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Section 2: Upper Limb
Figure 2
can be an option if the forces are transmitted through a component other than the anchors attaching the silicone to its frame. Photograph of a patient using a prosthesis with an adjust­able suspensio n system. The pos terior aspect of the frame has a window to allow for donning. The posterior side was chosen because the an­terior aspect is important for loading.
For heavy-duty use, silicone
components such as electrodes, bat­teries, switches, and charge ports can be embedded into the silicone. In ar­eas where greater elasticity is desired, such as the olecranon in a patient with a transradial amputation, the silicone can be made thinner or with a lower shore to allow increased stretching with elbow flexion.
Clinical Considerations
The high adhesion of HCR silicone to the skin renders it an ideal inter­face material. Because there is little shift in the socket relative to the skin, problems associated with shear forc­es and compromised suspensions are reduced. To don a silicone socket, a pull sock can be used or a lubricant liberally applied to the patient’s skin. A lubricant that is especially slippery, such as Cal-Stat Plus Antiseptic Han­drub with Enhanced Emollients (Steris
Figure 3
silicone as the interface. The components are set up and attached to simulate the nal product.
Healthcare), is preferred in this type of application. Importantly, lubricants or lotions with added fragrances should be avoided because they can cause skin irritation and rashes. If irritation occurs, the silicone interface can be sanitized by placing it in boiling water. Regular cleaning of HCR silicone can be accomplished with soap and water or isopropyl alcohol.
Normal HCR silicone interface con­struction allows for medium-duty use; however, if heavy-duty use is desired, special modifications can be performed to ensure that forces are applied to a
Photograph of a check socket tting with unpigmented high consistency rubber
Primary Socket and Suspension Approaches
Limb Protectors
In some instances, a silicone interface serves solely as a limb protector. The patient may choose to wear such an in­terface to protect a limb that is either especially sensitive or insensate. The pa tient may wear the silicone interface for special activities or use it for improved comfort during sleep. Using a check socket as a limb protector is a good use of a device that otherwise might be discarded when the definitive socket is
fabricated and delivered (Figure 4). more rigid external frame rather than the silicone itself (Figure 2). Maximiz­ing the surface contact area between the silicone and the frame can be accom­plished by gluing the two together.
For most prostheses, a check socket is fitted first (Figure 3). After the desired volume, range of motion, suspension, and functionality are achieved within the design, a definitive prosthesis is made. In contrast to some commonly used socket materials, it is very difficult to adjust the volume of a silicone socket, and it is best indicated for volumetrically stable limbs.
Fingertip Amputations
Many patients who play musical instru­ments desire an extension of the ampu­tated digit to resume playing. Providing an extension made of silicone has proven useful for patients who play instruments such as the guitar and piano. Typically, a flexion angle of approximately 45° has been found to be desirable in allowing the finger to apply pressure to the strings or keys. A length similar to the anatomic finger is created for the extension, and suspension is provided by suction (Figure 5).
-
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Chapter 26: Silicone Interface Options in Upper Limb Prostheses
Figure 4
fabricated for a patient with an insensate up­per limb who works as a chef. It provides pro­tection as well as a textured posterior surface to provide a gripping surface for manipulating objects.
Photograph of a limb protector
Partial Finger and Partial Hand Prostheses
HCR silicone has been used for vari­ous custom and use-specific prostheses (for example, allowing a drummer to hold a drumstick [Figure 6] or a car­penter to hold a hammer [Figure 7]). In addition, body-powered prostheses using M-fingers and partial M-fingers use HCR silicone in the contact areas with the skin (Figure 8). Silicone also has been used routinely for externally powered finger prostheses because it protects the often scarred residual limb and can be trimmed away at the wrist to allow for range of motion (Figure 9). In such applications, a forearm section can be fabricated to house the batter­ies; the switch; and the electrodes, with channels in the silicone going to the motors. Zippers in the forearm section can be used to provide access to a pouch housing the components and can open to make it easier to don and doff the prosthesis (Figur e 10).
Thumbs and Opposition Posts
The thumb is the most important fin­ger because it represents 40% of hand
Figure 5
extension that is helpful in playing the guitar.
