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- •Contents
- •Contributors
- •Series Editors' preface
- •Editors' preface
- •Acknowledgements
- •Chronic liver failure
- •Metabolic liver function
- •Measuring liver volume
- •Blood tests of liver function
- •Tests of liver function measuring substance clearance
- •Indocyanine green (ICG)
- •Hepatobiliary scintigraphy
- •Lidocaine (MEG-X)
- •Aminopyrine breath test
- •Urea synthesis
- •Glutathione synthesis
- •Measuring liver blood flow
- •Effect of major liver resection on hepatic blood flow
- •Effect of major liver resection on innate immunity
- •Liver regeneration
- •Molecular signals for hepatic regeneration
- •Cell populations involved in liver regeneration
- •Evidence-based practice in surgery
- •Overview of liver functions and evolution
- •Symptoms of liver failure: acute and chronic
- •Common causes of acute liver failure: hepatic insufficiency following liver resections
- •Consequences of surgery
- •Small-for-size syndrome
- •Hepatic steatosis
- •Assessment of steatosis
- •Chemotherapy-induced liver changes
- •Portal vein embolisation
- •Technique
- •Therapy for liver failure
- •N -Acetyl cysteine
- •Nutritional support in liver failure
- •Artificial extracorporeal liver support
- •Artificial liver support
- •Bioartificial liver systems
- •Liver transplantation
- •Cell therapy for liver failure: general principles
- •Haemopoetic stem cell therapy for liver disease in humans
- •Future developments
- •References
- •Liver
- •Overview of hepatic anatomy and terminology
- •Divisions of the liver based on the hepatic artery
- •Resectional terminology
- •Surgical anatomy for liver resections
- •Hepatic arteries and liver resections
- •Bile ducts and liver resections
- •Prevailing pattern and important variations of bile ducts draining the right hemiliver
- •Prevailing pattern and important variations of bile ducts draining the left hemiliver
- •Prevailing pattern of bile ducts draining the caudate lobe (Sg1)
- •Portal veins and liver resections
- •Ramification of the left portal vein (Figs 2.10 and 2.11)
- •Hepatic veins and liver resection (Fig. 2.13)
- •The plate/sheath system of the liver
- •Liver capsule and attachments
- •Surface anatomy
- •Gallbladder and extrahepatic bile ducts
- •Gallbladder
- •Agenesis of the gallbladder
- •Double gallbladder
- •Cystic duct
- •Cystic artery
- •Extrahepatic bile ducts
- •Anomalies of extrahepatic bile ducts
- •Extrahepatic arteries
- •Blood supply of bile ducts
- •Pancreas
- •Pancreatic ducts
- •Blood supply of the pancreas
- •Lymphatics of the pancreas
- •References
- •Introduction
- •Colorectal liver metastases
- •Transabdominal ultrasound
- •Computed tomography and magnetic resonance imaging
- •Positron emission tomography
- •Diagnostic laparoscopy and laparoscopic ultrasound
- •Staging and assesment of resectability
- •Hepatocellular carcinoma
- •Transabdominal ultrasound
- •Computed tomography and magnetic resonance imaging
- •Diagnostic laparoscopy and laparoscopic ultrasound
- •Staging and assesment of resectability
- •Pancreatic and periampullary carcinoma
- •Transabdominal ultrasound
- •Computed tomography and magnetic resonance imaging
- •Endoscopic retrograde cholangiopancreatography (ERCP)
- •Endoscopic ultrasound
- •Positron emission tomography
- •Diagnostic laparoscopy and laparoscopic ultrasound
- •Staging and assesment of resectability
- •Positron emission tomography
- •Diagnostic laparoscopy and laparoscopic ultrasound
- •Staging and assesment of resectability
- •References
- •Introduction
- •Proximal bile duct tumours
- •Transabdominal ultrasound
- •Computed tomography and magnetic resonance imaging
- •Endoscopic retrograde cholangiopancreatography
- •Classification
- •Haemangiomas
- •Pathology
- •Clinical presentation
- •Management
- •Liver cell adenoma
- •Pathology
- •Clinical presentation
- •Management
- •Focal nodular hyperplasia
- •Pathology
- •Clinical features
- •Management
- •Nodular regenerative hyperplasia (macroregenerative nodules)
- •Bile duct adenoma (bile duct hamartoma)
- •Hepatic pseudotumours
- •Miscellaneous benign tumours
- •Liver abscess
- •Clinical presentation
- •Management
- •Amoebic abscess
- •Hydatid cyst
- •Clinical presentation
- •Management
- •Simple cysts of the liver
- •Clinical presentation
- •Management
- •Polycystic liver disease (PCLD)
- •Clinical presentation
- •Management
- •Cystadenoma
- •References
- •Introduction
- •Hepatocellular carcinoma
- •Incidence of HCC
- •Risk factors for HCC
- •Cirrhosis
- •HBV infection
- •HCV infection
- •Human immunodeficiency virus (HIV) infection
- •Other viral infections
- •Alcohol
- •Non-alcoholic fatty liver disease (NAFLD)
- •Hereditary haemochromatosis
- •Cirrhosis of other aetiologies
- •Aflatoxin
- •Metabolic liver diseases
- •Adenoma, contraceptives and androgens
- •Pathology of HCC and nodular lesions in chronic liver disease
- •Clinical presentation
- •Liver function tests and tumour markers
- •Liver function tests
- •Serum tumour markers
- •α-Fetoprotein
- •Others serum tumour markers
- •Radiological studies
- •Ultrasound
- •Computed tomography
- •Magnetic resonance imaging
- •Contrast-enhanced ultrasound
- •Other imaging
- •Angiography
- •Positron emission tomography
- •Accuracy of imaging techniques
- •Requirement for and reliability of histological assessment
- •Diagnosis of HCC
- •Natural history of HCC and staging systems
- •Screening for HCC
- •Treatment options
- •HCC in normal livers
- •Liver resection of HCC in cirrhotic patients
- •Liver resection
- •Main limitations
- •Risk of surgery and patient selection
- •Technique
- •Outcome after resection
- •Treatment of recurrence
- •Liver transplantation (LT)
- •Rationale
- •Patient selection
- •Treatment on the waiting list
- •Transarterial chemoembolisation (TACE)
- •Technique
- •Contraindications
- •Morbidity and mortality
- •Monitoring
- •Efficacy
- •Percutaneous local ablative therapy
- •Technique
- •Advantages and drawbacks
- •Contraindications and limitations
- •Methods and margins
- •Indication
- •Other palliative treatments
- •Conventional systemic chemotherapy
- •Anti-angiogenic targeted therapies
- •Radioembolisation
- •Other treatments
- •Defining a treatment strategy
- •Uncomplicated HCC associated with chronic liver disease
- •Treatment of complicated HCC
- •HCC with macroscopic portal vein invasion
- •HCC with macroscopic invasion of hepatic veins
- •Ruptured HCC
- •Fibrolamellar carcinoma (FLC)
- •Intrahepatic cholangiocarcinoma (ICCA)
- •Incidence
- •Risk factors
- •Classification and staging
- •Pathology and progression analysis
- •Clinical presentation and laboratory tests
- •Imaging studies
- •Diagnosis
- •Treatment
- •Angiosarcoma
- •Primary hepatic lymphoma
- •References
- •Introduction
- •Preoperative staging: the key to selection of candidates for curative treatment
- •Computed tomography (CT)
- •Magnetic resonance imaging (MRI)
- •Positron emission tomography (PET)
- •Staging laparoscopy
- •Cardiopulmonary exercise testing
- •Surgery: the old and the new standards for resection
- •Criteria for resection
- •Surgical strategies to improve resectability
- •Portal vein embolisation
- •Two-stage hepatectomy
- •Repeat hepatectomy
- •Extreme liver surgery
- •Extrahepatic colorectal disease
- •Techniques of surgical resection
- •Transection techniques
- •Fibrin sealants
- •Laparoscopic liver surgery: less is more?
