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Clinically, Fumagalli etal. evaluated 96 patients in TAPP inguinal hernia repair and found no differences between the tack group and the self-gripping mesh group. Follow-up was 13.8months, and there was one recurrence in the tack group. They also concluded there trended to be less chronic pain in the self-grip­ping mesh group [12].
N. Stoikes et al.
Open Anterior Approach
Classic xation in open inguinal hernia repair has been suture xation of all various types. Data supports the use of a slowly absorbable suture for best results from a recurrence and chronic pain standpoint. More recently, brin glue has been proven effective in the open inguinal hernia space. Campanelli etal. produced the TIMELI trial which compared brin glue to suture xation in Lichtenstein hernia repair. It was found that at 12months, there were only 3 total recurrences out of 319 patients. The brin glue group had less disabling complications. At 1 and 6months, the brin glue group had less pain, and it was concluded that the use of brin glue decreases the risks of pain, numbness, or discomfort by 45% [13].
Self-gripping mesh is also used in the open inguinal hernia space and has been found to have similar outcomes to both suture xation and brin glue. Ronka etal. did a randomized trial comparing suture, brin glue, and self-gripping mesh for Lichtenstein hernia repair. An even distribution of the xation forms was evaluated in 625 patients. There were four total recurrences at 12months follow-up, and there were no differences between the groups regarding chronic groin pain [14].
Ventral Hernia
Fixation for the ventral hernia space is complicated because there are so many types of repairs that can be done. Mesh xation is dependent upon the space where the prosthetic is being placed: intraperitoneal, retrorectus/preperitoneal, and onlay.
Intraperitoneal Mesh Placement
Historically, intraperitoneal mesh placement for ventral hernia repair stems from the Rives retrorectus repair, which was developed in the 1970s. The idea was that plac­ing the mesh behind the defect was better than on top of the defect. Prior to the popularity of the Rives repair, in the United States, it was standard to bridge a hernia defect with a prosthetic by suturing it to the fascial edges of the defect. Recurrence rates were signicant since the tissue the mesh was xated to was not strong enough to resist high intra-abdominal pressures. With the introduction of the laparoscopic repair of ventral/incisional hernias, the technique required, at that time, that the mesh be placed intraperitoneally. Initially point xation with staples was used, and this was then soon replaced by the “tack,” which gave better xation than the classic staple. We used our early experience with the Rives open repair, where suture
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xation of the mesh is done, to add suture xation to the laparoscopic intraperito­neal repair, and this became the standard approach for long-term success.
Basic science data comparing suture xation and tack xation for intraperitoneal mesh xation has shown that transfascial suture xation is biomechanically stron­ger. Van’t Riet etal. conducted a porcine model evaluating the differences in xa­tion strength between suture and tack in 1–5 different locations on a 7cm piece of mesh. For one point of xation, suture was signicantly stronger (67N vs 28N). For two points of xation, suture was again statistically stronger (115N vs 42N). For ve points of xation, there were no statistical differences though suture trended to be stronger (150N vs 82N) [15].
The standard of transfascial xation combined with tack xation of mesh has produced excellent clinical results. Heniford etal. reviewed 850 laparoscopic repairs with this technique and found a recurrence rate of 4.7% with mean of 20.2months follow-up [16]. For those surgeons not wanting to add suture xation to their repair, Morales-Conde described the “double-crown” method of intraperitoneal mesh xa­tion wherein an inner and outer ring of tacks are used for mesh xation. They reviewed 140 patients with 40months follow-up and found a recurrence rate of 2.1% [17]. Baccari etal. reviewed 200 patients with a double-crown tack technique with mean defects of 107cm2 and found a recurrence rate of 3.5% at 22months [18]. Wassenaar randomized three groups: tacks and permanent suture, double-crown tacks, and tacks and absorbable sutures. A total of 199 patients were studied, and there were only 2 recurrences (1 double-crown and 1 absorbable suture with tacks) [19]. Brill etal. conducted a meta-analysis reviewing 6015 patients with tacks and sutures and 2045 with tacks only and found no signicant differences in recurrence or chronic pain [20]. Alternatively, Leblanc etal. reviewed his rst 100 patients in 2001 and found that the recurrence rate was 9.3%. All patients with recurrence had been identied to have tack or staple xation without transfascial suture xation [21]. He followed up that study in 2007 with a meta-analysis reviewing whether transfacial sutures were necessary, but no rm conclusions could be made as the variations in suture placement could not be accounted for. By the numbers recurrence rates with suture xation were 4% and without were 1.8%. He did conclude that if no sutures were used, a larger overlap of the defect [35] was needed [22].
