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68 Vascular Surgery
Данная книга находится в списке для перевода на русский язык сайта https://meduniver.com/
Fig. 7.1. Arteriogram demonstrating aneurysms of the right common iliac artery and left internal iliac artery.
Question 3
Which of the following are indications for operative treatment of popliteal artery aneurysm?
A. Size greater than 2 cm.
B. Swelling or pain in the affected leg.
C. Aneurysm of any size with mural thrombus.
D. Distal embolization.
Popliteal Artery Aneurysm 69
Fig. 7.2. Arteriogram demonstrating bilateral popliteal artery aneurysms.
Treatment
The patient underwent operative exploration of the left popliteal fossa through a medial approach. After proximal and distal control was obtained, the aneurysm was opened and all collateral flow into the aneurysm was obliterated. An interposition vein graft was placed from the distal superficial femoral artery to the distal popliteal artery. The patient subsequently underwent surgical treatment of the right popliteal artery aneurysm and endovascular treatment of the right common iliac artery aneurysm.
70 Vascular Surgery
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Question 4
Which of the following statements regarding the treatment of popliteal artery aneurysm is false?
A. Bypass and exclusion of the aneurysm is safe and effective.
B. Resection and endoaneurysmorrhaphy is safe and effective.
C. The medial approach is the preferred route of exposure.
D. Endoluminal stent grafting may be indicated in a high-risk patient.
E. For acute thrombosis, surgical thrombectomy has a higher limb salvage rate
than thrombolysis followed by surgical reconstruction.
Question 5
All of the following are true regarding the treatment of acute thrombosis of a popliteal artery aneurysm except:
A. Limb loss occurs in up to 50 percent of cases.
B. Thrombolysis improves the run-off and increases limb salvage.
C. Thrombolysis alone is adequate treatment.
D. Surgical thrombectomy is inferior to thrombolysis followed by surgical
reconstruction.
Commentary
Popliteal artery aneurysm is the most common type of peripheral aneurysm; the vast majority are caused by atherosclerosis. The typical patient is a male in his sixth or seventh decade. Popliteal artery aneurysm occurs bilaterally in approximately 60 percent of cases [1]. Approximately 80 percent of patients with bilateral popliteal artery aneurysm have other aneurysms elsewhere, and 1 percent of patients with abdominal aortic aneurysm (AAA) have popliteal artery aneurysm [2].
Diagnosis of popliteal artery aneurysm is relatively straightforward. Examination reveals a prominent pulsation or a pulsatile mass in the popliteal fossa. Duplex ultrasonography is the initial diagnostic test of choice because it can differentiate an aneurysm from other masses in the popliteal fossa and it can determine whether thrombus is present in the aneurysm. [Q1: C] Angiography is not sensitive for the documentation of an aneurysm, but it is crucial for evaluating the status of the distal arterial system. If the diagnosis can be made on physical examination, then one can proceed directly to angiography for operative planning.
The majority of patients with popliteal artery aneurysm are symptomatic at the time of diagnosis. Distal embolization is the most common form of presentation, followed by pain and/or swelling of the affected extremity due to compression of the
Popliteal Artery Aneurysm 71
adjacent nerves and veins. Rupture is rare and usually not life threatening. [Q2: D] However, rupture can lead to limb loss in 50–75% of cases due to associated limb ischemia [3].
Indications for operation include size of 2 cm or greater, aneurysm of any size with mural thrombus, any patient with pain and/or swelling due to compression of adjacent structures, and any symptoms of embolization. While some surgeons prefer to delay operation in asymptomatic patients until the aneurysm reaches 3 cm in size, we believe that an aggressive approach is justified because the majority of patients ultimately become symptomatic. Some authors advocate an aggressive approach to any small, asymptomatic popliteal artery aneurysm containing mural thrombus due to the high frequency of embolization in these cases [4]. [Q3: A, B, C, D] It is important to note that thromboembolization is the most common form of pre­sentation. Accepted forms of surgical treatment include bypass with complete exclusion of the aneurysm, bypass with partial or complete resection of the aneurysm if compressive symptoms are present, or endoaneurysmorrhaphy like the open repair of AAA. The medial approach is preferred over the posterior approach because it allows for better exposure of the distal superficial femoral artery and tibioperoneal trunk, easier access to the saphenous vein, and the ability to perform distal bypass if it becomes necessary. Autogenous vein is the preferred conduit since it provides better patency than prosthetic graft. Endoluminal stent grafting has not been proven, and theoretically it would seem to be inferior to surgical repair due to the small size of the stent graft required and the lower patency rates of prosthetic graft in this position. Nevertheless, it may be an option in a patient who is at high risk for a surgical procedure.
Distal embolization can cause tissue loss, but the more troubling consequence is the destruction of the run-off bed. This results in decreased patency of bypass grafts and an increased rate of limb loss. Further, there is a significant reduction in limb salvage and graft patency in symptomatic patients compared with asymptomatic patients. Numerous studies indicate that virtually all patients will become sympto­matic and that graft patency and limb salvage approach 100 percent in elective reconstruction [1–6]. This demonstrates the increased risk of complications and limb loss in untreated patients and underscores the importance of early treatment.