- •Morbidity, mortality and survival after liver resection for CRLMs
- •Classification of CRLMs
- •Staging systems and terminology
- •Chemotherapy for CRLMs
- •Agents
- •Clarifying the intent of chemotherapy in CRLMs
- •Conversion/induction chemotherapy
- •Perioperative chemotherapy
- •Pathological response to chemotherapy as a predictor of long-term outcome
- •Chemotherapy-associated hepatotoxicity
- •Liver-targeted therapies
- •Hepatic arterial infusion
- •Drug-eluting beads for TACE (DEB-TACE)
- •Selective internal radiation treatment (SIRT)
- •Ablative therapies for CRLMs
- •Radiofrequency ablation
- •Microwave ablation
- •Multidisciplinary team approach
- •Conclusions
- •References
- •Introduction
- •Pathophysiology and molecular basis of liver metastases
- •Treatment strategies
- •Neuroendocrine tumours
- •Gastrointestinal stromal tumours
- •Breast cancer
- •Ovarian cancer
- •Renal cell carcinoma
- •Melanoma
- •Non-colorectal gastrointestinal adenocarcinoma
- •Testicular cancer
- •Urothelial cancer
- •Lung cancer
- •Adrenocortical tumours
- •Endometrial cancer
- •Conclusion
- •References
- •Introduction
- •Aetiology and pathophysiology of portal hypertension
- •The natural history of portal hypertension
- •Presentation
- •Imaging
- •Management of varices
- •Therapeutic aims for pharmacological therapy in portal hypertension
- •Oesophageal varices
- •Primary prophylaxis for the prevention of variceal haemorrhage
- •Prevention of re-bleeding from oesophageal varices (secondary prophylaxis)
- •Treatment for bleeding oesophageal varices
- •Gastric varices
- •Portal hypertensive gastropathy
- •Second-line therapies
- •TIPS (transjugular intrahepatic portosystemic shunt)
- •TIPS for variceal bleeding
- •Surgical options
- •Portal systemic shunts
- •Liver transplantation
- •Selection of second-line therapy
- •Non-cirrhotic
- •Cirrhotic
- •Management of ascites
- •Budd–Chiari syndrome
- •Acute Budd–Chiari syndrome
- •Chronic Budd–Chiari syndrome
- •Non-cirrhotic portal hypertension
- •Portal vein thrombosis
- •Segmental portal hypertension
- •TIPS and portal vein thrombosis
- •References
- •Introduction
- •Postsplenectomy sepsis
- •Trauma
- •Elective indications for splenectomy
- •Immune thrombocytopenic purpura
- •Evans syndrome
- •Hereditary spherocytosis
- •Elliptocytosis
- •Thallassaemias
- •Sickle cell anaemia
- •Autoimmune haemolytic anaemia
- •Lymphoma
- •Myeloid disease
- •Volvulus
- •Haemangiomas
- •Cysts
- •Portal hypertension
- •Preparation for splenectomy
- •Technique
- •Open splenectomy
- •Laparoscopic splenectomy
- •Postoperative management and complications
- •Summary
- •References
- •Introduction
- •Composition, formation and risk factors
- •Presentation
- •Cholecystolithiasis
- •Pathophysiology
- •Clinical features
- •Choledocholithiasis
- •Pathophysiology
- •Clinical features
- •Investigation
- •Blood tests
- •Ultrasonography
- •Endoscopic ultrasound (EUS)
- •Computed tomography (CT)
- •Radioisotope scanning
- •Magnetic resonance cholangiopancreatography (MRCP)
- •Percutaneous transhepatic cholangiography (PTC)
- •Endoscopic retrograde cholangiopancreatography (ERCP)
- •Management of gallbladder stones
- •Asymptomatic stones
- •Non-operative treatments for gallstones
- •Dissolution
- •Lithotripsy
- •Operative treatment of gallbladder stones
- •Open cholecystectomy
- •Mini-laparotomy cholecystectomy
- •Laparoscopic cholecystectomy
- •Symptomatic gallstones
- •Acute cholecystitis
- •Complications
- •Day-case laparoscopic cholecystectomy
- •Needlescopic cholecystectomy
- •Bile duct injury
- •Cholecystostomy
- •Subtotal cholecystectomy
- •Intraoperative cholangiography (IOC)
- •Routine IOC
- •Selective IOC
- •Bile duct injury
- •Laparoscopic ultrasound (LUS)
- •Management of common bile duct stones
- •Laparoscopic transcystic common bile duct exploration
- •Laparoscopic choledochotomy
- •Open choledochotomy
- •Endoscopic retrograde cholangiopancreatography (ERCP)
- •ERCP stent insertion
- •Preoperative ERCP
- •Intraoperative ERCP
- •Postoperative ERCP
- •Laparoscopic exploration of the CBD versus preoperative or postoperative ERCP
- •Recurrent or retained CBD stones
- •Transhepatic stone retrieval
- •Acalculous biliary pain
- •References
- •Introduction
- •Congenital anomalies
- •Biliary atresia
- •Choledochal cysts
- •Classification
- •Risk of malignancy
- •Management
- •Special operative techniques
- •Iatrogenic biliary injury
- •Aetiology
- •Techniques to avoid injury
- •Classification
- •Presentation
- •Management
- •Intraoperative recognition
- •Postoperative recognition: biliary fistula
- •Postoperative recognition: biliary obstruction
- •The timing of repair
- •Early repair
- •Delayed repair
- •Associated vascular injury
- •Further imaging
- •Operative techniques
- •Management of complications related to repair
- •Revisional surgery
- •Liver resection and transplantation
- •Prognosis
- •Success of repair
- •Survival
- •Quality of life
- •Associated malignancy
- •Benign biliary strictures
- •Mirizzi's syndrome
- •Presentation
- •Management
- •Hepatolithiasis
- •Management
- •Parasitic infestation causing jaundice
- •Liver flukes (trematodes)
- •Echinococcus
- •Treatment
- •Ascaris lumbricoides
