Добавил:
Sekretar
kiopkiopkiop18@yandex.ru
t.me/Prokururor I Вовсе не секретарь, но почту проверяю
Опубликованный материал нарушает ваши авторские права? Сообщите нам.
Вуз:
Предмет:
Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5883_Библиотеки_им_академика_М_И_Перельмана
.pdf
Medicinal Plants – Chemical, Biochemical, and Pharmacological Approaches
41
https://t.me/medicina_free
Secondary metabolite Host plant Endophyte Strain Ref
Lycopodium
serratum
H. serrata Shiraia sp. Fungal [155]
Phlegmariurus
phlegmaria
H. serrata Colletotrichum sp., Ascomycota sp.,
Phlegmariurus
taxifolius
H. serrata Fusarium sp. Fungal [170]
CPT and active derivative 10-hydroxyCPT, podophyllotoxin, deoxypodophyllotoxin act as anticancer, and Huperzine A
approved for treatment of Alzheimer’s disease.
Penicillium chrysogenum Fungal [154]
Cladosporium cladosporioides Fungal [156]
Aspergillus flavus Fungal [157]
Shiraia bambusicola Fungal [158]
Colletotrichum gloeosporioides Fungal [159]
Trichoderma sp. Fungal [160]
Paecilomyces tenuis Fungal [161]
Penicillium sp. Fungal [162]
Ceriporia lacerate Fungal [163]
Sarcosomataceae sp., Dothideomycetes sp.
Penicillium sp. Fungal [165]
Alternaria brassicae Fungal [166]
Penicillium polonicum, Colletotrichum
gloeosporioides
Mucor racemosus, M. fragilis, Fusarium
verticillioides, F. oxysporum,Trichoderma
harzianum
Fusarium sp. Fungal [169]
Fungal [164]
Fungal [167]
Fungal [168]
Table 3.
Production of plant-derived secondary metabolites by endophytic microorganisms.
3.4 Podophyllotoxin
Podophyllotoxin is an aryltetralin lignin that uses in the synthesis of anticancer
drugs. It is originally isolated from the resins of the Podophyllum emodi, which is
traditionally used to treat genital warts [16]. Podophyllotoxin is a strong inhibitor of
microtubules, while its derivatives inhibit topoisomerase 2. These derivatives are used
to treat bronchial and testicular cancers. Podophyllotoxin production from endophytic
fungi isolated from Podophyllum [syn. Sinopodophyllum] hexandrum, Diphylleia
sinensis, and Dysosma veitchii were reported for the first time [134]. After that, two
strains of the endophytic fungus Phialocephala fortinii from the rhizome of
P. peltatum, which could produce podophyllotoxin under axenic culture conditions,
were isolated and identified [138]. The fungus Trametes isolated from P. hexandrum is
another endophyte capable of producing podophyllotoxin and podophyllotoxin glycosides [139]. In addition, F. oxysporum and Aspergillus endophytes isolated from
10
The
42
https://t.me/medicina_free
Endophytes: A New Resource for Vulnerable Plant Bioactive Compounds
ITexLi.112931
Juniperus
phyllotoxin,
reported
found
fungi
and
podophyllotoxin-producing
ium
among
Fungal production of podophyllotoxin is promising for mass production, and it is
possible
cultivation
reducing
producing
3.5
recurva and Juniperus communis produced podophyllotoxin and deoxypado-
respectively [141, 151]. Podophyllotoxin production has also been
from Mucor fragilis, and Alternaria tenuissima isolated from P. emodi was
to
produce podophyllotoxin [143, 144]. Podophyllotoxin-producing endophytic
Penicillium sp., Trametes sp., Purpureocillium sp., Aspergillus sp. Ganoderma sp.,
Fusarium spp. were isolated from plants of Dysosma spp. [149, 150].
fungi belong to Penicillium sp., Alternaria sp., and Fusar-
spp. genera, respectively, While there is no report of podophyllotoxin production
endophyte bacteria (Table 3).
to
provide affordable resources for commercial production by optimizing the
methods and genetic changes of the producing microorganisms and
the pressure of harvesting from plant resources and giving the chance to
plants for save from extinction.
