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Table 37.2 Recommended revisional surgery based on index procedure
Index procedure Recommended revisional surgery
Adjustable gastric band RYGB, BPD/DS
Roux-en-Y gastric bypass DRGB and BPD/DS or SADI-S
Nonadjustable band/vertical banded
gastroplasty
Sleeve gastrectomy Re-sleeve, RYGB, BPD/DS, SADI-S
RYGB Roux-en-Y gastric bypass, DS duodenal switch, DRBG distal Roux-en-Y gastric bypass,
BPD/DS biliopancreatic diversion with duodenal switch, SADI-S single anastomosis duodeno-ileal
bypass and sleeve gastrectomy
RYGB
S. Ardila et al.
considered consensus. Consensus was achieved in several points including but not
limited to (1) RBS is justied in some patients; (2) RBS is more technically challenging than the respective primary bariatric surgery; (3) second or third RBS can
be justied in some patients; (4) candidates should undergo a nutritional assessment, psychological evaluation, endoscopy, and a contrast series; (5) RYGB, oneanastomosis gastric bypass (OAGB), and SADI-S are options after gastric banding;
and (6) OAGB, BPD/DS, and SADI-S are options after sleeve gastrectomy.
Regarding revision for primary RYGB, the only consensus obtained was lengthening of the biliopancreatic limb as RBS option for RYGB or OAGB [13].
37.5.1 Adjustable Gastric Band
Adjustable gastric band (ABG) remains one of the most common bariatric surgeries
performed worldwide and the procedure that most commonly requires revision with
estimated rates of 30 to 60% [6]. Given its primary restrictive effects, reported failure rates range between 40 and 50%. For weight regain, conversion to a malabsorptive procedure is recommended, such as RYGB or BPD/DS.If the cause of weight
regain can be attributed to band slippage or pouch dilation, re-banding or conversion
to sleeve gastrectomy is another option [8]. For the years 2015 to 2017, the most
common revision was laparoscopic gastric banding (LAGB) to SG, followed by
LAGB to RYGB [14].
37.5.2 Non-adjustable Band/Vertical Banded Gastroplasty
Non-adjustable gastric bands have fallen out of favor secondary to its long-term
complications. Conversion to RYGB is the procedure of choice. Conversion of vertical banded gastroplasty has been described to RYGB, SG, OAGB, and DS [6].
Conversion to RYGB remains the gold standard for both of these primary procedures.

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37.5.3 Roux-En-Y Gastric Bypass
Roux-en-Y gastric bypass is one of the most common weight loss procedures performed worldwide and is considered by many to be the gold standard. Unfortunately,
approximately 10–34% of patients experience inadequate weight loss or weight
gain and may ultimately require revision. The most common etiology of weight
regain is pouch dilation. Other reported etiologies include enlarged gastric pouch
greater than 5cm in diameter, wide gastro-jejunal anastomosis (GJA), anastomosis
greater than 1cm, GJA>1.5cm in diameter, dilated GJA greater than or equal to
2cm, pouch >30mL, pouch dilation >120mL, weight recidivism with or without
gastric stula, gastric stula, short-limb bypass, and hyperphagic behavior [12].
Multiple revisional surgeries have been described. In a recent systemic review
and meta-analysis, distal Roux-en-Y gastric bypass (DRGB) alone showed the
highest decrease in BMI at 1-year follow-up versus biliopancreatic diversion with
duodenal switch (BPD/DS) or single anastomosis duodeno-ileal bypass and sleeve
gastrectomy (SADI-S) at 3-year follow-up. Overall, they found maximal BMI
decrease in DRGB alone, followed by BPD/DS or SADI-S, laparoscopic pouch
and/or GJA resizing, and endoscopic pouch and/or GJA resizing.
37.5.4 Sleeve Gastrectomy
Sleeve gastrectomy (SG) is currently the most commonly performed bariatric procedure worldwide [1]. Its relatively simple technique and low complication rate
contribute to it being preferred over some other procedures [15]. Revision is estimated in up to 30% of cases for multiple etiologies, including weight regain. Loss
of restriction is one of the main anatomic factors contributing to weight regain.