- •Primary sclerosing cholangitis
- •Aetiology
- •Presentation
- •Investigation
- •Management
- •Exclusion of associated malignant stricture
- •Biliary strictures imitating malignancy
- •Lymphoplasmacytic sclerosing pancreatitis
- •Functional biliary disorders
- •References
- •Introduction
- •Cholangiocarcinoma
- •General considerations
- •Epidemiology
- •Natural history
- •Aetiology
- •Histopathology
- •Cholangiocarcinoma involving the proximal bile ducts (hilar cholangiocarcinoma)
- •Clinical presentation and diagnosis
- •Radiological investigation
- •Direct cholangiography
- •Computed tomography
- •Duplex ultrasonography
- •Magnetic resonance cholangiopancreatography (MRCP)
- •Preoperative evaluation and assessment of resectability
- •Treatment options
- •Resection
- •Results of resection
- •Adjuvant therapy
- •Palliation
- •Percutaneous biliary drainage
- •Intrahepatic biliary-enteric bypass
- •Radiation therapy
- •Photodynamic therapy
- •Chemotherapy
- •Cholangiocarcinoma involving the distal bile duct
- •Clinical presentation and diagnosis
- •Staging and assessment of resectability
- •Treatment options
- •Cholangiocarcinoma involving the intrahepatic bile ducts
- •Clinical presentation
- •Diagnosis
- •Radiological investigations
- •Staging and assessment of resectability
- •Treatment options
- •Gallbladder cancer
- •Epidemiology/aetiology
- •Clinical presentation and diagnosis
- •Histopathology and staging
- •Evidence for an aggressive surgical approach
- •Surgical therapy
- •T1 tumours
- •T2 tumours
- •T3 tumours
- •T4 tumours
- •Preoperative suspicion of malignancy
- •Unsuspected malignancy at exploration
- •Malignancy diagnosed post-cholecystectomy
- •Adjuvant therapy
- •Palliation
- •References
- •General description
- •Pathophysiology
- •Natural history
- •Diagnosis
- •Aetiology
- •Obstructive factors
- •Biliary disease
- •Benign pancreatic duct stricture
- •Tumours of the ampulla or pancreas
- •Toxic factors
- •Metabolic factors
- •Genetic defects
- •Trauma
- •Iatrogenic causes
- •Inflammatory
- •Physiological
- •Sphincter manometric abnormalities
- •Assessment of severity
- •Single biochemical measures
- •C-reactive protein (CRP)
- •Other single predictive markers
- •Intra-abdominal hypertension (IAH)
- •Repeated clinical assessment
- •Imaging
- •Role of ultrasound (US)
- •Role of CT
- •Role of magnetic resonance (MR)/magnetic resonance cholangiopancreatography (MRCP)
- •Endoscopic ultrasound (EUS)
- •Management
- •Initial management
- •Supportive management
- •Specific medical management
- •Prevention of infection
- •Nutritional support
- •Nutritional delivery in the patient with acute pancreatitis
- •Disease modulation through content or mode of delivery
- •Other medical therapies
- •Inhibition of pancreatic secretion
- •Inhibition of pancreatic enzymes
- •Inhibition of the inflammatory response
- •Role of ERCP
- •Definitive management issues
- •Prevention of recurrent acute pancreatitis
- •Management of gallstones
- •Investigation of non-gallstone-associated pancreatitis
- •Peripancreatic fluid collections
- •Management of an early fluid collection
- •Management of a pseudocyst
- •Percutaneous drainage
- •Endoscopic drainage
- •Surgical drainage of an acute post-inflammatory collection
- •Management of a pancreatic duct fistula
- •Management of necrosis
- •Management of sterile necrosis
- •Management of infected necrosis (early phase, 2–6 weeks)
- •Methods of necrosectomy
- •Open laparotomy/debridement
- •Minimally invasive approaches to infected necrosis
- •Management of pancreatic abscess
- •Specific late complications
- •Haemorrhage
- •Segmental portal hypertension and gastrointestinal haemorrhage
- •Pancreatic duct stricture
- •Gastric outlet obstruction
- •References
- •Summary
- •Definition
- •Incidence
- •Aetiology
- •Clinical course
- •Pathophysiological findings and pain mechanisms in chronic pancreatitis
- •Calcifying CP
- •Autoimmune pancreatitis
- •Hereditary CP
- •Pathogenesis of pain in chronic pancreatitis
- •Preoperative assessment and investigations
- •Laboratory evaluation
- •Imaging studies
- •Treatment
- •Conservative therapy
- •Endoscopic and interventional treatment
- •Endoscopy
- •Surgical therapy, timing and indications
- •Surgical techniques
- •Selection of the surgical intervention
- •Pancreatico-duodenectomy
- •Distal and total pancreatectomy
- •Partington–Rochelle procedure
- •Longitudinal pancreatico-jejunostomy and cyst drainage
- •Beger procedure
- •Frey procedure
- •Berne procedure
- •Hamburg procedure
- •V-shaped excision
- •Selection of the procedure
- •Salvage procedures
- •Complications of chronic pancreatitis
- •References
- •Introduction
- •Epidemiology
- •Risk factors (see Box 15.1)
- •Smoking
- •Diet and alcohol
- •Occupation
- •Past medical history
- •Hereditary pancreatic cancer
- •Precursor lesions
- •Presentation
- •Investigation
- •Serology
- •Markers
- •Diagnosis
- •Imaging studies
- •Cytology/histology
- •Advanced staging techniques
- •Laparoscopy
- •Pathology
- •Treatment
- •Resection
- •Pancreatico-duodenectomy
- •Extended lymph node and vascular dissection
- •Distal pancreatectomy
- •Laparoscopic pancreatectomy
- •Total pancreatectomy