Huperzine A
Most
The lycopod
called
Huperzine A (HupA), which has attracted worldwide attention for its potential
the treatment of Alzheimer’s disease. This compound is an acetylcholinesterase
in
inhibitor
by
highly selective and reversible inhibition of this enzyme and blocking its activity.
bulk of HupA is obtained from the Huperziaceae family. The H. serrata has a
The
narrow
which
phyte
HupA
cladosporioides isolated from H. serrata leaves also produced HupA [155, 156, 158].
general,
These
ing
Xia and colleagues isolated endophytic fungi
verticillioides,
can
cessfully
acetylcholinesterase
phytes,
tion
strategy
genetic
geographical distribution, slow growth rate, and very low HupA content,
limits its natural harvest and HupA extraction. In the first report, the endo-
Acremonium sp. isolated from H. serrata has been capable of production
[152]. Similarly, the endophyte Shiraia sp. Slf14 and Cladosporium
32
fungal endophytes were isolated from members of Huperziaceae family, includ-
H. serrata, Phlegmariurus phlegmaria, and Phlegmariurus taxifolius (Table 3) [171].
inhibit acetylcholinesterase enzyme [168]. The endophyte Ceriporia lacerate suc-
transformed HupA into five different compounds that showed potential
is
of
HupA has positive economic and environmental effects. This will be a practical
to
manipulation of the source fungi.
Huperzia serrata is the main source of a natural lycopodium
that increases the availability of acetylcholine in central cholinergic synapses
alkaloid
of
endophytic fungi belonging to 15 genera were recorded to produce Hup A.
Mucor racemosus, M. fragilis, Fusarium
F. oxysporum, and Trichoderma harzianum from the H. serrata, which
inhibitory activity [172]. Biotransformation, using fungal endo-
also a valuable approach to producing HupA derivatives. Microbial produc-
meet the global market demand through microbial fermentation and
In
4. Industrial
The role of plant compounds in the production of many clinically effective anti-
cancer
expected.
many
certain
of
11
drugs is undeniable, but the production of herbal drugs is not always as
of
environmental conditions, stress, or availability of nutrients. Also, the growth
plants is slow, and to collect and extract some products, they must reach acceptable
aspects
Because their production from plant resources faces serious challenges,
these compounds are produced at a certain stage of plant growth or under
Medicinal Plants – Chemical, Biochemical, and Pharmacological Approaches
43
https://t.me/medicina_free
growth. On the other hand, production in plant cell culture also faces technical challenges. Also, due to the extent and variety of bioactive in plants, the purification
processes of the desired effective substances will be complicated and therefore
expensive. Due to the limitations identified with the productivity and vulnerability of
plant species as sources of new metabolites, microorganisms act as an available and
inexhaustible resource of new pharmaceuticals [173].
Over many years, seasonal and climatic factors have caused failure in
traditional methods of extracting bioactive from natural resources. The environmental
issues that researchers face during the extraction of bioactive from plants make it
necessary to adopt new approaches to obtain these compounds [174]. In the future,
with the increase in population, the demand for pharmaceutical and agricultural
products will increase day by day, and the future of endophytic fungi for the
isolation of various beneficial compounds is bright. There is a great need to discover
bioactive compounds from natural resources that can be used to treat various diseases.
Recently, more attention has been paid to the production of bioactive from endophytic fungi because they are excellent for exploiting the biosynthetic pathway for the
synthesis of bioactive. The main challenge is the low yield of desired active compounds obtained from endophytes. However, to meet the demand of pharmaceutical
companies to increase the commercial production of drugs, genetic engineering technologies, drug design techniques, and microbial fermentation technology can be solutions to increase the rate of endophyte production [2]. In addition, the use of cell cocultures of host plants and endophytes has improved the production rate. Some
secondary metabolites may be produced by combined endophyte and host activity.