Although revision to RYGB or DS has been recommended as the standard of care,
some studies have described revision with re-sleeve for dilation of the residual
stomach as the cause [15]. The overall %EWL following re-sleeve can be up to 57%
at 12months and up to 60% at 20months [16].
A retrospective study analyzed conversion from SG to either RYGB or SADI for
insufcient weight loss or weight regain. Out of 140 patients, 66 patients underwent
SG to SADI, and 74 patients underwent SG to RYGB.SADI was found to achieve
8.7%, 12.4%, and 19.4% more total body weight loss at 6, 12, and 24months compared to RYGB for weight regain alone. RYGB is preferred when symptoms of
reux accompany weight regain [16].
For patients with super morbid obesity and weight regain after SG, in the absence
of reux symptoms, conversion to biliopancreatic diversion with duodenal switch
(BPD/DS) is recommended for maximal weight loss, with %EWL ranging from 70
to 80% at 2years [3].

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S. Ardila et al.
37.5.5 Biliopancreatic Diversion Withor Without
Duodenal Switch
Biliopancreatic diversion with duodenal switch (BPD/DS) has been shown to be the
most effective bariatric procedure with maintained long-term %EWL of 82.2%,
81.9%, 81%, and 83% at 2, 3, 4, and 5years [17]. Despite its weight loss benets,
it is associated with the highest early mortality and complications at 1-year follow up of all procedures [18]. Limited data exists on revision for weight regain at this
time given its proven efcacy. Reducing the gastric volume has been described giving limited results [19].
37.6 Role andImpact ofDuodenal Switch
Duodenal switch as a primary bariatric surgery has been associated with the highest
%EWL estimated at 74.1, compared to sleeve gastrectomy at 58.3%EWL, RYGB at
56.7%EWL, and gastric banding at 45.9%EWL [20]. It is therefore not surprising that
as a revisional procedure, it has also been shown to be associated with more weight
loss. A recent retrospective study comparing SADI and RYGB for patients with failed
SG found that patients who underwent SADI experienced 8.7%, 12.4%, and 19.4%
more weight loss compared to RYGB at 6, 12, and 24months postoperatively [3].
Its long-term weight loss efcacy has led to BPD/DS growing popularity as a
primary and revisional bariatric surgery, experiencing a 63.7% and 114.1% growth
in total cases and revision cases, respectively, from 2015 to 2017 [18].
Duodenal switch has also been shown to be the primary and revisional procedure
of choice for superobese patients, classied with a body mass index of >50kg/m2.
A retrospective study compared 83 BPD/DS and 97 RYGB procedures performed
from 2002 to 2009 for patients with an initial body mass index of 55kg/m2. At
3-year follow-up, the mean %EWL was 63.7% after RYGB versus 84% after BPD/
DS [21].
In summary, biliopancreatic diversion with duodenal switch (BPD/DS) has been
shown to be benecial as revisional surgery for select populations:
• Superobese patients.
• Weight regain following SG in the absence of reux symptoms.
37.7 Weight Loss Following Revisional Surgery
Weight loss after revisional bariatric surgery leads to signicant weight loss in the
long term, rates varying per procedure performed. A single-center retrospective
study for patients who underwent revisional surgery for weight regain (52.4%)

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analyzed weight loss at 3-, 6-, 9-, and 12-month intervals. Patients with a primary
restrictive procedure and reux symptoms underwent conversion to either RYGB or
BPD/DS and experienced 50–65.3%EWL at 3 months and 50.1–79.1%EWL at
12 months. Patients with initial RYGB underwent GJ revision for pouch or GJ
abnormalities. For those without anatomic abnormalities, they underwent conversion to distal bypass. At 3months, %EWL was 36.6 for GJ revision and 37.5% for
distal revision [7].
37.8 Complications ofRevisional Surgery
Revisional bariatric surgery is complex, is technically demanding, and is therefore
associated with higher morbidity and mortality. Compared to primary surgery, revisional surgery has been associated with higher rates of postoperative complications,
longer operative times, longer hospital stay, conversion to open surgery, readmission, and unplanned admission to the critical care unit [3, 6]. In comparing primary
versus revisional RYGB, revisional surgery was associated with higher rates of leak,
hemorrhage, wound infection, stricture, ulcer, perforation, and hernia [6].
