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Файл:Antibiotics. Study aid
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51
Task 6. Match chemotherapy drugs to their point of application (A–E) and
type of action (a, b) depending on the mechanism of action (1–3).
Drugs
Application point
Mechanism of
action
Action type
Cefotaxime
A. Inhibits peptidyl
translocase, disrupts the
transfer of amino acids to a
new polypeptide growing
on the ribosome
1. Protein synthesis
in a microbial cell is
disrupted
a.
Bacteriostatic
Azithromycin
B. Interacts with the
aminoacyl part of the
tRNA-amino acid complex,
the interaction of the tRNA-amino acid complex
with the large subunit of the
ribosome is disrupted
2. Violates the
synthesis of the cell
wall
b.
Bactericidal
D А В
С
52
Streptomycin
C. Inhibits transpeptidase,
disrupts the closure of the
polypeptide bridge between
the heteropolymer chains in
murein
3. Increases the
permeability of the
cell membrane of
the microorganism
for both intra- and
extracellular
components
Сhloramphenicol
D. Interacts with anionic
sites of the cell membrane
of the microorganism, the
structure of the membrane
is damaged (detergent-like
action)
Polymyxin
E. Interacts with a region of
the small subunit of the
ribosome, the interaction of
i-RNA with the ribosome in
the microbial cell is
disrupted
Task 7. Determine the compliance of drugs with the point of application
and establish the direction of action (+ or –).
Drugs
Enzymes
Lamivudine
Dihydropteroate synthetase
Azithromycin
Dihydrofolate reductase
Sulbactam
DNA gyrase
Terbinafine
Reverse transcriptase
Trimethoprim
Penicillinase
Sulfadimezin
Squalene epoxidase
Cefotaxime
Transpeptidase
Ciprofloxacin
Peptidyltranslocase
53
BIBLIOGRAPHY
1. Kharkevitch D.A. Pharmacology : textbook for medical students / translation
of Russian textbook «Pharmacology» (2017), 12th edition, revised and improved. —
2nd edition. — Moscow : GEOTAR Media, 2018. — 680 p.
2. Венгеровский А.И. Фармакология : учебник. — Москва : ГЭОТАР-
Медиа, 2020. — 848 с.
3. Михайлов И.Б. Клиническая фармакология : учебник для студентов
медицинских вузов. — 6-е изд., перераб. и доп. — Санкт-Петербург : СпецЛит,
2019. — 637 с.
4. Аляутдин Р.Н., Преферанский Н.Г., Преферанская Н.Г. Фармакология /
под редакцией Р.Н. Аляутдина. — М.: ГЭОТАР-Медиа, 2020. — 441 с.
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