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13 Mitral Valve Infective Endocarditis
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Fig. 13.3 (a) Perforation of
the anterior mitral valve
leaet caused by the presence
of a vegetation and infective
destruction of the native
tissue, and (b) repair with
bovine pericardium patch
augmentation of the anterior
leaet and ring annuloplasty
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Fig. 13.4 Operative images illustrating (a) 0.7cm vegetation lying on
the atrial surface A3 scallop of the anterior leaet, (b) resected vegetation and surrounding infected tissue, (c) closure of the defect in the A3
segment of the leaet with a bovine pericardial patch, and (d) implantation of an annuloplasty ring to support the repair

100
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N. Moorjani
ab
Fig. 13.5 (a) Perforation of the posterior leaet caused by the presence of a vegetation and infective destruction of the native tissue, and (b) repair
with bovine pericardium patch augmentation of the posterior leaet and ring annuloplasty
Fig. 13.6 (a) Prolapse of the
posteromedial commissure
caused by the presence of a
vegetation and infective
destruction of the underlying
native tissue, (b) debridement
of the infected tissue, (c)
repair with sliding plasty
advancement of the medial
half of the posterior leaet
and commissuroplasty, and
(d) ring annuloplasty to
support the repair
tion may also be required to support the commissural
reconstruction.
The vegetation and any resected tissue should be sent for
microbiological analysis. Any underlying mitral valve
pathology, which may have contributed to the development
of the infective endocarditis, should also be treated during
the repair procedure using standard techniques. Degenerative
mitral valve prolapse is the most common underlying cardiac
lesion that predisposes to mitral valve infective
endocarditis.
Once the repair procedure has been completed, it is
important to stabilise the mitral valve annulus with an annuloplasty band or ring, thereby relieving the tension on the
leaets by optimising the coaptation zone. Although some
advocate avoidance of using prosthetic material in these
patients, there is no evidence that using an annuloplasty ring

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13 Mitral Valve Infective Endocarditis
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101
or band increases the risk of recurrent endocarditis but it
does increase the longevity of the repair.
Following implantation of the annuloplasty ring or band,
injecting cold saline allows the mitral valve to be assessed for
competency, adequate depth of coaptation (>8mm) and that
the coaptation line runs parallel to the posterior annulus.
annulus and the abscess cavity, followed by reconstruction of
the posterior annulus and atrioventricular groove (Fig.13.7).
An oversized fresh autologous or bovine pericardial patch is
used to cover the defect in the atrioventricular groove and
attached to the adjacent posterior walls of the left ventricle
and left atrium using a continuous 4/0 prolene suture. It is
important to place the sutures in the ventricle distant from
the edges of the resected material to ensure a strong suture
Annular Reconstruction
line. Left atrial and ventricular pressures help to maintain
apposition of the patch against the posterior wall of the heart.
In patients with infective endocarditis of the mitral valve, it
is important to explore the surrounding tissues to assess for
the presence of any peri-annular abscess or spread onto the
aorto-mitral curtain. If present, extension of the infective
process into the posterior annulus with resulting peri-annular
abscess formation will require extensive debridement of the
Fig. 13.7 (a) Abscess of the
posterior mitral valve annulus,
(b) debridement of infected
tissue extending into the
atrioventricular groove, (c)
bovine pericardium patch
reconstruction of the
atrioventricular groove,
extending onto the posterior
wall of the left ventricle and
left atrium, (d) bovine
pericardium patch
reconstruction of the posterior
leaet, and (e) ring
annuloplasty to support the
repair
The reconstructed posterior annulus with pericardial patch
can then be used to receive the interrupted valve annulo-
plasty or replacement sutures, which will additionally help to
secure the patch in situ.
If repair is not possible and replacement is necessary, the
choice between a mechanical or biological valve should be
e

