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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_998_Библиотеки_им_академика_М_И_Перельмана
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Index
https://t.me/medicina_free
469
radial forearm ap, 351–354
radial forearm harvest, 350
split thickness skin graft, 353, 354
traditional reconstructive ladder, 349
Predictive index scores, 453
Predictive Salvage Index (PSI), 453
Premarket approval (PMA), 214, 216
Pressure ulcer coverage, 435
Primary end-to-end neurorrhaphy, 396, 398
Primary lower limb amputation, 452
Primary suture repair, 396, 398
Priority Medicines (PRIME), 234
Product’s claimed mode of action, 233
Profunda femoris artery, 438
Proline hydroxylated (Pro-OH) HIF-1α, 204
Propeller aps, 435
Prophylactic antibiotics, 70
Prosthetic joint infections (PJI), 93
Prosthetic valve endocarditis (PVE), 87
Pseudomonas aeruginosa, 93, 161
Public Health Service Act (PHS), 236
Pullulan, 136
Pulsed dye laser (PDL), 333
Pyridoxatin, 119
Pyrvinium, 11
Q
Q submissions/Q-subs, 237
R
Radial forearm free ap (RFFF), 246, 351, 352, 446
Random pattern cutaneous aps, 435
Random pattern skin aps, 433
Reactive oxygen species (ROS), 205
Reanimation
free muscle transfers, 402, 403
regional muscle transfers, 403
Reconstruction plates, 358
Reconstruction surgeries’ methods, 284
Reconstructive ladder, 430, 432
Rectus abdominis muscle aps, 450
Regeneration, denition, 159
Regenerative medicine (RM), 3, 337
academic initiatives, 241
collaborative parties formation, 240
distribution models
cultural, 239
economics, 239
ethics, 239, 240
EU and US
ATMPs, 230
CAT issues, 234
CHMP, 234
combination products, 231, 233
drugs/biological products, 231
essential function, 233
GTMPs, 230
high risk, 232
HCT/Ps, 232, 233
legal framework, 236–238
medicinal devices, of human tissues, 231
PRIME, 234
product’s claimed mode of action, 233
RMAT designation, 231, 232
SCMPs, 230
similarities, 232
substantially (major) manipulated vs. non-
substantially (minimally) manipulated, 233
TEPs, 230
regulation
framework and jurisdiction, 238
regulatory clarity, 238
Regenerative Medicine Advanced Therapy (RMAT)
designation, 231
Regenerative treatment
breast asymmetry, 247
breast augmentation, 247
breast reconstruction, 246
facial rejuvenation, 248
gluteal augmentation, 248
replacement vs. regeneration
fat tissue defects, 252
muscle, tendon, and ligament tissue defects, 250
nerve defects, 252
skin and subcutaneous tissue defects, 250
scar formation vs. regeneration
muscle, tendon, and ligament tissue defects, 249
nerve defects, 249, 250
skin and subcutaneous tissue defects, 248
scars and burns, 247, 248
Regional muscle transfers, 403
Reinnervation technique, 249
nerve grafts, 398, 399
nerve reconstruction and transfers
babysitter procedure, 401
cross-facial nerve grafting, 400, 401
hypoglossal facial nerve, 399
masseteric nerve, 400
primary suture repair, 396, 398
tissue adhesives, 397
Requests for Designations (RFDs), 231
Retigeric acid B, 119
RNA interference (RNAi), 11, 263
S
Saphenous artery perforator ap, 438, 441
Saphenous ap, 447
Scaffold based treatment
fat tissue defects, 259
muscle, tendon, and ligament tissue defects, 256, 257
nerve defects, 257–259
skin and subcutaneous tissue defects, 256
Scaffold bioengineering, 130
Scaffolds, 286, 345
Scar formation, 35
Scar mitigation, 35
Schwann cells, 249, 250, 257, 261, 262
470
https://t.me/medicina_free
Index
Scientic research
defensive publications, 223, 224
ling IP rights, 225
IP protection, 222, 223, 225, 226
patent ling, 223
trade secret, 224, 225
Self-commercialization, 219
Sensory nerve injury, 360
Sharpey's bers, 152
Short interfering RNAs (siRNAs), 263
Silicone granulomas, 420
Silicone implants
