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C. Manuele and M. Antonio
Take-Home Message
• Recent evidence suggests that OSA might be associated with alterations in the
auditory and vestibular systems, increasing the risks of Hearing Loss (HL), tin-
nitus, and dizziness.
• OSA could cause damage to other ENT organs by altering sensitive and motor
functions of the pharynx and larynx.
• Newer intra-pharyngeal remodelling surgical procedures, less invasive or mor-
bid, improving patients’ compliance, and nasal surgery make OSA surgery a
reasonable alternative. To patients that do not tolerate CPAP. Also, nasal surgery
provides a way of improving CPAP adherence by reducing nasal resistance.
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Dentistry inObstructive Sleep Apnea
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LuisD.AneybaLópez, AntonioLuigiGracco, S.R.Falardo,
FrancescaMilano, GiovanniBruno, AlbertoDe Stefani,
FrancescaZalunardo, AntonioRomero-Garcia,
CarlosA.CarrascoRueda, IlanVinitzkyBrener,
MiguelMeiraeCruz, EmmaPatriciaGarcíaCampos,
andDominikEttlin
L. D. AneybaLópez (*)
Mexican Association of Oral Sleep Medicine, Sleepadent Dental Sleep Center,
Monterrey, Nuevo Leon, Mexico
e-mail: info@sleepadent.com
A. L. Gracco
Italian Society of Dental Sleep Medicine, University of Padova, Padova, Italy
e-mail: antonio.gracco@unipd.it
S. R. Falardo
Atalaia Sleep Academy, Atalaia-Montijo, Portugal
F. Milano
University of Padova, Padova, Italy
G. Bruno · A. De Stefani · F. Zalunardo
Dental Sleep Medicine, University of Padova, Padova, Italy
A. Romero-Garcia
University of Valencia, Valencia, Spain
e-mail: tonirome@uv.es
C. A. CarrascoRueda · I. V. Brener
Stomatology Department, Instituto Nacional de Enfermedades Respiratorias,
Ciudad de México, Mexico
Mexican Association of Oral Sleep Medicine, Monterrey, Nuevo Leon, Mexico
M. MeiraeCruz
Sleep Unit, Cardiovascular Center of University of Lisbon, Lisbon School of Medicine and
Centro Europeu do Sono, Lisbon, Portugal
e-mail: mcruz@medicina.ulisboa.pt
E. P. G. Campos
Mexican Association of Oral Sleep Medicine, Monterrey, Nuevo Leon, Mexico
Instituto Mexicano de Medicina Integral del Sueño, Ciudad de México, Mexico
D. Ettlin
Center of Dental Medicine, University of Zurich, Zurich, Switzerland
e-mail: Dominik.Ettlin@zzm.uzh.ch
12
© The Author(s), under exclusive license to Springer Nature
Switzerland AG 2023
P. M. Baptista et al. (eds.), Obstructive Sleep Apnea,
https://doi.org/10.1007/978-3-031-35225-6_12
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12.1 Introduction
In the vast universe of sleep medicine, the dentist is also part of the multidisciplinary team described in this book.
The dentist must undergo training in dental sleep medicine. Apart from reviewing respiratory sleep disorders (OSA), it also deals with issues such as orofacial
pain, oral moisture disorders, gastroesophageal reux disorders, and jaw movement
disorders [1].
There is an actual amount of information in the literature on this subject promoted globally by various academies and associations. The most important ones are
the American Academy of Dental Sleep Medicine and the European Academy of
Dental Sleep Medicine. In other countries, dental colleagues are organizing to promote, train and treat these patients suffering from obstructive sleep apnea (OSA).
Within this training, the dentist must explore beyond the topics of conventional
dentistry, searching to understand the physiology of breathing and the diversity of
tests available to measure sleep. There is also a need for collaboration with various
medical specialists focused on this eld of sleep medicine. It becomes a very important barrier for the dentist who wants to embark on this path in sleep medicine and
treat the various respiratory sleep disorders such as Obstructive Sleep Apnea and
Snoring.
In their daily practice, dentists can identify various observable clinical, such as
the narrow maxillary, mandibular arches with high palatal vaults, tonsillar hypertrophy, macroglossia, retrognathia or micrognathia, and chronic periodontitis, tooth
loss, deep overbite, and neck circumference size [2]. These signs make us suspect
of OSA, especially if they are accompanied by daytime sleepiness (falling asleep
during the dental procedure), the referral of with important snoring with respiratory
pauses in our clinical history.
The presence of obstructive sleep apnea should be determined before proposing
treatment with oral appliances.
There are many indications for the use of oral appliances:
1. Patients diagnosed with primary snoring,
2. UARS, patients with mild obstructive sleep apnea,
3. Patients with moderate obstructive sleep apnea and low BMI,
4. Patients diagnosed with moderate–severe obstructive sleep apnea with a failure
of CPAP tting,
5. Patients who have undergone oropharyngeal surgery by our otolaryngologist
colleagues and who have failed the procedure,
6. Patients who are CPAP users and prefer the Oral Appliance (they must be
candidates),
7. Patients who need to use the appliance when traveling,
8. And the use in conjunction with CPAP, which is rare [3].

