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37 Grafting andMicrografting inWound Care
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grafts to optimise outpatient wound management. Int Wound J. 2016;14:241–9.
13. Billings E, May JW. Historical review and present status of free fat graft autotransplantation in plas­tic and reconstructive surgery. Plast Reconstr Surg. 1989;83:368–81.
14. Coleman SR. Long-term survival of fat transplants: controlled demonstrations. Aesthet Plast Surg. 1995;19:421–5.
15. Gentile P, Sterodimas A, Calabrese C, Garcovich S.Systematic review: advances of fat tissue engineer­ing as bioactive scaffold, bioactive material, and source for adipose-derived mesenchymal stem cells in wound and scar treatment. Stem Cell Res Ther. 2021;12:318.
https://doi.org/10.1186/s13287- 021- 02397- 4.
16. Mazini L, Rochette L, Admou B, Amal S, Malka G. Hopes and limits of adipose-derived stem cells (adscs) and mesenchymal stem cells (mscs) in wound healing. Int J Mol Sci. 2020;21:1306.
17. Stasch T, Hoehne J, Huynh T, De Baerdemaeker R, Grandel S, Herold C. Débridement and autologous lipotransfer for chronic ulceration of the diabetic foot and lower limb improves wound healing. Plast Reconstr Surg. 2015;136:1357–66.
18. Luu CA, Larson E, Rankin TM, Pappalardo JL, Slepian MJ, Armstrong DG.Plantar fat grafting and tendon balancing for the diabetic foot ulcer in remis­sion. Plastic and Reconstr Surg. 2016;4:e810. https://
doi.org/10.1097/gox.0000000000000813.
19. Cervelli V, Gentile P, Grimaldi M.Regenerative sur­gery: use of fat grafting combined with platelet-rich plasma for chronic lower-extremity ulcers. Aesthet Plast Surg. 2009;33:340–5.
20. Maroesjka Spiekman | MD/phd-student | MD, Phd ­researchgate. https://www.researchgate.net/prole/
Maroesjka- Spiekman.
21. Klinger M, Marazzi M, Vigo D, Torre M.Fat injection for cases of severe burn outcomes: a new perspective of scar remodeling and reduction. Aesthet Plast Surg. 2008;32:465–9.
22. Nicoletti G, Brenta F, Jaber O, Laberinti E, Faga A.Lipolling for functional reconstruction of the sole of the foot. Foot. 2014;24:21–7.
23. Cuomo R, Giardino FR, Nisi G, Han J, Diluiso G, Tresoldi MM, Pieretti G, Brandi C, Grimaldi L.Fat graft for reducing pain in chronic wounds. Wound Repair Regen. 2020;28:780–8.
24. Chih-Chun Y, Tsi-Siang S, Te-An C, Wei-Shia H, Shou-Yen K, Yen-Fei C.The intermingled transplan­tation of auto- and homografts in severe burns. Burns. 1980;6:141–5.
25. Ming-liang Z, Zhi-de C, Xun H, Ming Z.Microskin grafting. I. Animal experiments. Burns. 1986;12:540–3.
26. Ming-liang Z, Chang-yeh W, Zhi-de C, Da-xin C, Xun H.Microskin grafting. II.Clinical report. Burns. 1986;12:544–8.
27. Zhang M-L, Chang Z-D, Wang C-Y, Fang C-H.Microskin grafting in the treatment of extensive burns. J Trauma. 1988;28:804–7.
28. Yeh FL, Yu GS, Fang CH, Carey M, Alexander JW, Robb EC. Comparison of scar contracture with the use of microskin and Chinese-type intermingled skin grafts on rats. J Burn Care Rehabil. 1990;11:221–3.
29. Blair S. Microscopic split-skin grafts: a new tech­nique for 30-fold expansion. Lancet. 1987;330:483–4.
30. Najarian JS, Mccorkle HJ.Experimental grafting of a suspension of skin particles. Surg Forum. 1957;30:43.
https://pubmed.ncbi.nlm.nih.gov/13433327/.
31. Najarian JS, Crane JT. An experimental study of the grafting of a suspension of skin particles. Plast Reconstr Surg. 1957;20:342.
32. Xie W, Wang L, Tan H, Wang D, Liu J, Hu B, Huang W, Ren S, Sun K.Microskin grafting by spraying in burn management. Chin J Burns. 2002;18(1):26–8.
https://pubmed.ncbi.nlm.nih.gov/12515663/.