biointegration, 304, 305
cysteinyl leukotrienes, 304, 305
functionalizing/modifying surgical implants, 304
locations
midface, 309
nasal, 309, 310
Silicone tape, 330
Skin-aging
biological basis, 201
collagen, 203
elastin, 203
elastosis, 203
extrinsic aging, 202
HIF-1
HIF-1α pathway, 205
iron chelation, 205, 206
Ln-332, 205
modulation pathway regulation, 204
oxygen-sensitive prolyl-hydroxylases, 203
physiological activation, 203
Pro-OH HIF-1α, 204
subunits, 203
VHL E3 ligase protein, 204
intrinsic/innate aging, 202
layers of skin, 201
MMPs, 203
young vs. aged skin, 202
Skin and subcutaneous tissue defects, 245, 246
Skin lesions, 161
Skin tissue regeneration, 263
Small and Medium sized Enterprises (SMEs), 241
Small Business Innovation Research (SBIR), 218
Small Business Technology Transfer (STTR) Programs,
218
Smart Negative Pressure (SNaP) Wound Care System, 323
Smooth implants, 308
Soft tissue defects
fat tissue defects, 246
muscle, tendon, and ligament tissue defects, 246
nerve defects, 246
skin and subcutaneous tissue defects, 245, 246
Soft tissue regeneration
antioxidant treatment, 10
bioactive dressings, 12
biomimetic collagen hydrogels, 12
biomimetic scaffolds, 12
chronic wounds, 7
genetic and epigenetic indicators, 12
growth factor therapy, 8–9
mesenchymal stem cells (MSCs), 12
monotone diet, 7
neovascularization, 12
NPWT, 9, 10
Pullulan (a polysaccharide polymer)-collagen
matrices, 12
RNA-interference-based therapy, 11
ROS, 10
stem cell-based therapy, 11–12
surgical techniques
fat tissue defects, 255, 256
muscle, tendon, and ligament tissue defects,
254
nerve defects, 254, 255
skin and subcutaneous tissue defects, 254
wnt pathway, 11
wound healing, 7
Solar elastosis, 203
Soleus, 443
Solid implants
complications, 306
GoreTex, 308, 309
MedPor, 308
Mersilene mesh, 309
silicone, 308
in facial reconstruction, 305, 306
implant shaping, 313
infection, 311, 312
intraoperative antibiotics, 312
intraoperative techniques and implant placement
chin Implantation, 313–314
mandibular implantation, 314
midfacial implantation, 314
nasal implantation, 314, 315
locations
mandibular, 310
midface, 309
mandibular augmentation, 305
midface augmentation, 305
patient selection, 311
postoperative antibiotic use, 313
preoperative antibiotic soak/impregnation, 312
procedure, 311
surgical approach, 313
Somatic cell therapy medicinal products
(SCMPs), 230
Spirulina platensis, 117
Spring water, 161, 162
Standard Operating Procedures (SOPs), 237
Staphylococcus epidermidis, 161
Stem cell-based therapies, 337
Stem cell differentiation
breast reconstruction
ADM, 62
biodegradable scaffolds, 62
mammary adipose tissue, 64, 65
mammary epithelial tissue, 65
mastectomy, 62
tissue engineering scaffolds, 62
material cues, 64
mechanical cues, 63, 64
Index
https://t.me/medicina_free
471
Stem cells, 3
adipose tissue
advantages, 191
challenges and potential strategies, 191, 192
delivery system, 193, 194
harvesting method, 193
optimization, 193
pathology and aging, 192
pro-angiogenic growth factors, 190
SVF, 189
transcriptomic and proteomics analysis, 190
wound healing mechanisms, 190, 191
iPSCs, 194
recruitment, 165
research, 454
wound healing, 188, 189
Stem cells isolated from the root apical papilla of the
human teeth (SCAP), 340
Steroid tape, 330
Streptomyces hawaiiensis, 117
Stress shielding, 152
Stretching wounds, 330
Stromal cell-derived factor 1 (SDF-1) signaling
bone marrow (BM) maintenance, 49, 50
cell migration and behavior, 47
chetomin, 53
disease states
over-expression, 52, 53
under-expression, 52
embryological development, 48
molecular mechanisms, 47
Sitagliptin inhibits dipeptidylpeptidase-IV (DPP-IV),
53
small molecule CXCR4 antagonists, 53
structure and function, 47, 48
