Добавил:
Sekretar
kiopkiopkiop18@yandex.ru
t.me/Prokururor I Вовсе не секретарь, но почту проверяю
Опубликованный материал нарушает ваши авторские права? Сообщите нам.
Вуз:
Предмет:
Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_888_Библиотеки_им_академика_М_И_Перельмана
.pdf
90
Clinically, Fumagalli etal. evaluated 96 patients in TAPP inguinal hernia repair
and found no differences between the tack group and the self-gripping mesh
group. Follow-up was 13.8months, and there was one recurrence in the tack
group. They also concluded there trended to be less chronic pain in the self-gripping mesh group [12].
N. Stoikes et al.
Open Anterior Approach
Classic xation in open inguinal hernia repair has been suture xation of all various
types. Data supports the use of a slowly absorbable suture for best results from a
recurrence and chronic pain standpoint. More recently, brin glue has been proven
effective in the open inguinal hernia space. Campanelli etal. produced the TIMELI
trial which compared brin glue to suture xation in Lichtenstein hernia repair. It
was found that at 12months, there were only 3 total recurrences out of 319 patients.
The brin glue group had less disabling complications. At 1 and 6months, the brin
glue group had less pain, and it was concluded that the use of brin glue decreases
the risks of pain, numbness, or discomfort by 45% [13].
Self-gripping mesh is also used in the open inguinal hernia space and has been
found to have similar outcomes to both suture xation and brin glue. Ronka etal.
did a randomized trial comparing suture, brin glue, and self-gripping mesh for
Lichtenstein hernia repair. An even distribution of the xation forms was evaluated
in 625 patients. There were four total recurrences at 12months follow-up, and there
were no differences between the groups regarding chronic groin pain [14].
Ventral Hernia
Fixation for the ventral hernia space is complicated because there are so many types
of repairs that can be done. Mesh xation is dependent upon the space where the
prosthetic is being placed: intraperitoneal, retrorectus/preperitoneal, and onlay.
Intraperitoneal Mesh Placement
Historically, intraperitoneal mesh placement for ventral hernia repair stems from the
Rives retrorectus repair, which was developed in the 1970s. The idea was that placing the mesh behind the defect was better than on top of the defect. Prior to the
popularity of the Rives repair, in the United States, it was standard to bridge a hernia
defect with a prosthetic by suturing it to the fascial edges of the defect. Recurrence
rates were signicant since the tissue the mesh was xated to was not strong enough
to resist high intra-abdominal pressures. With the introduction of the laparoscopic
repair of ventral/incisional hernias, the technique required, at that time, that the
mesh be placed intraperitoneally. Initially point xation with staples was used, and
this was then soon replaced by the “tack,” which gave better xation than the classic
staple. We used our early experience with the Rives open repair, where suture

7 Prosthetic Fixation Options
Данная книга находится в списке для перевода на русский язык сайта https://meduniver.com/
91
xation of the mesh is done, to add suture xation to the laparoscopic intraperitoneal repair, and this became the standard approach for long-term success.
Basic science data comparing suture xation and tack xation for intraperitoneal
mesh xation has shown that transfascial suture xation is biomechanically stronger. Van’t Riet etal. conducted a porcine model evaluating the differences in xation strength between suture and tack in 1–5 different locations on a 7cm piece of
mesh. For one point of xation, suture was signicantly stronger (67N vs 28N).
For two points of xation, suture was again statistically stronger (115N vs 42N).
For ve points of xation, there were no statistical differences though suture trended
to be stronger (150N vs 82N) [15].
The standard of transfascial xation combined with tack xation of mesh has
produced excellent clinical results. Heniford etal. reviewed 850 laparoscopic repairs
with this technique and found a recurrence rate of 4.7% with mean of 20.2months
follow-up [16]. For those surgeons not wanting to add suture xation to their repair,
Morales-Conde described the “double-crown” method of intraperitoneal mesh xation wherein an inner and outer ring of tacks are used for mesh xation. They
reviewed 140 patients with 40months follow-up and found a recurrence rate of 2.1%
[17]. Baccari etal. reviewed 200 patients with a double-crown tack technique with
mean defects of 107cm2 and found a recurrence rate of 3.5% at 22months [18].
