
- •Conclusions
- •Diastolic Reverse Flow
- •Multiple Pregnancy
- •Summary
- •18 Doppler Sonography of the Fetal Venous Circulation
- •Anatomy
- •Physiology
- •The Right Path from the Inferior Vena Cava to the Right Atrium
- •Ultrasound Display and Doppler Sonography of the Venous System
- •Results of the Doppler Studies
- •Summary
- •1—Fetal Growth Restriction
- •2—Extreme Fetal Growth Restriction Due to Endarteritis Obliterans
- •3—Exclusion of Potter Syndrome
- •4—Closely Coordinated Preventive Care for High-Risk Patients
- •5—Patient with Antiphospholipid-Antibody Syndrome
- •6—Marked Fetal Growth Restriction
- •7—Twin Pregnancy with Twin-to-Twin Transfusion Syndrome
- •20 Doppler Ultrasound in Gynecology
- •Tumor Angiogenesis
- •Essential Considerations for Clinical Practice
- •Examination Procedure and Instrumentation for Ultrasound Diagnosis of the Pelvis
- •Evaluation
- •Ovarian Diagnosis
- •Conventional Ultrasound Examination of the Ovary: Procedure and Results
- •Normal Findings in the Doppler Ultrasound Examination of the Ovaries
- •Doppler Ultrasound and Myomas
- •Essential Considerations for Clinical Practice
- •Endometrial Diagnosis
- •Essential Considerations for Clinical Practice
- •Application of Ultrasound in Diagnosis of the Uterine Tube
- •Display of the Tube by Contrast Sonography
- •Comparison to Other Procedures
- •Supplementation by Doppler
- •22 Diagnostic Sonography of Blood Flow in Breast Tumors
- •Biological Background
- •Instrumentation
- •Continuous Wave Doppler
- •Pulsed Wave Doppler
- •Color-Coded PW Doppler
- •Angio Color, Angio Mode, Power Doppler
- •Introduction of Ultrasound Contrast Media
- •Color-Coded Doppler Ultrasound in the Differential Diagnosis of Breast Tumors
- •Advanced Topics in Obstetrics and Gynecological Doppler Ultrasound: References
- •Doppler Ultrasound and the Cardiotocogram
- •Doppler Ultrasound Findings Near Term
- •Diagnostic and Clinical Significance of Doppler Ultrasound in Obstetrics
- •Doppler Ultrasound in Gynecology
- •Diagnosis of the Uterine Tube by Transvaginal Ultrasound
- •Index

2
Umbilical Cord Complications and Doppler Ultrasound
Table 14.1 Elucidation of umbilical cord findings by various ultrasound procedures
Umbilical cord finding Ultrasound procedures suit-
able for displaying finding
Localization Gray-scale B-mode image/
color Doppler ultrasound
Number of perfused vessels Color Doppler ultrasound
Thickness of umbilical cord Gray-scale B-mode image
Flow restriction Doppler sonogram
(waveform)/color Doppler
ultrasound
Fig. 14.3 Late systolic notch on the waveform of the umbilical
a., possibly caused by a knot in the umbilical cord.
134
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Umbilical Cord Complications and Doppler Ultrasound
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Advanced Topics
in Obstetrics and
Gynecological
Doppler Ultrasound
Advanced Topics
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3
138

15 Doppler Ultrasound and the Cardiotocogram
Increased impedance values in the umbilical aa. and
the fetal aorta correlate well with fetal asphyxia. The
link between the diagnostic significance of Doppler
flow curves and an abnormal antepartum cardiotoco-
gram (CTG) can only be examined when fetal asphyxia
is due to chronic placental insufficiency. Reduced
Apgar scores at 5 minutes or acidotic pH values can
only be used as criteria for fetal asphyxia in primary
cesarean sections, since it is very unlikely that fetal hypoxia was present before delivery in infants who have
survived vaginal delivery or even a secondary section
after hours of labor. A consideration in such cases is
that asphyxia may be induced by umbilical cord complications during the first stage of labor or the second
stage, even when blood supply to the fetus was pre-
viously undisturbed.
Attempts to interpret abnormal Doppler findings as
opposed to abnormal CTGs lead to different prognostic
evaluations of the condition of the fetus. The Doppler
Comparing Tests
Table 15.1 Cardiotocogram and Doppler ultrasound
왘 A normal CTG
reflects the circulation and cerebral function of the fetus.