Figure 7
such as a hammer.
Figure 8
prepreg carbon frame.
Photograph of a silicone nger
Photograph of a partial hand prosthesis designed for grasping tools with handles,
Photograph of a partial M-nger prosthesis, with a silicone suction socket with a
function and provides opposition to the remaining fingers.4 In addition to its traditional use in aesthetic prostheses, silicone is used in opposition posts and in conjunction with simple mechanical thumbs (Figures 11 and 12).
Figure 6
thesis that allows a drummer to hold a drum stick. The prosthesis grasps the stick yet allows exibility for percussion.
Photograph of a custom pros-
Wrist Disarticulation
Silicone prostheses for wrist disarticu­lation have the advantages of provid­ing suction suspension and allowing retention of residual pronation and supination.5 Because the silicone brim
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323
Section 2: Upper Limb
Figure 9
The wrist area is exposed to allow free range of motion.
Figure 11
of silicone for the oppositional post for a miss­ing rst digit.
is flexible, it does not impinge on the epicondyles, and range of motion can be maximized (Figure 13). If the residual limb is bulbous, an air expulsion valve with a carbon frame can be added at the distal end to make donning and doffing easier. Another option for a bulbous dis­tal end is to create an air space between the inner silicone socket and external frame to allow the silicone to expand as the styloids pass through. Alternatively, a zipper can be added to simplify don­ning and doffing if suction suspension of the prosthesis is not required.
Photograph of an e xternally powered nger prosthesis with a silicone check socket.
Photograph showing the use
Figure 12
prosthesis for use by a patient with a missing thumb but in whom digits 2 to 5 are present. A zipper was added to make it easier to don and do the prosthesis.
Transradial Sockets
HCR silicone has been successfully in­tegrated into passive, body-powered, and externally powered transradial socket designs (Figure 14). Compared with more rigid socket materials, the enhanced comfort provided by silicone is especially important for individuals with an amputation at the transradial level. The use of silicone is compatible with traditional supracondylar socket designs, but the softer properties of sil­icone may alleviate the discomfort com­monly experienced in the epicondylar
Photograph of an M-thumb
Figure 10
battery-powered nger prosthesis with em­bedded batteries, myoelectrodes, an on/o switch, a charge port, and channels for wires. A zipper in the forearm section allows for ease in donning and dong the prosthesis, and em­bedded anchors in the silicone hand shell are used to screw to the frame. A space is present where the inta ct fth digit ex its the silicone. The silicone is pigmented to match the patient’s skin tone.
Photograph of a denitive,
area because the epicondyles are no longer compressed as they pass be­tween rigid socket materials. In addi­tion, the elastic properties of silicone permit increased range of motion at the antecubital fold and olecranon. At the antecubital fold, the rigid forearm shell can be trimmed distal to the fold to permit stretching the silicone and allow for tissue expansion (Figure 15, A). At the olecranon, this elastic accommoda­tion can be facilitated by either creating space between the silicone and the rigid forearm shell or by creating a window over the olecranon as described by Sau­ter et al6 (Figure 15, B).
Transradial Socket With Integrated Humeral Sleeve
The use of silicone has created a new transradial socket design in which the interface can extend proximally into an integrated humeral sleeve (Figure 16). Although all lengths of transradial sockets have been fitted successfully, this can be especially useful on a very short residual limb where suspension is either difficult or very restrictive. The silicone of the sleeve itself is fabricated to be thinner than that of the socket to
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Chapter 26: Silicone Interface Options in Upper Limb Prostheses
allow greater elbow range of motion, and the sleeve can be rolled down for donning. To don, the patient can spray the outside of the sleeve with alcohol to make it easier to reflect over the socket, push his or her lubricated limb into the socket, and roll the sleeve up onto the humeral section of the arm.
