Добавил:
kiopkiopkiop18@yandex.ru t.me/Prokururor I Вовсе не секретарь, но почту проверяю Опубликованный материал нарушает ваши авторские права? Сообщите нам.
Вуз: Предмет: Файл:

Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_827_Библиотеки_им_академика_М_И_Перельмана

.pdf
Скачиваний:
0
Добавлен:
31.08.2026
Размер:
39 Мб
Скачать
134 B.J. Orandi et al.
https://t.me/med1917
References
1. Makary MA, Winter JM, Cameron JL, Campbell KA, Chang D, Cunningham SC et elderly. J Gastrointest Surg 10(3):347–356
2. Filsoufi F, Rahmanian PB, Castillo JG, Chikwe J, Silvay G, Adams DH (2008) Excellent early and late outcomes of aortic valve replace­ment in people aged 80 and older. J Am Geriatr Soc 56(2):255–261
3. Boyd JB, Bradford B Jr, Watne AL (1980) Operative risk factors of colon resection in the elderly. Ann Surg 192:743–746
4. Hamel MB, Henderson WG, Khuri SF, Daley J (2005) Surgical out­comes for patients aged 80 and older: morbidity and mortality from major noncardiac surgery. J Am Geriatr Soc 53(93):424–429
5. Fried LP, Walston J (1993) Frailty and failure to thrive. In: Principles of geriatric medicine and gerontology, 3rd edn. McGraw-Hill, New York, pp 241–248
6. Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J et
al (2001) Frailty in older adults: evidence for a phenotype. J
Gerontol A Biol Sci Med Sci 56:M146–M156
7. Taylor HL, Jacobs DR Jr, Schuker B, Knudsen J, Leon AS, Debacker G (1978) A questionnaire for the assessment of leisure-time physi­cal activities. J Chronic Dis 31:745–755
8. Orme J, Reis J, Herz E (1986) Factorial and discriminate validity of the Center for Epidemiologic Studies depression (CES-D) scale. J Clin Psychol 42:28–33
9. Rothman RD, Leo-Summers L, Gill TM (2008) Prognostic signifi­cance of potential frailty criteria. J Am Geriatr Soc 56(12):2211–2216
10. Walston J, Hadley EC, Ferrucci L, Guralnik JM, Newman AB, Studenski SA et al (2006) Research agenda for frailty in older adults: toward a better understanding of physiology and etiology: summary from the AGS/NIA on Aging Research Conference on Frailty in Older Adults. J Am Geriatr Soc 54(6):991–1001
11. Walston J, McBurnie MA, Newman A, Tracy RP, Kop WJ, Hirsch CH et al (2002) Frailty and activation of the inflammation and coag­ulation systems with and without clinical comorbidities: results from the Cardiovascular Health Study. Arch Intern Med 162:2333–2341
12. Harris TB, Ferrucci L, Tracy RP, Corti MC, Wacholder S, Ettinger WH Jr et al (1999) Associations of elevated IL-6 and C-reactive pro­tein levels with mortality in the elderly. Am J Med 106:506–512
13. Ershler WB, Keller ET (2000) Age-associated increased interleu­kin-6 gene expression, late-life diseases, and frailty. Annu Rev Med 51:245–270
14. Stookey JD, Purser JL, Pieper CF, Cohen HJ (2004) Plasma hyper­tonicity: another marker of frailty? J Am Geriatr Soc 52:1313–1320
15. Kamath PS, Wiesner RH, Malinchoc M et al (2001) A model to predict survival in patients with end-stage liver disease. Hepatology 33(2):464–470
16. Makary MA, Segev DL, Fried LP, Syin D, Bandeen-Roche K, Patel P et al (2006) Frailty as a predictor of surgical outcomes in older
al (2006) Pancreaticoduodenectomy in the very
patients. Paper presented at first annual academic surgical congress, San Diego, CA, 7–10 February 2006
17. Saklad M (1941) Grading of patients for surgical procedures. Anesthesiology 2:281–284
18. Lee TH, Marcantonio ER, Mangione CM, Thomas EJ, Polanczyk CA, Cook EF et a simple index for prediction of cardiac risk of major noncardiac surgery. Circulation 100(10):1043–1049