Adhesive xation in the intraperitoneal space has not proven to be effective as a primary form of xation. Shug Pass etal. evaluated the strength of brin glue xa­tion of mesh to peritoneum and to muscle in a basic science model and a pig model. There was a signicant difference in xation strength between muscle and perito­neum (47N vs 11N) suggesting that brin glue should not be used to xate mesh to the peritoneum [23]. As previously mentioned, Melman etal. did an acute xa­tion study comparing permanent tacks, absorbable tacks, suture, and brin glue. Suture was signicantly stronger than all other methods of xation. Glue was the weakest xative, and permanent tacks were stronger than absorbable tacks [3]. Multiple reasons can be theorized as to why brin glue does not xate mesh well to the peritoneum. One reason is that coated meshes inherently do not xate well with brin glue due to the inability of the glue to permeate the entire surface of the mesh. Secondly, the peritoneum is a uid structure that classically has slower ingrowth of mesh compared to muscle and fascia.
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N. Stoikes et al.
Retrorectus Mesh Placement
The retrorectus space refers to the Rives retrorectus repair and the newer transver­sus abdominis release (TAR). Options for xation in this space are classically transfascial suture xation though brin glue is gaining some popularity in the space. Biomechanically, the principles and ndings of intraperitoneal mechanical xation apply, but it is likely that brin glue xation is stronger than it is in the intraperitoneal space because uncoated and wider pore mesh is being xated to fascia and muscle instead of coated mesh being xated to peritoneum. A recent study by Moazzez etal. described their technique for brin glue use in the retrorec­tus space for ventral hernia repair. In their description a few sutures are used to xate the mesh to the posterior sheath, and then after closing the posterior sheath and securing the mesh to it, brin glue is used to xate the mesh to the entire sur­face area of the posterior sheath [24]. Currently there is a paucity of basic science data evaluating brin glue use in the retrorectus space. Historically, the Rives repair is a tension-based repair, which inherently required the use of sutures to accomplish the retrorectus xation of the mesh thereby decreasing forces on the anterior fascial closure (Fig.7.4). This foundational principle of the repair calls
Fig. 7.4 Rives’ retrorectus repair with tension-based mesh xation (Picture comes from Atlas of Hernia by Wantz 1991 Lippincott)
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into question the potential utility of brin glue xation. As newer preperitoneal and retrorectus techniques like laparoscopic and robotic preperitoneal ventral hernia repairs mature clinically, there will be a greater need for understanding the behav­ior of brin glue in this space.
Onlay
At the same time that Rives was describing his retrorectus repair, Chevrel, also in France, described his onlay method for incisional hernia repair. Chevrel’s goals of repair were to recreate the linea alba with the anterior rectus sheath. This concept was based on cadaver studies he conducted that revealed the anterior rectus sheath was the next strongest part of the abdominal wall secondary to the linea alba. In his repair, he reconstructed the abdominal wall in three layers, which included a dou­ble-layer midline closure using the anterior rectus sheath and then placement of an onlay prosthetic. Chevrel’s approach to xation was revolutionary for the time. He sutured his onlay mesh but also described how to make and place brin glue on the midline closure. His outcomes were excellent with up to 20-year follow-up and a recurrence rate of 4.9% [25].