Transhumeral Prostheses
As with other levels of amputation, silicone sockets can be custom fabri­cated for a passive, a body-powered, or an electric transhumeral prosthesis. The elasticity of HCR silicone sockets is especially beneficial for elbow disar­ticulations and transhumeral level am­putations when partial or full suction suspension is used. The elasticity allows the socket to be made slightly under­sized, requiring the material to stretch during donning. This helps maintain contact between the silicone and skin as the user moves the prosthesis during activities. A donning sleeve can be used for pulling the residual limb into the socket, and a distal one-way air valve can be added in the silicone interface. In such instances, a reinforcing pre­preg carbon frame is required to create a stable platform for securing the two­piece valve. Because the carbon frame is bonded to the silicone socket over its entire surface, it also prevents the flex­ible silicone around the distal end from
inverting because of distraction forces created by the weight of the prosthesis
does not bulge under clothing7 (Figures 18, C and 19).
(Fi g ure 17).
Suspension of an HCR silicone trans­humeral prosthesis can be achieved through a pin system, a harness, or suction (Fig ure 18). The flexibility and comfort provided around the shoulder area make silicone a choice material for transhumeral prostheses. With a Sauter integrated shoulder saddle modification, the silicone stays in contact with the in­dividual’s skin as he or she moves, and it
Figure 13
lation. The prosthesis allows elb ow range of motion in exte nsion and exion. Neithe r pronation (A) nor supination (B) is limited by the material.
Clinical photographs of a patient with a silicone prosthesis after a wrist disarticu-
Shoulder Disarticulations
When applied to a shoulder disarticu­lation prosthesis, HCR silicone provides a comfortable interface next to the pa­tient’s skin and reduces edge pressure from the frame.
6,8
The silicone extends slightly beyond the trim lines of the frame and makes moving and bending more comfortable. A thoracic pad made of silicone can be added to the harness
Figure 14
prosthesis (B), and total silicone myoelectric system (C).
Clinical photographs of patients tted with silicone sockets after transradial amputations. A passive prosthesis (A), body-powered
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Section 2: Upper Limb
Figure 15
silicone to stretch as the limb changes shape relative to the joint position.
Figure 16
tient with a transradial socket with an integrat­ed humeral sleeve that provides additional suspension and security.
A and B, Photographs of prostheses with areas of silicone exposed from the frame in areas where elasticity is desired. This allows the
Photograph of a tr anshumeral silicone so cket with a suction val ve that is suppor ted
Clinical photograph of a pa-
Figure 17
by a carbon frame.
Figure 18
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Photographs of transhumeral silicone sockets suspended via a pin (A), a harness (B), and suction (C).
Chapter 26: Silicone Interface Options in Upper Limb Prostheses
Figure 19
tient with a pros thesis with a silicone socket a nd a silicone shoulder saddle. The use of silicone is especially advantageous for this patient be­cause of severe scarring. Silicone gel is embed­ded in the saddle at the clavicle.
Clinical photograph of a pa-
to make a more comfortable and hygien­ic option compared to a cloth webbing or elastic strap (Figure 20). Some pa­tients prefer the silicone thoracic pad be­cause it organizes the straps and makes donning easier.
Summary
The use of HCR silicone can facilitate prosthetic sockets in being more com­fortable, having better range of motion, and improving suspension and func­tionality. These interfaces are beneficial to the skin because of good adhesion, biocompatibility, and resistance to bac­terial and fungal growth. The elastic properties of HCR silicone, as well as its allowance for varied thicknesses and ability to have various components em­bedded with the interface, permit HCR socket designs to address many of the challenges encountered when fitting an upper limb amputee or a patient with an upper limb deficiency.
References
1. Dodson R, Jowid B: e custom sili­cone interface: Clinical applications and observations. Proceedings of the 2008 MyoElectric Controls/Powered Prosthetics Symposium. Available
Figure 20
icone thoracic pad. The pads are comfortable and hygienic and help to organize the straps (B).
at: http://dukespace.lib.duke.edu/
dspace/bitstream/handle/10161/2766/ Dodson%202008.pdf?sequence=3.
Accessed September 26, 2014.
2. Charles H: Silicone rubber for medi­cal applications. Medical Device and Diagnostic Industry. Available at:
http://www.mddionline.com/article/ silicone-rubber-medical-device-ap­plications. Accessed September 26,
2014.