Some endophytic bacteria produce secondary metabolites in medicinal plants. For
example, Bacillus altitudinis, Burkholderia sp., and Flavobacterium sp. act as
effective stimulators that increase ginsenoside concentrations by converting the
major ginsenoside Rb1 to the minor ginsenoside Rg3 in the valuable medicinal plant
ginseng [175–177]. Such biotransformations using endophytic bacteria have
significant potential to intensify the accumulation of rare active substances in
medicinal plants. The endophytic Pseudomonas fluorescens can increase the
production of sesquiterpenoids in Macrocephala Atractylodes [178]. The endophyte
Bacillus subtilis in the plant Chuanxiong Ligusticum enhances ligustrazine
accumulation [179].
The interaction of endophytes with plant tissues asymptomatically increases the
production of secondary metabolites. A double synthesis of podophyllotoxin was
obtained from the interaction of endophytic fungi Phialocephala fortinii and rhizomes
of P. peltatum [138]. Endophytic fungi Stemphylium amaranthi and Gliomastix
masseei can be used as fungal stimulants to improve indole alkaloid production from
C. roseus [180].
5. Conclusion
Throughout history, humans have used plants and plant-derived products to treat
various ailments. Plant secondary metabolites or bioactive are known to be synthesized by plants. Microbes living inside host plant tissues are also known for their
ability to synthesize substances similar to those synthesized by the host plant. Secondary metabolites, such as alkaloids, flavonoids, terpenoids, steroids, etc. synthesized by microbes, are known for their vital role as antioxidants and anticancer. The
discovery of the ability to produce plant secondary metabolites in endophytes has
12
The
44
https://t.me/medicina_free
Endophytes: A New Resource for Vulnerable Plant Bioactive Compounds
ITexLi.112931
many hopes for the production of these compounds on an industrial scale.
raised
Microorganisms
substances
possibility of their genetic manipulation is easier, and the fermentation conditions
the
them are simpler, cheaper, and more diverse.
for
reduce environmental concerns about the production of biological
in
plants because endophytic microbes have a high reproduction ability,
Medicinal Plants – Chemical, Biochemical, and Pharmacological Approaches
45
https://t.me/medicina_free
References
[1] Ezeobiora CE, Igbokwe NH, Amin DH,
Mendie UE. Endophytic microbes from
Nigerian ethnomedicinal plants: A
potential source for bioactive secondary
metabolites—A review. Bulletin of the
National Research Centre. 2021;45(1):1-10
[2] Rana KL, Kour D, Kaur T, Devi R,
Negi C, Yadav AN, et al. Endophytic
fungi from medicinal plants: Biodiversity
and biotechnological applications. In:
Microbial Endophytes. Sawston, UK:
Elsevier; 2020. pp. 273-305
[3] Segaran G, Sathiavelu M. Fungal
endophytes: A potent biocontrol agent
and a bioactive metabolites reservoir.
Biocatalysis and Agricultural
Biotechnology. 2019;21:101284
[4] Hassani M, Durán P, Hacquard S.
Microbial interactions within the plant
holobiont. Microbiome. 2018;6(1):1-17
[5] Wu W, Chen W, Liu S, Wu J, Zhu Y,
Qin L, et al. Beneficial relationships
between endophytic bacteria and
medicinal plants. Frontiers in Plant
Science. 2021;12:646146
associated plant secondary metabolites:
Progress, challenges, and opportunities.
In: Metabolomics. Rijeka, Croatia:
InTechOpen; 2012. pp. 241-266
[10] Kaul S, Gupta S, Ahmed M,
Dhar MK. Endophytic fungi from
medicinal plants: A treasure hunt for
bioactive metabolites. Phytochemistry
Reviews. 2012;11:487-505
[11] Kusari S, Spiteller M. The promise of
endophytic fungi as sustainable resource
of biologically relevant pro-drugs: A
focus on Cameroon. In: Fungi. Boca
Raton, FL, USA: CRC Press; 2018.
pp. 1-13
[12] Saxena S, Meshram V, Kapoor N.
Muscodor tigerii sp. nov.-volatile
antibiotic producing endophytic fungus
from the Northeastern Himalayas. Annals
of Microbiology. 2015;65(1):47-57
[13] Ludwig-Müller J. Plants and
endophytes: Equal partners in secondary
metabolite production? Biotechnology
Letters. 2015;37:1325-1334
[6] Gouda S, Das G, Sen SK, Shin H-S,
Patra JK. Endophytes: A treasure house
of bioactive compounds of medicinal
importance. Frontiers in Microbiology.