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12.2 Radiographic Analysis inPatients withOSA
Dentists and in particular, orthodontists can play a crucial role in identifying patients
with facial features that may predispose them to OSA.However, another helpful
tool is given by radio diagnostics.
Patients with a Class II skeletal malocclusion or maxillomandibular retrusion
have a greater risk of presenting OSA due to greater ease of collapse of the soft tissues, which are contained by a skeletal compartment of insufcient size.
One of the most used radiological investigations to identify any predisposing
features to OSA is the lateral x-ray of the skull in a lateral–lateral projection.
Although this radiograph has the limitations of two dimensions, a cephalometric
analysis can be done [4]. A hyoid bone positioned in a particularly caudal position
with a distance from the mandibular plane greater than 15mm is a risk factor for the
onset of respiratory sleep disturbances. Mandibular retrusion and increased anterior
facial heights, easily observed in the lateral x-ray, can also predispose to obstruction
in the retrolingual site [5, 6] (Fig.12.1).
In addition to the bone characteristics, it is also possible to evaluate any adenotonsillar hypertrophy.
Other measurements to be taken into account in cephalometry are tongue baseposterior nasal spine, sella-nasion-B point angle (SNB), maximum uvula thickness,
tongue base-tongue tip, and nasion-anterior nasal spine (N-ANS) [7]. A retrospective cephalometric study on upper airway spaces in different facial types determined
a difference in the median posterior-palatal space measurement, in the oropharynx
region, that was reduced for individuals with a dolichofacial pattern [8].
Fig. 12.1 Example of
teleradiography in lateral
projection of the skull in
which the aforementioned
structures can be observed

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The advantages of the lateral x-ray are the ease of execution, noninvasiveness,
reproducibility, and low cost. These characteristics are balanced by some disadvantages: the two-dimensionality, the upright position, the waking state in the execution, and the insufcient recognition of relevant anatomical landmarks.
In some cases, the two-dimensionality of teleradiography can represent a limit
that can mislead the clinician: the sagittal size of the airways and pharyngeal airway
space is difcult to evaluate using teleradiography.
This radiography is a support tool for the clinical evaluation of the patient, but it
cannot represent a screening or diagnostic tool. In fact, there are no cephalometric
values that identify the patient with OSA.
Radiodiagnosis also makes three-dimensional images available to the clinician
thanks to Computed Tomography (CT). It allows for delineating the anatomy of the
maxillofacial region with greater precision. CBCT provides detailed and threedimensional images of the entire facial massif, overcoming the overlaps between
the different structures and the distortion of the image of the lateral radiography [9].
Therefore, it is widely used to evaluate the upper airways and to identify predisposing factors of an anatomical nature in patients with OSA, be they adults or pediatrics. Through the CBCT, it is possible to evaluate, the size of the pharyngolaryngeal
space through software analysis (Fig.12.2).
Fig. 12.2 The image
highlights the airspace of
the upper airways. The
point with the smallest
caliber is highlighted in
green

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Furthermore, there is the possibility to evaluate pharyngeal wall thickness in the
presence of bone or some soft tissues anomalies. Some characteristics that alter
physiological respiration and which are identiable in CBCT are nasal polyps, nasal
turbinates hypertrophy, concha bullosa or paradoxical curvature, hypertrophy of the
soft palate or uvula, reduced transverse dimension of the jaws and dental arches,
hypertrophy of the palatine tonsils or obliteration of the maxillary sinuses (Fig.12.3).
Thanks to the sagittal projection reconstructions, it is possible to evaluate the
length of the soft palate and the lingual structure, especially concerning the oral
oor and the mandibular plane (Fig.12.4).
Fig. 12.3 Coronal and axial cuts highlight problems affecting the maxillary sinuses

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Fig. 12.4 Sagittal slice of
a CBCT
L. D. AneybaLópez et al.
CBCT of the skull can also be used to plan any oropharyngeal or maxillofacial
surgery [10].
The anatomical features that inuence the anteroposterior dimensions of the airways are multiple; however, the sagittal pharyngeal diameter is not seem to be
affected by being overweight [11, 12].
Furthermore, CBCT is used more and more frequently by dentists who treat
patients with OSAS using mandibular advancement devices (MAD) to investigate
the state of health of the condyles, and the temporomandibular joint (TMJ).
In any case, it is necessary to consider the high cost of CBCT and the increased
exposure to radiation. It has been suggested that a CBCT should be requested for an
adult patient with a diagnosis or solid clinical suspicion of OSA before starting
treatment identify all potential predisposing anatomical factors and establish the
best therapeutic strategy [13].
On the other hand, in the case of children, they should be thoroughly examined
before requesting a CBCT, and only in cases that are nonresponsive to treatment.
Magnetic Resonance (MRI) provides added information. Its use allows information of the soft tissues in the oropharyngeal area.. Evaluation of the lingual
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