3. Uellendahl J, Mandacina S, Ramdial S: Custom silicone sockets for myo­electric prostheses. J Prosthet Orthot 2006;18(2):35-40. DOI
4. Ullendahl JE, Uellendahl EN: Use of HCR silicones for upper-limb prostheses. Journal of the Proceed-
ings American Academy of Ortho­tists and Prosthetists, 37th Annual Meeting and Scientic Symposium, Orlando, Florida, 2011. Available at:
http://www.oandp.org/publications/ jop/2011/2011-57.pdf. Accessed No-
vember 10, 2014.
5. Engleberg A: Guides to the Evalua- tion of Permanent Impairment, ed
A, Clinical photograph of a patient with a shoulder disarticulation wearing a sil-
3. Chicago, IL, American Medical Association, 1988, pp 20-21.
6. Sauter WF, Naumann S, Milner M: A three-quarter type below-elbow socket for myoelectric prostheses. Prosthet Orthot Int 1986;10(2):79-82.
Medline
7. Bush G: Powered upper extremity programme: Above elbow ttings, in
Rehabilitation Engineering Annual Report. Ontario, Canada, Hugh Mac-
Millan Rehabilitation Centre, 1990, pp 35-37.
8. Uellendahl J, Uellendahl E: Use of high consistency rubber (HCR) sili­cones for upper extremity prostheses.
Conference Proceedings of the Inter­national Society for Prosthetics and Orthotics World Congress, Leipzig, Germany, ISPO, Brussels, Belgium,
2010, p 481.
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Chapter 27
Targeted Muscle Reinnervation for Prosthetic Control and Treatment of Neuroma Pain
Gregory A. Dumanian, MD, FACS Jason M. Souza, MD
Abstract
Targeted muscle reinnervation is a surgical procedure that transfers nerve endings to the motor nerve of a nearby muscle. Aer neurotization, the muscle acts as a biologic ampli­er of the information still contained within the amputated nerve. e electromyographic signals provide intuitive control of myoelectric prostheses. In addition, providing a function for these nerves may be an optimal strategy for the treatment of chronic, local pain caused by postamputation neuromas.
Keywords: nerve transfer; neuroma; prosthetic control; targeted muscle reinnervation
Introduction
Refinements in amputation techniques throughout the 20th century led to great improvement in the durability and func­tionality of the residual limb. Strategies for controlling the prosthesis primar­ily remained the responsibility of the prosthetist. However, continuing im­provements in the capabilities of myo­electric prosthetic devices have led to the need for an improved control strat­egy. In 1995, Kuiken et al1 found that an amputated rat nerve transferred into a nearby denervated muscle produced a transcutaneously detectable electromyo­graphic (EMG) signal corresponding to the transferred nerve. This finding led to the use of the targeted muscle rein­nervation (TMR) technique in humans. The use of TMR was reported in 2004 in a patient with a shoulder disarticulation and subsequently in patients with trans­humeral amputation. to bridge the gap between prosthetic ca­pability and control. The TMR surgical
Neither of the following authors nor any immediate family member has received anything of value from or has stock or stock options held in a commercial company or institution related directly or indirectly to the subject of this chapter: Dr. Dumanian and Dr. Souza.
2-6
TMR was found
procedure effectively salvages and am­plifies information contained in motor nerve endings that had been rendered functionless by major limb amputation.
The TMR technique is best char­acterized as a series of nerve transfers between the amputated brachial nerves and muscle targets within the resi dual limb or chest wall. After successful neurotization, the target muscles pro­duce myoelectric activity that is easily detected by surface electrodes and can be harnessed to control the function of a prosthesis. Importantly, TMR enables intuitive pairing between a transferred nerve’s myoelectric signal and prosthetic functions that correspond to the nerve’s premorbid function (for example, a me­dian nerve signal for closing the hand).
TMR represents a dramatic improve­ment over both body-powered and conventional myoelectric prostheses, in which control signals are provided by muscles that are at best indirectly related to the prosthetic functions they
control. The intuitive pairing provided by TMR greatly reduces the duration and difficulty of a patient’s early pros­thetic rehabilitation.7 By increasing the number and variety of available control signals, TMR offers the potential for si­multaneous functionality of prosthetic hands, wrists, and elbows with multiple degrees of freedom.