102
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N. Moorjani
made with the usual considerations, as there is no difference
in recurrent endocarditis rates between the two valve choices.
Following all surgery for mitral valve endocarditis (repair
or replacement), organism-specic intravenous antibiotics
should be continued as dictated by current international recommendations, usually for 4–6 weeks. If organisms are
grown from the resected material, it is the authors recommendation that antibiotic treatment should continue for
6 weeks with a full endocarditis screen 2 weeks after the
completion of the treatment.
Surgical Tips
1. Complete debridement of the vegetation and adjacent infected and inamed tissue is necessary to
reduce the risk of recurrence.
2. Assess that there is enough residual tissue after
resection to allow for repair.
3. Augment any defects in the leaet tissue or annulus
with bovine or autologous pericardium.
4. Support the leaet repair procedure with an annuloplasty ring or band.
Comment
For endocarditis patients who have limited valve destruction,
the results of mitral valve repair have shown excellent outcomes, with an in-hospital mortality of 3% and a low perioperative complication rate. In general, however, patients
with acute mitral valve endocarditis have an operative mortality of 10–20%. Long-term outcome measures at 10years
of patients who have undergone repair have also demonstrated excellent freedom from recurrent mitral regurgitation
(91% with no or 1+ MR), freedom from reoperation (91%),
and survival (80%). Meta-analyses and large series comparing repair versus replacement in patients with mitral valve
infective endocarditis have shown better short- and longterm outcome measures, with a lower operative mortality,
increased long-term survival, reduced risk of recurrent endo-
carditis, and reduced need for a reoperation in patients
undergoing repair. The increased incidence of reoperation in
patients undergoing replacement for mitral valve endocarditis is related to paravalvular leaks, structural valve deterioration, and prosthetic valve endocarditis.
Suggested Reading
AATS Surgical Treatment of Infective Endocarditis Consensus
Guidelines Writing Committee Chairs, Pettersson GB, Coselli JS,
Writing Committee, Pettersson GB, Coselli JS, Hussain ST, Grifn
B, Blackstone EH, Gordon SM, LeMaire SA, Woc-Colburn LE.The
2016 the American Association for Thoracic Surgery (AATS) consensus guidelines: surgical treatment of infective endocarditis. J
Thorac Cardiovasc Surg. 2017;153(6):1241–58.
de Kerchove L, Price J, Tamer S, Glineur D, Momeni M, Noirhomme
P, ElKhoury G.Extending the scope of mitral valve repair in active
endocarditis. J Thorac Cardiovasc Surg. 2012;123(4 Suppl):S91–5.
Evans CF, Gammie JS.Surgical management of mitral valve infective
endocarditis. Semin Thorac Cardiovasc Surg. 2011;23(3):232–40.
Harky A, Hof A, Garner M, Froghi S, Bashir M. Mitral valve repair
or replacement in native valve endocarditis? Systematic review and
meta-analysis. J Card Surg. 2018;33(7):364–71.
Kitai T, Masumoto A, Okada T, Koyama T, Furukawa Y.Optimal timing
of surgery for patients with active infective endocarditis. Cardiol
Clin. 2021;39(2):197–209.
Okada Y, Nakai T, Kitai T.Role of mitral valve repair for mitral infec-
tive endocarditis. Cardiol Clin. 2021;39(2):189–96.
Otto CM, Nishimura RA, Bonow RO, Carabello BA, Erwin JP 3rd,
Gentile F, Jneid H, Krieger EV, Mack M, McLeod C, O'Gara PT,
Rigolin VH, Sundt TM 3rd, Thompson A, Toly C. 2020 ACC/
AHA guideline for the management of patients with valvular heart
disease: executive summary: a report of the American College
of Cardiology/American Heart Association Joint Committee on
Clinical Practice Guidelines. Circulation. 2021;143(5):e35–71.
Sareyyupoglu B, Schaff HV, Suri RM, Connolly HM, Daly RC, Orszulak
TA.Safety and durability of mitral valve repair for anterior leaet
perforation. J Thorac Cardiovasc Surg. 2010;139(6):1288–93.
Shimokawa T, Kasegawa H, Matsuyama S, Seki H, Manabe S, Fukui T,
Morita S, Takanashi S.Long-term outcome of mitral valve repair for
infective endocarditis. Ann Thorac Surg. 2009;88(3):733–9.
Toyoda N, Itagaki S, Egorova NN, Tannous H, Anyanwu AC,
El-Eshmawi A, Adams DH, Chikwe J.Real-world outcomes of surgery for native mitral valve endocarditis. J Thorac Cardiovasc Surg.
2017;154(6):1906–12.
Zegdi R, Debièche M, Latrémouille C, Lebied D, Chardigny C, Grinda
JM, Chauvaud S, Deloche A, Carpentier A, Fabiani JN.Long-term
results of mitral valve repair in active endocarditis. Circulation.
2005;111(19):2532–6.

Part IV
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Valve Surgery: Tricuspid Valve Surgery

