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160
Chapter 3 Biometry of the Fetal Brain
Table 3–50. MEASUREMENTS OF THE FRONTAL LOBE DISTANCE
Mean ± 2 SD
Gestational Age (weeks)
16 1.4 ± 0.4 1.0 1.4 1.5 1.6 1.8
17 1.6 ± 0.2 1.5 1.6 1.6 1.8 1.8
18 1.6 ± 0.2 1.4 1.4 1.7 1.7 1.8
19 1.7 ± 0.2 1.4 1.5 1.8 1.9 1.9
20 1.7 ± 0.2 1.7 1.7 1.9 1.8 1.9
21 1.8 ± 0.4 1.4 1.5 2.0 2.0 2.1
22 1.8 ± 0.4 2.3 2.3 2.3 2.3 2.3
23 1.8 ± 0.4 1.8 1.9 2.1 2.2 2.3
24 1.9 ± 0.2 2.0 2.0 2.0 2.0 2.0
25 2.2 ± 0.4 2.0 2.0 2.3 2.4 2.5
26 2.3 ± 0.4 2.0 2.1 2.3 2.4 2.5
27 2.5 ± 0.6 2.5 2.5 2.7 3.1 3.2
28 2.8 ± 0.2 2.4 2.5 2.6 2.6 2.7
29 2.7 ± 0.2 2.7 2.7 2.8 2.8 2.8
30 2.8 ± 0.6 2.6 2.6 2.7 3.2 3.4
31 2.9 ± 0.4 2.7 2.7 2.8 3.0 3.0
32 3.0 ± 0.6 3.0 3.0 3.3 3.6 3.8
33 3.1 ± 0.6 2.5 2.6 3.2 3.4 3.4
34 3.2 ± 0.2 2.9 3.0 3.1 3.2 3.3
35 3.2 ± 0.4 3.2 3.4 3.5 3.7 4.0
36 3.2 ± 0.4 2.9 2.9 3.2 3.4 3.4
37 3.4 ± 0.4 3.1 3.2 3.4 3.6 3.8
38 3.5 ± 0.4 3.2 3.2 3.5 3.9 4.0
39 3.7 ± 0.6 3.5 3.5 3.7 4.2 4.3
40 4.0 ± 0.6 3.8 3.8 3.9 4.5 4.5
(cm)
Percentile
10th 25th 50th 75th 90th
SD, standard deviation
From Goldstein and colleagues, 1988,
29
with permission.
Chapter 3 Biometry of the Fetal Brain
Table 3–51. MEASUREMENTS OF THALAMIC FRONTAL LOBE DISTANCE
Mean ± 2 SD
Gestational Age (weeks)
15 3.2 ± 0.4 3.2 3.2 3.2 3.2 3.2
16 3.2 ± 0.4 2.9 3.1 3.2 3.4 3.5
17 3.6 ± 0.6 3.2 3.4 3.5 3.8 4.5
18 3.7 ± 0.6 3.3 3.3 3.7 3.9 3.9
19 3.8 ± 0.4 3.5 3.5 3.7 3.9 4.0
20 4.1 ± 0.4 4.0 4.0 4.0 4.3 4.4
21 4.1 ± 0.4 3.9 3.9 4.1 4.4 4.5
22 4.6 ± 0.4 4.6 4.6 4.6 4.6 4.6
23 4.6 ± 0.4 4.6 4.6 4.6 4.6 4.6
24 4.7 ± 0.4 4.6 4.6 4.6 4.9 4.9
25 5.1 ± 0.6 4.7 4.8 5.2 5.3 5.4
26 5.2 ± 0.6 4.8 5.0 5.3 5.4 5.5
27 5.6 ± 0.8 5.3 5.6 5.6 6.8 7.2
28 5.7 ± 0.4 5.5 5.6 5.7 6.0 6.2
29 6.1 ± 0.4 6.0 6.0 6.1 6.4 6.4
30 6.2 ± 1.2 5.5 5.7 5.9 6.4 7.4
31 6.2 ± 0.8 6.1 6.1 6.1 6.2 6.2
32 6.4 ± 0.8 6.2 6.2 6.4 6.9 7.1
33 6.5 ± 0.6 5.9 6.0 6.3 6.5 6.6
34 6.7 ± 0.6 6.2 6.4 6.7 7.0 7.2
35 6.9 ± 0.6 6.6 6.7 7.1 7.2 7.3
36 7.0 ± 0.4 6.5 6.5 6.6 6.9 6.9
37 7.2 ± 0.6 6.2 6.4 6.7 7.0 7.1
38 7.3 ± 0.8 6.5 6.6 7.2 7.3 7.4
39 7.5 ± 0.8 7.1 7.0 7.4 7.7 7.8
40 7.7 ± 0.8 7.4 7.4 7.6 8.1 8.1
(cm)
10th 25th 50th 75th 90th
161
Percentile
SD, standard deviation.