A single-center retrospective study analyzed complications after revisional surgeries performed at their center for weight regain between 2012 and 2015. Of 84
patients, 43 presented for weight regain (52.4%). Complications included incarcerated ventral hernia following AGB conversion to SG, anastomotic leak and recurrent intussusception following gastro-jejunostomy revision, and stricture and
marginal ulcer following AGB conversion to RYGB [7].
In summary, reported complications of revisional bariatric surgery are:
• Hernia.
• Anastomotic leak.
• Stricture.
• Marginal ulcer.
• Wound infection.
• Hemorrhage.
• Perforation.
• Obstruction.
37.9 Conclusion
Weight regain after primary bariatric surgery is multifactorial. It is imperative to
establish guidelines for classifying weight gain in order to guide subsequent intervention and thus to aid bariatric teams internationally in the management of this
clinical entity. Revisional surgery has been shown to be a successful treatment
option for patients presenting with weight gain, with rates of weight loss nearing

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those seen after primary surgery. Furthermore, the importance of revisional surgery
lies in its ability to readdress many of the obesity-related comorbidities which
prompted the primary procedure. When indicated, it is important to tailor the type
of revisional surgery to each patient. Although Roux-en-Y gastric bypass remains
the most common type of revisional surgery after primary surgery of any type, duodenal switch is emerging as the revision procedure of choice for superobese patients
and patients with failed sleeve gastrectomy secondary to weight regain in the
absence of reux symptoms.
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11. Karmali S, Brar B, Shi X, Sharma AM, De Gara C, Birch DW.Weight recidivism post- bariatric
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19. Topart PA, Becouarn G.Revision and reversal after biliopancreatic diversion for excessive side
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20. O’Brien PE, Hindle A, Brennan L, etal. Long-term outcomes after bariatric surgery: a systematic review and meta-analysis of weight loss at 10 or more years for all bariatric procedures
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21. Topart P, Becouarn G, Ritz P.Weight loss is more sustained after biliopancreatic diversion with
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Chapter 38
Conversion ofSleeve Gastrectomy
toDuodenal Switch andSADI-S
AlminoCardosoRamos andEduardoLemosDeSouzaBastos
38.1 Introduction
Sleeve gastrectomy (SG) has increasingly seduced surgeons and patients worldwide. Initially derived from classic biliopancreatic diversion/duodenal switch
(BPD-DS), SG began to be employed years later as a rst stage in patients with
severe obesity and at high surgical risk. Based on the encouraging results, the second stage was gradually discontinued, and the SG was subsequently recognized as
a stand-alone bariatric procedure. Currently, SG accounts for about 60% of all interventional bariatric and metabolic procedures worldwide [1–3]. Long-lasting weight
loss, control of obesity-related comorbidities, and virtual absence of signicant gastrointestinal and nutritional adverse events can help explain such expressive percentages [4, 5].
Despite the current widespread acceptance of the SG, some setbacks are still a
source of heated debates in the scientic community. Food intolerance due to torsion of the axis or stenosis, worsening or onset of “de novo” gastroesophageal reux
disease (GERD), and the challenging treatment of high leaks are some examples of
concern among bariatric surgeons. In addition, the ineffectiveness in controlling
obesity due to inadequate weight loss (IWL) or mainly weight regain (WR) has
shown worrying rates in recent times.
IWL is a disappointing outcome usually seen as soon as 6–12months after the
procedure. Its incidence is unclear, perhaps underreported, but it does not seem to
have a concerning rate. On the other hand, the long-term follow-up of patients
A. C. Ramos (*)
Gastro-Obeso-Center—Advanced Institute for Metabolic Optimization, São Paulo, Brazil
E. L. D. S. Bastos
Division of Gastrointestinal Surgery, Marilia Medicine School, Marilia, Brazil
© The Author(s), under exclusive license to Springer Nature
Switzerland AG 2023
A. Teixeira et al. (eds.), Duodenal Switch and Its Derivatives in Bariatric and
Metabolic Surgery, https://doi.org/10.1007/978-3-031-25828-2_38
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A. C. Ramos and E. L. D. S. Bastos
undergoing SG has shown a higher rate of obesity recurrence. In any case, failed SG
brings intense distress to the patient and the surgical team, sometimes requiring
reoperation. Several options are currently available to the surgeon in the face of
weight loss failure after SG.However, the main challenge is to accurately identify
which patients would actually benet with a second procedure in the long term.