Over the past few years, the onlay repair with brin glue xation has slowly increased in popularity in the United States and has been supported by basic science research (see section “The Science of Fixation”). A large series of 97 patients by Shahan etal. reviewed the onlay technique on large ventral hernias that were com­plex and required myofascial advancement aps. In this technique the primary form of xation is with brin glue with some skin staples used as place holders to orient the mesh onto the abdominal wall for application of the brin glue. Mean BMI was 32kg in this study with a mean hernia defect size of 150cm2. Follow-up was 1year, and there were no recurrences reported in the series. As with all ventral hernia repairs, the main issue was persistent seroma, which was found in 21% of patients. Due to other various wound complications (seroma included), 9% of patients required operative wound management. However, 100% of mesh was salvaged in the series, and it was found that contamination status at initial operation did not affect the need for reoperation [26].
Hiatal Hernia
The routine use of mesh (as well as type) remains a controversial topic that contin­ues to be debated. Hundreds of clinical articles have looked at mesh placement in this location, but few have looked at types of xation for the mesh. Due to the move­ment of the diaphragm and esophagus thousands of times a day, strong xation in this area is key since migration can lead to esophageal erosion due to the movement of the diaphragm and esophagus thousands of times a day. Generally speaking, bio­logic mesh or absorbable biosynthetic mesh approved for intra-abdominal use is recommended if mesh is to be placed. Krpata etal. have reviewed sutures vs. brin glue xation of mesh at the hiatus. He used a porcine model and a biologic mesh to
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Fig. 7.5 Fixation of biosynthetic mesh at the hiatus with brin glue
N. Stoikes et al.
evaluate the two forms of xation. A 30-day survival study was done, and the bio­mechanics revealed no migrations in either group and similar ingrowth implying similar xation strengths [27]. Fortelny etal. did a similar study in a porcine model using brin glue to xate titanized polypropylene mesh at the hiatus. At 4weeks they found excellent integration and no mesh migrations [28].
Clinically, Powell et al. reviewed 70 patients with cruroplasty reinforcement with bio-absorbable mesh and brin glue as the sole xation method for hiatal her­nia repair. The short-term study revealed no immediate complications [29]. We have used this method of mesh xation in over 200 hiatal hernia repairs with no known case of mesh erosion into the esophagus (Fig.7.5).
Good-quality xation data in the hiatal hernia space is sparse. This is partially due to the inherent controversy surrounding mesh use, but also repair outcomes can be hard to follow as imaging and clinical suspicion are necessary to evaluate for recurrence. Regardless, continued study is necessary to optimize xation.
Conclusions
The need for optimal mesh xation spans all types of hernia repairs. The type of
hernia, the technique selected, and the type of mesh determine xation options.
Understanding the basic science helps to provide an underlying logic that can
help formulate an approach to each hernia situation. Realizing that “strongest”
xation is not always “best” xation leads to the real question that must be
answered: “how strong is strong enough?” Fixation continues to evolve, and fur-
ther study using “out of the box” thinking will be needed to tailor optimal xa-
tion of mesh for a given hernia presentation.
References
1. Stoikes N, Sharpe J, Tasneem H, etal. Biomechanical evaluation of xation properties of brin
glue for ventral hernia repair. Hernia. 2013;19:161–6.
2. Golani S, Middleton P.Long-term follow-up of laparoscopic total extraperitoneal (TEP) repair
in inguinal hernia without mesh xation. Hernia. 2017;21(1):37–43.
7 Prosthetic Fixation Options
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3. Melman L, Jenkins ED, Deeken CR, Brodt MD, Brown SR, Brunt LM, Eagon JC, Frisella
M, Matthews BD.Evaluation of acute xation strength for mechanical tacking devices and brin sealant versus polypropylene suture for laparoscopic ventral hernia repair. Surg Innov. 2010;17(4):285–90.
4. Jourdan IC, Bailey ME. Initial experience with the use of N-butyl 2-cyanoacrylate glue for
the xation of polypropylene mesh in laparoscopic hernia repair. Surg Laparosc Endosc. 1998;8(4):291–3.