19. Fleisher LA, Beckman JA, Brown KA, Calkins H, Chaikof EL, Fleischmann KE et erative cardiovascular evaluation and care for noncardiac surgery: executive summary a report of the American College of Cardiology/ American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery). Circulation 116:1971–1996
20. O’Connell JB, Maggard MA, Ko CY (2004) Cancer-directed sur­gery for localized disease: decreased use in the elderly. Ann Surg Oncol 11(11):962–969
21. Ryynanen OP, Myllykangas M, Kinnunen J, Takala J (1997) Doctors’ willingness to refer elderly patients for elective surgery. Fam Pract 14(3):216–219
22. Bouma BJ, van der Meulen JH, van den Brink RB, Arnold AE, Smidts A, Teunter LH et al (2001) Variability in treatment advice for elderly patients with aortic stenosis: a nationwide survey in The Netherlands. Heart 85(2):196–201
23. Studenski S, Hayes RP, Leibowitz RQ, Bode R, Lavery L, Walston J, Duncan P, Perera S (2004) Clinical global impression of change in physical frailty: development of a measure based on clinical judgment. J Am Geriatr Soc 52:1560–1566
24. Lawrence VA, Hazuda HP, Cornell JE, Pederson T, Bradshaw PT, Mulrow CD, Page CP (2004) Functional independence after major abdominal surgery in the elderly. J Am Coll Surg 199(5): 762–772
25. Milne AC, Potter J, Avenell A (2002) Oral protein and energy sup­plements reduce all-cause mortality in elderly persons. Cochrane Database Syst Rev (3):CD003288
26. Leung JM, Dzankic S (2001) Relative importance of preoperative health status versus intraoperative factors in predicting postopera­tive adverse outcomes in geriatric surgical patients. J Am Geriatr Soc 49:1080–1085
27. Hutchings LF, Unger JM, Crowley JJ, Coltman CA JR, Albain KS (1999) Underrepresentation of patients 65 years of age or older in cancer-treatment trials. New Engl J Med 34:2061–2067
28. Benson AB III, Pregler JP, Bean JA, Rademaker AW, Eshler B, Anderson K (1991) Oncologists’ reluctance to accrue patients onto clinical trials: an Illinois Cancer Center study. J Clin Oncol 9:2067–2075
29. Leng S, Chaves P, Koenig K, Walston J. Serum interleukin-6 and hemoglobin as physiological correlates in the geriatric syndrome of frailty: a pilot study. J Am Geriatr Soc 50(7):1268–1271
al (1999) Derivation and prospective validation of
al (2007) ACC/AHA 2007 guidelines on periop-
Section II
https://t.me/med1917
Social/Societal Issues
https://t.me/med1917
Chapter 10
https://t.me/med1917
Invited Commentary
Michael E. Zenilman
Introduction
In this new section of our textbook, topics which have been in the background of surgery in elderly patients are now spotlighted. In the 10 years since publication of our first edition, it has been very gratifying for me to watch as more interest in the ramifications of surgery in the older patients – not just technical prowess – has developed; it brings us to the basics of medicine – “Primum Non Nocere.”
The increased interest has two mutually-non-exclusive sources. First, there has been more academic attention to the older surgical patient. For example, in 1976, the nine surgical journals I typically read published a total of 358 articles in which patients aged greater than 65 or 85 years were operated, in 1989 there were 368, in 1999 the number was 513, and in 2009 there were 893 articles. My impression is that the quality of the papers has drastically improved. Early articles proved – using simple and then more complex analyses – that we could do surgery safely, and discussed how to deal with the older patients, some­times via editorial comments. The message was that chrono­logic age was not equal to physiologic age – especially if we controlled comorbid illnesses and emergency surgery. In fact, these concepts were the main message of our first edition.