The traditional BPD-DS is a malabsorptive operation that has long been recognized as one of the most effective bariatric procedures. The single anastomosis
duodenal-ileal bypass with sleeve gastrectomy (SADI-S), also called “oneanastomosis duodenal switch” (OADS), is fundamentally a variant of the BPD-DS
operation that was already endorsed by both the International Federation for the
Surgery of Obesity and Metabolic Disorders (IFSO) and American Society for
Metabolic and Bariatric Surgery (ASMBS) [6–8]. Both BPD-DS and SADI-S/
OADS appear to be highly effective as primary bariatric procedures in morbidly
obese patients [9–14]. However, some technical complexity, mainly related to
DBP-DS, and side effects associated with malabsorption of fat-soluble vitamins,
micronutrients, and proteins, as well as steatorrhea, have limited the use of largescale duodenal switch surgeries.
Despite the limited acceptance as a primary procedure, BPD-DS and SADI-S/
OADS should be seen as the natural rescue procedure in sleeved patient, since the
gastric step of these two techniques has already been done, saving operative time
and minimizing the risk of complications related to the SG itself. However, the bariatric community in general still seems to opt more frequently for conversion to
gastric bypass, considered a less technically demanding procedure. Nonetheless, the
greater technical simplicity attributed to the emerging SADI-S/OADS surgery compared to classic BPD-DS can provide a broader acceptance of duodenal switch surgery as a suitable revisional option after failed SG in the following years.
Therefore, the purpose of this chapter is to discuss duodenal switch surgery,
either by two- or one-anastomosis, as a safe and feasible option to rescue patients
undergoing SG and failure in obesity disease control.
38.2 Weight Loss Failure After SG
Unarguably, SG is currently considered a very effective treatment for morbid obesity. However, weight recidivism has been reported at varying rates after the sleeve.
This wide variation seems to depend, above all, on the time of postoperative follow up and on the denition adopted for the diagnosis of WR. An interesting study
highlighted how the WR rates can be strongly impacted by the type of denition
adopted. Six different types of denitions were applied to the same cohort of 868
patients undergoing bariatric surgery with at least 5years of follow-up. Depending
on the type of denition, WR ranged from 16 to 87% [15]. Similarly, a systematic
review addressing the WR following SG showed a high variation in rates, ranging
from 5.7% to 75.6%, depending on the follow-up period and the denition
adopted [16].

38 Conversion ofSleeve Gastrectomy toDuodenal Switch andSADI-S
355
Worryingly, the lack of a universally accepted denition seems to be the rule. A
systematic review carried out to describe how the failure of bariatric surgery is commonly dened in the literature retrieved 60 studies comprising more than 4000 revisional procedures. The clear indication was provided in only 2741 cases. Among
these, IWL and WR were responsible for almost 60% of the indications. Despite
this relevance rate, most published studies have not precisely dened the failure of
bariatric surgery, but excess weight loss (EWL) below 50% at 18months postoperatively appeared to be the most frequently used denition [17]. An online survey
using a social media platform was carried out to capture the current denitions for
post-sleeve WR and what revision procedures are commonly offered in such cases.
Not surprisingly, gastric bypass surgery (RYGB and OAGB-MGB) far surpassed
the duodenal switch technique, whether through one- or two-anastomosis. In addition, the survey exposed the concerning lack of a scientically robust denition for
WR after SG [18].
Amid this lack of standardization, a multitude of conicting data have been published. Data from case series followed prospectively in the short term (1–2years)
demonstrated recurrence of obesity in about 10% of patients undergoing SG.In this
study, WR was dened as a recovery of at least 5% of the body weight initially lost
[19], a somewhat rigorous denition. A retrospective study with longer postoperative follow-up (6years on average) found that almost 70% of post-sleeve patients
met the WR criterion, dened as at least an increase in body weight of 5–10kg from
the nadir, an equally very strict criterion [20].