Wassenaar randomized three groups: tacks and permanent suture, double-crown
tacks, and tacks and absorbable sutures. A total of 199 patients were studied, and
there were only 2 recurrences (1 double-crown and 1 absorbable suture with tacks)
[19]. Brill etal. conducted a meta-analysis reviewing 6015 patients with tacks and
sutures and 2045 with tacks only and found no signicant differences in recurrence
or chronic pain [20]. Alternatively, Leblanc etal. reviewed his rst 100 patients in
2001 and found that the recurrence rate was 9.3%. All patients with recurrence had
been identied to have tack or staple xation without transfascial suture xation
[21]. He followed up that study in 2007 with a meta-analysis reviewing whether
transfacial sutures were necessary, but no rm conclusions could be made as the
variations in suture placement could not be accounted for. By the numbers recurrence
rates with suture xation were 4% and without were 1.8%. He did conclude that if no
sutures were used, a larger overlap of the defect [3–5] was needed [22].
Adhesive xation in the intraperitoneal space has not proven to be effective as a
primary form of xation. Shug Pass etal. evaluated the strength of brin glue xation of mesh to peritoneum and to muscle in a basic science model and a pig model.
There was a signicant difference in xation strength between muscle and peritoneum (47N vs 11N) suggesting that brin glue should not be used to xate mesh
to the peritoneum [23]. As previously mentioned, Melman etal. did an acute xation study comparing permanent tacks, absorbable tacks, suture, and brin glue.
Suture was signicantly stronger than all other methods of xation. Glue was the
weakest xative, and permanent tacks were stronger than absorbable tacks [3].
Multiple reasons can be theorized as to why brin glue does not xate mesh well to
the peritoneum. One reason is that coated meshes inherently do not xate well with
brin glue due to the inability of the glue to permeate the entire surface of the mesh.
Secondly, the peritoneum is a uid structure that classically has slower ingrowth of
mesh compared to muscle and fascia.

92
N. Stoikes et al.
Retrorectus Mesh Placement
The retrorectus space refers to the Rives retrorectus repair and the newer transversus abdominis release (TAR). Options for xation in this space are classically
transfascial suture xation though brin glue is gaining some popularity in the
space. Biomechanically, the principles and ndings of intraperitoneal mechanical
xation apply, but it is likely that brin glue xation is stronger than it is in the
intraperitoneal space because uncoated and wider pore mesh is being xated to
fascia and muscle instead of coated mesh being xated to peritoneum. A recent
study by Moazzez etal. described their technique for brin glue use in the retrorectus space for ventral hernia repair. In their description a few sutures are used to
xate the mesh to the posterior sheath, and then after closing the posterior sheath
and securing the mesh to it, brin glue is used to xate the mesh to the entire surface area of the posterior sheath [24]. Currently there is a paucity of basic science
data evaluating brin glue use in the retrorectus space. Historically, the Rives
repair is a tension-based repair, which inherently required the use of sutures to
accomplish the retrorectus xation of the mesh thereby decreasing forces on the
anterior fascial closure (Fig.7.4). This foundational principle of the repair calls
Fig. 7.4 Rives’ retrorectus repair with tension-based mesh xation (Picture comes from Atlas of
Hernia by Wantz 1991 Lippincott)

7 Prosthetic Fixation Options
Данная книга находится в списке для перевода на русский язык сайта https://meduniver.com/
93
into question the potential utility of brin glue xation. As newer preperitoneal and
retrorectus techniques like laparoscopic and robotic preperitoneal ventral hernia
repairs mature clinically, there will be a greater need for understanding the behavior of brin glue in this space.
Onlay
At the same time that Rives was describing his retrorectus repair, Chevrel, also in
France, described his onlay method for incisional hernia repair. Chevrel’s goals of
repair were to recreate the linea alba with the anterior rectus sheath. This concept
was based on cadaver studies he conducted that revealed the anterior rectus sheath
was the next strongest part of the abdominal wall secondary to the linea alba. In his
repair, he reconstructed the abdominal wall in three layers, which included a double-layer midline closure using the anterior rectus sheath and then placement of an
onlay prosthetic. Chevrel’s approach to xation was revolutionary for the time. He
sutured his onlay mesh but also described how to make and place brin glue on the
midline closure. His outcomes were excellent with up to 20-year follow-up and a
recurrence rate of 4.9% [25].