- •Central pancreatectomy
- •Surgical palliation
- •Obstructive jaundice
- •Upper GI tract outflow obstruction
- •Adjuvant therapies
- •Neoadjuvant therapy
- •Future areas of interest
- •References
- •Introduction
- •Intraductal papillary mucinous neoplasms
- •Clinical presentation
- •Investigation
- •Pathology
- •Management
- •Outcome
- •Pancreatic neuroendocrine tumours
- •Clinical presentation
- •Investigations
- •Biochemical
- •Radiology
- •Treatment
- •Metastatic disease
- •Pathology and outcome
- •Other tumours
- •References
- •Introduction
- •Liver trauma
- •Mechanisms of liver injury
- •Classification of liver injury
- •Diagnosis of liver injury
- •Other diagnostic/therapeutic modalities for the assessment and treatment of liver injury
- •Management of liver injury: selection of patients for non-operative management
- •Operative management of liver injury
- •General strategy
- •Choice of incision
- •Intraoperative assessment
- •Perihepatic packing
- •Techniques for surgical haemostasis
- •Resectional debridement
- •Anatomical liver resection
- •Selective ligation of the hepatic artery
- •Management of hepatic venous and retrohepatic caval injury
- •Ex vivo surgery and liver transplantation
- •Complications of liver trauma
- •Complications of non-operative management
- •Postoperative complications after surgery for liver trauma
- •Outcome after liver injury
- •Extrahepatic biliary tract trauma
- •Incidence of biliary injury
- •Classification of biliary injury
- •Presentation and diagnosis of biliary injury
- •Operative management of biliary injury
- •Outcome after biliary injury
- •Pancreatic trauma
- •Mechanisms of pancreatic injury
- •Diagnosis of pancreatic injury
- •Classification of pancreatic injury
- •Initial management of pancreatic injury
- •Operative management of pancreatic injury
- •Complications of pancreatic injury
- •Conclusion
- •References
- •Index

Index
Gallbladder cancer 232–238
adjuvant therapy 237
clinical presentation/diagnosis 233–234
epidemiology/aetiology 232–233, 233f
histopathology/staging 234, 234t, 235t
palliation 237–238
surgical approach, aggressive 235
surgical therapy 235–237
post-cholecystectomy malignancy 236–237
suspected malignancy 236
T1 tumours 236
T2 tumours 236
T3 tumours 236
T4 tumours 236
unsuspected malignancy 236–237
Gallstones 174–195
acalculous biliary pain 190–192
acute pancreatitis 244, 246
asymptomatic 178–179
common bile duct (CBD) stones 183–190
composition/formation/risk factors 174–175, 175f
gallbladder stones 178–183
investigation 176–178
blood tests 177
computed tomography (CT) 177
endoscopic retrograde cholangiopancreatography
(ERCP) 178, 178f
endoscopic ultrasound (EUS) 177
magnetic resonance cholangiopancreatography
(MRCP) 178
percutaneous transhepatic cholangiography (PTC) 178
radioisotope scanning 177–178
ultrasonography 177
management 251
operative treatments 179
cholecystostomy 181
common bile duct (CBD) injury 181, 182–183, 182f, 183f
endoscopic retrograde cholangiopancreatography
(ERCP) 187–190, 188b, 188f
intraoperative cholangiography (IOC) 181–182
laparoscopic cholecystectomy 180–181
laparoscopic choledochotomy 187, 187b
laparoscopic transcystic common bile duct (CBD)
exploration 184f, 185, 185f, 187b
laparoscopic ultrasound (LUS) 183
mini-laparotomy cholecystectomy 180
open cholecystectomy 179–180
open choledochotomy 187
recurrent common bile duct (CBD) stones 190
subtotal cholecystostomy 181
non-operative treatments 179
dissolution agents 179
lithotripsy 179
presentation 175–176
Gastric outlet obstruction 257
Gastric varices
classification 149t
therapy 152–154
Gastrinoma 296t
Gastroduodenal artery 36–37
Gastrointestinal (GI) tract
adenocarcinoma 139–140
haemorrhage 256–257
outflow obstruction, upper 284–285
stromal tumours (GISTs) 136–137
Gastrointestinal Study Group (GITSG) 285
GLOBOCAN series (IARC) 80
Glucagonoma syndrome 296t
γ-Glutamyl transpeptidase (GGT) 177
Glutathione synthesis (GSH) 7, 10
GRETCH staging system 91
H
Haemangiomas 60–64, 168
clinical presentation 61–63, 62f, 63f
management 63–64
pathology 60–61, 61f
Haemophilus influenzae 284
Haemopoetic (haematopoietic) stem cell therapy 14–15
Haemorrhage
acute pancreatitis 256, 256f
gastrointestinal (GI) 256–257
variceal 149–152, 151f, 153f, 155
Hamburg procedure 269, 269f
Hemihepatectomy, defined 18f, 20–21
HepatAssist device 13
Hepatectomy 22, 93
defined 18f, 20–21
repeat 116
two-stage 116
Hepatic arterial infusion (HAI) 124
Hepatic arteries
anatomy 17–20, 18f, 19f, 20f
resection 21–22, 21f
ligation 314
Hepatic dysfunction see Liver failure; Liver function
Hepatic injury scale 305t
Hepatic insufficiency, liver resection 2–3
Hepatic progenitor cells (HPCs) 9–10
Hepatic pseudotumours 68
Hepatic steatosis 11, 11f
assessment 11, 11f
Hepatic veins
acute Budd–Chiari syndrome 158
anatomy 25f, 26–27, 26f
invasion, macroscopic 100
Hepatic venous pressure gradient (HVPG) 149, 150
Hepatic venous thrombosis see Budd–Chiari syndrome
Hepatitis, autoimmune 83
Hepatitis B virus (HBV) 80, 81–82
see also Hepatocellular carcinoma (HCC)
Hepatitis C virus (HCV) 80, 82
see also Hepatocellular carcinoma (HCC)
Hepatitis D virus (HDV) 82
Hepatitis E virus (HEV) 82