Now papers are more scientific, and highly complex statistical analyses of large databases have allowed researchers to focus on outcomes and quality measures. We are only now on the cusp of defining that consequence of chronologic age and the aging process on surgical outcomes, and there is a real effect. The impact of frailty and disability, two non­reversible aging processes, on surgical outcomes is significant. Because of them and not comorbidity, the ultimate outcomes of major interventions may not be as good as we hope. While not reversible, these two processes are to some extent preventable; lifestyle changes can delay their onset.
M.E. Zenilman (*) School of Public Health, SUNY Downstate, Brooklyn, NY and Department of Surgery, Johns Hopkins School of Medicine, Baltimore, MD e-mail: mzenilman@downstate.edu
Second, the sheer increase in number of patients in the older group has affected the population of patients we care for; the baby boomers have come of age. The predictions of the past – that the percentage of patients older than 65 and 85 in our population will grow – are coming true. While some papers wrongly predicted that Medicare would be financially insolvent by now, it is getting there. The shape of the age distribution in the USA has changed from a classic pyramid – where the small number of older population rest on top with increasing numbers of persons at the bottom – to a more rectangular (or trapezoidal) shape, where similar proportions of younger and older persons exist at multiple age levels. As our population pyramid changes, the demands on health care are changing too.
The societal burden for the expansion of the elderly patient population is intuitive, impressive, and expensive. An Institute of Medicine report in 2008 from the National Academy of Sciences entitled “Retooling for an Aging America: Building the Health Care Workforce” showed that the bulk of acute and chronic disease – diabetes, cardiac, hypertension, and cancer – rests in patients over 75 age. The older patient population uses more services. For example, 12% of our population uses up to one-third of total hospitalizations, and a similar percentage uses emergency medical responses and prescriptions for medication. The expanding use of nursing homes, short term rehabilitation facilities, and home care also has a cost.
The report suggested three goals to enhance the care of elderly patients: use education to improve the competence of health care providers, increase the number of geriatric specialists, and establish new models of care.
Achieving these goals will not be cheap. The IOM report noted that not only are chronic disease management, multi­disciplinary care, and transitional care important for the elderly population, but also that to date, they have been underfunded. Bluntly, reimbursements for geriatricians, home care nurses, and even surgical care in this population is not very high, and the combination of low funding in all three areas is also problematic.
While surgical training programs have been asked to focus on education in geriatrics, to date it is mostly theoretical, and
years of
R.A. Rosenthal et al. (eds.), Principles and Practice of Geriatric Surgery, DOI 10.1007/978-1-4419-6999-6_10, © Springer Science+Business Media, LLC 2011
137
138 M.E. Zenilman
https://t.me/med1917
very few hospitals or institutions have active geriatric services which work closely with surgeons. The foundation of surgical training is to care for patients, not to just perform procedures. But there is very little in the surgical training for the topics described below.
The American Geriatrics Society has been an advocate in retooling the education practice of surgeons. Through their Jahnigan Scholars program, over 20 surgical specialists, in all disciplines, have been selected to do research, publish scholarly work, and teach geriatrics. Some basic curricula have been developed, and there is even one geriatric surgery fellowship available in the USA.
The real future of geriatric surgery is embedded in the chapters of this section; the foundation of education is evolving to a level of complexity higher than that described in the first edition of this textbook, and the need for multidisciplinary
management is clear. To provide the elderly patient with quality care, we must be well versed in recognizing and addressing frailty and disability, not just controlling the estab­lished comorbidities of cardiac, pulmonary, kidney, and endocrine systems. Palliative care, do-not-resuscitate orders, and use of rehabilitation facilities and hospice need to be integrated early in a patient’s care. As you will read, the American College of Surgeons, through the National Surgical Quality Improvement Project and the Task Force on Geriatric Surgery, is establishing quality indicators for the elderly patient, which will likely lead the change. In the future, these indicators will be just as important as the “core measures” we now follow.