33. Quintero EC, Machado JF, Robles RA.Meek micro­grafting history, indications, technique, physiol­ogy and experience: a review article. J Wound Care. 2018;27:S12. https://doi.org/10.12968/jowc.2018.27.
sup2.s12.
34. Ottomann C, Hartmann B, Branski L, Krohn C.A trib­ute to Cicero Parker meek. Burns. 2015;41:1660–3.
35. Peeters R, Hubens A. The mesh skin graft—true expansion rate. Burns. 1988;14:239–40.
36. Kok YO, Chong SJ, Liang WH, Tan BK, Tan KC. Revolutionizing major burns management with micrografting—improved healthcare costs, time and burns resources. Plast Reconstr Surg. 2015;136:64.
37. Hackl F, Bergmann J, Granter SR, Koyama T, Kiwanuka E, Zuhaili B, Pomahac B, Caterson EJ, Junker JP, Eriksson E. Epidermal regeneration by micrograft transplantation with immediate 100-fold expansion. Plast Reconstr Surg. 2012;129:443e.
https://doi.org/10.1097/prs.0b013e318241289c.
38. Kreis RW, Mackie DP, Vloemans AWFP, Hermans RP, Hoekstra MJ. Widely expanded postage stamp skin grafts using a modied meek technique in combina­tion with an allograft overlay. Burns. 1993;19:142–5.
39. Rode H, Martinez R, Potgieter D, Adams S, Rogers AD. Experience and outcomes of micrografting for major paediatric burns. Burns. 2017;43:1103–10.
40. Hu G, Zhang P, Chen Y, Yuan Z, Song H.Efcacy of two-stage meek micrografting in patients with severe burns. J Burn Care Res. 2021;43:1081. https://doi.
org/10.1093/jbcr/irab241.
41. Zhang P, Wang W, Hu G, Yuan L, Ma S, Luo J, Song H, Huang Y, Xiang F. A retrospective study of fac­tors inuencing the survival of modied meek micro­grafting in severe burn patients. J Burn Care Res. 2020;42:331–7.
42. Mustoe TA, O’ Shaughnessy K, Kloeters O.Chronic wound pathogenesis and current treatment strat­egies: a unifying hypothesis. Plast Reconstr Surg. 2006;117:35S. https://doi.org/10.1097/01.
prs.0000225431.63010.1b.
43. Ennis WJ, Meneses P. Wound healing at the local level: the stunned wound. Ostomy Wound Manage. 2000;46:39S. https://pubmed.ncbi.nlm.nih.
gov/10732639/.
428
https://t.me/medicina_free
A. Bolletta et al.
44. Astarita C, Arora CL, Trovato L.Tissue regeneration: An overview from stem cells to micrografts. J Int Med Res. 2020;48:030006052091479.
45. Zanzottera F, Lavezzari E, Trovato L, Icardi A, Graziano A.Adipose derived stem cells and growth factors applied on hair transplantation. Follow-up of clinical outcome. J Cosmet Dermatol Sci Appl. 2014;04:268–74.
46. Purpura V, Bondioli E, Graziano A, etal. Tissue char­acterization after a new disaggregation method for skin micro-grafts generation. J Vis Exp. 2016;109:e53579.
https://doi.org/10.3791/53579.
47. Monti M, Graziano A, Rizzo S, Perotti C, Del Fante C, d'Aquino R, Redi CA, Baena RRY. In vitro and in vivo differentiation of progenitor stem cells obtained after mechanical digestion of human dental pulp. J Cell Physiol. 2016;232:548–55.
48. Senesi L, De Francesco F, Farinelli L, Manzotti S, Gagliardi G, Papalia GF, Riccio M, Gigante
A. Mechanical and enzymatic procedures to isolate the stromal vascular fraction from adipose tissue: preliminary results. Front Cell Dev Biol. 2019;7:88.
https://doi.org/10.3389/fcell.2019.00088.
49. De Francesco F, Graziano A, Trovato L, Ceccarelli G, Romano M, Marcarelli M, Cusella De Angelis GM, Cillo U, Riccio M, Ferraro GA.A regenerative approach with dermal micrografts in the treatment of chronic ulcers. Stem Cell Rev Rep. 2016;13:139–48.