Hepatobiliary scintigraphy 6
Hepatocellular adenoma (HCAs) 84
Hepatocellular carcinoma (HCC) 42–44, 80–100, 210f
biliary injury 209, 210f
clinical presentation 85–86, 86f
diagnosis 89–90
histological assessment 89
incidence 80–81, 81t
laparoscopy/laparoscopic ultrasound (LUS) 43
liver function tests 86
natural history/staging 90–91, 91t
pathology 84–85, 85f
radiological studies 86–89
accuracy 89
angiography 89
331

Index
Hepatocellular carcinoma (HCC) (Continued)
computed tomography (CT) 42–43, 87
contrast-enhanced ultrasound (CEUS) 88–89
magnetic resonance imaging (MRI) 42–43, 87–88
positron emission tomography (PET) 89
ultrasound 87
resectability, staging/assessment 40f, 43–44, 43t
risk factors 81–84
screening 91–92
serum tumour markers 86
transabdominal ultrasound 42, 42f
treatment 92–99
complicated HCC 99–100
uncomplicated HCC 100
ablation see Percutaneous local ablative therapy
chemoembolisation see Transarterial
chemoembolisation (TACE)
normal livers 92–93
palliative 98–99
resection see under Liver resection
strategy, defining 99–100
transplantation see Liver transplantation (LT)
variant, fibrolamellar carcinoma (FLC) 100
Hepatolithiasis 211, 219
management 211
Hepato-pancreato-biliary (HPB) malignancy see
Colorectal liver metastases (CRLMs);
Hepatocellular carcinoma (HCC); Pancreatic/
periampullary carcinoma; Proximal bile duct tumours
Hereditary chronic pancreatitis (HCP) 263
Hereditary haemochromatosis (HH) 83
Hereditary pancreatic cancer 276
Hereditary spherocytosis 167
Hilar cholangiocarcinoma 219–220, 221–229
adjuvant therapy 227
classification 223–224, 224b, 224t
clinical presentation/diagnosis 221–222
palliation 227–229
chemotherapy 229
intrahepatic biliary-enteric bypass 228
percutaneous biliary drainage 228
photodynamic therapy 228
radiation therapy 228
preoperative evaluation 223–225, 223f
radiological investigation 222–223
computed tomography (CT) 222
direct cholangiography 222
duplex ultrasonography 222, 222f
magnetic resonance cholangiopancreatography
(MRCP) 223, 223f
resection 223f, 225–226, 225f, 225t, 227t
results 226–227
T-stage criteria 224t
treatment options 225
Hilar marginal artery 32, 33f
Hjortsjo’s crook 23, 23f
Hodgkin’s lymphoma 167
Human immunodeficiency virus (HIV) infection 82
Hydatid cyst 71–73, 72f
clinical presentation 71–72
management 72–73
Hydatid sand 71
Hydrojet 117
Hydroxy-imino-diacetic acid (HIDA) 177–178
5-Hydroxyindoleacetic acid (5-HIAA) 136
Hyperamylasaemia 246
Hyperplasia, nodular regenerative 68
Hypertension
intra-abdominal (IAH) 247
portal see Portal hypertension
Hyperthermic intraperitoneal chemotherapy
(HIPEC) 138
I
Iatrogenic biliary injury 199–209
aetiology 199
avoiding, techniques 199–201, 200f
classification 201, 201t, 202f
management 203–209, 204f
biliary fistula 203–204
biliary obstruction 204–205
complications 206f, 208–209, 209f
operative techniques 207–208
prognosis 209
repair, timing 205–207, 205f, 206f, 207f
vascular injury 206, 206f, 207f
presentation 201–203
Imatinib 136–137
Immune thrombocytopenic purpura (ITP) 166–167, 168
Immunity, innate 8–9
Indocyanine green (ICG) 6, 6f
Infection, prevention 250
Inferior vena cava (IVC) 17, 18–20, 18f, 114–115
acute Budd–Chiari syndrome 158
hepatic veins and 26–27
liver capsule and 29–30
Inferior vena caval ligament 27
Inflammatory response, inhibition 251
Innate immunity, liver resection 8–9
Insulinoma 296t
International Agency for Research on Cancer (IARC) 80,
275–276
International Association of Pancreatology (IAP)
292–293, 292b, 294
International Classification of Diseases for Oncology
(ICD) 101
International Symposium on Acute Pancreatitis, Atlanta
Conference 244–245
Intra-abdominal hypertension (IAH) 247
Intraductal papillary mucinous neoplasms (IPMNs) 277,
289–295
clinical presentation 289–290
investigations 290–291, 290f, 291t
management 292–294
outcome 294–295, 294t
pathology 291–292, 292f
Intrahepatic biliary-enteric bypass 228
Intrahepatic cholangiocarcinoma (ICCA) 80, 100–103
classification/staging 101
clinical presentation 102
diagnosis 102
imaging studies 102, 102f, 103f
incidence 101
pathology/progression 101–102
risk factors 101
treatment 102–103
Intraoperative cholangiography (IOC) 181–182
Irinotecan 120
-based regimes 120–121, 122, 123, 124
Ischaemia/reperfusion (I/R) injury 3, 10
332

Index
J
Jarnagin–Blumgart clinical T staging system 52–53,
53t
Jaundice, obstructive 284
see also Parasitic infestation, jaundice
Johns Hopkins-Mayo Clinic Collaborative Study 285
K
Karnofsky index 90
Kasai’s operation (porto-enterostomy) 196, 208
Kausch–Whipple procedure 268
King’s College Hospital, acute liver failure criteria 1
Klatskin tumours, classification 53f
Klebsiella spp 221
Kocher manoeuvre 320
Kocherisation 283
KRAS proto-oncogene 120, 121, 122
Kupffer cells 1
L
Laparoscopic surgery 117–118
Laparoscopic ultrasound (LUS)
colorectal liver metastases (CRLMs) 41, 112–113
gallstones 183
hepatocellular carcinoma (HCC) 43
pancreatic/periampullary carcinoma 46–47, 47f
proximal bile duct tumours 51
Laparotomy, open 254–255
Left adrenal gland 36
Left lateral sectional bile duct 23–24, 23f
Leucovorin 122
see also FOLFOX
Lidocaine (MEG-X) 6
Lithotripsy 179
Liver
lesions see Benign liver lesions