Last, what about the elderly surgeon? While society has not yet mandated removal of driving licenses from older drivers, the elderly surgeon still has the same mandate as the younger “above all, do no harm.”
Chapter 11
https://t.me/med1917
The Demography of Aging and Disability
Samir K. Sinha and Colleen Christmas
Over the previous century, there has been an extraordinary demographic shift which will no doubt persist well into this one. The lengthening of life span by over 50% and consequent increase in the proportion of the population that we refer to as the “elderly” has created a new and different social, economic, and medical imperative. We are now faced with the daunting task of providing health and social care for a huge number of persons living well into old age with more chronic illnesses, and increased needs and expectations. Anticipating the kinds of health care services, this population requires coordinated and creative efforts by many sectors of society and consider­able educational and research activities to determine the best methods to deliver services. Indeed, this textbook has been written to respond to some of these challenges by addressing the specialized needs of older persons facing surgery.
The Demography of Aging
In the USA, as in other developed countries, the absolute numbers and relative proportions of older populations have continually increased to the point where there is now a higher percentage of older people than at any time in history. Indeed, while the overall US population had almost quadrupled in size over the course of the twentieth century, the portion of the population 65 years and older had increased 11-fold. The older population has grown from 3.1 million (4.1% of the overall population) in 1900 to 35 million (12.4%) in 2000 [1]. Among this latter figure, 18.4 million (53%) were aged 65–74,
12.4 million (35%) aged 75–84, and 4.2 million (12%) age 85 and older [2]. While it is predicted that these figures will increase slowly over the next few years, what follows is a period of marked accelerated growth in the second and third decades of this century. This pattern of shifting demographics
largely reflects the impact of birth rates; the slower change in the near future reflecting low fertility rates during World War II and the preceding worldwide economic depression, while the subsequent growth surge stems from the “baby boom” that characterized the postwar years (1946–1964) in many nations. The first members of this “baby boom generation” will reach age 65 in 2011. As a result, by 2030 the older popu­lation is projected to be twice as large as in 2000, growing from 35 million to 72 million, which will then represent nearly 20% of the total US population. Predictions are that this trend persists at least until the mid-century. In 2050, the older population is projected to number 86.7 million [
The most rapid and profound change in numbers has been seen among the oldest old individuals, defined here as those aged 85 years and older. In 1900, there were only 122,000 of these individuals, but by 2000, their number had increased 34-fold to 4.2 million. This trend is expected to continue with this population doubling to 9.6 million by 2030 and then more than doubling again to 20.9 million by 2050 [1].
The USA, despite the growth projections for its older population, remains a relatively young population when compared with other developed countries. While its propor­tion of older adults stood at 12.4% in 2000, at least a dozen developed countries were reporting proportions ranging between 15 and 18% (Table 11.1). Part of what explains this difference is that the USA has experienced higher levels of fertility and immigration in recent decades than those of other developed countries [ expectancy at birth in the USA reached a high of 76.9 years, the highest rates were being reported for Swedish males and Japanese females at 77.6 and 84.1 years, respectively [1].
1]. In 2000, while average life
1].