5. Kukleta J, Freytag C, Weber M.Efciency and safety of mesh xation in laparoscopic inguinal
hernia repair using n-butyl cyanoacrylate: long term biocompatibility in over 1300 mesh xa­tions. Hernia. 2012;16:153–62.
6. Katkhouda N, Mavor E, Friedlander MH, Mason RJ, Kiyabu M, Grant SW, Achanta K,
Kirkman EL, Narayanan K, Essani R. Use of brin sealant for prosthetic mesh xation in laparoscopic extraperitoneal inguinal hernia repair. Ann Surg. 2001;233(1):18–25.
7. Schwab R, Schumacher O, Junge K, Binnebösel M, Klinge U, Becker HP, Schumpelick
V. Biomechanical analyses of mesh xation in TAPP and TEP hernia repair. Surg Endosc. 2008;22(3):731–8.
8. Kes E, Lange J, Bonjer J, Stoeckart R, Mulder P, Snijders C, Kleinrensink G.Protrusion of
prosthetic meshes in repair of inguinal hernias. Surgery. 2004;135(2):163–70.
9. Novik B, Hagedorn S, Mork UB, etal. Fibrin glue for securing mesh in laparoscopic totally
extraperitoneal inguinal hernia repair: a study with a 40-month prospective follow up period. Surg Endosc. 2006;20:462–7.
10. Kaul A, Hutess S, Le H, etal. Stapled versus brin glue xation in laparoscopic totally
extrperitoneal repair of inguinal hernia: a systematic review and meta-analysis. Surg Endosc. 2012;26:1269–78.
11. Shahan CP, Stoikes NN, Roan E, etal. Short term strength of nonpenetrating mesh xation:
Lifemesh, Tisseel, and Progrip. Surg Endosc. 2017;31:1350–3.
12. Fumagalli Romario U, Puccetti F, Elmore U, Massaron S, Rosati R.Self-gripping mesh versus
staple xation in laparoscopic inguinal hernia repair: a prospective comparison. Surg Endosc. 2013;27(5):1798–802.
13. Campanelli G, Pascual M, Hoeferlin A, etal. Randomized controlled blinded trial of tisseel/
tissucol for mesh xation in patients undergoing Lichtenstein technique for primary inguinal hernia repair. Ann Surg. 2012;255:650–7.
14. Ronka K, Vironen J, Kossi J, etal. Randomized multicenter trial comparing glue xation, self grip-
ping mesh, and suture xation of mesh, in Lichtenstein hernia repair. Ann Surg. 2015;262:714–9.
15. Van’t Riet M, De vos Van S, Kleinrensink G.Tensile strength of mesh xation methods in
laparoscopic incisional hernia repair. Surg Endosc. 2002;16:1713–6.
16. Heniford T, Park A, Ramshaw B, et al. Laparoscopic repair of ventral hernias: nine years’
experience with 850 consecutive hernias. Ann Surg. 2003;238:391–9.
17. Morales-Conde S, Cadet H, Cano A.Laparoscopic ventral hernia repair without sutures-dou-
ble crown technique: our experience after 140 cases with a mean follow up of 40 months. Int Surg. 2005;90:S56–62.
18. Baccari P, Nifosi J, Ghiradelli L, etal. Laparoscopic incisional and ventral hernia repair with-
out sutures: a single center experience with 200 cases. J Laparoendosc Adv Surg Tech A. 2009;19:175–9.
19. Wassenaar A, Schoenmaakers E, Raymakers J.Mesh xation method and quality of life after
laparoscopic ventral or incisional hernia repair: a randomized trial of three xation techniques. Surg Endosc. 2010;24:1296–302.
20. Brill JB, Turner PL.Long term outcomes with transfascial sutures versus tacks in laparoscopic
ventral hernia repair: a review. Am Surg. 2011;77:458–65.
