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Gastrointestinal Oncology

Gastrointestinal
Oncology
A Critical Multidisciplinary
Team Approach
EDITED BY
Professor Janusz A. Z. Jankowski JP
MBChB (Glasgow) MSc (Oxford) MD (Dundee) PhD (London)
PCME (Cambridge) PGCM (C Lancs.) PGCC (Warwick)
AGAF (USA). FACG (USA) FRCP (Edinburgh & London) SFHEA (UK)
Clinical Professor
University College London, London, UK
Non-Executive Director
Tavistock and Portman NHS Foundation Trust, London
Consultant Physician and Gastroenterologist
National Health Service, UK
Provost, Dubai Medical College, United Arab Emirates
&
Former Sir James Black Senior Fellow
University of Oxford, Oxford, UK
SECOND EDITION

This edition first published 2024
© 2024 John Wiley & Sons Ltd
Edition History
Blackwell Publishing (1e, 2008)
All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic,
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The right of Janusz A. Z. Jankowski to be identified as the author of the editorial material in this work has been asserted in accordance with law.
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The contents of this work are intended to further general scientific research, understanding, and discussion only and are not intended and should not
be relied upon as recommending or promoting scientific method, diagnosis, or treatment by physicians for any particular patient. In view of ongoing
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A catalogue record for this book is available from the Library of Congress
Hardback ISBN: 9781119756392; ePub ISBN: 9781119756415; ePDF ISBN: 9781119756408; oBook ISBN: 9781119756422
Cover images: CT imaging courtesy of Prof P. Milkiewicz, Dr K. Korzeniowski and Dr G. Rosiak; Dietary interventions courtesy of Helena Jankowska;
Neuroendocrine histology courtesy of Atsuko Kasajima, Günter Klöppel, Stefano La Rosa
Cover design by Wiley
Set in 9.5/12 pts Minion Pro by Integra Software Services Pvt. Ltd, Pondicherry, India

Contents
https://t.me/medicina_free
List of Contributors , vii
Preface , xvii
Foreword , xviii
Screening, Surveillance, and Prevention for
11
Colorectal Cancer, 170
12
Colorectal Cancer, 181
Section I: Upper Gastrointestinal Cancer, 1
1 Epidemiology, Microbiome, and Risk Factors Involved
in Carcinogenesis of Esophagus, Gastric, and
Intestine, 3
2 Genomics, Molecular Pathology, and Pathology of
Esophageal and Gastric Cancer, 23
3 Screening, Surveillance, and Prevention of
Esophageal and Gastric Cancers, 42
4 Management of Esophageal Dysplasia and
Esophageal Adenocarcinoma, 63
5 Esophageal Squamous Cell Carcinoma, 82
6 Management of Diffuse Gastric Cancer, 116
7 Intestinal-type Gastric Cancer, 120
8 Cancer of the Small Intestine, 139
Section II: Colorectal and Anal Cancer, 145
9 Epidemiology, Microbiome, and Risk Factors Involved
in Carcinogenesis of Colorectal Cancer, 147
10 Genomics, Histopathology, and Molecular
Pathology of Sporadic and Hereditary
Colorectal Cancer, 149
13 Epidemiology, Pathology, Diagnosis, Prevention, and
Management of Anal Cancer, 235
Section III: Hepatobiliary and Pancreas
Cancer, 249
14 Epidemiology and Risk Factors of Hepatocellular
Carcinoma, 251
15 Pathology, Molecular Pathology, and Genomics of
Hepatobiliary and Pancreatic Cancer, 264
16 Screening, Surveillance, and Prevention of
Hepatocellular Carcinoma, 271
17 Pancreatic and Biliary Tract Cancers: Risk Factors and
Etiology, Screening, Surveillance, and Biomarkers of
Detection and Prognosis, 291
18 The Multidisciplinary Management of Primary
Hepatocellular Carcinoma, 321
19 Management of Metastatic Liver Cancer, 347
20 Management of Primary Pancreatic Cancer, 386
21 Management of Intrahepatic and Extrahepatic
Cholangiocarcinoma, 407
22 Management of Cystic Neoplasms of the Pancreas, 438
v

VI CONTENTS
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Section IV: Specialist Abdominal Cancer
Management Teams, 455
23 Epidemiology, Pathology, Diagnosis, Prevention,
and Management of GI Stromal Tumors and
Other GI Sarcomas, 457
24 Neuroendocrine Neoplasms of the Digestive
System, 470
25 Epidemiology, Pathology, Diagnosis, Prevention,
and Management of Unknown Primary
Cancer, 538
26 Diagnosis and Management of Gastrointestinal
Lymphomas, 546
27 Palliative and Supportive Medicine in Gastrointestinal
Oncology, 561
28 Psychological Oncology and Wellbeing: Wellbeing
(part 1) and narrative practices in child palliative care
(part 2), 576
29 Nutrition for Cancer Prevention, Adjunctive Cancer
Care, and Rehabilitation: Nutrition and Cancer, 587
Cancer – The Road Less Traveled, 591
Index, 593