50. Marcarelli M, Trovato L, Novarese E, Riccio M, Graziano A. RIGENERA protocol in the treat­ment of surgical wound dehiscence. Int Wound J. 2016;14:277–81.
51. Svolacchia F, De Francesco F, Trovato L, Graziano A, Ferraro GA.An innovative regenerative treatment of scars with dermal micrografts. J Cosmet Dermatol. 2016;15:245–53.
Surgical Debridement inWound
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StefanoBottosso, SilviaPasquali, RiccardoRicci, andZoranM.Arnež
38
38.1 Introduction
Wound bed preparation has been dened as “a changing paradigm that links treatment to the cause and focuses on three components of local wound care: debridement, wound-friendly moist interactive dressings and bacterial balance” [1].
The acronym TIME, created from this con-
cept, was rst published in 2003 [2]:
• T: Tissue nonviable or decient.
• I: Infection/inammation.
• M: Moisture balance.
• E: Epidermis, nonmigrating (later modied).
The last component was then changed to E for the edge of the wound, nonadvancing, or under­mined because this is not necessarily related to a problem of the migration of epidermal cells [3].
This concept then evolved to the acronym DIME [4], where D stands for the Debridement of the nonviable tissue within the wound. The purpose was to underline the surgical action that should be practised in order to support the re­epithelialization of a chronic wound.
Of course, the DIME approach is just a global concept that stresses the key points for chronic wound management but, to reach a wound reso-
S. Bottosso · S. Pasquali · R. Ricci · Z. M. Arnež (*) Plastic Surgery Clinic, University of Trieste, Trieste, Italy e-mail: zoran.arnez@siol.net
lution, this concept can be extrapolated in a more detailed pathway.
In this chapter, we will focus on the D, the debridement, in particular the surgical one in order to differentiate this from the other types of debridement: autolytic, enzymatic, and mechanic.
38.2 Denition
We can dene debridement as the process of removing devitalized and/or contaminated tis­sue from a traumatic or infected lesion until the achievement of surrounding healthy tissue and also the removal of the foreign material that has become embedded in the wound. In particular, when talking about chronic wounds, debride­ment is the process of removing necrotic tissue [5]. Debridement can be considered the rst necessary step for the healing process because it is able to provide a good substrate for the subse­quent healing of the tissues [6]. In fact, the pres­ence of slough inhibits the migration of epithelial cells and also hard eschar prevents epidermal cell migration and epithelialization. In addition, devitalized or dead tissue can also predispose the clinical infection of the wound because it provides an ideal environment for many microorganisms. Due to these reasons, the removal of the devitalized tissue can be consid­ered the most effective method to stimulate the healing process [7].
© The Author(s), under exclusive license to Springer Nature Switzerland AG 2023 M. Maruccia et al. (eds.), Pearls and Pitfalls in Skin Ulcer Management,
https://doi.org/10.1007/978-3-031-45453-0_38
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38.3 Surgical or Sharp Debridement
We have to distinguish surgical debridement from sharp debridement.
38.3.1 Surgical Debridement
Surgical debridement changes a chronic wound into an acute one and it is achieved, thanks to sur­gical techniques by the excision, sometimes also in an aggressive way, of all the dead or devital­ized tissues. Surgical debridement can also involve the amputation of a necrotic digit as well as the opening of sinus tracts and wound pockets in order to drain pus or exudate [8, 9]. This pro­cedure can be painful and extensive and requires a skilled surgeon. It is better performed in an operating theater under anesthesia. A local anes­thesia directly inltrated into the wound bed can be enough for some patients in case of smaller wounds. In others, it is better to use a regional anesthesia with a nerve block, spinal, or epidural anesthesia, or in the most extreme cases general anesthesia. We also have to consider that some patients may be insensitive if they have diabetic neuropathy, whereas other neuropathic patients may have hyperesthesia and may be hypersensi­tive [10]. An example of surgical debridement is portrayed in Fig.38.1.