Causes and Consequences of Population Aging
C. Christmas (*) Program Director, Johns Hopkins Bayview Medical Center, 4940 Eastern Avenue, B1-114E, Baltimore, MD 21224, USA e-mail: cchristm@jhmi.edu
R.A. Rosenthal et al. (eds.), Principles and Practice of Geriatric Surgery, DOI 10.1007/978-1-4419-6999-6_11, © Springer Science+Business Media, LLC 2011
The term population aging refers to the process through which the proportions of older individuals within an overall population age structure increase. Changes in the age struc­tures of populations principally result from changes over
139
Ta b l e 11.1 Countries with significant elderly (65 years and over) populations as a percentage at 2000, 2030, and 2050
2000 2030 2050 2000 2030 2050
Africa Europe
Ghana 3.4 6.6 11.8 Albania 7.1 17.3 22.1 Mauritius 6.1 16 21.6 Austria 15.5 26 30.1 Reunion 5.6 11.4 17.1 Belgium 16.8 25 27.7 South Africa 4.7 11.6 13.6 Bosnia and Herzegovina 8.6 20.6 26 Algeria 4.3 10.3 21.3 Bulgaria 16.6 24.6 33.8 Egypt 4 8.8 14.8 Croatia 15.1 24.4 29.6 Libya 3.9 7.6 15.7 Czech Republic 13.8 24.3 33.1 Morocco 4.6 9.1 16.2 Denmark 14.8 22.7 24.6 Tunisia 6.1 12.9 23.8 Finland 14.9 26 27.3
Near East
France 16 23.7 26.8
Iraq 3.1 5 10.9 Germany 16.4 27.5 30 Israel 9.9 14.9 20.1 Greece 17.4 24.9 32.1 Jordan 3.2 7.7 16.4 Hungary 14.6 21.9 29.4 Lebanon 6.7 10.2 23.2 Ireland 11.3 18.4 25.1 Qatar 2.3 16.3 19.6 Italy 18 27.2 33.5 Syria 3.2 6.1 13 Macedonia 9.8 18.2 25.1 Turkey 6 12.9 22.4 Netherlands 13.6 23.5 26 United Arab Emirates 2.2 16.8 16.2 Norway 15.2 22.4 25
Asia
Poland 12.3 22.2 29.6
Bangladesh 3.3 6 11 Portugal 16 23.2 30.6 Burma 4.7 9.8 18.3 Romania 13.3 19.6 30 China 6.9 16.4 24.5 Slovakia 11.4 21.3 30 East Timor 2.6 6.9 10.7 Slovenia 14 26.3 34 Hong Kong SAR 11.5 29.3 39.3 Spain 17 25.3 34.5 India 4.6 9 14.6 Sweden 17.2 24.4 25.7 Indonesia 4.5 10.9 18 Switzerland 15.1 24.7 29 Iran 4.6 9.3 21.3 UK 15.6 22.5 25.7 Japan 17.1 28.8 34.3 Yugoslavia 14.1 20.8 27.2
Korea, North 6.3 14.6 21.4
Latin America and the Caribbean
Korea, South 7 20.6 29.2 Argentina 10.2 14.8 21.2 Malaysia 4.1 9.4 13.4 Bolivia 4.5 8 13.8 Mongolia 3.7 8.1 16.2 Brazil 5.3 13.1 21.9 Pakistan 4 6 10.8 Chile 7.2 16.4 22.1 Phillipines 3.7 7.7 12.9 Colombia 4.7 11.5 16.6 Singapore 7 24.4 37.1 Costa Rica 5.2 12.8 19.7 Sri Lanka 6.5 15.2 23.1 Cuba 9.5 20.3 28.1 Thailand 6.4 16.2 23.7 Dominican Republic 4.8 10.2 14 Taiwan 8.7 21 29.3 Ecuador 4.6 9.7 16.3 Vietnam 5.5 11 19.2 El Salvador 5 7.7 12.7
Central Asia
Honduras 3.5 6.2 10.3
Estonia 15 24.5 32.2 Jamaica 6.8 12.5 22.3
Latvia 14.7 23.1 31.2 Mexico 5 11.5 19
Lithuania 13.7 23.7 32 Nicaragua 2.8 6.6 13.8
Armenia 8.9 16.1 25.2 Panama 5.8 12.1 18.5
Azerbaijan 6.9 11.4 16.2 Paraguay 4.7 7.9 10.8
Belarus 13.7 19.5 26.6 Peru 4.7 10.4 17.2
Georgia 13.5 23.4 28.8 Puerto Rico 11.2 22.8 30.3
Kazakhstan 6.5 14 20.4 Trinidad and Tobago 7.3 24.2 33.9
Kyrgyzstan 5.8 8.5 12.4 Uruguay 12.9 17 23.2 Moldova 9.8 14.9 20 Venezuela 4.6 11.6 18.5
Russia 12.5 21.5 28.3
Oceania