2016;7:1538
[7] Priyadarshini MS, Panigrahi S,
Rath C. Endophytes: Novel
Microorganisms for Plant Growth
Promotion. Tamil Nadu, India: Darshan
publishers; 2022
[8] Hodkinson TR, Doohan FM,
Saunders MJ, Murphy BR. Endophytes
for a Growing World. Cambridge, UK:
Cambridge University Press; 2019
[9] Kusari S, Spiteller M. Metabolomics
of endophytic fungi producing
[14] Ek-Ramos MJ, Gomez-Flores R,
Orozco-Flores AA, Rodríguez-Padilla C,
González-Ochoa G, Tamez-Guerra P.
Bioactive products from plantendophytic gram-positive bacteria.
Frontiers in Microbiology. 2019;10:463
[15] Pan S-Y, Zhou S-F, Gao S-H, Yu Z-L,
Zhang S-F, Tang M-K, et al. New
perspectives on how to discover drugs
from herbal medicines: CAM's
outstanding contribution to modern
therapeutics. Evidence-Based
Complementary and Alternative
Medicine. 2013;2013:627375
[16] Meshram V, Gupta M. Endophytic
fungi: A quintessential source of
The
46
https://t.me/medicina_free
Endophytes: A New Resource for Vulnerable Plant Bioactive Compounds
ITexLi.112931
potential bioactive compounds.
Endophytes for a Growing World. 2019;
277:277-309
[17] Stierle A, Strobel G, Stierle D. Taxol
and taxane production by taxomyces
andreanae, an endophytic fungus of
Pacific yew. Science. 1993;260(5105):
214-216
[18] Stierle AA, Stierle DB. Bioactive
secondary metabolites produced by the
fungal endophytes of conifers. Natural
Product Communications. 2015;10(10):
1671-1682
[19] Strobel G, Hess W, Ford E, Sidhu R,
Yang X. Taxol from fungal endophytes
and the issue of biodiversity. Journal of
Industrial Microbiology. 1996;17:417-423
[20] Li J-y, Strobel G, Sidhu R, Hess W,
Ford EJ. Endophytic Taxol-producing
fungi from bald cypress, taxodium
distichum. Microbiology. 1996;142(8):
2223-2226
[21] Landry N. Bacterial Mass Production
of Taxanes with Erwinia. US5561055A:
Google Patents; 1996
[22] Strobel GA, Hess W, Li J-Y, Ford E,
Sears J, Sidhu RS, et al. Pestalotiopsis
guepinii, a Taxol-producing endophyte
of the Wollemi pine, Wollemia nobilis.
Australian Journal of Botany. 1997;45(6):
1073-1082
[23] Li J, Sidhu R, Ford E, Long D,
Hess W, Strobel G. The induction of
Taxol production in the endophytic
fungus—Periconia sp from Torreya
grandifolia. Journal of Industrial
Microbiology and Biotechnology. 1998;
20:259-264
[24] Su K. Screening of Taxol-producing
endophytic fungi from Ginkgo biloba
and Taxus cuspidate in Korea.
Agricultural Chemistry and
Biotechnology. 1999;42:97-99
[25] Caruso M, Colombo A, Fedeli L,
Pavesi A, Quaroni S, Saracchi M, et al.
Isolation of endophytic fungi and
actinomycetes taxane producers. Annals
of Microbiology. 2000;50(1):3-14
[26] Page M, Landry N, Boissinot M,
Helie M-C, Harvey M, Gagne M.
Bacterial Mass Production of Taxanes
and Paclitaxel. WO1999032651A1:
Google Patents; 2000
[27] Wang B, Li A, Wang X. An
endophytic fungus for producing Taxol.
Science in China Series C. 2001;31:271-274
[28] Guo B, Wang Y, Zhou X, Hu K,
Tan F, Miao Z, et al. An endophytic
Taxol-producing fungus BT2 isolated
from Taxus chinensis var. mairei.