metastases see Colorectal liver metastases (CRLMs);
Non-colorectal hepatic metastases
tumours see Primary malignant tumours, liver
Liver abscess 69–70, 70f
clinical presentation 69
management 69–70
Liver, anatomy 17–30
overview 17–21
hepatic artery 17–20, 18f, 19f, 20f
resectional terminology 18f, 19f, 20–21, 20f
resections 21–30
bile ducts 22–24, 22f, 23f
hepatic arteries 21–22
hepatic veins 25f, 26–27, 26f
plate/sheath system 28–30, 28f, 29f
portal veins 24–26, 24f, 25f
Liver Cancer Study Group of Japan (LCSGJ) 90, 91t, 94,
101, 220–221
Liver cell adenoma 64–65
clinical presentation 65
management 65, 66f
pathology 64–65, 64f
Liver cysts, simple 73–74
clinical presentation 73–74, 73f
management 74
Liver Dialysis Device 13
Liver failure 1–16
future developments 14–15
symptoms 1–5, 2b
acute 2–3, 5t
chronic 3, 3t, 5t
therapy 13–14
artificial support 13–14
extracorporeal support 13
N-acetyl cysteine 13
nutritional support 13
stem cell 14–15
transplantation (LT) 14
Liver flukes (trematodes) 211–212
Liver function 1–16
blood tests 5, 5t
future developments 14–15
metabolic 3–4
overview 1
substance clearance tests 5–12
tests (LFTs) 177, 184
volume measurement 4–5, 4f, 5f
Liver regeneration 9
cell populations 9–10
molecular signals 9, 10f
Liver resection 208–209, 209f
anatomical 314
blood flow, effect on 8, 8f
chemotherapy 11
consequences 10
hepatocellular carcinoma (HCC) 93–98
limitations 93
outcome 94
recurrence, treatment 94–95
risks/patient selection 93–94
technique 94
innate immunity 8–9
resectional debridement 314, 314f
small-for-size syndrome 10–11
surgical anatomy see under Liver, anatomy
Liver transplantation (LT) 14, 95–96, 157, 208–209
patient selection 95
portal hypertension 157
rationale 95
trauma 315
treatment 95–96
Liver trauma 304–316
classification 305, 305t
complications 315–316
non-operative management 315
outcome 316
postoperative 315–316
diagnosis 305–308, 307f
mechanisms of injury 304–305
operative management 309–315
anatomical resection 314
ex vivo surgery/liver transplantation (LT) 315
haemostasis, techniques 313, 313f
hepatic artery ligation 314
hepatic venous/retrohepatic caval injury
314–315
incision 309–310
intraoperative assessment 310–311, 310f, 311f
perihepatic packing 311–313, 312f
resectional debridement 314, 314f
strategy 309
non-operative management 308–309, 315
333

Index
LiverMetSurvey group 122
Living-donor liver transplantation (LDLT) 95
Longitudinal pancreatico-jejunostomy 268
Lung cancer 141
Lymphoma 105, 167
Lymphoplasmacytic sclerosing pancreatitis 213
M
Macroregenerative nodules 68
Magnetic resonance cholangiopancreatography (MRCP)
acute pancreatitis 248–249
biliary disorders 205, 206–207, 229
cholangiocarcinoma 222
choledochal cysts 197
computed tomography (CT) 177
gallstones 178
hepatolithiasis 211
hilar cholangiocarcinoma 223, 223f
Mirizzi’s syndrome 210
primary sclerosing cholangitis 212–213
Magnetic resonance imaging (MRI)
acute pancreatitis 248–249, 249f
colorectal liver metastases (CRLMs) 40, 110–112
hepatocellular carcinoma (HCC) 42–43, 87–88
pancreatic/periampullary carcinoma 45, 45f
proximal bile duct tumours 50–51
Malignancy
biliary see Biliary tract, malignancy
choledochal cysts 197, 197f
primary sclerosing cholangitis 213
see also Colorectal liver metastases (CRLMs);
Hepatocellular carcinoma (HCC); Pancreatic/
periampullary carcinoma
Marginal arteries 32, 33f
MARS (Molecular Absorbent Recirculating System)
device 13
Marseille Classification, chronic pancreatitis (CP) 260
Masitinib 137
Melanoma 139
MELD (Model for End-stage Liver Disease) score 6, 93,
95–96, 147–148, 148b, 157
Memorial Sloan–Kettering Cancer Center (MSKCC) 222,
226–227, 228, 230, 231, 235
clinical risk score (CRS) 112–113
staging system 52–53
Meningococcus C 284
Mesenchymal tumours, classification 60b
Metabolic liver disease 83–84
Metabolic liver function 3–4
Metastasectomy 140–141
Microwave ablation (MWA) 125
Milan criteria 95–96
Milano/Mazzaferro criteria 43–44
Mirizzi’s syndrome 209–211, 210f
management 210–211
presentation 210
Mixed mesenchymal/epithelial tumours, classification 60b
Molecular signals, liver regeneration 9, 10f
Monoethylglycinexylidide (MEG-X) 6
Mucinous cystic neoplasm (MCN) 277, 289, 292,
299–301
Multidisciplinary team (MDT) approach 125–126
Multiple organ dysfunction syndrome, defined 245b
Myeloid disease 168
N
N-acetyl cysteine 13
National Institute for Health and Clinical Excellence
(NICE) 120–121
Near-infrared spectroscopy 8
Necrosectomy, methods 254–256, 254f
Necrosis 253–256
infected 254–256
minimally invasive approaches 255–256
percutaneous drainage 255
surgery 255–256, 256f
necrosectomy, methods 254–256, 254f
open laparotomy/debridement 254–255, 254f
sterile 253–254
Neuroendocrine tumours (NETs) 132, 134–136, 135f, 136f
Nilotinib 137
Nitrogen homeostasis 3–4
Nitrogen metabolism 4
‘No-touch’ technique 226
Nodular regenerative hyperplasia 68
Non-alcoholic fatty liver disease (NAFLD) 82–83
Non-colorectal hepatic metastases 132–145
adrenocortical tumours 141
breast cancer 137
clinical approach 134
endometrial cancer 141
gastrointestinal (GI) adenocarcinoma 139–140
gastrointestinal (GI) stromal tumours (GISTs)
136–137
lung cancer 141
melanoma 139
neuroendocrine tumours (NETs) 132, 134–136, 135f,