List of Contributors
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Mostafa Abasseri
Department of Gastroenterology and Hepatology St. George Hospital
Sydney
New South Wales
Australia
School of Medicine
University of New South Wales
Sydney
Australia
Aidalena Abidin
Candiolo Cancer Institute
Italy
Pilar Acedo
Institute for Liver and Digestive Health
University College London
London
UK
Raja A.R. Ali
Gastroenterology Unit
Department of Medicine
Faculty of Medicine
Universiti Kebangsaan Malaysia
Kuala Lumpur
Malaysia
School of Medical and Life Sciences
Sunway University
Selangor
Malaysia
GUT Research Group
Faculty of Medicine
Universiti Kebangsaan Malaysia
Kuala Lumpur
Malaysia
Martin Anlauf
Institute of Pathology and Cytology
St. Vincenz Hospital Limburg
Limburg
Germany
Pietro Antonini
Section of Pathology
Department of Diagnostics and Public Health
University of Verona
Vero na
Italy
Nadir Arber
Oncology Unit
Tel Aviv Medical Center
Israel
Middle East
Maya Balakrishnan
Gastroenterology and Hepatology Section
Department of Medicine
Baylor College of Medicine
Houston
Texas
USA
Kirill Basiliya
Consultant Gastroenterologist
Leiden Medical Centre
Belgium
Charlotte Benson
Institute for Cancer Research
Royal Marsden Hospital
London
UK
Lauren E. Berninger
Division of General Internal Medicine
Department of Medicine
Palliative Care Program
Johns Hopkins Medical Institutions
Sidney Kimmel Comprehensive Cancer Center
Baltimore
Maryland
USA
Inga Boeck
Institute of Pathology and Cytology
St. Vincenz Hospital Limburg
Limburg
Germany
vii

VIII LIST OF CONTRIBUTORS
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Jessica A.L. Borbasi
Department of Palliative Medicine
Nelune Comprehensive Cancer Centre
Prince of Wales Hospital
Randwick
New South Wales
Australia
David Bowden
Department of Radiology
Addenbrooke’s Hospital
Cambridge University Hospitals NHS
Foundation Trust
Cambridge
UK
Ilene S. Browner
Palliative Medicine Program
Johns Hopkins Medical Institutions
Sidney Kimmel Comprehensive Cancer Center
Baltimore
Maryland
USA
Simon James Alexander Buczacki
Nuffield Department of Surgical Science
University of Oxford
Oxford
UK
Chang Gung University
Taiwan
Mingyi Chen
UT Southwestern Medical Center
Dallas
Texas
USA
Ka Shing Cheung
Department of Medicine
School of Clinical Medicine
The University of Hong Kong
Queen Mary Hospital
Hong Kong
China
Department of Medicine
The University of Hong Kong-Shenzhen Hospital
Shenzhen
China
Deborah Chia Hsin Chew
Gastroenterology Unit
Department of Medicine
Faculty of Medicine
Universiti Kebangsaan Malaysia
Kuala Lumpur
Malaysia
Amitabh Chak
Division of Gastroenterology and Hepatology
University Hospitals Cleveland Medical Center
Cleveland
Ohio
USA
Dedrick Kok Hong Chan
Division of Colorectal Surgery
University Surgical Cluster
National University Hospital
Singapore
Department of Surgery
Yong Loo Lin School of Medicine
National University of Singapore
Singapore
Annie On On Chan
Department of Medicine
School of Clinical Medicine
The University of Hong Kong
Queen Mary Hospital
Hong Kong
China
Hong Kong Sanatorium Hospital
Hong Kong
China
Yin-Kai Chao
Department of Thoracic Surgery
Chang Gung Memorial Hospital-Linkou
Zhikai Chi
UT Southwestern Medical Center
Dallas
Texas
USA
Francis Chu
Department of Upper Gastrointestinal and Hepatobiliary Surgery
St. George Hospital
Sydney
Australia
Wen-Yu Chuang
Department of Anatomic Pathology
Chang Gung Memorial Hospital-Linkou
Chang Gung University
Taiwan
David Church
Cancer Research UK Advanced Clinician
Scientist Fellow
Honorary Consultant Medical Oncologist
Wellcome Centre for Human Genetics
University of Oxford
Oxford
UK
D. Chamil Codipilly
Division of Gastroenterology and Hepatology
Mayo Clinic
SW Rochester
MN
USA