왘 A highly abnormal CTG
expresses a change in fetal cerebral function.
왘 A Doppler sonogram
reflects the circulation in a vascular region.
Circulation Cerebral function
Normal CTG 쐌쐌
Highly abnormal CTG 쐌
Doppler sonogram 쐌
sonogram displays the resistance in the fetoplacental
and uteroplacental circulation and is thus a chronic
parameter. An abnormal CTG displays hypoxic changes
in the fetal brain and is therefore an acute parameter.
When comparing the validity of the two methods
these differences between them must be borne in
Table
mind (
15.1).
Advanced Topics
Comparing Tests to Predict Neonatal
Asphyxia
An overview of the literature evaluating the CTG as a
basis for obstetric decision-making reveals a high false
positive rate, though specificity is good. Comparison of
the studies is made more difficult by the different composition and size of the populations studied (prevalence). A clinical study by Krebs (1978) using Fischer
scores improved the results by reducing the rates of
false positives. The design of the studies shown in
T
15.2 makes it possible to compare them.
able
15.3 shows the results of a study comparing
Table
the reliability of predictions of neonatal asphyxia by
CTG and umbilical cord Doppler sonography. Doppler
flow measurements showed a slight superiority because of their higher sensitivity. In all three studies
sensitivity was shown to be superior to CTG (by reduction in the false positive rate). At the same time specificity was slightly lower (because of a slight increase in
false positive results). According to these studies the
Doppler procedure seems to be more sensitive.
Tabelle 15.2 Prediction of neonatal asphyxia by CTG
Author Year Sensitivity Specificity
Flynn and Kelly 1977 59 % 85 %
Krebs 1978 54% 98%
Keane 1981 54% 87%
Our results 1991 69% 89%
Table 15.3 Comparison of the validity of predictions of
neonatal asphyxia by CTG and Doppler ultrasound examination
of the umbilical a.
Author Sensitivity
Trudinger et al.
1986
Weiss et al.
1989
Our results
199 1
Specificity %
Sensitivity %
Specificity %
Sensitivity %
Specificity %
Sensitivity %
Specificity %
CTG Doppler
36
88
67
74
69
89
UA
60
85
87
67
76
85
139

Doppler Ultrasound and the Cardiotocogram
3
Table 15.4 Comparison of the validity of predictions of
neonatal acidosis by CTG and Doppler ultrasound examination
of the umbilical a.
Author Sensitivity
Specificity
Weiss et al. 1989 Sensitivity %
Specificity %6774
Our results 1991 Sensitivity %
Specificity %8189
CTG Doppler
umbilical a.
87
67
84
84
Comparing Tests to Predict Neonatal Acidosis
Comparisons between tests that predict neonatal acidosis are not subject to the considerations applied to
Apgar scores. While lower Apgar scores are thought to
be more prevalent in a population that includes a
higher proportion of premature births and cesarean
sections, the pH of the umbilical cord is considered to
be a more objective parameter. Table
superiority of Doppler ultrasound, which is more sensitive, though this is again achieved at the cost of a reduced specificity (greater rate of false positives).
Information Lead Time Using Doppler Ultrasound
A test with greater lead time in providing information
relevant to a later event can contribute greatly to the
improvement of obstetric monitoring and decisionmaking. This is especially true of tests that capture and
monitor fetal risks developing over time into chronic
conditions. These conditions include growth restriction due to placental insufficiency, multiple pregnancies with discordant growth, and hypertension of pregnancy. Before the introduction of Doppler ultrasound,
the CTG was the method of choice for monitoring pregnancies that carried an increased perinatal risk.
%
100
90
80
70
60
50
40
30
20
10
0
< 1 1-2 3-5 6-10 11-30 31-50 Days
an early warning system when monitoring a high-risk
population before delivery, we examined in our own
population the interval from the first sign of an abnormal Doppler finding in the umbilical a. (reading of
쏜97% of the normal curve) to the development of an
abnormal CTG and the indication for a primary cesarean section (
curve shows an interval of three to five days and more
(up to 50 days) in 50% of this population. In 85% of
cases the interval was 24−48 hours, an interval that
gives an obstetric attendant a relatively long time to
prepare. In 15% of cases action was required on the
same day. This is a frequent observation in perinatal
centers, where high-risk patients arrive from outlying
clinics at short notice. The longest time intervals, i. e.,
the earliest advance warning compared to the CTG,
was obtained when Doppler ultrasound was introduced at the earliest possible moment, for example, at
the first hint of an impending problem, or when the
risk was suggested by history. In a literature review
Schneider et al. (1989) give an average time interval of
seven days. Laurin et al. (1987) and Jouppila et al.
