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68 Vascular Surgery
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Fig. 7.1. Arteriogram demonstrating aneurysms of the right common iliac artery and left internal iliac
artery.
Question 3
Which of the following are indications for operative treatment of popliteal artery
aneurysm?
A. Size greater than 2 cm.
B. Swelling or pain in the affected leg.
C. Aneurysm of any size with mural thrombus.
D. Distal embolization.

Popliteal Artery Aneurysm 69
Fig. 7.2. Arteriogram demonstrating bilateral popliteal artery aneurysms.
Treatment
The patient underwent operative exploration of the left popliteal fossa through a
medial approach. After proximal and distal control was obtained, the aneurysm was
opened and all collateral flow into the aneurysm was obliterated. An interposition
vein graft was placed from the distal superficial femoral artery to the distal popliteal
artery. The patient subsequently underwent surgical treatment of the right popliteal
artery aneurysm and endovascular treatment of the right common iliac artery
aneurysm.

70 Vascular Surgery
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Question 4
Which of the following statements regarding the treatment of popliteal artery
aneurysm is false?
A. Bypass and exclusion of the aneurysm is safe and effective.
B. Resection and endoaneurysmorrhaphy is safe and effective.
C. The medial approach is the preferred route of exposure.
D. Endoluminal stent grafting may be indicated in a high-risk patient.
E. For acute thrombosis, surgical thrombectomy has a higher limb salvage rate
than thrombolysis followed by surgical reconstruction.
Question 5
All of the following are true regarding the treatment of acute thrombosis of a
popliteal artery aneurysm except:
A. Limb loss occurs in up to 50 percent of cases.
B. Thrombolysis improves the run-off and increases limb salvage.
C. Thrombolysis alone is adequate treatment.
D. Surgical thrombectomy is inferior to thrombolysis followed by surgical
reconstruction.
Commentary
Popliteal artery aneurysm is the most common type of peripheral aneurysm; the
vast majority are caused by atherosclerosis. The typical patient is a male in his sixth
or seventh decade. Popliteal artery aneurysm occurs bilaterally in approximately 60
percent of cases [1]. Approximately 80 percent of patients with bilateral popliteal
artery aneurysm have other aneurysms elsewhere, and 1 percent of patients with
abdominal aortic aneurysm (AAA) have popliteal artery aneurysm [2].
Diagnosis of popliteal artery aneurysm is relatively straightforward.
Examination reveals a prominent pulsation or a pulsatile mass in the popliteal
fossa. Duplex ultrasonography is the initial diagnostic test of choice because it
can differentiate an aneurysm from other masses in the popliteal fossa and it
can determine whether thrombus is present in the aneurysm. [Q1: C]
Angiography is not sensitive for the documentation of an aneurysm, but it is
crucial for evaluating the status of the distal arterial system. If the diagnosis can
be made on physical examination, then one can proceed directly to angiography
for operative planning.
The majority of patients with popliteal artery aneurysm are symptomatic at the
time of diagnosis. Distal embolization is the most common form of presentation,
followed by pain and/or swelling of the affected extremity due to compression of the