tissue repair and regeneration, 49–51
Stromal vascular fraction (SVF), 189
Structural protein, 153, 154
Subatmospheric pressure treatment, 322
Suction inltration technique, 312
Sugar code, 137
Superior and inferior gluteal perforator aps (SGAP/
IGAP), 438
Sural fasciocutaneous ap, 447
Sural ap, 437, 440
Surgical Care Improvement Project (SCIP), 70
Surgical site infection (SSI), 69
Synthetic hydroxyapatite, 344
Synthetic polymers, 287
T
Technological commercialization, 219
Technology transfer ofce (TTOs), 215
Telomere length, 202
Temporomandibular joint (TMJ) disorders, 361
Tendon healing, 249, 263
Tensor fascia lata (TFL), 440, 442
Theranostics, 94
Three-dimensional (3D) culture systems, 61
Three-dimensional miniplates, 359
Tibialis anterior muscle, 444
Tinel-Hoffman sign, 126
Tinel’s sign, 402
Tissue adhesives, 397
Tissue Engineered Nerve Grafts (TENGs), 257, 261, 262
Tissue engineered products (TEPs), 230
Tissue engineering approach, 3, 286
Tissue expansion, 433
Titanium hollow-screw osteointegrated reconstruction
Titanium implants, 152
Topical bacterial lipopolysaccharide, 161
Trade-related Aspects of Intellectual Property Rights (the
Trade secret, 224, 225
Traditional block bone graft, 349
Traditional reconstructive ladder, 349
Transactivation domains (TAD), 204
Transforming growth factor (TGF), 259, 260, 262
Transforming growth factor beta (TGFβ), 9, 190, 289
Transplanting autologous lymph node fragments, 297
Transverse rectus abdominis myocutaneous (TRAM)
Transverse upper gracilis (TUG) ap, 436–437
Tumor anemia, 166
Tumor necrosis factor-α (TNF-α), 161, 190
Tumor-resected maxillomandibular defects, 349
Type B fasciocutaneous, 436
U
UniQure’sGlybera, 235
United States Patent and Trademark Ofce (USPTO),
Upper limb allotransplantation, 454
U.S.A.Human Microbiome Project (HMP), 160
US FDA-EMA-Health Canada Advanced Therapy
Use of porcine urinary bladder matrix (UBM-ECM)
plate (THORP), 358
TRIPS Agreement), 225
ap, 247
224
Medicinal Products Cluster, 240
acute trauma degloving type wounds, 369
clinical cases
facial soft tissues, 382–388
forehead and scalp, 372–374
nasal reconstruction, 374–382
facial scarring, 365, 366
forehead and scalp wound patients, 366
head and neck wound reconstruction, 365
limitations, 369
lyophilized sheet formulation, 369
MatriSome and MatriSome-associated proteins, 367
MicroMatrix
Mohs surgical management, 367, 368
nasal wounds, 366
normal inammatory healing response, 367
outcomes, 369
peptide fragments, 367
pustular dermatosis, 368
secondary skin graft, 366
vacuum-pressed sheets, 369
wound bed preparation, 366
wound devices, 365–367, 369
®
powder, 369
472
https://t.me/medicina_free
Index
V
Vacuum-Assisted Closure (VAC), 322
Vacuum-pressed sheets, 369
Vascular endothelial growth factor (VEGF), 9, 190, 259,
261, 262
Vascularization, 264
Vascularized Composite Allotransplant (VCA), 176
Vascularized grafts, 285
Vastus lateralis, 444
VEGFR-3 tyrosine kinase signaling pathway, 293
Vital signal molecules (HGF), 264
Vitreoscilla liformis, 162
Volumetric muscle loss, 246
Von Hippel-Landau (VHL) E3 ligase protein, 204
V-Y, bipedicled and keystone aps, 444, 446–447
V-Y aps, 436
W
Wallerian degeneration, 249
Wingless-type (WNT) signaling pathways, 455
World Intellectual Property Organization (WIPO), 222
World Trade Organization, 225
Wound care, 70
Wound healing, 7, 8, 159, 161, 165, 167, 169
microbiota role, 161, 162
proliferative phase, 159
stem cells
adult stem cells, 188
bone marrow derived stem cells, 189
embryonic stem cells, 188
MSCs, 188, 189
Wound stabilization treatments, 334
X
Xanthan, 136, 137
Y
Young's modulus, 152
Z
Zarlukast (Accolate), 413, 414
Zigzag sutures, 331
Z-plasties, 331
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