African Journal of Biotechnology. 2006;
5(10):875-877
[29] Hu K, Tan F, Tang K, Zhu S,
Wang W. Isolation and screening of
endophytic fungi synthesizing Taxol
from Taxus chinensis var. mairei. Journal
of Southwest China Normal University
(Natural Science Edition). 2006;31:
134-137
[30] Renpeng T, Qiao Y, Guoling Z,
Jingquan T, Luozhen Z, Chengxiang F.
Taxonomic study on a Taxol producing
fungus isolated from bark of Taxus
chinensis var. mairei. Wuhan zhi wu xue
yan jiu= Wuhan Botanical Research.
2006;24(6):541-545
[31] Cheng L, Ma Q, Tao G, Tao W,
Wang R, Yang J, et al. Systemic
identification of a paclitaxel-producing
endophytic fungus. Industrial
Microbiology. 2007;37:23-30
[32] Zhou X, Wang Z, Jiang K, Wei Y,
Lin J, Sun X, et al. Screening of Taxol-
Medicinal Plants – Chemical, Biochemical, and Pharmacological Approaches
47
https://t.me/medicina_free
producing endophytic fungi from Taxus
chinensis var. mairei. Applied
Biochemistry and Microbiology. 2007;
43:439-443
[33] Gangadevi V, Muthumary J. Taxol,
an anticancer drug produced by an
endophytic fungus Bartalinia
robillardoides Tassi, isolated from a
medicinal plant, Aegle marmelos Correa
ex Roxb. World Journal of Microbiology
and Biotechnology. 2008;24:717-724
[34] Gangadevi V, Murugan M,
Muthumary J. Taxol determination from
Pestalotiopsis pauciseta, a fungal
endophyte of a medicinal plant. Chinese
Journal of Biotechnology. 2008;24(8):
1433-1438
[35] Dai W, Tao W. Preliminary study on
fermentation conditions of Taxolproducing endophytic fungus. Chemical
Industry and Engineering Progress.
2008;27(6):883-886
[36] Kumaran RS, Muthumary J, Hur B-
K. Taxol from Phyllosticta citricarpa, a
leaf spot fungus of the angiosperm Citrus
medica. Journal of Bioscience and
Bioengineering. 2008;106(1):103-106
[37] Sun D, Ran X, Wang J. Isolation and
identification of a Taxol-producing
endophytic fungus from Podocarpus.
Wei sheng wu xue bao= Acta
Microbiologica Sinica. 2008;48(5):
589-595
[38] Venkatachalam R, Subban K,
Paul MJ. Taxol from Botryodiplodia
theobromae (BT 115)—AN endophytic
fungus of Taxus baccata. Journal of
Biotechnology. 2008;136:S189-SS90
[39] Chang-Tian L, Yu L, Wang Q-J,
Sung C-K. Taxol production by
Fusarium arthrosporioides isolated from
yew, Taxus cuspidata. Journal of Medical
Biochemistry. 2008;27(4):454-458
[40] Senthil Kumaran R, Muthumary J,
Hur B. Production of Taxol from
Phyllosticta spinarum, an endophytic
fungus of Cupressus sp. Engineering in
Life Sciences. 2008;8(4):438-446
[41] Kumaran RS, Muthumary J, Hur B-
K. Isolation and identification of an
anticancer drug, Taxol from Phyllosticta
tabernaemontanae, a leaf spot fungus of
an angiosperm, wrightia tinctoria. The
Journal of Microbiology. 2009;47(1):
40-49
[42] Chakravarthi B, Das P,
Surendranath K, Karande AA,
Jayabaskaran C. Production of paclitaxel
by Fusarium solani isolated from Taxus
celebica. Journal of Biosciences. 2008;33:
259-267
[43] Zhao K, Ping W, Li Q, Hao S,
Zhao L, Gao T, et al. Aspergillus Niger
var. taxi, a new species variant of Taxolproducing fungus isolated from Taxus
cuspidata in China. Journal of Applied
Microbiology. 2009;107(4):1202-1207
[44] Deng BW, Liu KH, Chen WQ,
Ding XW, Xie XC. Fusarium solani, Tax3, a new endophytic Taxol-producing
fungus from Taxus chinensis. World
Journal of Microbiology and
Biotechnology. 2009;25:139-143
[45] Liu K, Ding X, Deng B, Chen W.