(1986), who managed a caseload similar to our own,
agreed that the median interval was three days.
컅 Fig. 15.1 Relative incidence of time intervals from the first ab-
normal Doppler record in the umbilical a. to the development of
an abnormal CTG and the indication for primary cesarean section (after Voigt 1991).
15.4 shows the
In order to test if Doppler ultrasound can be used as
F
ig.
15.1). The cumulative percentage
140

Clinical Significance of Doppler Ultrasound
Clinical Significance of Doppler Ultrasound
The clinical significance of any new monitoring pro-
cedure in obstetrics can be judged by whether it pro-
vides a better basis for decision-making and improves
the condition of the neonate. Until the development
and validation of our own reference curves we could
only use retrospective reviews of study results. Once
obstetric attendants became aware of these Doppler
findings, they were able to use them to assess clinical
abnormalities and to make decisions, and prospective
studies became a reality. Since the previously established monitoring procedures and pediatric management did not change, it was possible to compare populations studied retrospectively and prospectively.
5.5 and 15.6 sho
bles 1
w the results of this comparison.
Ta-
In this study no significant differences between
groups were found when flows were normal. When
Doppler findings were abnormal, both populations required early delivery equally, on average at 34−35
weeks of gestation.
As regards type of delivery, in the prospective group
cesarean sections for asphyxia declined from 20% to
6%, emergency cesarean sections increased from 14.8%
to 23.9%, and elective cesarean sections from 18.5% to
30%. From these significant differences it can be concluded that in the prospective group the obstetric attendant was less frequently surprised by a threatening
asphyxia. When the circumstances leading to emer-
gency cesarean sections were examined, oxytocin
augmentation or induction of labor with prostaglandin
and stand-by cesarean section were found more
frequently. The clear increase in the rate of elective
cesarean sections demonstrated that the clinical situation often led to elective cesarean section before the
need to resort to emergency cesarean section.
Where Doppler findings were abnormal in the
younger population, the incidence of acidosis was significantly lower and could no longer be distinguished
from that of populations with normal flow rates. The
difference previously noted could no longer be demon-
15.7).
strated (
Table
Hence it remains established that Doppler sonography is an outstanding “early warning system” for a
slowly developing threat to fetal well-being resulting
from chronically impaired nutritional supply. In such
cases it offers advance warning of several days before
the CTG. Moreover,it can lead to a significant reduction
in the incidence of acidosis if the Doppler findings are
considered when making decisions regarding the type
of delivery.
However, we wish to point out again that threats to
the fetus arising acutely, such as acute placental in-
Table 15.5 Comparison of the history of one population examined “retrospectively” and one examined “prospectively” by
Doppler ultrasound. “Retrospective” means that a Doppler examination was performed, but no conclusions were drawn from
it; “prospective” means that the Doppler finding contributed
materially to the decision regarding the mode of delivery.
Doppler
finding
Umbilical a. Delivery weeks 39.5 40 n.s.
Doppler
finding
normal Median UA pH 7.27 7.29 n.s.
Umbilical a. Delivery weeks 34.4 35 n.s.
Doppler
finding
abnormal Median UA pH 7.23 7.28 *
Parameter Population examined
Mode of
delivery
Mode of
delivery
Retrospective
− − n.s.
Table 15.6 Table 15.6 *
Prospective
n.s. = not significant * p 쏝0.5
Table 15.6 Rate and type of section in the “retrospective” and
“prospective” populations with abnormal Doppler findings
Rate and type of section Population examined
Section rate 53.3% 59.9% n.s.
Emergency section,
section for asphyxia
Urgent section 14.8% 23.9% *
Elective section 18.5% 30% *
Retrospective Prospective
20% 6% **
n.s. = not significant * p ⬍ 0,05 ** p ⬍ 0,01
Table 15.7 pH values in the umbilical arteries of the “retrospective” and “prospective” populations with abnormal Doppler findings
Doppler
finding
Umbilical a Median n.s.