38.3.2 Sharp Debridement
On the other hand, sharp debridement requires a particular equipment, this procedure can damage the blood vessels below and it also requires a skilled practitioner. Bleeding complications are more frequent in this practice, especially in those patients who take anticoagulant agents or with bleeding disorders or clotting abnormality. In such a case a ligature or a suture is required of the bleeding point but more often a local pressure may be sufcient, especially if combined with hemostatic dressing. Sharp debridement (or con-
S. Bottosso et al.
Fig. 38.1 Example of surgical debridement in chronic ulcer of the foot
servative debridement) is a selective procedure that will not result in total debridement because it consists of the removal of loose avascular tissue by excising small quantities of dead or devital­ized tissue by using scissors or scalpel in a clini­cal setting. So, for the purpose of obtaining an adequate result, many sessions of debridement are required. We also have to underline that it may not be easy to identify correctly the devital­ized tissue, especially if there is a muscle at the base of the wound. In this case, it may be useful to remember the four “C”s:
• color,
• contraction,
• consistency,
• capacity to bleed.
In these cases, it is better to limit or delay
debridement and consider other procedures [11].
An example of sharp debridement of a leg
ulcer can be seen in Fig.38.2.
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Fig. 38.2 Example of sharp debridement in leg ulcer
38.4 Instruments
To perform an adequate debridement some instruments are mandatory: a high-quality scalpel with a blade size of 10 or 15 (both reusable or disposable), sharp scissors, and forceps that can hold and grasp necrotic tissue. In addition, a probe can be useful to check the depth and the track of the wound [9]. Curettes can be useful to scrape small cavities, bone, or granulation tissue.
Other, more sophisticated, instruments that can be used for surgical debridement are Hydrocision, Versajet ® (Smith-Nephew, Hull, UK), and the Ultrasound system [12, 13].
Hydrocision is particularly useful for soft tis­sue debridement: it permits contemporary cutting and removing of tissue with water, thanks to the high-pressure opening used by the device.
Versajet (Fig.38.3) seems to cause less dam­age to vital tissues compared to conventional sur­gical debridement and seems to be equally or more effective. In addition, it reduces surgical
431
Fig. 38.3 Example of debridement with Versajet
time and hospitalization. Studies conducted on wound biolms in a polymicrobial porcine model show how this tool is able to reduce inammatory neutrophil markers and bacterial colonies about 1000 times [14, 15].
Finally, low-frequency and low-dose ultra-
sounds are able to break down dead tissue.
These methods are all useful, painless, and capable of reducing the bacterial load, but they require several treatments [16, 17].
38.5 Aim oftheDebridement
Debridement accelerates the healing process. Necrotic tissue impedes the recovery of the wounds because of high bacterial counts. High bacterial load wounds are an obstacle to healing [18]. After the removal of the dead tissue, the wound can granulate and then epithelialize. The body is able to eliminate the necrotic tissue by itself, but it takes much longer [10].
Open skin wounds are all colonized by bacte­ria and if the bacterial load is >105 bacteria/g of tissue, healing is hindered. With quantitative cul­tures, it is possible to estimate the bacterial load of a wound [19]. With wide debridement we can eliminate the tissue most colonized by bacteria,
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and this reduces the necessity to perform quanti­tative cultures.
An important obstacle to wound healing is tis­sue infection. Usually, infected tissues show some inammation signs such as induration, warmth, pain with motion, erythema, and tender­ness. However, these signs can be reduced or absent in immunocompromised patients and those who take corticosteroids.
Another advantage of debridement is that it offers the possibility to take a piece of deep tissue that can be used for cultures and to determine its sensitivity to antibiotics. This is the best way to nd the bacteria responsible for the infection: from the deepest area of the debridement or from the pus. In fact, the dry surface swab is not very reliable, usually, it results in skin contaminants; indeed, the correlation between the cultured bac­teria of a surface swab and the bacteria responsi­ble for cellulitis is really low [10].
With debridement, it is also possible to reduce the odor of an infected wound, evacuate the pus, and drain unroofed pockets.
Another important advantage of debridement is that it helps to identify osteomyelitis that may be suspected during the physical examination with a positive probe to the bone [20]. Indeed, osteomyelitis is present in 85% of cases when a sterile cotton-tipped applicator is able to touch the bone; in the other 15% of cases, a layer of normal tissue usually overlies the bone and it is better not to remove it. In the operating room, during a general examination, the infected bone can be easily recognized: it usually does not bleed when biopsied and it is softer than the nor­mal bone. When debriding bone, it is important to reach the solid and bleeding bone.