From Goldstein and colleagues, 1988,
29
with permission.
162
Chapter 3 Biometry of the Fetal Brain
Table 3–52. WIDTH OF FETAL CORPUS CALLOSUM BY GESTATIONAL AGE
Gestational Age (weeks) Observations (n) Lower 95% CI Mean Width (mm) Upper 95% CI
16 4 1.61 2.38 3.14
17 8 2.08 2.63 3.17
18 7 2.82 3.99 5.15
19 18 3.80 4.18 4.55
20 21 3.93 4.43 4.93
21 21 4.40 5.02 5.64
22 18 4.56 4.99 5.43
23 22 4.90 5.39 5.88
24 18 5.49 6.16 6.83
25 23 5.26 5.68 6.11
26 18 5.74 6.40 7.06
27 12 5.72 6.69 7.66
28 9 6.50 7.19 7.88
29 10 5.35 6.18 7.01
30 12 6.45 7.16 7.87
31 10 5.92 6.63 7.34
32 7 5.43 6.61 7.80
33 4 4.81 6.58 8.34
34 6 5.90 7.32 8.73
35 5 5.43 7.16 8.89
36 2 5.60 8.60 8.80
37 3 2.98 7.67 12.36
CI, confidence interval.
From Achiron et al, 2001,95 by permission.
Chapter 3 Biometry of the Fetal Brain
Table 3–53. THICKNESS OF FETAL CORPUS CALLOSUM BY GESTATIONAL AGE
163
Gestational Age
(weeks) Observations (n) Lower 95% CI
Mean Thickness
(mm) Upper 95% CI
16 4 0.42 0.75 1.08
17 8 0.58 1.12 1.32
18 7 1.12 1.30 1.48
19 18 1.03 1.13 1.24
20 21 1.31 1.47 1.63
21 21 1.60 1.73 1.86
22 18 1.82 2.00 2.18
23 22 1.87 2.04 2.20
24 18 1.90 2.07 2.24
25 23 1.89 2.11 2.34
26 18 1.87 2.09 2.31
27 12 1.94 2.14 2.35
28 9 1.66 2.14 2.63
29 10 1.73 1.99 2.25
30 12 2.04 2.35 2.66
31 10 1.93 2.37 2.81
32 7 1.96 2.66 3.36
33 4 2.13 2.75 3.37
34 6 2.20 2.62 3.03
35 5 2.21 2.76 3.31
36 2 2.20 2.50 3.00
37 3 1.98 2.27 2.55
CI, confidence interval.
From Achiron et al, 2001,
95
by permission.
164
Chapter 3 Biometry of the Fetal Brain
Table 3–54. LENGTH OF NORMAL FETAL CORPUS CALLOSUM BY GESTATIONAL AGE
Gestational Age
(weeks)
16 14 8.0 9.4 10.7
17 15 10.5 12.0 13.5
18 11 12.2 14.0 15.8
19 18 15.7 16.6 17.5
20 20 17.7 18.7 19.7
21 21 21.0 22.2 23.4
22 26 22.8 23.9 24.9
23 33 24.6 25.6 26.5
24 25 25.1 26.0 26.9
25 30 28.1 29.0 29.9
26 30 30.9 31.8 32.8
27 35 32.9 33.8 34.7
28 25 33.3 34.6 35.8
29 36 34.2 35.5 36.8
30 29 36.3 37.7 39.1
31 17 36.0 36.5 37.0
32 28 37.6 38.5 39.5
33 30 37.1 38.2 39.3
34 12 37.8 39.8 41.9
35 27 41.0 42.6 44.2
36 14 42.4 44.7 47.0
37 12 42.4 45.0 47.6
38 25 43.2 44.2 45.3
39 16 41.8 43.2 44.6
No. of
Observations (n)
Lower Limit
95% CI
Mean Length
(mm)
Upper Limit
of 95% CI
CI, confidence interval.
From Hai-chun et al, 2009,87 by permission.