Over the past few years, the onlay repair with brin glue xation has slowly
increased in popularity in the United States and has been supported by basic science
research (see section “The Science of Fixation”). A large series of 97 patients by
Shahan etal. reviewed the onlay technique on large ventral hernias that were complex and required myofascial advancement aps. In this technique the primary form
of xation is with brin glue with some skin staples used as place holders to orient
the mesh onto the abdominal wall for application of the brin glue. Mean BMI was
32kg in this study with a mean hernia defect size of 150cm2. Follow-up was 1year,
and there were no recurrences reported in the series. As with all ventral hernia
repairs, the main issue was persistent seroma, which was found in 21% of patients.
Due to other various wound complications (seroma included), 9% of patients
required operative wound management. However, 100% of mesh was salvaged in
the series, and it was found that contamination status at initial operation did not
affect the need for reoperation [26].
Hiatal Hernia
The routine use of mesh (as well as type) remains a controversial topic that continues to be debated. Hundreds of clinical articles have looked at mesh placement in
this location, but few have looked at types of xation for the mesh. Due to the movement of the diaphragm and esophagus thousands of times a day, strong xation in
this area is key since migration can lead to esophageal erosion due to the movement
of the diaphragm and esophagus thousands of times a day. Generally speaking, biologic mesh or absorbable biosynthetic mesh approved for intra-abdominal use is
recommended if mesh is to be placed. Krpata etal. have reviewed sutures vs. brin
glue xation of mesh at the hiatus. He used a porcine model and a biologic mesh to

94
Fig. 7.5 Fixation of
biosynthetic mesh at the
hiatus with brin glue
N. Stoikes et al.
evaluate the two forms of xation. A 30-day survival study was done, and the biomechanics revealed no migrations in either group and similar ingrowth implying
similar xation strengths [27]. Fortelny etal. did a similar study in a porcine model
using brin glue to xate titanized polypropylene mesh at the hiatus. At 4weeks
they found excellent integration and no mesh migrations [28].
Clinically, Powell et al. reviewed 70 patients with cruroplasty reinforcement
with bio-absorbable mesh and brin glue as the sole xation method for hiatal hernia repair. The short-term study revealed no immediate complications [29]. We have
used this method of mesh xation in over 200 hiatal hernia repairs with no known
case of mesh erosion into the esophagus (Fig.7.5).
Good-quality xation data in the hiatal hernia space is sparse. This is partially
due to the inherent controversy surrounding mesh use, but also repair outcomes can
be hard to follow as imaging and clinical suspicion are necessary to evaluate for
recurrence. Regardless, continued study is necessary to optimize xation.
Conclusions
The need for optimal mesh xation spans all types of hernia repairs. The type of
hernia, the technique selected, and the type of mesh determine xation options.
Understanding the basic science helps to provide an underlying logic that can
help formulate an approach to each hernia situation. Realizing that “strongest”
xation is not always “best” xation leads to the real question that must be
answered: “how strong is strong enough?” Fixation continues to evolve, and fur-
ther study using “out of the box” thinking will be needed to tailor optimal xa-
tion of mesh for a given hernia presentation.
References
1. Stoikes N, Sharpe J, Tasneem H, etal. Biomechanical evaluation of xation properties of brin
glue for ventral hernia repair. Hernia. 2013;19:161–6.
2. Golani S, Middleton P.Long-term follow-up of laparoscopic total extraperitoneal (TEP) repair
in inguinal hernia without mesh xation. Hernia. 2017;21(1):37–43.

7 Prosthetic Fixation Options
Данная книга находится в списке для перевода на русский язык сайта https://meduniver.com/
95
3. Melman L, Jenkins ED, Deeken CR, Brodt MD, Brown SR, Brunt LM, Eagon JC, Frisella
M, Matthews BD.Evaluation of acute xation strength for mechanical tacking devices and
brin sealant versus polypropylene suture for laparoscopic ventral hernia repair. Surg Innov.