A signicant proof of the importance and the benet derived from surgical debridement comes from the study of Steed etal. [21] about a ran­domized blinded trial of PDGF (Regranex; Ortho-McNeil Pharmaceutical, Inc., Raritan, NJ) in the treatment of diabetic neurotrophic foot ulcers. In this study ve centers enrolled more than ten patients and ve centers enrolled less than or equal to ten patients each. The patients of these last ve centers were put together to facili-
tate the analysis of the data. Patients of both groups received the same good wound care and the same saline-moistened gauze with or without PDGF.Before entering into the trial, every patient received a wide debridement and all the granula­tion and necrotic tissues and the calluses were removed. Likewise, during the ulterior follow-up visits, these tissues were removed.
From this study it was noticeable that in both, the PDGF-treated group and in the control group, there was a direct relation between the incidence of debridement and healing rate: the more the wounds were debrided, the better they healed. It is important to stress that in every center, the group with PDGF showed a healing rate that was about twice higher compared to the control group. This means that clearly, PDGF helps in the process of wound healing independent of the level of care. Anyway, when PDGF was used in the context of wound care, the best healing rates were achieved.
To start from a similar starting point at the beginning of the trial, before entering the study, patients with chronic wounds were treated with complete excision. This could have affected the excellent healing rates but, on the other hand, without this step, comparisons between patients may not have been possible. Another limitation of the study was the difference in the age of the wound which could have led to a different heal­ing rate causing a bias in the system.
38.6 Wounds toDebride
All patients with necrotic tissue present in their wounds or/and with pus draining from the wound are eligible for debridement. Also, pale granula­tion tissue should be debrided. Some evidence shows how senescent broblasts of chronic wounds are less capable of producing proteins and of replication. In fact, removing granulation tissue from a chronic wound permits the repopu­lation of young broblasts that are capable to control and improve the healing process better than the senescent ones; in addition, it also gives a normal aspect to the wound.
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Another tissue that should be removed is the callus at the margins of the wound: in this tis­sue, the blood supply is poor and it does not help the healing process, especially in areas like the plantar surface of the foot. In this area, where bony prominence is poorly padded with muscle, the perfusion of the skin comes from the rich collateral network of vessels within the skin itself. Whereas, in other tissues, skin perfu­sion usually comes from small vessels that arise from the muscle bed under the skin and that per­forate the myofascia to perfuse the skin directly. In the foot, the callus that surrounds the wound can compress these vessels when pressure is applied to the plantar surface. For this reason, removing the callus can improve the perfusion of the wound.
Debridement needs a specic method at a specic time. Ischemic wounds may require debridement, but ischemic tissue usually desic­cates after debridement. Once debridement is carried on for normal tissue, the tissue dries and dies. In patients who need a revascularization procedure, it is better to perform a new blood supply into the wound as the rst step and only later the debridement can be conducted, even days or weeks later. For instance, it may be nec­essary to perform a limited debridement with the drainage of the pus at rst, followed by a bypass surgery, and nally a more extensive debridement once the new blood supply has been established.
When a wound is covered by a dry and black eschar, usually this needs to be removed. Anyway, sometimes, thanks to this eschar, the wound below is kept humid and it also works as an antibacterial barrier, in addition, if the wound heals, the eschar will fall off. Here, we can see some cases when the eschar does not need to be excised [10]:
• if there is no drainage from the wound,
• if the patient is afebrile,
• if the tissue all around the wound is not
tender,
• if it is rmly adherent,
• if there is no inammation around the wound.
38.6.1 Contraindications
We can also identify some contraindications to wound debridement. This can be in the case of dry and intact eschars without clinical evidence of an infection below, this often happens in the unstageable pressure ulcer (grade 0) with undam­aged eschar of the heel, sacrum, or buttock [22].
Other examples of wounds where debride­ment should be avoided are pathergy and wounds with pyoderma gangrenosum. In these cases, debridement worsens the wound unless there is undrained pus.
38.6.2 Debridement inDiabetic Foot
[22]
Sharp debridement can be considered a key point of wound control in patients with neuropathic and neuro-ischemic ulcers. In fact, this can prob­ably be considered the best way to remove the associated biolm that contains many species of bacteria and that forms communities of polymi­crobial species. An example of surgical debride­ment in a diabetic foot is shown in Fig.38.4.