Surgical Planning for TMR in the Upper Limb
The TMR procedure was designed to create control sites for the following four basic prosthetic functions in a patient with an upper limb amputation: elbow flexion, elbow extension, hand open­ing, and hand closing. If possible, the surgeon should create additional con­trol sites to allow greater wrist and hand control as well as the potential benefits offered by advanced control algorithms. The number of control sites can be max­imized by splitting residual limb mus­cles into separate segments based on neurovascular anatomy.
The most important considerations in planning a TMR procedure are the length of the amputated nerves and the availability of the residual limb or chest wall muscle targets. The amputa­tion level is defined by the presence or absence of recipient muscle motor entry points rather than by conventional skel­etal levels. All upper limb amputations can be categorized at three basic levels (transradial, transhumeral, and shoul­der disarticulation), which span the six commonly described skeletal amputa tion levels (Figure 1).
-
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Section 2: Upper Limb
Figure 1
amputation levels in the upper limb. The TMR level is dictated by the availability of recipient motor nerve entry points (black dots).
Amputation at the middle to distal forearm (the transradial level) leaves remnant forearm muscles with intact median, ulnar, and radial nerve mo­tor entry points. As a result, intuitive control of a myoelectric prosthesis is possible without the need for nerve transfers. Intrinsic ulnar and median nerve function is lost at this level, but can be regained through TMR. However, the currently available commercial pros­theses do not offer the digital dexterity and fine control mechanisms necessary to capitalize on the neural information salvaged through distal ulnar and me­dian nerve transfers. Consequently, the principal indication for TMR at this level is to manage symptomatic end neuromas.
In an amputation between the proxi­mal forearm and the proximal humerus, the forearm motor points responsible for native hand and wrist control are
Schematic drawing comparing targeted muscle reinnervation (TMR) and skeletal
responsible for elbow function remain intact. TMR at this level is called trans­humeral even though the elbow joint may be present and functional. Nerve transfers at the transhumeral level seek to restore functions previously con­trolled by the median, ulnar, and distal radial–posterior interosseous nerves, while preserving elbow function pro­vided by the intact musculocutaneous and proximal radial nerves.
At the shoulder disarticulation level, the upper arm motor points of the mus­culocutaneous and radial nerves have been removed. The proximal humerus and the shoulder joint may be present, but the remnant biceps and triceps lack the potential for reinnervation. The musculocutaneous, median, radial, and ulnar nerves all should be transferred. The pectoralis major, pectoralis minor, and latissimus dorsi most commonly are used as nerve transfer recipients.
lost, but the upper arm motor points
Transhumeral TMR
General Considerations
At the transhumeral level, TMR may be indicated if the patient has unsatisfac­tory prosthetic function with the use of a standard, body-powered myoelectric or hybrid system despite adequate train­ing. The optimal candidate is vibrant, in good health, and has adequate capacity for nerve healing. Although there is no specific age cutoff, younger patients of­ten have more capacity for nerve regen­eration. On physical examination, the amputee has strong biceps and triceps contractions and has a long residual limb with supple soft tissue. A patient with bilateral amputation may benefit from unilateral TMR surgery to enhance dexterity, with body-powered prosthesis use retained for the contralateral limb to allow robust activity. Patients with an amputation resulting from an avulsion mechanism should be screened to rule out a brachial plexopathy, because prox­imal damage to potential donor nerves precludes successful reinnervation. Brachial plexopathies can be difficult to diagnose clinically if the forearm and hand have been amputated. Clinically detectable pectoralis and latissimus muscle contractions are useful markers of brachial plexus function but cannot entirely rule out the presence of a partial brachial plexus injury. TMR can be done only with transected donor nerves that retain cortical control, and this critical element is lacking if the patient has a severe proximal brachial plexopathy.