136f
ovarian cancer 137–138, 138f
pathophysiology 133
renal cell carcinoma (RCC) 138–139
testicular cancer 140–141
treatment 134
urothelial cancer 141
Non-colorectal non-neuro-endocrine gastrointestinal (GI)
metastases 140b, 141
Non-Hodgkin’s lymphoma 167
Norfloxacin 152b
Nutritional support 250–251
delivery 250
disease modulation 250–251
liver failure 13
O
Obstructive jaundice 284
Occupation, risk factor 276
Octreotide 152–154
Oesophageal cancer 139–140
Oesophageal varices
classification 149t
management 148–149
therapy 149–152, 149t
Oliveira classification system 53t
OncoSurge computer model 126
Open laparotomy/debridement
closed lavage 255
drainage/closed packing 254
open packing 255
334

Index
Opisthorchis viverrini 101, 219
OPUS trial 121
Ovarian cancer 137–138, 138f
Oxaliplatin 120
see also FOLFOX
P
Paclitaxel 138
Palliation
gallbladder cancer 237–238
hilar cholangiocarcinoma 227–229
pancreatic adenocarcinoma 284–285
Pancreas
cancer, hereditary 276
enzymes, inhibition 251
secretion, inhibition 251
tumours 246
Pancreas, anatomy 34–37
blood supply 34–35, 35f
ligaments 36–37
lymphatics 35, 36f
pancreatic ducts 34
Pancreatectomy
central 284
distal 268, 284
laparoscopic 284
total 267, 284
Pancreatic abscess 256
defined 245b
Pancreatic adenocarcinoma 275–288
epidemiology 275
future trends 285–286
investigations 278–280
cytology/histology 280
diagnosis 279–280
imaging 279–280, 279f
markers 278
serology 278
pathology 281
precursor lesions 277, 279f
presentation 277–278, 278b
risk factors 275–276, 276b
diet/alcohol 276
hereditary pancreatic cancer 276
occupation 276
past medical history 276
smoking 275–276
staging techniques 280–281
laparoscopy 280–281, 280f, 281f
treatment 281–285, 282f, 282t
adjuvant therapies 285
neoadjuvant therapy 285
palliation 284–285
resection 281–284
Pancreatic duct
fistula 253
obstruction 244
stricture 246, 257
Pancreatic ductal adenocarcinoma (PDAC) 140
Pancreatic intraepithelial neoplasia (PanIN) 277
Pancreatic neuroendocrine tumours (PNETs) 295–299
clinical presentation 295
investigations 295–297
biochemical 295
radiology 295–297, 297f
Pancreatic neuroendocrine tumours (PNETs) (Continued)
metastatic disease 299
pathology/outcome 299
treatment 296t, 297–298, 298f
Pancreatic trauma 318–322
classification 319, 319f, 319t, 320f
complications 321–322
diagnosis 318–319, 318f
management
initial 320
operative 320–321
mechanisms of injury 318
Pancreatic/periampullary carcinoma 44–50
computed tomography (CT)/magnetic resonance
imaging (MRI) 45, 45f
endoscopic retrograde cholangiopancreatography
(ERCP) 45–46
endoscopic ultrasound (EUS) 46
laparoscopy/laparoscopic ultrasound (LUS) 46–47, 47f
positron emission tomography (PET) 46
resectability, staging/assessment 47–50, 47t, 48t,
49t, 50f
transabdominal ultrasound 44–45
Pancreatico-duodenectomy 268, 283
Pancreatico-jejunostomy, longitudinal 268
Pancreatitis
acute see Acute pancreatitis
chronic see Chronic pancreatitis (CP)
Parasitic infestation, jaundice 211–212
Partington–Rochelle procedure 268–269
Percutaneous biliary drainage 228
Percutaneous ethanol injection (PEI) 97, 98
Percutaneous local ablative therapy 97–98
advantages/disadvantages 97–98
contraindications 98
indications 98
methods 98
technique 97
Percutaneous transhepatic cholangiography (PTC) 178,
206–207, 222
Perihilar cholangiocarcinoma 52, 52t
Photodynamic therapy 228
Pneumococcus 284
POCHER study 122
Polycystic liver disease (PCLD) 74–75, 74f
clinical presentation 74, 75f
management 74–75
Polyvinyl alcohol (PVA) 124
Porcelain gallbladder 233
Portal hypertension 146–163
acute pancreatitis 256–257
aetiology/pathophysiology 146–147, 147t
ascites, management 157–158
Budd–Chiari syndrome 146–147,
158–159
acute 158–159
chronic 159
imaging 148
natural history 147–148, 148b, 148t
non-cirrhotic 157, 159–160
portal vein thrombosis 159–160
segmental 159
pharmacological therapy 149–154
gastric varices 152–154
oesophageal varices 149–152, 149t
portal hypertensive gastropathy (PHG) 154
335

Index
Portal hypertension (Continued)
presentation 148, 149t
second-line therapies 154–157
selection 157
surgical options 155–157, 156f
transjugular intrahepatic portosystemic shunt (TIPS)
154–155, 157, 159–160
splenectomy 168
varices, management 148–149
Portal hypertensive gastropathy (PHG) 154
Portal pedicle 28
Portal vein embolisation (PVE) 11–12, 12f, 93–94,
116
technique 12, 12f
Portal veins
anatomy 24–26, 24f, 25f
invasion, macroscopic 100
thrombosis 159
Porto-enterostomy (Kasai’s operation) 196, 208
positron emission tomography (PET)
colorectal liver metastases (CRLMs) 40–41, 40f, 110f,
112, 112f, 113f, 114f, 115f
hepatocellular carcinoma (HCC) 89
pancreatic/periampullary carcinoma 46
proximal bile duct tumours 51
Preoperative clinical T staging system 52–53, 53t
Primary biliary cirrhosis (PBC) 83
Primary malignant tumours, liver 80–108
angiosarcoma 104–105
epithelioid haemangioendothelioma (EHE)
103–104
fibrolamellar carcinoma (FLC) 100
lymphoma 105
see also Hepatocellular carcinoma (HCC); Intrahepatic
cholangiocarcinoma (ICCA)
Primary sclerosing cholangitis (PSC) 212–213, 219
aetiology 212
investigation 212–213
malignancy 213
management 213
presentation 212
Prometheus system 13