Nevertheless, the variable rates of post-sleeve WR do not mirror the percentage
of revision surgery, since not all patients identied as WR will need an interventional procedure. In a short-term case series of 500 morbidly obese patients who
underwent primary SG, 26 individuals (5.2%) required revisional surgery due to
poor weight loss (n=8) or WR (n=18). In this study, poor weight loss was dened
by a percentage of excessive weight loss (%EWL) of less than 50% after 1year, and
WR was dened as a regain of at least 30% of lost weight or a regain of 20% of
weight from the nadir [21]. Another case series also applied the %EWL as a parameter to proceed with a rescue procedure after SG.Of a total of 1300 patients, 36
(2.2%) required reoperation due to failure in weight control, dened by a %EWL
below 50% after 1year. In this study, both IWL and WR were included in the same
denition [22]. In a long-term case series of obese patients undergoing SG, 4
(2.2%) of 182 patients eligible for the study underwent BPD-DS as a second-stage
procedure due to IWL before reaching the endpoint. In this cohort, 114 patients
(62.6%) reached 10years of follow-up, and the WR, expressed as an increase in
weight≥25% from the nadir, occurred in 10.4% of patients [23]. And nally, a
retrospective analysis of a prospective cohort assessed long-term outcomes of 168
patients undergoing SG.After 8years of follow-up, 116 patients still had only the
index procedure and had an average EWL of 67%. Of the remainder, 29 lost followup, and 23 (13.7%) patients underwent revisional surgery for WR (n=14; 8.3%) or
for severe reux (n=9; 5.3%) at a mean time elapsed since the initial procedure of
50 months. Of these 14 patients, 5 went to duodenal switch surgery and 1 to
SADI-S/OADS [24].

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Therefore, although some studies have shown alarming rates, the percentage of
patients with failure in weight control requiring a revisional procedure after SG
appears to not exceed 5–10% in the long term. Moreover, the criteria for indicating
a reoperation remain somewhat arbitrary and surgeon-dependent. Importantly, the
potential surgical risks and possible long-term benets must be carefully weighted
in each individual patient.
38.3 Reoperative Procedures forFailure inWeight Control
After Sleeve
First of all, it is widely agreed that the rst approach for a patient with IWL or WR
must comprise complete multidisciplinary assessment and detailed investigation of
the sleeved stomach. In the absence of complete loss of the restrictive effect due to
huge sleeve dilation, reoperation should only be considered after the patient’s commitment to the multidisciplinary team. Otherwise, new failure is often the rule,
especially in the long term. Increased costs, reoperation probabilities, disappointing
results, and, mainly, surgical complications appear to be higher compared to the
index procedure [25, 26]. Therefore, every caution is strongly advisable before
going to surgical revision.
The ASMBS Revision Task Force established a nomenclature for reoperative
surgery into conversion, corrective, and reversal procedures [27]. Obviously, the
sleeve cannot be subjected to a reversal procedure, since 70–80% of the stomach is
removed. On the other hand, there are several corrective procedures that can be
applied to the sleeve: re-sleeve, banding, seromyotomy, and axis realignment,
among others.
Conversion procedures can be used in cases of complications or failure to control weight or obesity-related comorbidities. Currently, the main reasons for converting a sleeve into some other bariatric procedure are GERD and obesity
recidivism. In cases of GERD, the preferred rescue procedure seems to be Rouxen-Y gastric bypass (RYGB), since the surgical design of the sleeve may be the
cause of pathological reux and, therefore, this anatomy should be changed.
Notwithstanding, SADI-S/OADS can also be an acceptable revision choice for
sleeve patients suffering from GERD symptoms and weight recidivism. A retrospective analysis of a prospectively collected database of patients who underwent
SADI-S/OADS or one- anastomosis gastric bypass (OAGB-MGB) as a revisional
procedure for weight recidivism after primary SG included 91 patients. In the
SADI-S/OADS group (n=42), seven patients had GERD symptoms, and 57% had
either stopped or decreased their anti-reux medications after revisional surgery.
The sleeve was left untouched in all patients. It is very likely that the improvement/
resolution of GERD has reected the suitable control of the obesity disease, since
at 12months postoperatively, the average post-revisional %EWL was 51.3in the
SADI-S/OADS group [28]. Markedly, the small sample undermines more accurate
conclusions.
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