Acute thrombosis is a particularly vexing problem. While some may present with only claudication due to the previous development of collateral flow, many present with threatened limb loss. In the setting of acute thrombosis, the combined rate of primary and early amputation is 50 percent and operative mortality is 5 percent [7]. Thrombolysis followed by surgical treatment yields better graft patency and limb salvage than surgical thrombectomy. [Q4: E] Most likely, this is due to some degree of clearing of the run-off bed. Thrombolysis alone is inadequate treatment since surgical reconstruction is required to obliterate the aneurysm. [Q5: C]
References
1. Carpenter JP, Barker CF, Roberts B, Berkowitz HD, Lusk EJ, Perloff LJ. Popliteal artery aneurysms:
current management and outcome. J Vasc Surg 1994;19:65–72.
2. Whitehouse WM, Jr, Wake?eld TW, Graham LM, Kazmers A, Zelenock GB, Cronenwett JL, et al. Limb-
threatening potential of arteriosclerotic popliteal artery aneurysms. Surgery 1983;93:694–9.
3. Varga ZA, Locke-Edmunds JC, Baird RN. A multicenter study of popliteal aneurysms. J Vasc Surg
1994;20:171–7.
72 Vascular Surgery
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4. Ascher E, Markevich N, Schutzer RW, Kallakuri S, Jacob T, Hingorani AP. Small popliteal artery aneurysms: are they clinically significant? J Vasc Surg 2003;37:755–60.
5. Lowell RC, Gloviczki P, Hallett JW, Jr, Naessens JM, Maus TP, Cherry KJ, Jr, et al. Popliteal artery aneurysms: the risks of nonoperative management. Ann Vasc Surg 1994;8:14–23.
6. Anton GE, Hertzer NR, Beven EG, O’Hara PJ, Krajewski LP. Surgical management of popliteal aneurysms: trends in presentation, treatment and results from 1952 to 1984. J Vasc Surg 1986;3:125–34.
7. Reilly MK, Abbott WM, Darling RC. Aggressive surgical management of popliteal aneurysms. Am J Surg 1983;145:498–502.
8. Renal Artery Aneurysm
Lutz Reiher, Tomas Pfeiffer and Wilhelm Sandmann
A 45-year-old woman presented with a 10-year history of arterial hypertension. After initially successful conservative therapy with two antihypertensive drugs, arterial blood pressure was not controlled well during the last months. To exclude a renovascular origin of hypertension, an angiography was performed, which showed fibrodysplastic disease of the right renal artery with several stenotic segments and aneurysms (Fig. 8.1).
Question 1
Which of the following statements regarding renal artery aneurysm (RAA) is correct?
A. It has a marked female preponderance.
B. It is usually diagnosed during examination for flank pain.
C. It may cause arterial hypertension.
D. It typically leads to proteinuria by compression of the renal vein.
E. It can cause haematuria in rare cases.
Question 2
Which statements about the aetiology of the RAA are true ?
A. The most frequent underlying diseases of RAA are aortic coarctation with con-
comitant disease of the renal artery and renal artery dissection.
B. Fibromuscular dysplasia of the renal artery may present with renal artery steno-
sis (RAS), RAA or both.
C. Arteriosclerosis is a frequent cause of RAA.
73
74 Vascular Surgery
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Fig. 8.1. Selective intra-arterial renal artery angiography revealed RAA combined with renal artery stenosis due to fibromuscular dysplasia.
D. Some RAA present with inflammation of the arterial wall.
E. The incidence of RAAs is increased in Ehlers–Danlos syndrome and Marfan’s
syndrome
Question 3
Which risks of the spontaneous course of the RAA should you explain to your patient?
A. The RAA may rupture and lead to a life-threatening bleeding.
B. The risk of rupture decreases during pregnancy and childbirth.
C. Hypertension in RAA may be caused by concomitant stenosis of the renal artery
or its branches.
D. In cases of RAA and hypertension the angiography of the renal artery always
shows an additional RAS.
Renal Artery Aneurysm 75
E. The RAA may be a source of embolisation leading to a loss of renal function.
Question 4
Which of the following statements regarding the indication of renal artery repair (RAR) for RAA is correct?
A. There is an indication for RAR only in cases of symptoms other than
hypertension.
B. There is no reason to perform RAR in women of childbearing age if there is no
arterial hypertension.
C. There is a good indication for RAR if a concomitant RAS is found.
D. There is a good indication for RAR only if the RAA is larger than 5.5 cm.
E. There is an indication for RAR in patients presenting with RAA and hyperten-
sion even if an additional RAS is not detectable.
For RAR, a midline abdominal incision was performed for direct access to the infrarenal aorta, where an end-to-side anastomosis was performed with a segment of the patient’s greater saphenous vein. After Kocher’s manoeuvre, the distal renal artery was transected and anastomosed to the saphenous vein, which had been placed on the renal hilus dorsal to the inferior vena cava. Good results were shown by postoperative angiography (Fig. 8.2). At re-examination 3 years after the opera­tion, the patient had a normal blood pressure without antihypertensive medication.