2010;17(4):285–90.
4. Jourdan IC, Bailey ME. Initial experience with the use of N-butyl 2-cyanoacrylate glue for
the xation of polypropylene mesh in laparoscopic hernia repair. Surg Laparosc Endosc.
1998;8(4):291–3.
5. Kukleta J, Freytag C, Weber M.Efciency and safety of mesh xation in laparoscopic inguinal
hernia repair using n-butyl cyanoacrylate: long term biocompatibility in over 1300 mesh xations. Hernia. 2012;16:153–62.
6. Katkhouda N, Mavor E, Friedlander MH, Mason RJ, Kiyabu M, Grant SW, Achanta K,
Kirkman EL, Narayanan K, Essani R. Use of brin sealant for prosthetic mesh xation in
laparoscopic extraperitoneal inguinal hernia repair. Ann Surg. 2001;233(1):18–25.
7. Schwab R, Schumacher O, Junge K, Binnebösel M, Klinge U, Becker HP, Schumpelick
V. Biomechanical analyses of mesh xation in TAPP and TEP hernia repair. Surg Endosc.
2008;22(3):731–8.
8. Kes E, Lange J, Bonjer J, Stoeckart R, Mulder P, Snijders C, Kleinrensink G.Protrusion of
prosthetic meshes in repair of inguinal hernias. Surgery. 2004;135(2):163–70.
9. Novik B, Hagedorn S, Mork UB, etal. Fibrin glue for securing mesh in laparoscopic totally
extraperitoneal inguinal hernia repair: a study with a 40-month prospective follow up period.
Surg Endosc. 2006;20:462–7.
10. Kaul A, Hutess S, Le H, etal. Stapled versus brin glue xation in laparoscopic totally
extrperitoneal repair of inguinal hernia: a systematic review and meta-analysis. Surg Endosc.
2012;26:1269–78.
11. Shahan CP, Stoikes NN, Roan E, etal. Short term strength of nonpenetrating mesh xation:
Lifemesh, Tisseel, and Progrip. Surg Endosc. 2017;31:1350–3.
12. Fumagalli Romario U, Puccetti F, Elmore U, Massaron S, Rosati R.Self-gripping mesh versus
staple xation in laparoscopic inguinal hernia repair: a prospective comparison. Surg Endosc.
2013;27(5):1798–802.
13. Campanelli G, Pascual M, Hoeferlin A, etal. Randomized controlled blinded trial of tisseel/
tissucol for mesh xation in patients undergoing Lichtenstein technique for primary inguinal
hernia repair. Ann Surg. 2012;255:650–7.
14. Ronka K, Vironen J, Kossi J, etal. Randomized multicenter trial comparing glue xation, self grip-
ping mesh, and suture xation of mesh, in Lichtenstein hernia repair. Ann Surg. 2015;262:714–9.
15. Van’t Riet M, De vos Van S, Kleinrensink G.Tensile strength of mesh xation methods in
laparoscopic incisional hernia repair. Surg Endosc. 2002;16:1713–6.
16. Heniford T, Park A, Ramshaw B, et al. Laparoscopic repair of ventral hernias: nine years’
experience with 850 consecutive hernias. Ann Surg. 2003;238:391–9.
17. Morales-Conde S, Cadet H, Cano A.Laparoscopic ventral hernia repair without sutures-dou-
ble crown technique: our experience after 140 cases with a mean follow up of 40 months. Int
Surg. 2005;90:S56–62.
18. Baccari P, Nifosi J, Ghiradelli L, etal. Laparoscopic incisional and ventral hernia repair with-
out sutures: a single center experience with 200 cases. J Laparoendosc Adv Surg Tech A.
2009;19:175–9.
19. Wassenaar A, Schoenmaakers E, Raymakers J.Mesh xation method and quality of life after
laparoscopic ventral or incisional hernia repair: a randomized trial of three xation techniques.
Surg Endosc. 2010;24:1296–302.
20. Brill JB, Turner PL.Long term outcomes with transfascial sutures versus tacks in laparoscopic
ventral hernia repair: a review. Am Surg. 2011;77:458–65.
