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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_2679_Библиотеки_им_академика_М_И_Перельмана
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Published by
https://t.me/medicina_free
World Scientic Publishing Co. Pte. Ltd.
5 Toh Tuck Link, Singapore 596224
USA oce: 27 Warren Street, Suite 401-402, Hackensack, NJ 07601
UK oce: 57 Shelton Street, Covent Garden, London WC2H 9HE
British Library Cataloguing-in-Publication Data
A catalogue record for this book is available from the British Library.
CHRONIC PAIN
New Molecular Insights into Pain and Treatment
Copyright © 2024 by World Scientic Publishing Co. Pte. Ltd.
All rights reserved. This book, or parts thereof, may not be reproduced in any form or by any means,
electronic or mechanical, including photocopying, recording or any information storage and retrieval
system now known or to be invented, without written permission from the publisher.
For photocopying of material in this volume, please pay a copying fee through the Copyright Clearance
Center, Inc., 222 Rosewood Drive, Danvers, MA 01923, USA. In this case permission to photocopy
is not required from the publisher.
ISBN
978-981-4324-52-6 (hardcover)
ISBN 978-981-4324-53-3 (ebook for institutions)
For any available supplementary material, please visit
https://www.worldscientic.com/worldscibooks/10.1142/7931#t=suppl
Typeset by Stallion Press
Email: enquiries@stallionpress.com
Printed in Singapore
Key Abbreviations
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1 5-HT 5-hydroxytryptamine
2 AA arachidonic acid
3 AC adenylyl cyclase
4 ACC anterior cingulate cortex
5 ACSF artificial cerebro-spinal fluid
6 AKAP A-kinase anchoring protein
7 AM251 N-(piperidin-1-yl)-5-(4-iodophenyl)-
1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole3-carboxamide
8 AMPA
9 AMPAR
10 AP-5 D-2-amino-5-phosphonopentanoic acid
11 ATP adenosine triphosphate
12 BAPTA
13 BDNF brain-derived neurotrophic factor
14 CaMKII calcium/calmodulin-dependent protein kinase
15 CaMKIV calcium/calmodulin-dependent protein kinase
α-amino-3-hydroxy-5-methyl-4-isoxazole-
propionic acid
α-amino-3-hydroxy-5-methyl-4-
isoxazolepropionic acid receptor
1,2-bis(o-aminophenoxy)ethane-N,N,N′,N′-
tetraacetic acid
type II
type IV
v
vi Chronic Pain: New Molecular Insights into Pain and Treatment
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16 cAMP cyclic adenosine monophosphate
17 CB1R cannabinoid 1 receptor
18 CFA complete Freund’s adjuvant
19 ChR2 channelRhodopsin2
20 CNQX 6-cyano-7-nitroquinoxaline-2,3-dione
21 CNS central nervous system
22 CO carbonic oxide
23 CP-AMPARs Ca2+-permeable AMPARs
24 CPCCOEt 7-(hydroxyimino)cyclopropa[b]chromen-1a-
carboxylate ethyl ester
25 CPN common peroneal nerve
26 CPP 3-(R-2-carboxypiperazin-4-yl)-propyl-1-
phosphonic acid
27 CREB cAMP response element-binding protein
28 DHPG (RS)-3,5-dihydroxyphenyl-glycine
29 DRG dorsal root ganglion
30 DREAM downstream regulatory element antagonist
modulator
31 E-LTP early-phase long-term potentiation
32 EM electron microscopic
33 EPSC excitatory postsynaptic current
34 EPSP excitatory postsynaptic potential
35 Erk extracellular signal-regulated kinases,
36 fEPSP field excitatory postsynaptic potential
37 FMRP fragile X mental retardation protein
38 GABA gamma-aminobutyric acid
39 GluR1 GluA1
40 GluR2/3 GluA2/3
41 GRIP Glutamate receptor-interacting protein
42 GRP Gastrin-releasing peptide
43 HCN hyperpolarization activated cyclic
nucleotide-gated
Key Abbreviations vii
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44 HP hot plate
45 IBS irritable bowel syndrome
46 IC insular cortex
47 KA kainate acid
48 LFS low-frequency stimulation
49 L-LTP late-phase long-term potentiation
50 LTD long-term depression
51 LTP long-term potentiation
52 L-VGCCs L-type voltage-gated calcium channels
53 MAPK mitogen-activated protein kinase
54 mEPSC miniature excitatory post-synaptic current
55 mGluRs metabotropic glutamate receptors
56 MPEP 2-methyl-6-(phenylethynyl)-pyridine
57 NAPSM 1-naphthyl acetyl spermine N-[3-[[4-[(3-
Aminopropyl)amino]butyl]amino]propyl]-1naphthaleneacetamide trihydrochloride
58 NKA neurokinin A
59 NMDA N-methyl-D-aspartate
60 NMDAR N-methyl-D-aspartate receptors
61 NR2A GluN2A
62 NR2B GluN2B
63 NO Nitric Oxide
64 NSF N-ethylmaleimide-sensitive factor
65 NVP-
AAM077
[(R)-[(S)-1-(4-bromo-phenyl)-ethylamino](2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)methyl]-phosphonic acid
66 PAG periaqueductal gray
67 PBN parabrachial nucleus
68 PBS phosphate buffer solution
69 PDZ postsynaptic density-95/Discs large/zona
occludens-1
70 PFC prefrontal cortex
viii Chronic Pain: New Molecular Insights into Pain and Treatment
https://t.me/medicina_free
71 PhTx philanthotoxin-74
72 PICK1 protein interacting with C kinase 1
73 PKA Protein kinase A
74 PKC protein kinase C
75
PKCε
76
PKMζ protein kinase Mζ
protein kinase C isoform epsilon
77 PP1 protein phosphatase 1
78 PPF paired-pulse facilitation
79 PPR paired-pulse ratio
80 pre-LTP pre-synaptic LTP
81 post-LTP post-synaptic LTP
82 PGE2 prostaglandin E2
83 RVM rostral ventromedial medulla
84 S1 primary somatosensory cortex
85 S2 secondary somatosensory cortex
86 sEPSC spontaneous excitatory post-synaptic current
87 SP substance AP
88 STD short-term depression
89 TBS theta burst stimulation
90 TF test tail-flick test
91 TRP transient receptor potential
92 ZIP
ζ-pseudosubstrate inhibitory peptide; zeta
inhibitory peptide
Contents
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Key Abbreviations v
Introduction xi
Chapter 1 Basic Neurosciences and Pain 1
Chapter 2 Peripheral Nociceptors and Sensitization 33
Chapter 3 Spinal Dorsal Horn Synaptic Transmission and
Gate Theory 53
Chapter 4 Silent Synapse 87
Chapter 5 Cortical LTP 111
Chapter 6 Cortical Depression 141
Chapter 7 Cortical Sensitization and Reorganization 161
Chapter 8 NMDA NR2B 181
Chapter 9 Pain and Fear 209
Chapter 10 Pain and Anxiety 237
Chapter 11 Descending Pain Facilitation 265
Chapter 12 Current Drug and Novel Drug Target for Treating
Chronic Pain 285
Index 325
ix
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