We are going to see these mechanisms in detail:
38.6.2.1 Neuropathic Ulcer
As we stressed above, debridement is the most important component of wound control. It is able to remove all the dead and senescent cells that cover the wound bed. Debridement is also very useful in ulcers because it supports and acceler­ates the process of wound healing, especially if it is practised regularly at every visit. The steps requieredfor this procedure are the following:
• The removal of all calluses that surround the
ulcer by a sterile scalpel.
• All the necrotic tissue and the slough should
be cut away. With a pair of forceps, it is pos-
sible to grip the material that needs to be
removed, then gentle traction should be
applied (if too much strength, the tissue can be
torn and some dead material may remain on
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Fig. 38.4 Example of surgical debridement in diabetic foot
the surface) in order to keep the material under tension and to facilitate the cutting. Without this passage and only with the use of a scalpel blade, it is practically impossible to remove the moist slough. Forceps can also be used to probe an ulcer, in this way we can better esti­mate the true dimensions and depth of the ulcer itself. In addition, with dry gauze directly applied on the moist slough, it is possible to remove the moisture and so to facilitate the grip of the material to be removed.
• Probe ulcer: if the probe reaches the bone there could be osteomyelitis.
• It is important to send for culture a deep swab and tissue samples taken from the ulcer, but not from the surface callus because it is not very signicant.
• Ulcer should be cleaned with normal sterile saline or with an antiseptic such as Prontosan.
• Sterile dressing should be applied and held in place with a light bandage, a tubular one can be useful but it should not be too tight.
• The patient should be reviewed every week, and every time these steps need to be repeated in order to maintain a correct debridement of the ulcer. Of course, if there are some prob­lems before the planned control, the patient should return immediately for a visit.
38.6.2.2 Neuroischemic Ulcer
For neuroischemic ulcer, the procedures to fol­low are
• First, evaluation needs to be done about the vascular status of the limb, which should be estimated with the ABPI score, only after that we can eventually proceed with debridement. In fact, if the foot is very ischemic, with an
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ABPI inferior to 0.5, only very cautious and gentle debridement should be performed.
• Sometimes, ischemic ulcers develop a halo of thin glassy callus, this one can dry out and then become hard and curl up. In such cases, it can be useful to smooth off these areas because they can eventually catch on dressing and cause trauma to the tissue below.
• Some precautions should be taken in patients with a very sensitive foot: it can be useful to anchor with forceps the tissue to debride while it is cut away. In this way, the painful dragging of the scalpel blade through the slack tissues can be avoided.
• If in front of a thickened toenail we suspect a subungual ulcer, the nail should be cut off very gently or, alternatively, only some layers of the nail can be cut with a scalpel so that it is possible to expose and drain the ulcer below.
38.6.2.3 Infected Neuropathic Ulcer
Considering the neuropathic foot, the most chan­gelling condition is the diabetic foot.
Diabetic foot infections are very complicated.
In fact, they often are more extensive than they seem at the beginning, from an initial examina­tion and from the appearance of the surface. The best thing to do in this case is to perform an initial debridement in a clinical setting in order to understand the real dimensions of the lesion and to obtain a good tissue sample that can be ana­lyzed for culture. Frequently, in the diabetic foot, over the ulcer we can nd some calluses; only by removing these calluses we can reveal the real extension of the ulcer below, and then we can drain the pus and remove the infected sloughy tissue. With intravenous antibiotics, this kind of infection should heal, but it is necessary to follow the patients every day to detect the evidence of spread. Another useful trick is to draw on the foot an outline of the cellulitis area so that any varia­tion (both extension or reduction) can be easily and quickly detected.
If the infection is severe, in addition to the
ulcer we can also nd extensive infected slough­ing subcutaneous tissues, including tendon and fascia. In this case, the tissue starts to break down and liquefy, but it does not result in frankly
necrotic tissue. For correct treatment of this kind of lesion, this tissue should be removed with an operation. Here are the indications for urgent sur­gical operation in patients with infected neuro­pathic ulcers:
• Large area of infected sloughy tissue.
• The presence of pus and some localized uctuance.
• X-ray that shows the presence of crepitus gas in the soft tissue. We also have to consider that the air in an ulcer can mean the presence of gas in the deep tissue of the foot or leg, which is the worst option, but it also can mean that some air has entered into the foot through the ulcer, that is a less bad option.
• Purplish discoloration of the skin that usually stands for subcutaneous necrosis.