Isolation and characterization of
endophytic Taxol-producing fungi from
Taxus chinensis. Journal of Industrial
Microbiology and Biotechnology. 2009;
36(9):1171
[46] Zhang P, Zhou P-P, Yu L-J. An
endophytic Taxol-producing fungus
from Taxus media, Cladosporium
cladosporioides MD2. Current
Microbiology. 2009;59:227-232
[47] Zhang P, Zhou P-P, Yu L-J. An
endophytic Taxol-producing fungus
The
48
https://t.me/medicina_free
Endophytes: A New Resource for Vulnerable Plant Bioactive Compounds
ITexLi.112931
from Taxus x media, aspergillus
candidus MD3. FEMS Microbiology
Letters. 2009;293(2):155-159
[48] Miao Z, Wang Y, Yu X, Guo B,
Tang K. A new endophytic taxane
production fungus from Taxus chinensis.
Applied Biochemistry and Microbiology.
2009;45:81-86
[49] Kumaran RS, Muthumary J, Kim E-
K, Hur B-K. Production of Taxol from
Phyllosticta dioscoreae, a leaf spot
fungus isolated from Hibiscus rosasinensis. Biotechnology and Bioprocess
Engineering. 2009;14:76-83
[50] Gangadevi V, Muthumary J. A novel
endophytic Taxol-producing fungus
Chaetomella raphigera isolated from a
medicinal plant, Terminalia arjuna.
Applied Biochemistry and
Biotechnology. 2009;158:675-684
[51] Gangadevi V, Muthumary J. Taxol
production by Pestalotiopsis terminaliae,
an endophytic fungus of Terminalia
arjuna (arjun tree). Biotechnology and
Applied Biochemistry. 2009;52(1):9-15
[52] Zhao K, Sun L, Ma X, Li X, Wang X,
Ping W, et al. Improved Taxol
production in Nodulisporium sylviforme
derived from inactivated protoplast
fusion. African Journal of Biotechnology.
2011;10(20):4175-4182
[53] Pandi M, Kumaran RS, Choi Y-K,
Kim HJ, Muthumary J. Isolation and
detection of Taxol, an anticancer drug
produced from Lasiodiplodia
theobromae, an endophytic fungus of
the medicinal plant Morinda citrifolia.
African Journal of Biotechnology. 2011;
10(8):1428-1435
culture. African Journal of
Biotechnology. 2011;10(34):6647-6654
[55] Kumaran RS, Choi Y-K, Lee S,
Jeon HJ, Jung H, Kim HJ. Isolation of
Taxol, an anticancer drug produced by
the endophytic fungus, Phoma betae.
African Journal of Biotechnology. 2012;
11(4):950-960
[56] Mirjalili MH, Farzaneh M, Bonfill M,
Rezadoost H, Ghassempour A. Isolation
and characterization of Stemphylium
sedicola SBU-16 as a new endophytic
Taxol-producing fungus from Taxus
baccata grown in Iran. FEMS
Microbiology Letters. 2012;328(2):
122-129
[57] Garyali S, Kumar A, Reddy MS.
Taxol production by an endophytic
fungus, Fusarium redolens, isolated
from Himalayan yew. Journal of
Microbiology and Biotechnology. 2013;
23(10):1372-1380
[58] Yang Y, Zhao H, Barrero RA,
Zhang B, Sun G, Wilson IW, et al.
Genome sequencing and analysis of the
paclitaxel-producing endophytic fungus
Penicillium aurantiogriseum NRRL
62431. BMC Genomics. 2014;15(1):1-14
[59] Zaiyou J, Li M, Xiqiao H. An
endophytic fungus efficiently producing
paclitaxel isolated from Taxus
wallichiana var. mairei. Medicine. 2017;
96(27):e7406
[60] Qiao W, Ling F, Yu L, Huang Y,
Wang T. Enhancing Taxol production in
a novel endophytic fungus, Aspergillus
aculeatinus Tax-6, isolated from Taxus
chinensis var. mairei. Fungal Biology.