21. Leblanc K, Booth W, Whitaker J, etal. Laparoscopic incisional and ventral herniorraphy: our
initial 100 patients. Hernia. 2001;5:41–5.
22. Leblanc K.Laparoscopic incisional hernia repair: are transfascial sutures necessary? A review
of the literature. Surg Endosc. 2007;21:508–13.
23. Shug Pass C, Lippert H, Kockerling F.Fixation of the mesh to the peritoneum using brin
glue: investigations with a biomechanical model and an experimental laparoscopic porcine
model. Surg Endosc. 2009;23:2809–15.

96
24. Moazzez A, Dubina E.A novel approach to mesh xation retrorectus ventral hernia repair
using brin sealant. J Am Coll Surg. 2017;225:e1–4.
25. Chevrel J, Rath A. The use of brin glues in the surgical treatment of incisional hernias.
Hernia. 1997;1:9–14.
26. Shahan C, Stoikes N, Webb D. Sutureless onlay hernia repair: a review of 97 patients. Surg
Endosc. 2016;30:3256–61.
27. Krpata D, Blatnik J, Harth K, etal. Evaluation of brin sealant for biologic mesh xation at the
hiatus in a porcine model. Surg Endosc. 2012;26:3120–6.
28. Fortelny R, Petter-Puchner A, Glaser K, etal. Fibrin sealant (tisseel) for hiatal mesh xation in
an experimental model in pigs. J Surg Res. 2010;162:68–74.
29. Powell B, Wandrey D, Voeller G.A technique for placement of a bioabsorbable prosthesis with
brin glue xation for reinforcement of the crural closure during hiatal hernia repair. Hernia.
2013;17:81–4.
N. Stoikes et al.

How toChoose aMesh inHernia Repair
Данная книга находится в списке для перевода на русский язык сайта https://meduniver.com/
DavidEarle
Since the introduction of polypropylene (PP) mesh for hernia repair [1], surgeons
continue to discuss the use of mesh in a variety of settings for one of the most
common operations performed by general surgeons—hernia repair. This discussion has involved raw materials, cost, and outcomes and for many years referred
to only a few products, as manufacturing was limited. Nowadays, with multiple
permanent, absorbable, biologic, and hybrid products on the market, the choice of
mesh for a hernia repair can be daunting. Increasing clinical complexity further
emphasizes the need for individualizing care, but more frequently, hospital supply
chain personnel institute product procurement procedures for cost control, limiting mesh choice for surgeons. This can force surgeons into a “one-size-ts-all”
practice regarding mesh choice, which may not be ideal for some patients.
Conversely, current literature lacks denitive evidence supporting the use of one
mesh over another, a fact that has not escaped the radar screen of the hospital supply chain and mesh industry, both of which attempt to limit vendor and mesh
choice for nancial gain. It is unlikely that this type of “proof” will ever come to
fruition. This leaves us with choosing a mesh based on an algorithm that is centered on the patient and the patient’s unique clinical scenario [2]. This algorithm
(Fig.8.1) will culminate in mesh choice, but could also apply to non-mesh techniques as well.
Below are generic two examples, based on real cases, which will serve as background information. I will refer to these examples throughout the chapter to highlight how an algorithmic approach to mesh choice can be utilized.
8
D. Earle
Tufts University School of Medicine, Boston, MA, USA
New England Hernia Center, North Chelmsford, MA, USA
© Society of American Gastrointestinal and Endoscopic Surgeons (SAGES) 2019
S. S. Davis Jr. et al. (eds.), The SAGES Manual of Hernia Surgery,
https://doi.org/10.1007/978-3-319-78411-3_8
97

98
1. Identify goals of hernia repair
a
2. Evaluate the clinical scenario
3. Choose a technique
4. Choose a mesh designed for use with the chosen technique
5. Preoperative planning
findings dictate a change.
D. Earle
a. Explicitly ask patient about their goals – symptom relief, prevention, or
both.
b. Align those goals, and discuss the likelihood of their realization with herni
repair.
a. Is the case elective, urgent, or emergent?
b. Is the case clean, contaminated, or potentially contaminated?
c. Is the patient a better candidate for local or general anesthesia?
d. Does the patient’s history suggest higher likelihood of future operation?