LIST OF CONTRIBUTORS IX
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Natalie Collier
Department of Radiation Oncology
Wollongong Hospital and University of New South Wales
New South Wales
Australia
Alicia-Marie Conway
The Christie Hospital Foundation Trust
Manchester
UK
Gareth Corbett
Department of Gastroenterology
Addenbrooke’s Hospital
Cambridge University Hospitals NHS
Foundation Trust
Cambridge
UK
Eithne Costello
Institute of Systems
Molecular and Integrative Biology
University of Liverpool
Liverpool
UK
Philip I. Craig
Department of Gastroenterology and Hepatology
St. George Hospital Sydney and University of New South Wales Medical School
New South Wales
Australia
Brian Czito
Department of Radiation Oncology
Duke University School of Medicine
Durham
North Carolina
USA
S. Lindsey Davis
Department of Medical Oncology
University of Colorado School of Medicine
Aurora
Colorado
Levent Dizdar
Department of Surgery
Heinrich-Heine-University and University Hospital Duesseldorf
Duesseldorf
Germany
Yardenna Dolev
Oncology Unit
Tel Aviv Medical Center
Israel
Middle East
Michail Doukas
Department of Pathology
Erasmus University Medical Center
Rotterdam
The Netherlands
Clarisse Dromain
Department of Radiology
Lausanne University Hospital (CHUV)
Rue du Bugnon 46
1011 Lausanne
Switzerland
Emad M. El-Omar
UNSW Microbiome Research Centre
St. George and Sutherland Clinical Campuses
School of Clinical Medicine
Faculty of Medicine and Health
University of New South Wales
Sydney
New South Wales
Australia
Hashem B. El-Serag
Gastroenterology and Hepatology Section
Department of Medicine
Baylor College of Medicine
Houston
Texas
USA
Justin Davies
Cambridge Colorectal Unit
Addenbrooke’s Hospital
Cambridge University Hospitals NHS
Foundation Trust
Cambridge
UK
Mihir Desai
Department of Interventional Radiology
Prince of Wales Hospital
Sydney
New South Wales
Australia
Prince of Wales Clinical Campus
School of Clinical Medicine
University of New South Wales
New South Wales
Australia
Irene Esposito
Institute of Pathology
Heinrich-Heine University and University Hospital and of Dusseldorf
Germany
Oliver M. Fisher
Department of Surgery
St. George Hospital Sydney and University of New South Wales
New South Wales
Australia
Yuman Fong
Department of Surgery
City of Hope National Medical Center
Duarte
California
USA

X LIST OF CONTRIBUTORS
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Giuseppe K. Fusai
Institute for Liver and Digestive Health
University College London
London
UK
Department of HPB Surgery
Royal Free Hospital
London
UK
Robert C. Gandy
Department of General Surgery
Prince of Wales Hospital
Randwick
New South Wales
Australia
School of Clinical Medicine
Faculty of Medicine & Health
UNSW Sydney
New South Wales
Australia
Andres Garcia-Sampedro
Institute for Liver and Digestive Health
University College London
London
UK
Xing Gao
Department of Surgery
Erasmus MC Cancer Institute
Rotterdam
the Netherlands
Department of Thoracic Surgery
Chang Gung Memorial Hospital-Linkou
Chang Gung University
Taiwan
Elena Geuna
Candiolo Cancer Institute
Italy
Ravit Geva
Oncology Unit
Tel Aviv Medical Center
Israel
Middle East
Prithwish Ghosh
Division of Gastroenterology and Hepatology
Mayo Clinic
SW Rochester
MN
USA
Frederik L. Giesel
Department of Nuclear Medicine
Heinrich-Heine University and University Hospital of Düsseldorf
Düsseldorf
Germany
Brooke Glessing
Division of Gastroenterology and Hepatology
University Hospitals Cleveland Medical Center
Cleveland
Ohio
USA
William Greenhalf
Institute of Systems
Molecular and Integrative Biology
University of Liverpool
Liverpool
UK
David Goldstein
School of Clinical Medicine
Faculty of Medicine & Health
UNSW Sydney
New South Wales
Australia
Department of Medical Oncology
Nelune Comprehensive Cancer Centre
Prince of Wales Hospital
Randwick
New South Wales
Australia
Lena Häberle
Institute of Pathology
Heinrich-Heine University and University Hospital and of Dusseldorf
Germany
Koroush S. Haghighi
Department of General Surgery
Prince of Wales Hospital
Randwick
New South Wales
Australia
School of Clinical Medicine
Faculty of Medicine & Health
UNSW Sydney
New South Wales
Australia
Mahnur Haider
Department of Hepatology
Cleveland Clinic
Cleveland
Ohio
USA
Umar Hayat
Division of Gastroenterology and Hepatology
University Hospitals Cleveland Medical Center
Cleveland
Ohio
USA
Felix Ho
Department of Surgery
University of Colorado School of Medicine
Aurora
Colorado
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