Turkmenistan 4 6.6 10.4 Australia 12.4 21.1 24.6 Ukraine 13.9 19.7 26 Fiji 3.4 9.5 14.1 Uzbekistan 4.6 7.5 12.1 New Zealand 11.5 17.8 24.1
North America
Papua New Guinea 3.6 6.1 10.8
Canada 12.7 22.9 24.9 Solomon Islands 3 5.4 11.4
USA 12.4 19.6 20.6
Source: Data from [1], Current Population Reports, P23–209 (Table A–1)
https://t.me/med1917
14111 The Demography of Aging and Disability
Age and year
All races White Black
a
Both sexes Male Female Male Female Male Female
At Age 0
1900
b,c
47.3 46.3 48.3 46.6 48.7 32.5 33.5
1950
c
68.2 65.6 71.1 66.5 72.2 59.1 62.9
1960
c
69.7 66.6 73.1 67.4 74.1 61.1 66.3 1970 70.8 67.1 74.7 68.0 75.6 60.0 68.3 1980 73.7 70.0 77.4 70.7 78.1 63.8 72.5 1990 75.4 71.8 78.8 72.7 79.4 64.5 73.6 2000 76.9 74.1 79.5 74.8 80.0 68.2 74.9
At Age 65
1900–1902
b,c
11.9 11.5 12.2 11.5 12.2 10.4 11.4 1950
c
13.9 12.8 15.0 12.8 15.1 12.9 14.9 1960
c
14.3 12.8 15.8 12.9 15.9 12.7 15.1 1970 15.2 13.1 17.0 13.1 17.1 12.5 15.7 1980 16.4 14.1 18.3 14.2 18.4 13.0 16.8 1990 17.2 15.1 18.9 15.2 19.1 13.2 17.2 2000 17.9 16.3 19.2 16.3 19.2 14.5 17.4
At Age 75
1980 10.4 8.8 11.5 8.8 11.5 8.3 10.7 1990 10.9 9.4 12.0 9.4 12.0 8.6 11.2 2000 11.3 10.1 12.1 10.1 12.1 9.4 11.2
At Age 85
2000 6.3 5.6 6.7 5.5 6.6 5.7 6.5
a
Data shown for 1900–1960 are for the non-White population
b
Death registration area only. The death registration area increased from ten states and the District of Columbia in 1900 to the contiguous USA in 1933
c
Includes deaths of nonresidents of the USA
Source: Data from [1], Current Population Reports, P23–209 (Table 3-1); National Center for Health Statistics 2003 (Tables 11 and 28). For full
citations, see references at the end of the chapter
https://t.me/med1917
time in fertility, mortality, and migration patterns [3]. Measures of population aging that can also be used to com­pare populations and assess changes over time include the median age, aged-dependency ratios or, most commonly, the proportion of a given population that is aged 65 and older. It has been the combined effects of declines in both mortality and fertility rates during more recent times that have largely been responsible for the demographic transition that led to the aging of human populations.
The earliest and most important causes of the decline of human mortality during the past few centuries were the general improvements in living conditions resulting from social and economic developments. Innovations in industrial and agricultural production and distribution methods led to significant improvements in nutrition [4]. Industrialization also brought about enhanced standards of living by improving the quality and quantity of available housing, running water, and electricity, which enabled individuals to be protected from the hazards of nature. Thereafter, a complex interplay of advancements in public health efforts, particularly sanita­tion, and later in medical and preventative health care, coupled with new modes of familial, social, economic, and political organization helped to promote and sustain further gains in human longevity [5].