Popliteal Artery Aneurysm 71
adjacent nerves and veins. Rupture is rare and usually not life threatening. [Q2: D]
However, rupture can lead to limb loss in 50–75% of cases due to associated limb
ischemia [3].
Indications for operation include size of 2 cm or greater, aneurysm of any size
with mural thrombus, any patient with pain and/or swelling due to compression of
adjacent structures, and any symptoms of embolization. While some surgeons
prefer to delay operation in asymptomatic patients until the aneurysm reaches 3 cm
in size, we believe that an aggressive approach is justified because the majority of
patients ultimately become symptomatic. Some authors advocate an aggressive
approach to any small, asymptomatic popliteal artery aneurysm containing mural
thrombus due to the high frequency of embolization in these cases [4]. [Q3: A, B, C, D]
It is important to note that thromboembolization is the most common form of presentation. Accepted forms of surgical treatment include bypass with complete
exclusion of the aneurysm, bypass with partial or complete resection of the
aneurysm if compressive symptoms are present, or endoaneurysmorrhaphy like the
open repair of AAA. The medial approach is preferred over the posterior approach
because it allows for better exposure of the distal superficial femoral artery and
tibioperoneal trunk, easier access to the saphenous vein, and the ability to perform
distal bypass if it becomes necessary. Autogenous vein is the preferred conduit since
it provides better patency than prosthetic graft. Endoluminal stent grafting has not
been proven, and theoretically it would seem to be inferior to surgical repair due to
the small size of the stent graft required and the lower patency rates of prosthetic
graft in this position. Nevertheless, it may be an option in a patient who is at high
risk for a surgical procedure.
Distal embolization can cause tissue loss, but the more troubling consequence is
the destruction of the run-off bed. This results in decreased patency of bypass grafts
and an increased rate of limb loss. Further, there is a significant reduction in limb
salvage and graft patency in symptomatic patients compared with asymptomatic
patients. Numerous studies indicate that virtually all patients will become symptomatic and that graft patency and limb salvage approach 100 percent in elective
reconstruction [1–6]. This demonstrates the increased risk of complications and
limb loss in untreated patients and underscores the importance of early treatment.
Acute thrombosis is a particularly vexing problem. While some may present with
only claudication due to the previous development of collateral flow, many present
with threatened limb loss. In the setting of acute thrombosis, the combined rate of
primary and early amputation is 50 percent and operative mortality is 5 percent [7].
Thrombolysis followed by surgical treatment yields better graft patency and limb
salvage than surgical thrombectomy. [Q4: E] Most likely, this is due to some degree
of clearing of the run-off bed. Thrombolysis alone is inadequate treatment since
surgical reconstruction is required to obliterate the aneurysm. [Q5: C]
References
1. Carpenter JP, Barker CF, Roberts B, Berkowitz HD, Lusk EJ, Perloff LJ. Popliteal artery aneurysms:
current management and outcome. J Vasc Surg 1994;19:65–72.
2. Whitehouse WM, Jr, Wake?eld TW, Graham LM, Kazmers A, Zelenock GB, Cronenwett JL, et al. Limb-
threatening potential of arteriosclerotic popliteal artery aneurysms. Surgery 1983;93:694–9.
3. Varga ZA, Locke-Edmunds JC, Baird RN. A multicenter study of popliteal aneurysms. J Vasc Surg
1994;20:171–7.

72 Vascular Surgery
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4. Ascher E, Markevich N, Schutzer RW, Kallakuri S, Jacob T, Hingorani AP. Small popliteal artery
aneurysms: are they clinically significant? J Vasc Surg 2003;37:755–60.
5. Lowell RC, Gloviczki P, Hallett JW, Jr, Naessens JM, Maus TP, Cherry KJ, Jr, et al. Popliteal artery
aneurysms: the risks of nonoperative management. Ann Vasc Surg 1994;8:14–23.
6. Anton GE, Hertzer NR, Beven EG, O’Hara PJ, Krajewski LP. Surgical management of popliteal
aneurysms: trends in presentation, treatment and results from 1952 to 1984. J Vasc Surg
1986;3:125–34.
7. Reilly MK, Abbott WM, Darling RC. Aggressive surgical management of popliteal aneurysms. Am J
Surg 1983;145:498–502.