• Osteomyelitis that does not respond to conser­vative measures of therapy.
• The development of uid collections of pus that are improbable to detect clinically.
MRI has an important role in the identication
of the last two indications of surgery. Indeed, it can help both in detecting uid collection and identifying the presence of osteomyelitis. The contrast agent that is used, gadolinium, is injected intravenously and it tends to concentrate in the area of inammation, in this way MRI is useful in increasing the sensitivity of the diagnosis of these clinical features. Nevertheless, we also have to remember that MRI can show some false- positive diagnoses, so it has some limitations.
38.6.2.4 Infected Ischemic Ulcer
A procedure of surgical debridement can also be necessary for severely infected wounds. In this case, when we have to decide to operate a patient, we tend to use criteria that are very similar to those used for the neuropathic foot. Of course, considering that these patients have an ischemic substrate, surgical debridement also needs a study of the arterial perfusion of the foot in order to estimate the potential of the surgical wound to heal. For this reason, all these patients need urgent vascular investigation before a surgical plan.
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38.6.2.5 Additional Surgery
Sometimes debridement can be insufcient and other procedures such as digital or ray amputa­tion is necessary to establish a drainage. The techniques that can be performed are the following:
• For apical infection or apical osteomyelitis, a partial digital amputation can be performed. In the case of the infected toe, the wound can be left temporarily open and the closure can be delayed. Alternatively, the toe can be disar­ticulated at the interphalangeal joint and a skin ap of the plantar and the dorsal part of the foot can be considered.
• According to the Faraboeuf procedure, the amputation of the hallux may also include the removal of the metatarsal head and part of the shaft in order to facilitate the closure and to reduce as much as possible future ulceration of the skin.
• On the other hand, for the lesser toes the amputation should be performed through the metatarso-phalangeal joints.
• If there is an infection of the toe that spreads only to the forefoot, a ray amputation should be performed that includes the removal of the toe and part or all of its corresponding metatarsal.
• In case of extensive forefoot infection, the amputation performed can be an open trans­metatarsal one or a Lisfranc and Chopart’s partial foot amputation.
38.7 Larvatherapy
In particular cases such as neuroischemic foot, in order to debride ulcers we can also use the larvae of the green bottle y (Lucilia sericata). With the larvae, it is possible to achieve an atraumatic physical removal of the necrotic material. In addition, they are also able to produce secretions rich in antimicrobial activity against Gram­positive cocci, including methicillin-resistant Staphylococcus aureus (MRSA).
Furthermore, from a medical maggot farm, sterile maggots can be obtained that can be used for these purposes [22].
Take Home Messages
• Debridement consists of the removal of the necrotic area, dead tissues, and eventually the drainage of wound pock­ets with pus.
• It can be radical or conservative, the choice is related to the ability to distin­guish vital and nonvital tissues.
• Debridement is not only a procedure of wound cleaning but it is a fundamental step in the wound healing process.
• Removing necrotic tissue helps to reduce bacterial load and the risk of infection.
• It is important to pay attention when it is executed in patients with ischemic problems.
References
1. Sibbald R, Williamson D, Orsted H, Campbell K, Keast D, Krasner D, Sibbald D.Preparing the wound bed—debridement, bacterial balance and moisture balance. Ostomy Wound Manage. 2000;46:9.
2. Schultz G, Sibbald R, Falanga V, Ayello E, Dowsett C, Harding K, Romanelli M, Stacey M, Teot L, Vanscheidt W. Wound bed preparation: a system­atic approach to wound management. Wound Repair Regen. 2003;11:S1.
3. Chin G, Schultz G, Stacey M.Principles of wound bed preparation and their application to the treatment of chronic wounds. Primary Intention. 2004;11:171–4.
4. Sibbald R, Orsted HL, Coutts PM, Keast DH. Best practice recommendations for preparing the wound bed: update 2006. Adv Skin Wound Care. 2007;20:406.
5. Vowden KR, Vowden P. Wound debridement, Part 1: Non-sharp techniques. J Wound Care. 1999;8(5):237–40.
6. Fowler E, van Rijswijk L.Using wound debridement to help achieve the goals of care. Ostomy Wound Mange. 1995;41(7A Suppl):23s–35s.
7. Milward PA. Common problems associated with necrotic and sloughy wounds. Br J Nurs. 1995;4(15):896–900.