2017;121(12):1037-1044
[54] Bi J, Ji Y, Pan J, Yu Y, Chen H,
Zhu X. A new Taxol-producing fungus
(Pestalotiopsis malicola) and evidence
for Taxol as a transient product in the
[61] El-Sayed AS, Safan S, Mohamed NZ,
Shaban L, Ali GS, Sitohy MZ. Induction
of Taxol biosynthesis by Aspergillus
terreus, endophyte of Podocarpus
Medicinal Plants – Chemical, Biochemical, and Pharmacological Approaches
49
https://t.me/medicina_free
gracilior Pilger, upon intimate
interaction with the plant endogenous
microbes. Process Biochemistry. 2018;71:
31-40
[62] El-Sayed AS, Ali DM, Yassin MA,
Zayed RA, Ali GS. Sterol inhibitor
“fluconazole” enhance the Taxol yield
and molecular expression of its encoding
genes cluster from Aspergillus flavipes.
Process Biochemistry. 2019;76:55-67
[63] Gill H, Vasundhara M. Isolation of
Taxol producing endophytic fungus
Alternaria brassicicola from non-taxus
medicinal plant Terminalia arjuna.
World Journal of Microbiology and
Biotechnology. 2019;35:1-8
[64] Kumar P, Singh B, Thakur V,
Thakur A, Thakur N, Pandey D, et al.
Hyper-production of Taxol from
Aspergillus fumigatus, an endophytic
fungus isolated from Taxus sp. of the
Northern Himalayan region.
Biotechnology Reports. 2019;24:e00395
mutagenesis and immobilization
technique. Applied Microbiology and
Biotechnology. 2020;104(16):6991-7003
[68] Subramanian M, Marudhamuthu M.
Hitherto unknown terpene synthase
organization in Taxol-producing
endophytic bacteria isolated from
marine macroalgae. Current
Microbiology. 2020;77:918-923
[69] Abdel-Fatah SS, El-Batal AI, El-
Sherbiny GM, Khalaf MA, El-Sayed AS.
Production, bioprocess optimization and
γ-irradiation of Penicillium polonicum,
as a new Taxol producing endophyte
from Ginko biloba. Biotechnology
Reports. 2021;30:e00623
[70] Jagan EG, Sharma P, Sureshkumar S,
Pandi M. Isolation of Taxol and flavinlike fluorochrome from endophytic
fungi of Mangifera indica. Journal of
Pure & Applied Microbiology. 2021;15
(4):2195-2208
[65] El-Sabbagh SM, Eissa OAE,
Sallam MHE. Taxol production by an
endophytic fungus cladosporioides
isolated from Catheranthus roseus
Cladosporium. Egyptian Journal of
Experimental Biology (Botany). 2019;
15(1):13-28
[66] Suresh G, Kokila D, Suresh TC,
Kumaran S, Velmurugan P,
Vedhanayakisri KA, et al. Mycosynthesis
of anticancer drug Taxol by Aspergillus
oryzae, an endophyte of Tarenna
asiatica, characterization, and its activity
against a human lung cancer cell line.
Biocatalysis and Agricultural
Biotechnology. 2020;24:101525
[67] El-Sayed E-SR, Zaki AG, Ahmed AS,
Ismaiel AA. Production of the anticancer
drug Taxol by the endophytic fungus
Epicoccum nigrum TXB502: Enhanced
production by gamma irradiation
[71] Gauchan DP, Vélëz H, Acharya A,
Östman JR, Lundén K, Elfstrand M, et al.
Annulohypoxylon sp. strain MUS1, an
endophytic fungus isolated from Taxus
wallichiana Zucc., produces Taxol and
other bioactive metabolites. 3 Biotech.