The presence of a long residual limb is important for mechanical advantage and fitting of the prosthesis. Typically, the level of the donor nerve injury is relatively distal in a long residual limb. The nerve, therefore, can be aggressive­ly trimmed back to visualize healthy­appearing fascicles before transfer to the more proximal motor entry point. In addition, the brachialis muscle and its motor entry points frequently are preserved in a long transhumeral amputation. This muscle can be used
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Chapter 27: Targeted Muscle Reinnervation for Prosthetic Control and Treatment of Neuroma Pain
to provide a wrist control signal after reinnervation by the ulnar nerve. In a short transhumeral bone amputation, brachialis muscle sufficient for reinner­vation typically is lacking, and it is of­ten challenging to trim and mobilize the donor nerves without creating undue tension at the coaptation site. Supple, soft-tissue coverage is essential because it is difficult to obtain a wide dissection if the limb is scarred by skin grafts or heterotopic ossification.
The preoperative workup is straight­forward. Radiographs should be ob­tained to assess limb length and the extent of heterotopic ossification. Earl­ier surgical reports should be obtained. On physical examination, the level and location of the median, ulnar, and radial nerves are determined by evaluating the Tinel sign relative to the residual bone. The Tinel sign is identified at or proxi­mal to the level of nerve injury. Thus, a Tinel sign close to the end of the residual limb suggests the presence of a relatively long healthy donor nerve. Native inner­vation of the remnant biceps and triceps muscles is confirmed by visualization and palpation during voluntary muscle contraction. Additional nerve and vas­cular studies typically are not required. However, if the Tinel signs are difficult to reliably identify and the associated neuromas are not palpable, confirma tory MRI or ultrasound evaluation can be useful to confirm neuroma level and location.
Surgical Technique
The Tinel sign locations of the me dian, ulnar, and radial nerves are marked while the patient is in the preoperative holding area. The borders of the biceps and triceps muscles should be clearly outlined because it can be disorientat­ing to operate on an upper arm in the absence of forearm and hand landmarks to delineate true anterior and posterior surfaces. The transhumeral procedure is done through an anterior incision oriented longitudinally along the raphe
Figure 2
targeted muscle reinnervation. The medial antebrachial cutaneous (MABC), median (M), muscu­locutaneous (MCN), and ulnar (U) nerves are identied before nerve transfer. In this patient, the distal limb had been shortened, and a long segment of the lateral antebrachial cutaneous (LABC) nerve also is present. A recipient motor branch to the short head of the biceps (arrow) has been tagged with a vessel loop.
between the long and short heads of the biceps brachii muscle. The posterior in­cision mirrors the anterior incision and is positioned over the raphe between the long and lateral heads of the triceps. The orientation of these incisions is offset 90° from the incisions traditionally used to create anterior and posterior fish­mouth skin flaps. When TMR is done
-
at the time of the initial transhumeral amputation, the TMR incisions should maintain their anterior-posterior ori­entation; they can simply be ex tended distally to create medial and lateral skin flaps for distal limb coverage. Thin skin flaps are elevated on both sides of the incision, leaving a layer of fat on top of the deep fascia. A proximally based adipofascial flap is then elevated to re­veal the raphe between the short (me­dial) and long (lateral) heads of the biceps brachii. Blunt digital dissection reveals the musculocutaneous nerve, which is characterized by its trifurca­tion into the motor nerve to the long head of the biceps, the motor nerve to the short head of the biceps, and the
Photograph showing an anterior exposure in a patient undergoing transhumeral
distal continuation of the nerve as the brachialis motor branch and lateral an­tebrachial cutaneous nerve. Dissection on the medial aspect of the arm is done to identify the median nerve next to the brachial artery. The medial antebrachial cutaneous nerve often can be seen early in the dissection. This nerve can be dis­tinguished from the median or ulnar nerves by its smaller caliber and relative posterior position along the intermuscu­lar septum. A typical anterior exposure and the median, ulnar, musculocutane­ous, and medial antebrachial cutaneous nerves are shown in Figure 2. Because the hand is not present, the surgeon can­not stimulate the major mixed nerves to confirm their identities. Motor axon frozen section staining is possible but usually is unnecessary.
The median nerve is shortened un­til healthy fascicles are observed and is mobilized to the motor point of the short head of the biceps. The muscu­locutaneous nerve motor branch to the short head of the biceps is divided approximately 1 cm from its entry into
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