Question 5
Which of the following statements regarding the management of RAA is correct?
A. Replacement of the diseased renal artery by prosthetic graft is the RAR of first
choice.
B. Protection of the kidney against ischaemic injury is performed only during ex
situ reconstruction of the renal artery.
C. RAA exclusion and aortorenal vein graft interposition, or RAA resection and
end-to-end anastomosis or aneurysmorrhaphy, are valuable methods for RAR.
D. Ex situ repair of the renal artery may be needed in cases presenting with lesions
of the distal branch arteries.
E. Tailoring of RAA often leads to recurrent aneurysmatic dilation of the renal
artery.
Commentary
RAAs do not usually cause symptoms, and generally they are diagnosed accidentally during work-up for hypertension, as in our patient. In rare cases, flank pain has
76 Vascular Surgery
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Fig. 8.2. Postoperative angiography demonstrates a patent aortorenal venous graft.
been described as the initial symptom, which may be due either to the size of the RAA or to a renal artery dissection. Rupture of the aneurysm into the urinary tract will lead to haematuria. [Q1: A, C, E] The underlying disease is most frequently dys­plasia of the arterial wall followed by arteriosclerosis. In our case, fibromuscular dysplasia was found to be the aetiology of the RAA. Rare causes of RAA may be atypical aortic coarctation with concomitant disease of the renal arteries, inflamma­tion of the arterial wall, dissection or trauma, or disorders of the elastic and colla­gen fibres (i.e. Ehlers–Danlos syndrome or Marfan’s syndrome). [Q2: B, C, D, E]
RAA is found about twice as often in the right renal artery as in the left. Selective angiography often reveals concomitant RAS of mainstem and segmental arteries, and segmental arteries may also be aneurysmal. Concomitant renal artery dissec­tion is rare.
Rupture of RAA, development or deterioration of arterial hypertension, and loss of renal function by thrombosis or embolisation, are impending spontaneous con­sequences of RAA.
Renal Artery Aneurysm 77
As with all arterial aneurysms, rupture is a possible complication of RAA. While Tham et al. [1] experienced no rupture of RAA in 69 patients who had been treated conservatively during a mean observation time of 4.3 years, Henriksson et al. [2] observed RAA rupture in four cases (10.2 percent), and at the time of rupture only a nephrectomy could be performed. There are several case reports about RAA rupture in pregnancy and childbirth [3–5], and one author found the probability of RAA rupture during pregnancy to be as high as 80 percent [6].
As high arterial blood pressure is in itself a risk factor for rupture of arterial aneurysms of any localisation, one can argue that hypertension per se is an indica­tion to remove an RAA. Hypertension was found in 90 percent of all patients with ruptured RAA [7].
The larger the diameter of the RAA, the more likely the danger of rupture seems to be, which can be explained by Laplace’s law. However, RAAs of any diameter can rupture. In one patient cohort [8], the smallest (1 cm) and the largest (16.5 cm) RAAs ruptured.
About eighty percent of patients with RAA have arterial hypertension [9, 10]. If RAA is accompanied by RAS on the same or the contralateral side, as in our patient, then it is reasonable to remove both, with the intention to improve hypertension and eliminate the risk of rupture. However, an ipsilateral stenosis may be missed by angiography due to overprojection of the aneurysm. Furthermore, aneurysmal disease includes not only dilation of vessels but also elongation, which might cause kinking with a relevant stenosis [11]. [Q3: A, C, E]
There is an absolute indication to remove RAAs in all patients with arterial hypertension with and without concomitant RAS and in women of childbearing age. [Q2: C] RAAs with a diameter greater than 2 cm should be removed, even if there is no hypertension. There are good long-term results for autologous RAR; therefore, there is a relative indication for operation in younger patients without hypertension and concomitant RAS with RAA of diameter of 1 cm or more. [Q4: C, E]
The most promising method of RAR is by autogenous reconstruction. Methods of RAR are replacement of the renal artery by the greater saphenous vein, resection of diseased sections and reanastomosis. The autoplastic reconstruction by tailoring (synonym: aneurysmorrhaphy) is another appropriate technique. Although the aneurysmatic wall is only resected partially, recurrent RAAs have not been observed. The in situ reconstruction is less traumatic, but ex situ repair of the renal artery may be necessary in cases in which not only the distal mainstem artery but also the segmental arteries are involved. [Q5: C, D]
If arterial repair is restricted to renal arteries only, and if concomitant repair of the aorta is not necessary, then a postoperative mortality of less than 1 percent can be expected. Postoperative morbidity is due to temporary kidney insufficiency, graft thrombosis, bleeding, thrombosis and pancreatitis. Affected kidneys can be pre­served in more than 85 percent of cases. The number of patients who benefit from surgical therapy in terms of improvement of arterial hypertension varies consider­ably between authors, ranging from 5 to 50 percent and from 25 to 62 percent, respectively [12].
References
1. Tham G, Ekelund L, Herrlin K, Lindstedt EL, Olin T, Bergentz SE. Renal artery aneurysms. Natural history and prognosis. Ann Surg 1983;197:348–52.