The decline in human mortality has been the main driver of increased life expectancy throughout the world. The rapid mortality decline particularly among infants, children, and women of childbearing age increased average life expec­tancy from 47.3
years in 1900 to 68.2 years in 1950 [6]. The need to replace children lost to early mortality waned as the risk of death at younger ages declined rapidly [7]; this even­tually led to declines in total fertility rates. Death rates from chronic diseases were stable in the USA from 1954 to 1968; thereafter, research programs around chronic diseases inten­sified and reductions in mortality from chronic diseases fol­lowed. In recent years, continued advances in the management and treatment of chronic diseases are now largely driving reductions in mortality at older ages.
Sex and Racial Differences
Interestingly, reduced mortality rates have not benefited men and women equally, with women having gained several more years of life expectancy than men (Table 11.2). For example, in the USA over the past century, life expectancy had increased by 31.2 years for women (from 48.3 to 79.5 years)
Ta b l e 11.2 Life expectancy at birth, at age 65, 75, and 85 by race and sex: selected years, 1900–2000
142 S.K. Sinha and C. Christmas
Causes of death
Rank in 1900 Rank in 2005 All ages All ages 65+ 65–75 75–85 85+
Heart disease 4 1 1 2 1 1 Cancer 8 2 2 1 2 2 Stroke 5 3 3 4 4 3 Chronic lung
diseases
9 4 4 3 3 5
Alzheimer’s
dementia
10 7 5 10 5 4
Diabetes 6 7 5 6 7 Influenza/
pneumonia
1 8 6 8 7 6
Nephritis 6 9 8 7 8 8 Accidents 7 5 9 6 9 9 Septicemia 2 10 10 9 10 10 Diarrhea and
enteritis
3
Source: Data for 2005 from National Vital Statistics Report, Vol. 56, No. 10, April 24, 2008
https://t.me/med1917
but by only 27.8 years for men (from 46.3 to 74.1 years). It appears that women may have a natural advantage over men that should imply a difference of about 2 years in terms of life expectancy at birth. Several hypotheses have been proposed to explain sex differences in longevity, including more active female immune functioning, the protective effect of estrogen, compensatory effects of the second X chromo­some, and the influence of oxidative stress on aging and disease. At present, none of these hypotheses are strongly supported, although weak support is available for the oxida­tive stress hypothesis [8]. Nevertheless, other factors are thought to contribute to the much larger gap now being commonly observed between the sexes. Differences in life expectancy are attributed to differences in behaviors, social roles, attitudes, and biological risks between men and women, with the near-elimination of maternal mortality in developed countries explaining only a small fraction of this trend [9–12]. While these differential gains have been typical of developed countries, the gap has started to decline in recent years. Between 1900 and 1970, overall life expectancy in the USA increased by 26.4 years for women and 20.8 years for men, thereby increasing the gender gap in life expectancy from 2.0 to 7.6 years. This increase has been largely attrib­uted to higher male mortality due to ischemic heart disease and lung cancer, both of which are related to the widespread and early practice of cigarette smoking among men [13, 14]. However, between 1970 and 2000, overall life expectancy rose by 4.8 years for women and 7.0 years for men, thereby narrowing the gender gap from 7.6 to 5.4 years. This subse­quent decrease has been related to the proportionately larger increases in lung cancer mortality among women than men and a proportionately greater decline in heart disease mortality among men than women [13, 14].
In addition to the expected growth of the older popula­tion, demographic studies predict that the racial and ethnic diversity of this population in the USA also increases over the coming decades. Comparisons between racial groups in 2003 to what is predicted for 2050 suggest that while non­Hispanic whites decrease from representing 83–61% of the older population, the proportion of Blacks grows from 8 to 12%, Hispanics from 6 to 18%, and Asians from 3 to 8% [15]. While this growing diversity largely reflects the aging of a more diverse younger population, there is evidence that it also represents, to a small degree, the enhanced immigra­tion of older individuals [16]. These demographic changes continue to have important implications, especially since mortality rates among the elderly have also been shown to be unevenly distributed across racial and ethnic groups. These differences appear to reflect different disease profiles for underlying populations, unequal access to health care, and likely other socio-demographic factors, such as income and education that have yet to be completely understood.