Protein metabolism 3
Proton-pump inhibitor (PPI) 154, 296t
Proximal bile duct tumours 50–53
computed tomography (CT)/magnetic resonance
imaging (MRI) 50–51
endoscopic retrograde cholangiopancreatography
(ERCP) 51
laparoscopy/laparoscopic ultrasound (LUS) 51
positron emission tomography (PET) 51
resectability, staging/assessment 52–53, 52t, 53f, 53t
transabdominal ultrasound 50
Pseudocysts 252–253
acute, defined 245b
endoscopic drainage 252
percutaneous drainage 252
surgical drainage 252–253
Pseudotumours, hepatic 68
Pylorus-preserving pancreatico-duodenectomy (PPPDR)
283–284
Pyogenic liver abscess 70
Q
Quality of life, biliary injury 209
R
Radiation therapy 228
Radical antegrade modular pancreato-splenectomy
(RAMPS) 36
Radioembolisation 99
Radiofrequency ablation (RFA) 41, 125
gastric adenocarcinoma 140
liver tumours 97, 98
neuroendocrine tumours (NETs) 135–136
non-colorectal hepatic metastases 134
Radioisotope scanning 177–178
Remnant liver volume (RLV) 93–94
Renal cell carcinoma (RCC) 138–139
Replaced arteries 21–22
defined 21
Retropancreatic fat 36
Right anterior sectional bile duct (RASBD)
22, 22f, 23f
Right hepatic duct 22
Right posterior sectional bile duct (RPSBD)
22, 22f, 23f
S
Schistosomiasis 146–147
Selective internal radiation treatment (SIRT) 125
Sengstaken–Blakemore tube 152–154
Sepsis, postsplenectomy 164–165
Serous cystadenoma (SCA) 298f, 299–301
Severe acute pancreatitis, defined 245b
Shunts, portal systemic 155–157, 156f
Sickle cell anaemia 167
Small-bowel adenocarcinoma (SBA) 140
Smoking 275–276
Society for Surgery of the Alimentary Tract (SSAT),
Patient Care Guidelines 165–166, 166b
Somatostatin 134, 296t, 297–298
Somatostatinoma 296t
Sorafenib 99
Sphincter manometric abnormalities 247
Splenectomy 164–173
complications 171
elective indications 166–168
postsplenectomy sepsis 164–165, 165b
preparation 168
technique 168–171
laparoscopic 169–171, 169f, 170f
open 168–169
trauma 165–166, 165t, 166b
Splenic artery 36–37, 164
Splenic vein 164
thrombosis 147
Stem cell therapy 14
Stenosis, common bile duct (CBD) 271
Stent insertion 188–189, 188f
Strasberg classification, biliary complications
201, 202f
Streptococcus viridans 221
Sunitinib 134
Superior mesenteric artery (SMA) 31, 34–35, 36–37
Superior mesenteric vein (SMV) 35, 36–37
Surface anatomy, liver 30
Systemic inflammatory response syndrome,
defined 245b
336

Index
T
Teardrop sign 49–50
Terlipressin 152–154
Testicular cancer 140–141
Thallassaemias 167
TissueLink dissecting sealer 117
TNM staging system (AJCC)
ampullary carcinoma 48t
cholangiocarcinoma 49t
exocrine/endocrine tumours 47t
gallbladder cancer 234, 234t, 235t
hepatocellular carcinoma (HCC) 43–44, 43t
hilar cholangiocarcinoma 52, 52t
liver tumours 91t, 101
pancreatic neuroendocrine tumours (PNETs) 299
primary liver cancers 231
trauma 281, 282t
Todani classification, modified 197, 198f
Transabdominal ultrasound (TAUS)
Transarterial chemoembolisation (TACE) 96–97, 98, 99,
99b, 100, 134, 135–136, 138
chronic liver disease 99, 100
contraindications 96
drug-eluting beads for (DEB-TACE) 124
efficacy 96–97
monitoring 96, 97f
morbidity/mortality 96
technique 96
Transarterial embolisation (TAE) 134, 135–136
Transection technique 117
Transhepatic stone retrieval 190
Transjugular intrahepatic portosystemic shunts (TIPS)
ascites 158
Budd–Chiari syndrome 158, 159
portal hypertension 146, 152, 154–155, 157,
159–160
vs portal systemic shunts 155–157
Transplantation see Liver transplantation (LT)
Trauma
acute pancreatitis 246
biliary tract see Extrahepatic biliary tract trauma
liver see Liver trauma
pancreatic see Pancreatic trauma
Trematodes 211–212
TRIBE trial 122
T-stage system, hilar cholangiocarcinoma 223–224,
224b, 224t
Tumours
adrenocortical 141
ampulla/pancreas 246
benign, classification 60b
benign liver 68–69
bile duct see Proximal bile duct tumours
carcinoid 296t
cystic 298f, 299–301
endocrine 47t
exocrine 47t
Tumours (Continued)
gallbladder 236
gastrointestinal stromal (GISTs) 136–137
Klatskin classification 53f
liver see Primary malignant tumours, liver
neuroendocrine (NETs) 132, 134–136, 135f, 136f
pancreatic. see entries beginning Pancreatic
pseudotumours 68
U
Ultrasound (US)
acute pancreatitis 248
duplex 222, 222f
endoscopic see Endoscopic ultrasound (EUS)
laparoscopic see Laparoscopic ultrasound (LUS)
transabdominal 50
Umbilical vein (UV) 26–27, 26f
Union for International Cancer Control (UICC) staging
system 43t, 44
Upper gastrointestinal (GI) tract outflow obstruction
284–285
Urea synthesis 6–7
Urothelial cancer 141
Ursodeoxycholate (UDCA) 179
V
Variceal band ligation (VBL) 150
Variceal haemorrhage 149–152, 151f, 153f, 155
Vascular endothelial growth factor (VEGF) 120
receptors 99
Vascular injury, biliary repair 206, 206f, 207f
Veno-occlusive disease 146–147
Verner–Morrison syndrome, PNETs 296t
Video-assisted retroperitoneal debridement (VARD)
technique 255–256
VIPoma 296t
Virchow’s node 278
Volvulus 168
Von Hippel–Lindau syndrome 298f, 299
V-shaped incision 269–270, 269f
W
Whipple procedure 283
Whipple’s triad syndrome 296t
World Health Organization 90
Y
Yttrium-90 (Y-90) 125
Z
Zollinger–Ellison syndrome 296t
337
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