21. Leblanc K, Booth W, Whitaker J, etal. Laparoscopic incisional and ventral herniorraphy: our
initial 100 patients. Hernia. 2001;5:41–5.
22. Leblanc K.Laparoscopic incisional hernia repair: are transfascial sutures necessary? A review
of the literature. Surg Endosc. 2007;21:508–13.
23. Shug Pass C, Lippert H, Kockerling F.Fixation of the mesh to the peritoneum using brin
glue: investigations with a biomechanical model and an experimental laparoscopic porcine model. Surg Endosc. 2009;23:2809–15.
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24. Moazzez A, Dubina E.A novel approach to mesh xation retrorectus ventral hernia repair
using brin sealant. J Am Coll Surg. 2017;225:e1–4.
25. Chevrel J, Rath A. The use of brin glues in the surgical treatment of incisional hernias.
Hernia. 1997;1:9–14.
26. Shahan C, Stoikes N, Webb D. Sutureless onlay hernia repair: a review of 97 patients. Surg
Endosc. 2016;30:3256–61.
27. Krpata D, Blatnik J, Harth K, etal. Evaluation of brin sealant for biologic mesh xation at the
hiatus in a porcine model. Surg Endosc. 2012;26:3120–6.
28. Fortelny R, Petter-Puchner A, Glaser K, etal. Fibrin sealant (tisseel) for hiatal mesh xation in
an experimental model in pigs. J Surg Res. 2010;162:68–74.
29. Powell B, Wandrey D, Voeller G.A technique for placement of a bioabsorbable prosthesis with
brin glue xation for reinforcement of the crural closure during hiatal hernia repair. Hernia. 2013;17:81–4.
N. Stoikes et al.
How toChoose aMesh inHernia Repair
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DavidEarle
Since the introduction of polypropylene (PP) mesh for hernia repair [1], surgeons continue to discuss the use of mesh in a variety of settings for one of the most common operations performed by general surgeons—hernia repair. This discus­sion has involved raw materials, cost, and outcomes and for many years referred to only a few products, as manufacturing was limited. Nowadays, with multiple permanent, absorbable, biologic, and hybrid products on the market, the choice of mesh for a hernia repair can be daunting. Increasing clinical complexity further emphasizes the need for individualizing care, but more frequently, hospital supply chain personnel institute product procurement procedures for cost control, limit­ing mesh choice for surgeons. This can force surgeons into a “one-size-ts-all” practice regarding mesh choice, which may not be ideal for some patients. Conversely, current literature lacks denitive evidence supporting the use of one mesh over another, a fact that has not escaped the radar screen of the hospital sup­ply chain and mesh industry, both of which attempt to limit vendor and mesh choice for nancial gain. It is unlikely that this type of “proof” will ever come to fruition. This leaves us with choosing a mesh based on an algorithm that is cen­tered on the patient and the patient’s unique clinical scenario [2]. This algorithm (Fig.8.1) will culminate in mesh choice, but could also apply to non-mesh tech­niques as well.
Below are generic two examples, based on real cases, which will serve as back­ground information. I will refer to these examples throughout the chapter to high­light how an algorithmic approach to mesh choice can be utilized.
8
D. Earle Tufts University School of Medicine, Boston, MA, USA
New England Hernia Center, North Chelmsford, MA, USA
© Society of American Gastrointestinal and Endoscopic Surgeons (SAGES) 2019 S. S. Davis Jr. et al. (eds.), The SAGES Manual of Hernia Surgery,
https://doi.org/10.1007/978-3-319-78411-3_8
97
98
1. Identify goals of hernia repair
a
2. Evaluate the clinical scenario
3. Choose a technique
4. Choose a mesh designed for use with the chosen technique
5. Preoperative planning
findings dictate a change.