8. Renal Artery Aneurysm
Lutz Reiher, Tomas Pfeiffer and Wilhelm Sandmann
A 45-year-old woman presented with a 10-year history of arterial hypertension.
After initially successful conservative therapy with two antihypertensive drugs,
arterial blood pressure was not controlled well during the last months. To
exclude a renovascular origin of hypertension, an angiography was performed,
which showed fibrodysplastic disease of the right renal artery with several
stenotic segments and aneurysms (Fig. 8.1).
Question 1
Which of the following statements regarding renal artery aneurysm (RAA) is
correct?
A. It has a marked female preponderance.
B. It is usually diagnosed during examination for flank pain.
C. It may cause arterial hypertension.
D. It typically leads to proteinuria by compression of the renal vein.
E. It can cause haematuria in rare cases.
Question 2
Which statements about the aetiology of the RAA are true ?
A. The most frequent underlying diseases of RAA are aortic coarctation with con-
comitant disease of the renal artery and renal artery dissection.
B. Fibromuscular dysplasia of the renal artery may present with renal artery steno-
sis (RAS), RAA or both.
C. Arteriosclerosis is a frequent cause of RAA.
73

74 Vascular Surgery
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Fig. 8.1. Selective intra-arterial renal artery angiography revealed RAA combined with renal artery stenosis due
to fibromuscular dysplasia.
D. Some RAA present with inflammation of the arterial wall.
E. The incidence of RAAs is increased in Ehlers–Danlos syndrome and Marfan’s
syndrome
Question 3
Which risks of the spontaneous course of the RAA should you explain to your
patient?
A. The RAA may rupture and lead to a life-threatening bleeding.
B. The risk of rupture decreases during pregnancy and childbirth.
C. Hypertension in RAA may be caused by concomitant stenosis of the renal artery
or its branches.
D. In cases of RAA and hypertension the angiography of the renal artery always
shows an additional RAS.

Renal Artery Aneurysm 75
E. The RAA may be a source of embolisation leading to a loss of renal function.
Question 4
Which of the following statements regarding the indication of renal artery repair
(RAR) for RAA is correct?
A. There is an indication for RAR only in cases of symptoms other than
hypertension.
B. There is no reason to perform RAR in women of childbearing age if there is no
arterial hypertension.
C. There is a good indication for RAR if a concomitant RAS is found.
D. There is a good indication for RAR only if the RAA is larger than 5.5 cm.
E. There is an indication for RAR in patients presenting with RAA and hyperten-
sion even if an additional RAS is not detectable.
For RAR, a midline abdominal incision was performed for direct access to the
infrarenal aorta, where an end-to-side anastomosis was performed with a segment
of the patient’s greater saphenous vein. After Kocher’s manoeuvre, the distal renal
artery was transected and anastomosed to the saphenous vein, which had been
placed on the renal hilus dorsal to the inferior vena cava. Good results were shown
by postoperative angiography (Fig. 8.2). At re-examination 3 years after the operation, the patient had a normal blood pressure without antihypertensive medication.
Question 5
Which of the following statements regarding the management of RAA is correct?
A. Replacement of the diseased renal artery by prosthetic graft is the RAR of first
choice.
B. Protection of the kidney against ischaemic injury is performed only during ex
situ reconstruction of the renal artery.
C. RAA exclusion and aortorenal vein graft interposition, or RAA resection and
end-to-end anastomosis or aneurysmorrhaphy, are valuable methods for RAR.
D. Ex situ repair of the renal artery may be needed in cases presenting with lesions
of the distal branch arteries.
E. Tailoring of RAA often leads to recurrent aneurysmatic dilation of the renal
artery.
Commentary
RAAs do not usually cause symptoms, and generally they are diagnosed accidentally
during work-up for hypertension, as in our patient. In rare cases, flank pain has