Chapter 3 Biometry of the Fetal Brain
Table 3–55. LENGTH OF FETAL CORPUS CALLOSUM BY GESTATIONAL AGE
165
Gestational Age
(weeks)
16 4 2.95 3.75 4.55
17 8 4.77 6.24 7.70
18 7 10.04 12.51 14.99
19 18 14.51 15.78 17.05
20 21 18.13 18.95 19.77
21 21 19.54 20.38 21.23
22 18 21.53 22.39 23.24
23 22 23.19 24.45 25.72
24 18 26.32 27.61 28.90
25 23 28.66 29.65 30.64
26 18 29.91 31.44 32.98
27 12 32.75 34.33 35.92
28 9 32.30 34.44 36.59
29 10 34.21 36.40 38.59
30 12 37.14 38.33 39.52
31 10 36.18 37.30 38.42
32 7 38.37 40.43 42.49
33 4 31.44 38.50 45.56
34 6 41.40 42.50 43.60
35 5 40.82 45.60 50.38
36 2 40.00 44.00 45.00
37 3 42.5 44.67 46.84
Observations
(n)
Lower
95% CI
Mean Length
(mm)
Upper
95% CI
CI, confidence interval.
From Achiron et al, 2001,95 by permission.
166
Chapter 3 Biometry of the Fetal Brain
60
50
40
30
20
10
Corpus callosum length (mm)
0
1617181920212223242526272829303132333435363738
Gestational age (weeks)
Figure 3–24. Individual scatter plot of length of the corpus callosom
with gestational age of 258 normal fetuses showing a linear regression
( r = 0.779 ). (Reproduced, with permission, from Ultrasound Obstet
Gynecol. 2001;18:343–347.
12
10
8
6
4
95
)
2.5
2
1.5
1
Corpus callosum thickness (mm)
0.5
17 18 1920 21 2223 24 2526 27 2829 30 31 32 3334 3536
A
Gestational age (weeks)
10
8
6
4
2
Corpus callosum width (mm)
0
17 18 19 20 2122 2324 25 26 27 28 2930 31 32 33 34 3536
B
Gestational age (weeks)
2
Corpus callosum width (mm)
0
1617181920212223242526272829303132333435363738
Gestational age (weeks)
Figure 3–25. Individual scatter plot of width of the corpus callosom
with gestational age of 258 normal fetuses showing a linear regression
( r = 0.676 ). (Reproduced, with permission, from Ultrasound Obstet
Gynecol. 2001;18:343–347.
95
)
4
3
2
1
Corpus callosum thickness (mm)
0
1617181920212223242526272829303132333435363738
Gestational age (weeks)
Figure 3–26. Individual scatter plot of thickness of the corpus callosom
with gestational age of 258 normal fetuses showing a linear regression
( r = 0.494 ). (Reproduced, with permission, from Ultrasound Obstet
Gynecol. 2001;18:343–347.
95
)
40.5
30.5
20.5
10.5
Corpus callosum length (mm)
0.5
17 18 19 2021 22 2324 2526 27 2829 3031 32 3334 3536
C
Figure 3–27.
Maximum growth in thickness (A) and width (B) of the
Gestational age (weeks)
corpus callosum occurred between 19 and 21 weeks’ gestation, while its
length (C) followed a constant growth rate. (Reproduced, with permission, from Ultrasound Obstet Gynecol. 2001;18:343–347.
95
)
Figure 3–28.
2009;37:75–77.
Chapter 3 Biometry of the Fetal Brain
167
60
50
40
30
20
r = 0.93, p < 0.001
Corpus callosum length (mm)
10
0
16
17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39
Gestational age weeks
Scatterplot of the length of the corpus callosum by gestational age in 549 normal fetuses. (Reproduced, with permission, from JCU.
87
)
Figure 3–29.
2009;37:75–77.
50.00
45.00
40.00
35.00
30.00
25.00
20.00
15.00
10.00
Corpus callosum length (mm)
5.00
0.00
16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38
39
Gestational age (weeks)
Relationship between the mean length of the corpus callosum and gestational age. (Reproduced, with permission, from JCU.
87
)
168
Chapter 3 Biometry of the Fetal Brain
SUMMARY
The numeric information as well as their applications were
compiled in this chapter. At places more than one author’s
metrics are quoted since different ultrasound laboratories
or perinatal practitioners have one over another.
Most tables, graphs and the needed informations were
updated using the newest publications.
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