D. Earle
a. Explicitly ask patient about their goals – symptom relief, prevention, or
both.
b. Align those goals, and discuss the likelihood of their realization with herni
repair.
a. Is the case elective, urgent, or emergent?
b. Is the case clean, contaminated, or potentially contaminated?
c. Is the patient a better candidate for local or general anesthesia?
d. Does the patient’s history suggest higher likelihood of future operation? (e.g. pregnancy, Crohn’s disease, ostomy closure)
e. Evaluate the hernia details –previous repairs, location, size of defect, size of sac, associated skin issues.
a. A technique that is most likely to meet the goals in the given clinical scenario should be chosen. In the event this technique is not the one the surgeon is the most comfortable with or has the adequate resources, referral or a different technique and rationale should be discussed with the patient, and a joint decision can be made about how to proceed. This is obviously limited in emergency situations.
a. Consider the raw material –permanent, absorbable, synthetic, biological, hybrid
b. Consider the design –A high priority should be placed on the relative strength of the mesh, data that can be difficult to obtain. Porosity, fiber size, and barrier coating are also important to evaluate, as each mesh performs differently in different locations (e.g., intra-vs extra-peritoneal, bridging vs support).
a. Plan enhanced recovery strategies with anesthesia, and coordinate regional anesthetic blocks as necessary.
b. Define need for multidisciplinary coordination before you start, such as plastics, colorectal, gynecology, and urology.
Fig. 8.1 Algorithm for mesh choice for hernia repair
c. Make sure the mesh you have chosen is available, and in a variety of sizes.
d. Have an alternate plan and/or mesh available in the event intraoperative
8 How toChoose aMesh inHernia Repair
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Example 1: A 70 year old patient who works as a physician presents with a small,
asymptomatic incisional hernia after a laparotomy. The patient has a BMI of 26.
The patient is concerned it will grow, as it seems to have grown from the size of
a marble to that of a golf ball in a short period of time. There is no pain. The
surgeon may tell the patient not to worry about the hernia unless it starts causing
problems. As the hernia sac grows, the patient returns with an enormous hernia
sac, associated with overlying skin excoriation. Example 2: A 60 year old obese patient (BMI 52) with multiple medical problems
and actively smoking is concerned about progressively worsening pain from an
intermittently incarcerating primary ventral hernia, requiring two visits to the
emergency room within the past month. The patient noticed the symptoms for
several months before the ER visits, but the pain was never that severe. The inter-
mittent pain seems to be increasing in frequency and severity. The patient would
like to relieve the symptoms and avoid a life-threatening emergency. The bulge
is barely noticeable and located in the midline epigastrium. CT scan reveals the
defect is 6×6cm and contains omentum and a portion of the transverse colon.
Step 1: Goals oftheHernia Repair
It is important to identify the patient goals for the operation. Regarding hernia repair, this is usually associated with symptom relief, prevention of developing symptoms (including acute incarceration), or both. Symptoms include discomfort, pain, abnormal abdominal wall contour, skin changes, intermittent bowel obstruc­tion, and limitations of important activities. Prevention is typically the goal associ­ated with asymptomatic hernias found during a routine physical exam or during an imaging study performed for another problem. Often, a patient with mild, but slowly progressive symptoms, desires both to alleviate the current symptoms and avoid waiting until they become so severe it will compromise their care.
Once the goals of the repair are identied, the surgeon must align those goals with the healthcare team. This will allow the surgeon to identify and address unre­alistic goals, and formulate a strategy of repair, including mesh choice, which will most likely meet the goals. It is also important to explicitly discuss the likelihood of meeting the patient’s expectations, as patients and surgeons may have different per­ceptions of what is important [3, 4].
In example 1 (asymptomatic, marble-sized incisional hernia; goal is to prevent it from getting worse), there are a variety of techniques and mesh options available. As the hernia defect and/or sac enlarges, or if the hernia becomes acutely incarcer­ated with compromised bowel, the number of acceptable options dwindles, which affects the choice of mesh.
In example 2 (obese patient, escalating symptoms, 6cm primary defect; goals are pain relief and avoidance of an emergency operation), one option for the sur­geon is to recommend weight loss before an elective hernia repair is considered, as