Tricuspid Valve Disease Techniques
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NarainMoorjani, FrancisC.Wells, andSamerA.M.Nashef
14
As the name suggests the right-sided atrioventricular valve
has three primary leaets, the anterior, septal, and inferior
leaets. Other than that, the same basic components of papillary muscles and tendinous cords are present. The overall
shape is more a rounded triangle than the oval mitral valve
orice.
This shape required the development of the third, inferior,
leaet which may represent an enlarged commissural leaet.
The largest leaet is the anterior leaet, the third being the
septal leaet (Fig.14.1).
The relationships of the leaets to the supporting cardiac
chamber muscle are as follows and shown in Fig.14.1. The
origin of the anterior leaet is at the septal junction with the
aortic root and extends along the majority of the right ventricular muscular free wall. This is an important point as it is
this portion of the atrioventricular junction that stretches giving rise to type 1 annular dilatation and is the cause of secondary tricuspid regurgitation. As the right ventricle dilates
progressively with volume and pressure overload, this dilatation causes distraction of the tricuspid valve leaets from
their natural coaptation lines. Correction of the valve incompetence is achieved by reducing this part of the circumference of the orice.
The inferior leaet is associated with the remainder of the
right ventricular wall and its junction with the septum, and is
of variable length.
As in functional (secondary) mitral regurgitation, in tricuspid regurgitation there is no visible stretching of the septal portion nor of the aortic outow area.
N. Moorjani
Department of Cardiothoracic Surgery, Royal Papworth Hospital,
Cambridge, UK
F. C. Wells (*)
Royal Papworth Hospital, Cambridge University Group of
Hospitals, Cambridge, UK
e-mail: francis.wells@nhs.net
S. A. M. Nashef
Department of Surgery, Royal Papworth Hospital, Cambridge, UK
e-mail: sam.nashef@nhs.net
In the normal tricuspid valve, the plane of the valve in
relation to the atrioventricular junction is complicated with
more deviation from the neutral plane than is found in the
mitral valve (see Fig.14.1). Of how much this is of importance to the normal function of the valve is debatable.
Although some of the industry offer rigid annuloplasty rings
that pay homage to this differential planar, it is no more than
a gesture as they only adjust in one direction. The only annuloplasty support that more closely allows approximation to
the natural shape is one that is exible for the whole of the
right ventricular line of attachment. Whilst some would
argue that the draw string approach of the De Vega procedure
will allow for this, the suture is usually pulled so tight, to
reduce the orice size, as to become relatively stiff. The role
of any annuloplasty ring is to reduce the orice size to bring
the leaets back into coaptation and to stabilize the base of
the right ventricle. Allowing motion of the annulus throughout the cardiac cycle may be an added benet though none
has been shown. The most common cause of tricuspid regurgitation is atrial and ventricular dilatation, usually as a result
of chronic atrial brillation.
Whilst this statement is true, it is always important to look
out for loss of sub-valvar integrity through cordal or papillary muscle elongation, rupture, or congenital absence. In
Barlow’s disease, the changes that are seen in the mitral
valve are frequently found in the tricuspid valve.
Although as a result of the lower pressures on the right
side, the excess tissue seen in this condition prevents early
regurgitation, it can be seen in patients that present late with
raised pulmonary artery pressures and RV dilatation. In this
situation, an annuloplasty ring will usually sufce.
Causes of cordal and papillary muscle rupture include
endocarditis (particularly with Staphylococcus), trauma
(both blunt and sharp forms), and occasionally catheter
trauma from malpositioned Swan-Gantz catheters and pacing wires. Sudden and massive deceleration against the
closed valve in systole can cause rupture as in road trafc
accidents or falls from a height. Knife wounds are another
cause and should be thought of in penetrating chest injury.
© The Author(s), under exclusive license to Springer Nature Switzerland AG 2023
F. C. Wells (ed.), Atlas of Cardiac Surgery, Springer Surgery Atlas Series, https://doi.org/10.1007/978-3-031-43195-1_14
105

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Low RV apex
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Anteroseptal
commissure
N. Moorjani et al.
Anterior leaflet
Posterior
leaflet
Septal leafleft
Membranous
septum
AV
node
Coronary
sinus
Posteroseptal
commissure
c
Control
RA high
P
Fig. 14.1 (a) The functional anatomy of the tricuspid valve. (b) The site of annular dilatation of the valve orice. (c) The planar shape of the tri-
cuspid annulus in the normal and the dilated state
Much greater attention has been given to both primary
and secondary Tricuspid regurgitation (TR) of late, and the
morbidity and mortality from untreated TR have been
reported more widely in recent years [1]. The traditional
acceptance of the lesion as a bystander lesion, not needing
attention, has been consigned to the dustbin of cardiac surgical history.
Something less spoken of however is the production of
tricuspid stenosis from too great a reduction of orice circumference and hence orice area brought about by an
assumption that the greater the degree of coaptation the longer lasting the result. In choosing the appropriate ring size, it
should at least approximate to the size of the fully developed
Ao
valve
A
P
The ‘de Vega’ technique of suture annuloplasty has been
shown to have inferior results in most hands and is rarely
used in the modern era [2].
The development of worsening TR post left-sided valve
surgery is accompanied by worse long-term results. There is
a higher morbidity and mortality when tricuspid regurgitation is corrected at a second operation, hence restoration of
competency at the rst operation for mitral valve disease is
to be recommended if the orice is dilated signicantly, with
an orice diameter in the diagonal plane of greater than
4.0cm and there is more than mild regurgitation.
A tabular schema for the management of tricuspid regurgitation is shown in Fig.14.2 [3].
Functional TR
RA High
Low RV apex
anterior leaet.
A