76 Vascular Surgery
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Fig. 8.2. Postoperative angiography demonstrates a patent aortorenal venous graft.
been described as the initial symptom, which may be due either to the size of the
RAA or to a renal artery dissection. Rupture of the aneurysm into the urinary tract
will lead to haematuria. [Q1: A, C, E] The underlying disease is most frequently dysplasia of the arterial wall followed by arteriosclerosis. In our case, fibromuscular
dysplasia was found to be the aetiology of the RAA. Rare causes of RAA may be
atypical aortic coarctation with concomitant disease of the renal arteries, inflammation of the arterial wall, dissection or trauma, or disorders of the elastic and collagen fibres (i.e. Ehlers–Danlos syndrome or Marfan’s syndrome). [Q2: B, C, D, E]
RAA is found about twice as often in the right renal artery as in the left. Selective
angiography often reveals concomitant RAS of mainstem and segmental arteries,
and segmental arteries may also be aneurysmal. Concomitant renal artery dissection is rare.
Rupture of RAA, development or deterioration of arterial hypertension, and loss
of renal function by thrombosis or embolisation, are impending spontaneous consequences of RAA.

Renal Artery Aneurysm 77
As with all arterial aneurysms, rupture is a possible complication of RAA. While
Tham et al. [1] experienced no rupture of RAA in 69 patients who had been treated
conservatively during a mean observation time of 4.3 years, Henriksson et al. [2]
observed RAA rupture in four cases (10.2 percent), and at the time of rupture only a
nephrectomy could be performed. There are several case reports about RAA
rupture in pregnancy and childbirth [3–5], and one author found the probability of
RAA rupture during pregnancy to be as high as 80 percent [6].
As high arterial blood pressure is in itself a risk factor for rupture of arterial
aneurysms of any localisation, one can argue that hypertension per se is an indication to remove an RAA. Hypertension was found in 90 percent of all patients with
ruptured RAA [7].
The larger the diameter of the RAA, the more likely the danger of rupture seems
to be, which can be explained by Laplace’s law. However, RAAs of any diameter can
rupture. In one patient cohort [8], the smallest (1 cm) and the largest (16.5 cm)
RAAs ruptured.
About eighty percent of patients with RAA have arterial hypertension [9, 10]. If
RAA is accompanied by RAS on the same or the contralateral side, as in our patient,
then it is reasonable to remove both, with the intention to improve hypertension
and eliminate the risk of rupture. However, an ipsilateral stenosis may be missed by
angiography due to overprojection of the aneurysm. Furthermore, aneurysmal
disease includes not only dilation of vessels but also elongation, which might cause
kinking with a relevant stenosis [11]. [Q3: A, C, E]
There is an absolute indication to remove RAAs in all patients with arterial
hypertension with and without concomitant RAS and in women of childbearing age.
[Q2: C] RAAs with a diameter greater than 2 cm should be removed, even if there is
no hypertension. There are good long-term results for autologous RAR; therefore,
there is a relative indication for operation in younger patients without hypertension
and concomitant RAS with RAA of diameter of 1 cm or more. [Q4: C, E]
The most promising method of RAR is by autogenous reconstruction. Methods of
RAR are replacement of the renal artery by the greater saphenous vein, resection of
diseased sections and reanastomosis. The autoplastic reconstruction by tailoring
(synonym: aneurysmorrhaphy) is another appropriate technique. Although the
aneurysmatic wall is only resected partially, recurrent RAAs have not been
observed. The in situ reconstruction is less traumatic, but ex situ repair of the renal
artery may be necessary in cases in which not only the distal mainstem artery but
also the segmental arteries are involved. [Q5: C, D]
If arterial repair is restricted to renal arteries only, and if concomitant repair of
the aorta is not necessary, then a postoperative mortality of less than 1 percent can
be expected. Postoperative morbidity is due to temporary kidney insufficiency, graft
thrombosis, bleeding, thrombosis and pancreatitis. Affected kidneys can be preserved in more than 85 percent of cases. The number of patients who benefit from
surgical therapy in terms of improvement of arterial hypertension varies considerably between authors, ranging from 5 to 50 percent and from 25 to 62 percent,
respectively [12].
References
1. Tham G, Ekelund L, Herrlin K, Lindstedt EL, Olin T, Bergentz SE. Renal artery aneurysms. Natural
history and prognosis. Ann Surg 1983;197:348–52.
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