Doppler
finding
normal (range) (7.13−7.40)
Umbilical a Median *
Doppler
finding
abnormal (range) (6.98−7.32) (7.08−7.38)
pH value in
umbilical a.
umbilical a. pH 7.27 7.29
umbilical a. pH 7.23 7.28
Population examined
Retrospective
Prospective
n.s. = not significant * p 쏝0.5
sufficiency in a previously normal pregnancy, cannot
be detected by Doppler examination, especially after
the 38th week of pregnancy (cf.
Chap
16, p. 143). In
ter
this situation CTG is clearly superior.
Advanced Topics
141

3
142

16 Doppler Ultrasound Findings Near Term
To estimate the time of delivery and determine
whether the fetus is postterm, an ultrasound examina-
tion must be performed early in pregnancy. It should
include crown−rump measurement and correction of
gestational age if indicated.
Physiological Findings in the Late Stages of Pregnancy
Late pregnancy and delivery are marked by increased
demands by the fetus with only minimal growth of the
supply organ, the placenta.
The blood flow rate in the uterine aa. increases
steadily throughout pregnancy, from 190 mL/min
before pregnancy to about 680 mL/min in late pregnancy. The mean diameter of the uterine a. expands
from 1.6 mm before pregnancy to 3.7 mm near term.
The ratio of the mean peak systolic velocity to the
mean maximal end-diastolic velocity decreases from a
mean value in the non-pregnant woman of 5.3 (resistance index [RI]: 0.81) to 2.3 (RI: 0.57) near term.
The mass of the placenta increases steadily from
about 6 g at six weeks’ amenorrhea to over 500 g at
term. The fetus grows considerably faster than the
placenta, with the result that the ratio of the weight of
the placenta to that of the fetus decreases from 1.16 at
16weeks to 0.13 at term. Very early Doppler recordings
show a rise of mean placental perfusion in the course
of pregnancy from ca. 100 mL/min at 22 weeks of gestation to a maximum of over 320 mL/min at 37−38
weeks. After that the last two weeks show a regression
to ca. 300 mL/min. The relation of the infant’s weight to
blood flow volume is constant at 120 mL/kg/min until
the 36th to 37th week of pregnancy. During the final
stage of pregnancy this number, too, may regress to
90 mL/kg/min. At the same time the RI declines from
0.6 at 28 weeks of gestation to 0.5 at term.
Concurrently,the quantity of amniotic fluid declines,
and the vernix caseosa disappears from the fetal skin, a
sign that the nutritive function of the placenta is reduced.
The signs of maternal adaptation to the pregnancy
gradually disappear: The hematocrit rises again, the
blood pressure returns to its value before the pregnancy, the sensitivity to angiotensin II returns to normal values, and edema of pregnancy may subside.
The conditions affecting the responses of the fetal
circulation include a relative reduction in placental
tissue available for nutrition and gas exchange, as
well as an absolute reduction in fetoplacental blood
flow.
Aorta: Quantitative Analysis
In the early years of Doppler ultrasound use in obstetrics, quantitative measurements were obtained
from the uteroplacentofetal unit. The largest vessel
that can be accessed easily is the aorta. Hence one of
the first reported results was that of a relative blood
flow in the descending aorta of 185 (앧7.6)mL/min/kg
estimated fetal weight.
A number of groups determined and published other
parameters during the course of pregnancy. Mean
blood flow velocity (temporal average of spatial average velocity [TASAV]) ran between 26.5 cm/s and
34.6 cm/s, with a median of 29.0 cm/s. The relative
mean blood flow amounted to between 169 mL/min/
kg and 246 mL/min/kg, with a median of 220 mL/min/
kg. The systolic peak velocity (Mv
70 cm/s and 118 cm/s, with a median of 100 cm/s. At
term mean aortic stroke volume was reported to be 5.4
(앧 1.6) mL, the relative aortic stroke volume 1.8 (앧 0.5)
mL. The mean systolic diameter of the aorta was 7.3 (앧
1.1) mm, the mean diastolic diameter 6.3 (앧 1.1) mm.
The mean effective aortic diameter, determined by
echo markers, was 7.0 (앧 1.1) mm.
In our own study of blood flow in the descending
aorta we found that most values increased between
the 24th week of gestation and delivery, though the
range was wide.
All quantitative determinations of blood flow, then,
varied widely both in normal and abnormal pregnancies. One reason for this was the equivocal and imprecise determination of the diameter of fetal blood vessels by ultrasound. Clinicians were disappointed, since
their expectation that ultrasound would provide them
with a precise method to measure blood flows was not
fulfilled.
) was between
max
Advanced Topics
143
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