2021;11(3):152
[72] Koutb M, Hassan E, El-Sokkary G,
Saber S, Hussein N. Paclitaxel
production by endophytic fungus,
neopestalotiopsis clavispora KY624416
and subsequent extraction of chitosan
from fungal biomass wastes. Global Nest
Journal. 2021;23(3):370-380
[73] Abdel-Fatah SS, El-Sherbiny GM,
Khalaf MA, El-Batal AI. Enhancement of
Taxol production by endophytic
fungi from Hibiscus and moringa plant
using gamma irradiation. Egyptian
Journal of Medical Microbiology. 2021;
30(4):9-17
The
50
https://t.me/medicina_free
Endophytes: A New Resource for Vulnerable Plant Bioactive Compounds
ITexLi.112931
[74] Mohammadi Ballakuti N, Ghanati F,
Zare-Maivan H, Alipour M,
Moghaddam M, Abdolmaleki P. Taxoid
profile in endophytic fungi isolated from
Corylus avellana, introduces potential
source for the production of Taxol in
semi-synthetic approaches. Scientific
Reports. 2022;12(1):9390
[75] Chowdhury DR, Chattopadhyay SK,
Roy S. Isolation and partial
characterization of bioactive
components of Endophytic fungi
Penicillium singorense, isolated from
two Indian medicinal plants: Calotropis
procera and Catharanthus roseus.
American Journal of Microbiological
Research. 2022;10(3):84-93
[76] Pandy R, Kumar SS, Suresh P,
Annaraj J, Pandi M, Vellasamy S, et al.
Screening and characterization of fungal
Taxol-producing endophytic fungi for
evaluation of antimicrobial and
anticancer activities. Open Chemistry.
2023;21:1
endophyte from Taxus wallichiana.
Applied Biochemistry and
Biotechnology. 2015;175:2224-2231
[81] Omeje EO, Ahomafor JE,
Onyekaba TU, Monioro PO, Nneka I,
Onyeloni S, et al. Endophytic fungi as
alternative and reliable sources for
potent anticancer agents. In: Natural
Products and Cancer Drug Discovery.
London, UK, Norderstedt, Germany:
IntechOpen; 2017. pp. 52-60
[82] Vasundhara M, Kumar A, Reddy MS.
Molecular approaches to screen bioactive
compounds from endophytic fungi.
Frontiers in Microbiology. 2016;7:1774
[83] Zhao J, Zhou L, Wang J, Shan T,
Zhong L, Liu X, et al. Endophytic fungi
for producing bioactive compounds
originally from their host plants. Current
Research, Technology and Education
Topics in Applied Microbiology and
Microbial Biotechnology. 2010;1:567-576
[77] Adhikari P, Singh M, Pandey A.
Production of Taxol by endophytic fungi
isolated from roots of Himalayan yew
(Taxus wallichiana Zucc.). Journal of
Graphic Era University. 2022;10(2):
195-216
[78] Wang Y, Tang K. A new endophytic
Taxol-and baccatin III-producing fungus
isolated from Taxus chinensis var.
mairei. African Journal of Biotechnology.
2011;10(72):16379-16386
[79] Zaiyou J, Li M, Guifang X, Xiuren Z.
Isolation of an endophytic fungus
producing baccatin III from Taxus
wallichiana var. mairei. Journal of
Industrial Microbiology and
Biotechnology. 2013;40(11):1297-1302
[80] Li Y, Yang J, Zhou X, Zhao W,
Jian Z. Isolation and identification of a
10-deacetyl baccatin-III-producing
[84] Gond S, Kharwar R, White J Jr. Will
fungi be the new source of the
blockbuster drug Taxol? Fungal Biology
Reviews. 2014;28(4):77-84
[85] Tejesvi MV, Pirttilä AM. Endophytic
fungi, occurrence, and metabolites. In:
Anke T, Schüffler A, editors. Physiology
and Genetics: Selected Basic and Applied
Aspects. Cham: Springer International
Publishing; 2018. pp. 213-230
[86] Cao X, Xu L, Wang J, Dong M, Xu C,
Kai G, et al. Endophytic fungus
Pseudodidymocyrtis lobariellae KL27
promotes Taxol biosynthesis and
accumulation in Taxus chinensis. BMC
Plant Biology. 2022;22(1):1-18
[87] Liu Q , Li L, Chen Y, Wang S, Xue L,
Meng W, et al. Diversity of endophytic
microbes in Taxus yunnanensis and their
potential for plant growth promotion
Соседние файлы в папке Библиотека им академика М.И. Перельмана