14 Tricuspid Valve Disease Techniques
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107
FTR disease processes
Left-sided
heart
disease
Right
ventricular
(RV) afterload
increase
(with or without
pulmonary
hypertension)
RV
remodeling
Tr icuspid annular dilation.
(In some instances leaflet
tethering occurs with the
same triggering factors)
Abnormalities of tricuspid
anatomy and function
lead to functional
tricuspid regurgitation
Atrial
fibrillation
Altered
RV function
(FTR)
FTR assessments Diagnosis and treatment
Tricuspid regurgitation (TR)
TR is the leakage of blood
backwards through the
tricuspid valve each time the
right ventricle contracts
Color flow jet visualization is
used to evaluate PISA radius
and effective regurgitant
orifice or regurgitant volume
Annular dilation
The annular ring is attached
to the tricuspid valve leaflets.
Dilation can result in poor
leaflet apposition
2D-echocardiography
coupled with 3D imaging is
used to accurately measure
annular diameter
Leaflet coaptation mode
Coaptation is the surface
where the leaflets meet. If
decreased, contact is made
at the leaflet edge (edge-toedge), leaflet tethering can
restrict leaflet closure
3D echocardiography is
recommended to measure
tenting volume (TV) the area
within the tricuspid leaflets
Stage 1
TR severity:
None or mild
Annular
diameter:
<40 mm
Coaptation
mode: Normal
(body-to-body),
with no leaflet
tethering
Medical
treatment.
No surgical
Intervention
is indicated
Stage 2
TR severity:
Mild or moderate
Annular
diameter:
>40 mm
Coaptation
mode:
Abnormal
(edge-to-edge),
with or without
tethering of
<8 mm below
the annular
plane
Concomitant
tricuspid valve
annuloplasty is
recommended
the annular plane
Stage 3
TR severity:
Severe
Annular
diameter:
>40 mm
Coaptation
mode:
No coaptation,
with or without
tethering of
>8 mm below
Concomitant
tricuspid valve
annuloplasty
and leaflet
augmentation
(if tethering is
present)
Fig. 14.2 Tabular classication of tricuspid regurgitation. (From Dreyfus etal. [4]; with permission)
Insertion ofAnnuloplasty Band
may cause problems. In the A-V nodal area, that of heart
block and in the region of the right coronary artery, coronary
In placing the annuloplasty ring, suture care must be taken at
two sites in particular. The rst is in the region of the atrioventricular node and bundle and the second in the region of
the right coronary artery. Too deep placement in both areas
distortion and occlusion can occur to devastating effect [4].
It is most important the needle is directed down into ventricular muscle and not tangentially into the surrounding
atrial tissues (Fig.14.3).

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N. Moorjani et al.
Through hinge
Backhand
Forehand
Forehand
Backhand
Fig. 14.3 Suture techniques for tricuspid annuloplasty
Aortic segment
De Vega Technique
2mm
from hinge
2mm
from hinge
Through
hinge
The de Vega annuloplasty is a simple suture technique
with which to narrow down the annulus of the tricuspid
valve. Although it was the most common procedure to
correct TR, it has largely fallen out of favour because of
evidence of higher rates of recurrent tricuspid regurgitation, largely due to sutures cutting out of the imsy tricuspid ‘annulus’, resulting in the return of annular
enlargement and the ‘guitar string sign’ of sutures crossing the orice. This can be avoided by a slight modication of the technique: the rst suture is taken inferiorly at
the septal-posterior leaet commissure, with the second
suture going back on itself to start at the midpoint of the
rst suture (Figs.14.4 and 14.5). This is continued until
the point where conduction tissue begins (X in the gure),
then the course of the suture is reversed to anticlockwise
and the suture line is completed in the same way back to
the starting point. This results in a double line of cinching
sutures that simply cannot cut out. In the overwhelming
majority of cases, the annulus can be reduced to the
desired diameter with two sutures lines as above. Where
the annulus is enlarged to an exceptional degree, a third or
even a fourth suture line may be needed.
As mentioned earlier this was the mainstay of manage-
ment of tricuspid annular dilatation. Several recent papers
Fig. 14.4 Classical de Vega suture technique
have shown the relative inferiority of this technique over ring
annuloplasty, but the double row of suturing technique as
shown here seems to be more stable over long follow-up
periods. The important points to stress with this modication
are as follows. First the suture line must start and nish at the
same end points as they would for an annuloplasty ring, and
secondly, a two-layer approach as shown should be used
rather than the single traditional layer.

a
b
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109
c
Fig. 14.5 Modied de Vega technique
The Clover Leaf Stitch
In this technique, the central coaptation point of each leaet
is sewn together giving a central point of xation, analogous
to the Aleri edge-to-edge technique in the mitral valve
(Fig.14.6).
Fig. 14.6 (a–c) Clover stitch
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