What partly explains our lack of understanding is that “minority” older adults have largely been excluded from studies or categorized together as “non-White,” ignoring the significant heterogeneity that also characterize these groups, their differences in physiological aging, access to health care, educational levels, health habits, disease prevalence and progression, response to treatments, and social contribu­tors to health. Indeed, the increasing heterogeneity of the older population in the coming decades will certainly have important implications for the delivery of health and social care services and associated research studies.
Shifting Mortality Patterns
With individuals now being better able to survive acute illnesses, increasing longevity has contributed to the rising incidence of chronic illness and greater likelihood that indi­viduals die as a result of complications associated with chronic conditions. While the proportion of elderly fatalities caused by heart disease, strokes, and cancer fell over the last 25 years, this decrease was partially offset by a concurrent increase in the number of deaths attributable to other chronic diseases, such as diabetes, chronic lung disease, renal dis­ease, and dementia. Today, the pattern of death at older ages generally reflects that of the population as a whole. However, while the leading causes of death are essentially the same, differences in the rankings become apparent when mortality rates across age groups are considered (Table 11.3). While heart disease and cancer remain the leading two causes of death across all older age groups, over the past 25 years the
Ta b l e 11.3 Changes in most common causes of death in the USA at
all ages and those 65 years and older cohorts
14311 The Demography of Aging and Disability
2030
2000
20.0
16.3
5.9
12.0
14.0
21.6
5.6
11.9
4.4
8.4
12.4
3.7
10.1
2.9
Asia
Latin America/Caribbean
Near East/North Africa
Northern America
Sub-Saharan Africa
Europe
Oceania
https://t.me/med1917
largest decrease in heart disease mortality (−55.5%) was experienced by individuals between the ages of 65 and 74 years, followed by those between the ages of 75 and 84 years (−49.7%), and those 85 years and over (−37.0%). While cancer mortality has increased slightly for individuals 75 years and over (+3.8%), it decreased somewhat for the 65–74 age group (−7.7%). The more significant drop in heart disease as opposed to cancer mortality within the 65–74 age group has meant that cancer mortality is now the most com­mon cause of death among individuals in this subgroup. Further shifts in mortality rates has meant that chronic lung disease and diabetes-related mortality now have their great­est impact among the youngest older age groups, while stroke, dementia, influenza, and pneumonia-related mortal­ity have their greatest impact among the oldest age groups.
Fertility
Historically, the decline in human mortality has been fol­lowed, in most regions of the world, with a decline in fertility. This has caused some concern as extremely low levels of fer­tility, sustained over a period of time, are causing some popu­lations to decline. The implications of population decline in conjunction with population aging can be significant. Governments, for example, may encounter the challenge of financing social security programs and health care costs while facing possible labor shortages. Further, these labor
shortages may disproportionately impact low-wage work, such as those providing personal care to the elderly. These concerns have led some countries to develop progressive immigration policies in recent decades to help counter declin­ing fertility rates and fuel overall population growth.
Developing Countries
Fertility and mortality rates have fallen in most developing countries, but usually not to the same degree as with their developed counterparts. These falls are partly due to economic growth but are mostly due to the adoption of modern medical and public health practices. While the populations of virtually every nation are aging, the level and pace with which they are doing so varies within regions (Fig. 11.1). Surprisingly, the most rapid proportionate increases among older populations are and will continue to be in the devel­oping world. In 2000, 249 million people 65 and older living in developing countries represented 59% of the world’s older population; their proportion of the global elderly is projected to rise to nearly 80% or 1.2 billion elderly people living in developing nations by 2050. In contrast, 171 million people were aged 65 and older in developed countries in 2000, and they are projected to grow to 327 million by 2050. Although developing regions had lower overall proportions of older people than developed regions in 2000, these proportions are
Fi g u r e 11.1 Percentage of the
population aged 65 and over for regions of the world: 2000 and 2030 (from US Census Bureau 2004, International Programs Center, International Data Base, at http://www.census.gov/ipc/
www/idbnew.html.).