(e.g. pregnancy, Crohn’s disease, ostomy closure)
e. Evaluate the hernia details –previous repairs, location, size of defect, size
of sac, associated skin issues.
a. A technique that is most likely to meet the goals in the given clinical
scenario should be chosen. In the event this technique is not the one the
surgeon is the most comfortable with or has the adequate resources,
referral or a different technique and rationale should be discussed with the
patient, and a joint decision can be made about how to proceed. This is
obviously limited in emergency situations.
a. Consider the raw material –permanent, absorbable, synthetic, biological,
hybrid
b. Consider the design –A high priority should be placed on the relative
strength of the mesh, data that can be difficult to obtain. Porosity, fiber
size, and barrier coating are also important to evaluate, as each mesh
performs differently in different locations (e.g., intra-vs extra-peritoneal,
bridging vs support).
a. Plan enhanced recovery strategies with anesthesia, and coordinate
regional anesthetic blocks as necessary.
b. Define need for multidisciplinary coordination before you start, such as
plastics, colorectal, gynecology, and urology.
Fig. 8.1 Algorithm for mesh choice for hernia repair
c. Make sure the mesh you have chosen is available, and in a variety of
sizes.
d. Have an alternate plan and/or mesh available in the event intraoperative

8 How toChoose aMesh inHernia Repair
Данная книга находится в списке для перевода на русский язык сайта https://meduniver.com/
99
Example 1: A 70 year old patient who works as a physician presents with a small,
asymptomatic incisional hernia after a laparotomy. The patient has a BMI of 26.
The patient is concerned it will grow, as it seems to have grown from the size of
a marble to that of a golf ball in a short period of time. There is no pain. The
surgeon may tell the patient not to worry about the hernia unless it starts causing
problems. As the hernia sac grows, the patient returns with an enormous hernia
sac, associated with overlying skin excoriation.
Example 2: A 60 year old obese patient (BMI 52) with multiple medical problems
and actively smoking is concerned about progressively worsening pain from an
intermittently incarcerating primary ventral hernia, requiring two visits to the
emergency room within the past month. The patient noticed the symptoms for
several months before the ER visits, but the pain was never that severe. The inter-
mittent pain seems to be increasing in frequency and severity. The patient would
like to relieve the symptoms and avoid a life-threatening emergency. The bulge
is barely noticeable and located in the midline epigastrium. CT scan reveals the
defect is 6×6cm and contains omentum and a portion of the transverse colon.
Step 1: Goals oftheHernia Repair
It is important to identify the patient goals for the operation. Regarding hernia
repair, this is usually associated with symptom relief, prevention of developing
symptoms (including acute incarceration), or both. Symptoms include discomfort,
pain, abnormal abdominal wall contour, skin changes, intermittent bowel obstruction, and limitations of important activities. Prevention is typically the goal associated with asymptomatic hernias found during a routine physical exam or during an
imaging study performed for another problem. Often, a patient with mild, but slowly
progressive symptoms, desires both to alleviate the current symptoms and avoid
waiting until they become so severe it will compromise their care.
Once the goals of the repair are identied, the surgeon must align those goals
with the healthcare team. This will allow the surgeon to identify and address unrealistic goals, and formulate a strategy of repair, including mesh choice, which will
most likely meet the goals. It is also important to explicitly discuss the likelihood of
meeting the patient’s expectations, as patients and surgeons may have different perceptions of what is important [3, 4].
In example 1 (asymptomatic, marble-sized incisional hernia; goal is to prevent it
from getting worse), there are a variety of techniques and mesh options available.
As the hernia defect and/or sac enlarges, or if the hernia becomes acutely incarcerated with compromised bowel, the number of acceptable options dwindles, which
affects the choice of mesh.
In example 2 (obese patient, escalating symptoms, 6cm primary defect; goals
are pain relief and avoidance of an emergency operation), one option for the surgeon is to recommend weight loss before an elective hernia repair is considered, as
Соседние файлы в папке Библиотека им академика М.И. Перельмана
